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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Concept</span><p id="par0005" class="elsevierStylePara elsevierViewall">The metabolic syndrome &#40;MS&#41; has been recognized for several decades&#44; although under different names and with different definitions&#44; but in recent years controversy has arisen concerning its definition and significance&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a> The term does not refer to a specific disease&#44; but to a cluster of metabolic risk factors that tend to occur together&#58; central &#40;or abdominal&#41; obesity&#44; elevated triglycerides&#44; low HDL cholesterol&#44; glucose intolerance and hypertension&#46; It is thus not a genuine clinical entity caused by a single factor&#44; but varies in its components between individuals&#44; particularly between different ethnic groups&#46; Although the concept is well established&#44; there are differences in the criteria for a diagnosis of MS published by various organizations&#44; including the World Health Organization &#40;WHO&#41;&#44; the European Group for Study of Insulin Resistance &#40;EGIR&#41;&#44; the International Diabetes Federation &#40;IDF&#41;&#44; the National Cholesterol Education Program Third Adult Treatment Panel &#40;NCEP-ATPIII&#41;&#44; the American Diabetes Association &#40;ADA&#41; and the American Association of Clinical Endocrinologists &#40;AACE&#41;&#46; Out of this disagreement came a consensus on a worldwide definition of MS&#44; on the initiative of the IDF and the American Heart Association&#47;National Heart&#44; Lung and Blood Institute &#40;AHA&#47;NHLBI&#41;&#44; together with the World Heart Federation&#44; the International Atherosclerosis Society&#44; and the International Association for the Study of Obesity&#44; published in 2009&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> The main difference between the IDF and NCEP-ATP III definitions of MS was in the cutoff used for waist circumference&#44;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;5</span></a> but a single overall value is no longer obligatory&#44; and national or regional cutoffs for waist circumference can be used&#46; In this worldwide definition&#44; the criteria for the clinical diagnosis of MS are&#58; elevated waist circumference &#40;population- and country-specific definitions&#41;&#59; elevated triglycerides &#40;&#8805;150<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#41; or under drug treatment with fibrates or nicotinic acid or taking high-dose omega-3 fatty acids&#59; reduced HDL cholesterol &#40;&#60;40<span class="elsevierStyleHsp" style=""></span>mg&#47;dl in males and &#60;50<span class="elsevierStyleHsp" style=""></span>mg&#47;dl in females&#41; or under drug treatment with fibrates or nicotinic acid&#59; elevated blood pressure &#40;systolic<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>130 and&#47;or diastolic<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>85<span class="elsevierStyleHsp" style=""></span>mmHg&#41; or under antihypertensive therapy&#59; and elevated fasting glucose &#40;&#8805;100<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#41; or under antidiabetic medication&#46; Nevertheless&#44; the definition of MS is not fully harmonized&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Prevalence</span><p id="par0010" class="elsevierStylePara elsevierViewall">The prevalence of MS varies according to age&#44; gender&#44; ethnic origin and the definition used&#44;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7&#8211;10</span></a> the IDF&#47;AHA&#47;NHLBI criteria being more sensitive than those of the NCEP-ATPIII in identifying MS&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9&#44;10</span></a> The prevalence is lower in adolescents than in young adults and the elderly&#59; and lower in males&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7&#8211;9&#44;12</span></a> However&#44; it is estimated that 20&#8211;30&#37; of adults in most countries could be considered to have MS&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">11&#44;13</span></a></p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Risk</span><p id="par0015" class="elsevierStylePara elsevierViewall">It is accepted that individuals with MS are more prone to diabetes and cardiovascular disease&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> A recent meta-analysis shows that in those with MS according to the 2001 NCEP-ATP III criteria and the revised 2004 criteria&#44; the relative risk of cardiovascular events and death is 2 and 1&#46;5&#44; respectively&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a> However&#44; most studies indicate that the ability of the syndrome to predict cardiovascular events or disease progression is no greater than that based on the sum of its components&#46;<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">16&#44;17</span></a> On the other hand&#44; a meta-analysis published in 2006 showed increased risk after adjustment for traditional cardiovascular risk factors&#59; the association was stronger in women&#44; in individuals at lower risk &#40;&#60;10&#37;&#41; and in studies based on the WHO definition rather than the NCEP-ATP III or other definitions&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a> In this meta-analysis the risk associated with MS was greater than the sum of its components&#44; but the question of whether MS is a better predictor of risk than traditional risk factors remains the subject of debate&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Causes</span><p id="par0020" class="elsevierStylePara elsevierViewall">The pathogenesis of MS and of each of its components is not fully understood&#44; but central obesity and insulin resistance are the most important variables in its expression&#46; Excessive visceral adiposity triggers the onset of MS&#44; leading to hyperinsulinemia which may not cause raised fasting or postprandial glucose for years&#44; so long as beta cells continue to respond&#46; However&#44; in genetically predisposed individuals these alterations occur as a result of impaired insulin secretion or reduced glucose tolerance&#46; This pathogenic mechanism&#44; insulin resistance &#40;which is difficult to assess in routine clinical practice&#41;&#44; and the inflammatory process triggered by obesity&#44; underlie virtually all aspects of MS&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a> Adipose tissue dysfunction lies behind the risk arising from visceral obesity&#44; which is associated with atherogenic dyslipidemia &#40;raised triglycerides&#44; low HDL cholesterol&#44; and raised ApoB&#44; small dense LDL particles and small HDL particles&#41;&#44; endothelial dysfunction and hypertension&#46;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">13&#44;19</span></a> Metabolic and pathological factors other than obesity also play a part in this complex process&#58; inflammatory factors&#44; adipocytokines &#40;leptin&#44; adiponectin&#44; resistin&#41;&#44; cortisol&#44; oxidative stress&#44; vascular factors&#44; heredity and lifestyle&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> Not all can be explained by genetics&#44; since the prevalence of MS has risen in recent years but the human genetic profile has not changed&#46; This suggests that the interaction of environmental factors with genetic predisposition leads individuals with MS to accumulate energy in the form of fat&#46; The most likely culprits are excessive consumption of high-energy foods&#44; especially saturated fats&#44; and sedentary lifestyles&#44; all influenced by various factors related to the home&#44; transport&#44; and the workplace&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Prevention and treatment</span><p id="par0025" class="elsevierStylePara elsevierViewall">The evidence indicates that individuals with MS have high cardiovascular risk&#46; The hypothesis that MS results from insulin resistance points the way to a control strategy&#59; since weight loss frequently reduces insulin resistance&#44; measures that can be adopted to prevent and treat MS include a healthy&#44; low-energy diet together with regular exercise<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a> and possibly other measures such as bariatric surgery&#46; Besides&#44; there are currently no drugs that can modulate the mechanisms underlying MS as a whole and reduce the metabolic and cardiovascular effects of the associated risk factors&#46; In individuals in whom lifestyle modification has been insufficient and who are considered at high cardiovascular risk&#44; the residual risk may justify using appropriate therapies to control glucose metabolism abnormalities&#44; lipid disorders and hypertension&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">To summarize&#44; clinicians should treat individuals with MS as a high-risk group and advise them to adopt a healthy lifestyle&#44; while estimating their overall risk with a view to prescribing the therapies recommended for cardiovascular prevention in clinical practice&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">The study by Rossa et al&#46; in this issue of the <span class="elsevierStyleItalic">Journal</span> aimed to determine the prevalence of MS and to identify variables related to its development in a population of hospital workers in Porto Alegre&#44; Brazil&#46; The methodology was that of a cross-sectional study&#44; in which a representative sample of the target population was analyzed&#44; selected on the basis of an estimated MS prevalence of 25&#37;&#44; a figure in agreement with the literature&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">11&#44;13</span></a> Components of MS and variables related to its clinical consequences &#40;diabetes and cardiovascular disease&#41; were excluded from the multivariate analysis&#46; Since one aim of the study was to identify socioeconomic&#44; demographic and occupational factors related to the development of MS&#44; it was necessary to control for variables that are part of its definition&#46; The figure for MS prevalence determined by the study &#40;13&#37;&#41; was lower than estimated&#44; but this is due to the participants&#8217; relatively young mean age &#40;35 years&#41;&#46; It is also not surprising that this figure is lower than in another Brazilian study with a similarly sized sample but of cardiological outpatients &#40;62&#37; in men and 65&#37; in women&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a> and lower than in population studies in Portugal &#8211; 27&#37; in a population with a mean age of 59<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> and 24&#37; in a national survey &#40;mean age 58&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> The higher prevalence of MS in those with a lower educational level is noteworthy&#59; this is further evidence of an environmental component in the pathogenesis of MS interacting with genetic factors&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">The literature on MS is vast and there is still disagreement concerning both its definition and its prevalence&#46; It should be borne in mind that MS prevalence depends on methodological aspects of sampling and diagnosis&#44; and so comparative studies are often of limited value&#46; At all events&#44; MS is common&#44; and is considered a high-risk obesity state&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">23</span></a> At the same time&#44; as obesity increases in the young&#44; the prevalence of MS is also set to rise&#46; Strategies should therefore be defined to raise awareness in different population groups&#44; from schools to the workplace&#46; It is essential to prevent obesity by adopting healthy eating habits and taking regular exercise to lose weight or to avoid weight gain&#46; If this behavioral component is not effectively modified&#44; the result will be an increasingly medicated society&#46; To avoid this scenario&#44; it will be necessary to involve health professionals&#44; educators&#44; organizations working in health-related areas&#44; political decision-makers and public health authorities&#44; since the metabolic syndrome is beginning to take on the dimensions of a pandemic&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conflicts of interest</span><p id="par0045" class="elsevierStylePara elsevierViewall">The author has no conflicts of interest to declare&#46;</p></span></span>"
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Editorial comment
Metabolic syndrome: What is it and how useful is the diagnosis in clinical practice?
Síndrome metabólica: a sua existência e utilidade do diagnóstico na prática clínica
Evangelista Rocha
Serviço de Cardiologia, Hospital Militar Principal, Lisboa, Portugal
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    "titulo" => "Metabolic syndrome&#58; What is it and how useful is the diagnosis in clinical practice&#63;"
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Concept</span><p id="par0005" class="elsevierStylePara elsevierViewall">The metabolic syndrome &#40;MS&#41; has been recognized for several decades&#44; although under different names and with different definitions&#44; but in recent years controversy has arisen concerning its definition and significance&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a> The term does not refer to a specific disease&#44; but to a cluster of metabolic risk factors that tend to occur together&#58; central &#40;or abdominal&#41; obesity&#44; elevated triglycerides&#44; low HDL cholesterol&#44; glucose intolerance and hypertension&#46; It is thus not a genuine clinical entity caused by a single factor&#44; but varies in its components between individuals&#44; particularly between different ethnic groups&#46; Although the concept is well established&#44; there are differences in the criteria for a diagnosis of MS published by various organizations&#44; including the World Health Organization &#40;WHO&#41;&#44; the European Group for Study of Insulin Resistance &#40;EGIR&#41;&#44; the International Diabetes Federation &#40;IDF&#41;&#44; the National Cholesterol Education Program Third Adult Treatment Panel &#40;NCEP-ATPIII&#41;&#44; the American Diabetes Association &#40;ADA&#41; and the American Association of Clinical Endocrinologists &#40;AACE&#41;&#46; Out of this disagreement came a consensus on a worldwide definition of MS&#44; on the initiative of the IDF and the American Heart Association&#47;National Heart&#44; Lung and Blood Institute &#40;AHA&#47;NHLBI&#41;&#44; together with the World Heart Federation&#44; the International Atherosclerosis Society&#44; and the International Association for the Study of Obesity&#44; published in 2009&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> The main difference between the IDF and NCEP-ATP III definitions of MS was in the cutoff used for waist circumference&#44;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;5</span></a> but a single overall value is no longer obligatory&#44; and national or regional cutoffs for waist circumference can be used&#46; In this worldwide definition&#44; the criteria for the clinical diagnosis of MS are&#58; elevated waist circumference &#40;population- and country-specific definitions&#41;&#59; elevated triglycerides &#40;&#8805;150<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#41; or under drug treatment with fibrates or nicotinic acid or taking high-dose omega-3 fatty acids&#59; reduced HDL cholesterol &#40;&#60;40<span class="elsevierStyleHsp" style=""></span>mg&#47;dl in males and &#60;50<span class="elsevierStyleHsp" style=""></span>mg&#47;dl in females&#41; or under drug treatment with fibrates or nicotinic acid&#59; elevated blood pressure &#40;systolic<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>130 and&#47;or diastolic<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>85<span class="elsevierStyleHsp" style=""></span>mmHg&#41; or under antihypertensive therapy&#59; and elevated fasting glucose &#40;&#8805;100<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#41; or under antidiabetic medication&#46; Nevertheless&#44; the definition of MS is not fully harmonized&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Prevalence</span><p id="par0010" class="elsevierStylePara elsevierViewall">The prevalence of MS varies according to age&#44; gender&#44; ethnic origin and the definition used&#44;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7&#8211;10</span></a> the IDF&#47;AHA&#47;NHLBI criteria being more sensitive than those of the NCEP-ATPIII in identifying MS&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9&#44;10</span></a> The prevalence is lower in adolescents than in young adults and the elderly&#59; and lower in males&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7&#8211;9&#44;12</span></a> However&#44; it is estimated that 20&#8211;30&#37; of adults in most countries could be considered to have MS&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">11&#44;13</span></a></p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Risk</span><p id="par0015" class="elsevierStylePara elsevierViewall">It is accepted that individuals with MS are more prone to diabetes and cardiovascular disease&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> A recent meta-analysis shows that in those with MS according to the 2001 NCEP-ATP III criteria and the revised 2004 criteria&#44; the relative risk of cardiovascular events and death is 2 and 1&#46;5&#44; respectively&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a> However&#44; most studies indicate that the ability of the syndrome to predict cardiovascular events or disease progression is no greater than that based on the sum of its components&#46;<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">16&#44;17</span></a> On the other hand&#44; a meta-analysis published in 2006 showed increased risk after adjustment for traditional cardiovascular risk factors&#59; the association was stronger in women&#44; in individuals at lower risk &#40;&#60;10&#37;&#41; and in studies based on the WHO definition rather than the NCEP-ATP III or other definitions&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a> In this meta-analysis the risk associated with MS was greater than the sum of its components&#44; but the question of whether MS is a better predictor of risk than traditional risk factors remains the subject of debate&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Causes</span><p id="par0020" class="elsevierStylePara elsevierViewall">The pathogenesis of MS and of each of its components is not fully understood&#44; but central obesity and insulin resistance are the most important variables in its expression&#46; Excessive visceral adiposity triggers the onset of MS&#44; leading to hyperinsulinemia which may not cause raised fasting or postprandial glucose for years&#44; so long as beta cells continue to respond&#46; However&#44; in genetically predisposed individuals these alterations occur as a result of impaired insulin secretion or reduced glucose tolerance&#46; This pathogenic mechanism&#44; insulin resistance &#40;which is difficult to assess in routine clinical practice&#41;&#44; and the inflammatory process triggered by obesity&#44; underlie virtually all aspects of MS&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a> Adipose tissue dysfunction lies behind the risk arising from visceral obesity&#44; which is associated with atherogenic dyslipidemia &#40;raised triglycerides&#44; low HDL cholesterol&#44; and raised ApoB&#44; small dense LDL particles and small HDL particles&#41;&#44; endothelial dysfunction and hypertension&#46;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">13&#44;19</span></a> Metabolic and pathological factors other than obesity also play a part in this complex process&#58; inflammatory factors&#44; adipocytokines &#40;leptin&#44; adiponectin&#44; resistin&#41;&#44; cortisol&#44; oxidative stress&#44; vascular factors&#44; heredity and lifestyle&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> Not all can be explained by genetics&#44; since the prevalence of MS has risen in recent years but the human genetic profile has not changed&#46; This suggests that the interaction of environmental factors with genetic predisposition leads individuals with MS to accumulate energy in the form of fat&#46; The most likely culprits are excessive consumption of high-energy foods&#44; especially saturated fats&#44; and sedentary lifestyles&#44; all influenced by various factors related to the home&#44; transport&#44; and the workplace&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Prevention and treatment</span><p id="par0025" class="elsevierStylePara elsevierViewall">The evidence indicates that individuals with MS have high cardiovascular risk&#46; The hypothesis that MS results from insulin resistance points the way to a control strategy&#59; since weight loss frequently reduces insulin resistance&#44; measures that can be adopted to prevent and treat MS include a healthy&#44; low-energy diet together with regular exercise<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a> and possibly other measures such as bariatric surgery&#46; Besides&#44; there are currently no drugs that can modulate the mechanisms underlying MS as a whole and reduce the metabolic and cardiovascular effects of the associated risk factors&#46; In individuals in whom lifestyle modification has been insufficient and who are considered at high cardiovascular risk&#44; the residual risk may justify using appropriate therapies to control glucose metabolism abnormalities&#44; lipid disorders and hypertension&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">To summarize&#44; clinicians should treat individuals with MS as a high-risk group and advise them to adopt a healthy lifestyle&#44; while estimating their overall risk with a view to prescribing the therapies recommended for cardiovascular prevention in clinical practice&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">The study by Rossa et al&#46; in this issue of the <span class="elsevierStyleItalic">Journal</span> aimed to determine the prevalence of MS and to identify variables related to its development in a population of hospital workers in Porto Alegre&#44; Brazil&#46; The methodology was that of a cross-sectional study&#44; in which a representative sample of the target population was analyzed&#44; selected on the basis of an estimated MS prevalence of 25&#37;&#44; a figure in agreement with the literature&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">11&#44;13</span></a> Components of MS and variables related to its clinical consequences &#40;diabetes and cardiovascular disease&#41; were excluded from the multivariate analysis&#46; Since one aim of the study was to identify socioeconomic&#44; demographic and occupational factors related to the development of MS&#44; it was necessary to control for variables that are part of its definition&#46; The figure for MS prevalence determined by the study &#40;13&#37;&#41; was lower than estimated&#44; but this is due to the participants&#8217; relatively young mean age &#40;35 years&#41;&#46; It is also not surprising that this figure is lower than in another Brazilian study with a similarly sized sample but of cardiological outpatients &#40;62&#37; in men and 65&#37; in women&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a> and lower than in population studies in Portugal &#8211; 27&#37; in a population with a mean age of 59<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> and 24&#37; in a national survey &#40;mean age 58&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> The higher prevalence of MS in those with a lower educational level is noteworthy&#59; this is further evidence of an environmental component in the pathogenesis of MS interacting with genetic factors&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">The literature on MS is vast and there is still disagreement concerning both its definition and its prevalence&#46; It should be borne in mind that MS prevalence depends on methodological aspects of sampling and diagnosis&#44; and so comparative studies are often of limited value&#46; At all events&#44; MS is common&#44; and is considered a high-risk obesity state&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">23</span></a> At the same time&#44; as obesity increases in the young&#44; the prevalence of MS is also set to rise&#46; Strategies should therefore be defined to raise awareness in different population groups&#44; from schools to the workplace&#46; It is essential to prevent obesity by adopting healthy eating habits and taking regular exercise to lose weight or to avoid weight gain&#46; If this behavioral component is not effectively modified&#44; the result will be an increasingly medicated society&#46; To avoid this scenario&#44; it will be necessary to involve health professionals&#44; educators&#44; organizations working in health-related areas&#44; political decision-makers and public health authorities&#44; since the metabolic syndrome is beginning to take on the dimensions of a pandemic&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conflicts of interest</span><p id="par0045" class="elsevierStylePara elsevierViewall">The author has no conflicts of interest to declare&#46;</p></span></span>"
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        "nota" => "<p class="elsevierStyleNotepara">Please cite this article as&#58; Rocha&#44; E&#46; S&#237;ndrome metab&#243;lica&#58; a sua exist&#234;ncia e utilidade do diagn&#243;stico na pr&#225;tica cl&#237;nica&#46; Rev Port Cardiol 2012&#46; <span class="elsevierStyleInterRef" href="http://dx.doi.org/10.1016/j.repc.2012.07.001">http&#58;&#47;&#47;dx&#46;doi&#46;org&#47;10&#46;1016&#47;j&#46;repc&#46;2012&#46;07&#46;001</span></p>"
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