array:24 [
  "pii" => "S2174204921001884"
  "issn" => "21742049"
  "doi" => "10.1016/j.repce.2021.07.019"
  "estado" => "S300"
  "fechaPublicacion" => "2021-07-01"
  "aid" => "1738"
  "copyrightAnyo" => "2021"
  "documento" => "simple-article"
  "crossmark" => 1
  "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
  "subdocumento" => "dis"
  "cita" => "Rev Port Cardiol. 2021;40:499-500"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:1 [
    "total" => 0
  ]
  "Traduccion" => array:1 [
    "en" => array:19 [
      "pii" => "S0870255121001748"
      "issn" => "08702551"
      "doi" => "10.1016/j.repc.2021.04.001"
      "estado" => "S300"
      "fechaPublicacion" => "2021-07-01"
      "aid" => "1738"
      "documento" => "simple-article"
      "crossmark" => 1
      "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
      "subdocumento" => "dis"
      "cita" => "Rev Port Cardiol. 2021;40:499-500"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:1 [
        "total" => 0
      ]
      "en" => array:10 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Editorial comment</span>"
        "titulo" => "Contrast-induced nephropathy&#58; Can we better predict and prevent it&#63;"
        "tienePdf" => "en"
        "tieneTextoCompleto" => "en"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "499"
            "paginaFinal" => "500"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "pt" => array:1 [
            "titulo" => "Nefropatia induzida por contraste&#58; poderemos prever e preveni-la melhor&#63;"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "en" => true
        ]
        "contienePdf" => array:1 [
          "en" => true
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Pedro Pinto Cardoso"
            "autores" => array:1 [
              0 => array:2 [
                "nombre" => "Pedro Pinto"
                "apellidos" => "Cardoso"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "en"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S2174204921001884"
          "doi" => "10.1016/j.repce.2021.07.019"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204921001884?idApp=UINPBA00004E"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255121001748?idApp=UINPBA00004E"
      "url" => "/08702551/0000004000000007/v1_202107090532/S0870255121001748/v1_202107090532/en/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S2174204921001264"
    "issn" => "21742049"
    "doi" => "10.1016/j.repce.2020.07.016"
    "estado" => "S300"
    "fechaPublicacion" => "2021-07-01"
    "aid" => "1616"
    "documento" => "article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "sco"
    "cita" => "Rev Port Cardiol. 2021;40:501-4"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "titulo" => "Is there a gender gap in national Cardiology research&#63; Data review from the Portuguese Journal of Cardiology"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "pt"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "501"
          "paginaFinal" => "504"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "pt" => array:1 [
          "titulo" => "Ainda persiste um <span class="elsevierStyleItalic">gap</span> de g&#233;nero na investiga&#231;&#227;o cardiol&#243;gica nacional&#63; Uma revis&#227;o de dados da Revista Portuguesa de Cardiologia"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "pt" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Ana Teresa Tim&#243;teo"
          "autores" => array:1 [
            0 => array:2 [
              "nombre" => "Ana Teresa"
              "apellidos" => "Tim&#243;teo"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "pt" => array:9 [
        "pii" => "S0870255120304145"
        "doi" => "10.1016/j.repc.2020.07.010"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "pt"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255120304145?idApp=UINPBA00004E"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204921001264?idApp=UINPBA00004E"
    "url" => "/21742049/0000004000000007/v1_202107150708/S2174204921001264/v1_202107150708/en/main.assets"
  ]
  "itemAnterior" => array:20 [
    "pii" => "S2174204921001872"
    "issn" => "21742049"
    "doi" => "10.1016/j.repce.2021.07.018"
    "estado" => "S300"
    "fechaPublicacion" => "2021-07-01"
    "aid" => "1654"
    "copyright" => "Sociedade Portuguesa de Cardiologia"
    "documento" => "article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "fla"
    "cita" => "Rev Port Cardiol. 2021;40:489-97"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>"
      "titulo" => "Predictive value of oxidant and antioxidant status for contrast-induced nephropathy after percutaneous coronary intervention for ST-segment elevation myocardial infarction"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "pt"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "489"
          "paginaFinal" => "497"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "pt" => array:1 [
          "titulo" => "Valor preditivo dos estados oxidante e antioxidante na nefropatia de contraste ap&#243;s interven&#231;&#227;o coron&#225;ria percut&#226;nea em enfarte do mioc&#225;rdio com eleva&#231;&#227;o do segmento ST"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "pt" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 1012
              "Ancho" => 1341
              "Tamanyo" => 72101
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Receiver operating characteristics curve with calculated area under the curve and optimal cut-off point for oxidative stress index&#44; total antioxidant capacity&#44; and total oxidant status to identify the presence of contrast-induced nephropathy&#46; OSI&#58; oxidative stress index&#59; TAS&#58; total antioxidant status&#59; TOS&#58; total oxidant status&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Fatih Aksoy, Hasan Ayd&#305;n Ba&#351;, Ali Ba&#287;c&#305;, Hasan Basri Sava&#351;"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "Fatih"
              "apellidos" => "Aksoy"
            ]
            1 => array:2 [
              "nombre" => "Hasan"
              "apellidos" => "Ayd&#305;n Ba&#351;"
            ]
            2 => array:2 [
              "nombre" => "Ali"
              "apellidos" => "Ba&#287;c&#305;"
            ]
            3 => array:2 [
              "nombre" => "Hasan"
              "apellidos" => "Basri Sava&#351;"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S0870255120304947"
        "doi" => "10.1016/j.repc.2020.08.010"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255120304947?idApp=UINPBA00004E"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204921001872?idApp=UINPBA00004E"
    "url" => "/21742049/0000004000000007/v1_202107150708/S2174204921001872/v1_202107150708/en/main.assets"
  ]
  "en" => array:12 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Editorial comment</span>"
    "titulo" => "Contrast-induced nephropathy&#58; Can we better predict and prevent it&#63;"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "499"
        "paginaFinal" => "500"
      ]
    ]
    "autores" => array:1 [
      0 => array:3 [
        "autoresLista" => "Pedro Pinto Cardoso"
        "autores" => array:1 [
          0 => array:4 [
            "nombre" => "Pedro Pinto"
            "apellidos" => "Cardoso"
            "email" => array:1 [
              0 => "pedropintocardoso@gmail.com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Structural and Coronary Heart Disease Unit&#44; Centro Cardiovascular da Universidade de Lisboa&#44; Faculdade de Medicina&#44; Universidade de Lisboa&#44; Lisboa&#44; Portugal"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Servi&#231;o de Cardiologia&#44; Departamento de Cora&#231;&#227;o e Vasos&#44; CHULN Hospital de Santa Maria&#44; Lisboa&#44; Portugal"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "pt" => array:1 [
        "titulo" => "Nefropatia induzida por contraste&#58; poderemos prever e preveni-la melhor&#63;"
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Contrast-induced nephropathy &#40;CIN&#41; is a major concern in daily practice for everyone working in interventional cardiology&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">The use of contrast agents has been growing due to the increasing number of procedures that use them&#44; such as&#58; structural heart therapies and primary angioplasty for ST-segment elevation myocardial infarction &#40;STEMI&#41;&#46; Contrast-induced nephropathy has a major impact on prognosis after primary percutaneous coronary intervention &#40;PCI&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">1&#44;2</span></a> In this particular setting&#44; it is problematic due to the clinical instability of the patient and the impossibility of prevention in an emerging situation&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">3</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Contrast-induced nephropathy is a well-known cause of acute renal failure but the underlying mechanisms are yet to be fully understood&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The evidence is in favor of a combination of direct toxic effects on tubular epithelial cells and renal ischemia as the pathogenetic role&#46; The generation of reactive oxygen species&#44; which in turn scavenge nitric oxide&#44; further increases hypoxia&#46;<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">4&#44;5</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Identified risk factors for CIN are the baseline renal function itself&#44; diabetes&#44; acute myocardial infarction&#44; shock and the volume of contrast medium administered during the procedure&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">4</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Among patients with STEMI&#44; the role of contrast agents has been questioned in acute kidney injury &#40;AKI&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">6</span></a> In this study&#44; Caspi et al&#46; concluded that the risk for AKI was similar among STEMI patients regardless of exposure to contrast material&#46; Independent predictors of AKI in patients who underwent primary PCI included age &#8805;70 years&#44; insulin-treated diabetes&#44; diuretic therapy&#44; previous infarction&#44; baseline estimated glomerular filtration rate&#44; and variables related to the presence of pump failure &#40;higher Killip class&#44; intra-aortic balloon pump use&#41; and reduced left ventricular ejection fraction but not contrast agent dose&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">In this issue Fatih Aksoy et al&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">7</span></a> assessed the association between total oxidant status &#40;TOS&#41;&#44; total antioxidant capacity &#40;TAC&#41; and CIN in patients with STEMI&#46; They assessed a cohort of 341 patients&#46; In a multivariate regression analysis&#44; they concluded that high-sensitivity C-reactive protein&#44; uric acid and oxidative status index predicted the development of CIN&#46; They also suggest that incorporating these variables into existing risk scores like the Mehran risk score<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">8</span></a> could improve its accuracy&#46; Nevertheless&#44; only 16&#46;7&#37; of these patients developed CIN&#44; which the authors acknowledged could have influenced their results&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">The results suggest&#44; nonetheless&#44; that TOC&#44; TAC and oxidative stress index are associated with the development of CIN&#44; reinforcing the possibility that oxidative stress may be partially responsible for the development of CIN&#44; as already suggested by others&#46;<a class="elsevierStyleCrossRefs" href="#bib0120"><span class="elsevierStyleSup">9&#44;10</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Preventive measures for CIN&#44; such as fluid administration&#44; pharmacological strategies&#44; use of different contrast agents and renal replacement therapies&#44; have been extensively assessed in many trials&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">There seems to be some consensus on fluid administration as a means of protecting from CIN&#44; but the results from trials are conflicting&#46;<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">11&#44;12</span></a> The addition of sodium bicarbonate may provide additional kidney protection by alkalinizing renal tubular fluid and thereby minimizing tubular damage&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">13</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">Fluid administration possibly associated with furosemide forced diuresis seems to be a good strategy&#44; although there is the risk of hypovolemia&#46; The fear of giving too much volume&#44; mainly in patients with low ejection fraction can&#44; on the other hand&#44; lead to suboptimal protection&#46; Renal Guard&#44; a device enabling volume administration to be balanced with urine output&#44; showed that a high urine output was achievable&#44; while avoiding hypovolemia&#44; thus protecting from CIN&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">14</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">Randomized trials with N-acetylcysteine had conflicting results but this drug can have a protective effect&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">15</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">The authors tried to identify further markers of increased risk of AKI&#46; Still&#44; measuring TOC and TAC in daily practice does not seem feasible&#46; The result of this study may however contribute to further investigation on the mechanisms of CIN and possibly lead to novel therapeutic options to prevent CIN&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">Currently&#44; hydration and possibly sodium bicarbonate&#47;N-acetylcysteine seem to be the best and only way to prevent CIN&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of interest</span><p id="par0080" class="elsevierStylePara elsevierViewall">The author has no conflicts of interest to declare&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:2 [
        0 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Conflicts of interest"
        ]
        1 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:15 [
            0 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Impact of renal insufficiency in patients undergoing primary angioplasty for acute myocardial infarction"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "H&#46;M&#46; Sadeghi"
                            1 => "G&#46;W&#46; Stone"
                            2 => "C&#46;L&#46; Grines"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/01.CIR. 0000103623.63687.21"
                      "Revista" => array:3 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "2003"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29752376"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Contrast-induced nephropathy in patients undergoing primary angioplasty for acute myocardial infarction"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "G&#46; Marenzi"
                            1 => "G&#46; Lauri"
                            2 => "E&#46; Assanelli"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jacc.2004.07.043"
                      "Revista" => array:3 [
                        "tituloSerie" => "J Am Coll Cardiol"
                        "fecha" => "2004"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27151352"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Incidence and prognostic importance of acute renal failure after percutaneous coronary intervention"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "C&#46;S&#46; Rihal"
                            1 => "S&#46;C&#46; Textor"
                            2 => "D&#46;E&#46; Grill"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/01.CIR. 0000016043.87291.33"
                      "Revista" => array:3 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "2002"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29752376"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pathophysiology of contrast-induced nephropathy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "P&#46;C&#46;Y&#46; Wong"
                            1 => "Z&#46; Li"
                            2 => "J&#46; Guo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ijcard.2011.06.115"
                      "Revista" => array:3 [
                        "tituloSerie" => "Int J Cardiol"
                        "fecha" => "2012"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21757243"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Contrast-induced kidney injury&#58; mechanisms&#44; risk factors&#44; and prevention"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "E&#46; Seeliger"
                            1 => "M&#46; Sendeski"
                            2 => "C&#46;S&#46; Rihal"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/eurheartj/ehr494"
                      "Revista" => array:3 [
                        "tituloSerie" => "Eur Heart J"
                        "fecha" => "2012"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27141094"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0105"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Acute kidney injury after primary angioplasty&#58; is contrast-induced nephropathy the culprit&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "O&#46; Caspi"
                            1 => "M&#46; Habib"
                            2 => "Y&#46; Cohen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/JAHA.117.005715"
                      "Revista" => array:2 [
                        "tituloSerie" => "J Am Heart Assoc"
                        "fecha" => "2017"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0110"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Predictive value of oxidant and antioxidant status for contrast-induced nephropathy after percutaneous coronary intervention for ST-segment elevation myocardial infarction"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "F&#46; Aksoy"
                            1 => "H&#46; Ayd&#305;n Ba&#351;"
                            2 => "A&#46; Ba&#287;c&#305;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.repc.2020.08.010"
                      "Revista" => array:3 [
                        "tituloSerie" => "Rev Port Cardiol"
                        "fecha" => "2021"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2631811"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0115"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A simple risk score for prediction of contrast-induced nephropathy after percutaneous coronary intervention&#58; development and initial validation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "R&#46; Mehran"
                            1 => "E&#46;D&#46; Aymong"
                            2 => "E&#46; Nikolsky"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jacc.2004.06.068"
                      "Revista" => array:3 [
                        "tituloSerie" => "J Am Coll Cardiol"
                        "fecha" => "2004"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27151352"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0120"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Oxygen free radicals and contrast nephropathy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "R&#46;E&#46; Katholi"
                            1 => "W&#46;T&#46; Woods"
                            2 => "G&#46;J&#46; Taylor"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1053/ajkd.1998.v32.pm9669426"
                      "Revista" => array:2 [
                        "tituloSerie" => "Am J Kidney Dis"
                        "fecha" => "1998"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0125"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Renal effects of N-acetylcysteine in patients at risk for contrast nephropathy&#58; decrease in oxidant stress-mediated renal tubular injury"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "L&#46;F&#46; Drager"
                            1 => "L&#46; Andrade"
                            2 => "J&#46;F&#46; Barros de Toledo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/ndt/gfh261"
                      "Revista" => array:3 [
                        "tituloSerie" => "Nephrol Dial Transplant"
                        "fecha" => "2004"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22773240"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0130"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prophylactic intravenous hydration to protect renal function from intravascular iodinated contrast material &#40;AMACING&#41;&#58; long-term results of a prospective&#44; randomised&#44; controlled trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "E&#46;C&#46; Nijssen"
                            1 => "P&#46;J&#46; Nelemans"
                            2 => "R&#46;J&#46; Rennenberg"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.eclinm.2018.10.007"
                      "Revista" => array:2 [
                        "tituloSerie" => "EClinicalMedicine"
                        "fecha" => "2018"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0135"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prevention of contrast media-associated nephropathy&#58; randomized comparison of 2 hydration regimens in 1620 patients undergoing coronary angioplasty"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "C&#46; Mueller"
                            1 => "G&#46; Buerkle"
                            2 => "H&#46;J&#46; Buettner"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/archinte.162.3.329"
                      "Revista" => array:3 [
                        "tituloSerie" => "Arch Intern Med"
                        "fecha" => "2002"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/13704490"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0140"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sodium bicarbonate vs sodium chloride for the prevention of contrast medium-induced nephropathy in patients undergoing coronary angiography&#58; a randomized trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "S&#46;S&#46; Brar"
                            1 => "A&#46;Y&#46;J&#46; Shen"
                            2 => "M&#46;B&#46; Jorgensen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/jama.300.9.1038"
                      "Revista" => array:2 [
                        "tituloSerie" => "JAMA - J Am Med Assoc"
                        "fecha" => "2008"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0145"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "RenalGuard system in high-risk patients for contrast-induced acute kidney injury"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "C&#46; Briguori"
                            1 => "G&#46; Visconti"
                            2 => "M&#46; Donahue"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ahj.2015.12.005"
                      "Revista" => array:3 [
                        "tituloSerie" => "Am Heart J"
                        "fecha" => "2016"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32866454"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0150"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prevention of radiographic-contrast-agent-induced reductions in renal function by acetylcysteine"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "M&#46; Tepel"
                            1 => "M&#46; van der Giet"
                            2 => "C&#46; Schwarzfeld"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/nejm200007203430304"
                      "Revista" => array:3 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2000"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32222134"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/21742049/0000004000000007/v1_202107150708/S2174204921001884/v1_202107150708/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "9917"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Original Articles"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/21742049/0000004000000007/v1_202107150708/S2174204921001884/v1_202107150708/en/main.pdf?idApp=UINPBA00004E&text.app=https://revportcardiol.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204921001884?idApp=UINPBA00004E"
]
Share
Journal Information

Statistics

Follow this link to access the full text of the article

Editorial comment
Contrast-induced nephropathy: Can we better predict and prevent it?
Nefropatia induzida por contraste: poderemos prever e preveni-la melhor?
Pedro Pinto Cardosoa,b
a Structural and Coronary Heart Disease Unit, Centro Cardiovascular da Universidade de Lisboa, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal
b Serviço de Cardiologia, Departamento de Coração e Vasos, CHULN Hospital de Santa Maria, Lisboa, Portugal
Read
2759
Times
was read the article
1294
Total PDF
1465
Total HTML
Share statistics
 array:24 [
  "pii" => "S2174204921001884"
  "issn" => "21742049"
  "doi" => "10.1016/j.repce.2021.07.019"
  "estado" => "S300"
  "fechaPublicacion" => "2021-07-01"
  "aid" => "1738"
  "copyrightAnyo" => "2021"
  "documento" => "simple-article"
  "crossmark" => 1
  "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
  "subdocumento" => "dis"
  "cita" => "Rev Port Cardiol. 2021;40:499-500"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:1 [
    "total" => 0
  ]
  "Traduccion" => array:1 [
    "en" => array:19 [
      "pii" => "S0870255121001748"
      "issn" => "08702551"
      "doi" => "10.1016/j.repc.2021.04.001"
      "estado" => "S300"
      "fechaPublicacion" => "2021-07-01"
      "aid" => "1738"
      "documento" => "simple-article"
      "crossmark" => 1
      "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
      "subdocumento" => "dis"
      "cita" => "Rev Port Cardiol. 2021;40:499-500"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:1 [
        "total" => 0
      ]
      "en" => array:10 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Editorial comment</span>"
        "titulo" => "Contrast-induced nephropathy&#58; Can we better predict and prevent it&#63;"
        "tienePdf" => "en"
        "tieneTextoCompleto" => "en"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "499"
            "paginaFinal" => "500"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "pt" => array:1 [
            "titulo" => "Nefropatia induzida por contraste&#58; poderemos prever e preveni-la melhor&#63;"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "en" => true
        ]
        "contienePdf" => array:1 [
          "en" => true
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Pedro Pinto Cardoso"
            "autores" => array:1 [
              0 => array:2 [
                "nombre" => "Pedro Pinto"
                "apellidos" => "Cardoso"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "en"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S2174204921001884"
          "doi" => "10.1016/j.repce.2021.07.019"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204921001884?idApp=UINPBA00004E"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255121001748?idApp=UINPBA00004E"
      "url" => "/08702551/0000004000000007/v1_202107090532/S0870255121001748/v1_202107090532/en/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S2174204921001264"
    "issn" => "21742049"
    "doi" => "10.1016/j.repce.2020.07.016"
    "estado" => "S300"
    "fechaPublicacion" => "2021-07-01"
    "aid" => "1616"
    "documento" => "article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "sco"
    "cita" => "Rev Port Cardiol. 2021;40:501-4"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "titulo" => "Is there a gender gap in national Cardiology research&#63; Data review from the Portuguese Journal of Cardiology"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "pt"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "501"
          "paginaFinal" => "504"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "pt" => array:1 [
          "titulo" => "Ainda persiste um <span class="elsevierStyleItalic">gap</span> de g&#233;nero na investiga&#231;&#227;o cardiol&#243;gica nacional&#63; Uma revis&#227;o de dados da Revista Portuguesa de Cardiologia"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "pt" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Ana Teresa Tim&#243;teo"
          "autores" => array:1 [
            0 => array:2 [
              "nombre" => "Ana Teresa"
              "apellidos" => "Tim&#243;teo"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "pt" => array:9 [
        "pii" => "S0870255120304145"
        "doi" => "10.1016/j.repc.2020.07.010"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "pt"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255120304145?idApp=UINPBA00004E"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204921001264?idApp=UINPBA00004E"
    "url" => "/21742049/0000004000000007/v1_202107150708/S2174204921001264/v1_202107150708/en/main.assets"
  ]
  "itemAnterior" => array:20 [
    "pii" => "S2174204921001872"
    "issn" => "21742049"
    "doi" => "10.1016/j.repce.2021.07.018"
    "estado" => "S300"
    "fechaPublicacion" => "2021-07-01"
    "aid" => "1654"
    "copyright" => "Sociedade Portuguesa de Cardiologia"
    "documento" => "article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "fla"
    "cita" => "Rev Port Cardiol. 2021;40:489-97"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>"
      "titulo" => "Predictive value of oxidant and antioxidant status for contrast-induced nephropathy after percutaneous coronary intervention for ST-segment elevation myocardial infarction"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "pt"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "489"
          "paginaFinal" => "497"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "pt" => array:1 [
          "titulo" => "Valor preditivo dos estados oxidante e antioxidante na nefropatia de contraste ap&#243;s interven&#231;&#227;o coron&#225;ria percut&#226;nea em enfarte do mioc&#225;rdio com eleva&#231;&#227;o do segmento ST"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "pt" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 1012
              "Ancho" => 1341
              "Tamanyo" => 72101
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Receiver operating characteristics curve with calculated area under the curve and optimal cut-off point for oxidative stress index&#44; total antioxidant capacity&#44; and total oxidant status to identify the presence of contrast-induced nephropathy&#46; OSI&#58; oxidative stress index&#59; TAS&#58; total antioxidant status&#59; TOS&#58; total oxidant status&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Fatih Aksoy, Hasan Ayd&#305;n Ba&#351;, Ali Ba&#287;c&#305;, Hasan Basri Sava&#351;"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "Fatih"
              "apellidos" => "Aksoy"
            ]
            1 => array:2 [
              "nombre" => "Hasan"
              "apellidos" => "Ayd&#305;n Ba&#351;"
            ]
            2 => array:2 [
              "nombre" => "Ali"
              "apellidos" => "Ba&#287;c&#305;"
            ]
            3 => array:2 [
              "nombre" => "Hasan"
              "apellidos" => "Basri Sava&#351;"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S0870255120304947"
        "doi" => "10.1016/j.repc.2020.08.010"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255120304947?idApp=UINPBA00004E"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204921001872?idApp=UINPBA00004E"
    "url" => "/21742049/0000004000000007/v1_202107150708/S2174204921001872/v1_202107150708/en/main.assets"
  ]
  "en" => array:12 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Editorial comment</span>"
    "titulo" => "Contrast-induced nephropathy&#58; Can we better predict and prevent it&#63;"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "499"
        "paginaFinal" => "500"
      ]
    ]
    "autores" => array:1 [
      0 => array:3 [
        "autoresLista" => "Pedro Pinto Cardoso"
        "autores" => array:1 [
          0 => array:4 [
            "nombre" => "Pedro Pinto"
            "apellidos" => "Cardoso"
            "email" => array:1 [
              0 => "pedropintocardoso@gmail.com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Structural and Coronary Heart Disease Unit&#44; Centro Cardiovascular da Universidade de Lisboa&#44; Faculdade de Medicina&#44; Universidade de Lisboa&#44; Lisboa&#44; Portugal"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Servi&#231;o de Cardiologia&#44; Departamento de Cora&#231;&#227;o e Vasos&#44; CHULN Hospital de Santa Maria&#44; Lisboa&#44; Portugal"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "pt" => array:1 [
        "titulo" => "Nefropatia induzida por contraste&#58; poderemos prever e preveni-la melhor&#63;"
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Contrast-induced nephropathy &#40;CIN&#41; is a major concern in daily practice for everyone working in interventional cardiology&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">The use of contrast agents has been growing due to the increasing number of procedures that use them&#44; such as&#58; structural heart therapies and primary angioplasty for ST-segment elevation myocardial infarction &#40;STEMI&#41;&#46; Contrast-induced nephropathy has a major impact on prognosis after primary percutaneous coronary intervention &#40;PCI&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">1&#44;2</span></a> In this particular setting&#44; it is problematic due to the clinical instability of the patient and the impossibility of prevention in an emerging situation&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">3</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Contrast-induced nephropathy is a well-known cause of acute renal failure but the underlying mechanisms are yet to be fully understood&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The evidence is in favor of a combination of direct toxic effects on tubular epithelial cells and renal ischemia as the pathogenetic role&#46; The generation of reactive oxygen species&#44; which in turn scavenge nitric oxide&#44; further increases hypoxia&#46;<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">4&#44;5</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Identified risk factors for CIN are the baseline renal function itself&#44; diabetes&#44; acute myocardial infarction&#44; shock and the volume of contrast medium administered during the procedure&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">4</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Among patients with STEMI&#44; the role of contrast agents has been questioned in acute kidney injury &#40;AKI&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">6</span></a> In this study&#44; Caspi et al&#46; concluded that the risk for AKI was similar among STEMI patients regardless of exposure to contrast material&#46; Independent predictors of AKI in patients who underwent primary PCI included age &#8805;70 years&#44; insulin-treated diabetes&#44; diuretic therapy&#44; previous infarction&#44; baseline estimated glomerular filtration rate&#44; and variables related to the presence of pump failure &#40;higher Killip class&#44; intra-aortic balloon pump use&#41; and reduced left ventricular ejection fraction but not contrast agent dose&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">In this issue Fatih Aksoy et al&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">7</span></a> assessed the association between total oxidant status &#40;TOS&#41;&#44; total antioxidant capacity &#40;TAC&#41; and CIN in patients with STEMI&#46; They assessed a cohort of 341 patients&#46; In a multivariate regression analysis&#44; they concluded that high-sensitivity C-reactive protein&#44; uric acid and oxidative status index predicted the development of CIN&#46; They also suggest that incorporating these variables into existing risk scores like the Mehran risk score<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">8</span></a> could improve its accuracy&#46; Nevertheless&#44; only 16&#46;7&#37; of these patients developed CIN&#44; which the authors acknowledged could have influenced their results&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">The results suggest&#44; nonetheless&#44; that TOC&#44; TAC and oxidative stress index are associated with the development of CIN&#44; reinforcing the possibility that oxidative stress may be partially responsible for the development of CIN&#44; as already suggested by others&#46;<a class="elsevierStyleCrossRefs" href="#bib0120"><span class="elsevierStyleSup">9&#44;10</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Preventive measures for CIN&#44; such as fluid administration&#44; pharmacological strategies&#44; use of different contrast agents and renal replacement therapies&#44; have been extensively assessed in many trials&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">There seems to be some consensus on fluid administration as a means of protecting from CIN&#44; but the results from trials are conflicting&#46;<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">11&#44;12</span></a> The addition of sodium bicarbonate may provide additional kidney protection by alkalinizing renal tubular fluid and thereby minimizing tubular damage&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">13</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">Fluid administration possibly associated with furosemide forced diuresis seems to be a good strategy&#44; although there is the risk of hypovolemia&#46; The fear of giving too much volume&#44; mainly in patients with low ejection fraction can&#44; on the other hand&#44; lead to suboptimal protection&#46; Renal Guard&#44; a device enabling volume administration to be balanced with urine output&#44; showed that a high urine output was achievable&#44; while avoiding hypovolemia&#44; thus protecting from CIN&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">14</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">Randomized trials with N-acetylcysteine had conflicting results but this drug can have a protective effect&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">15</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">The authors tried to identify further markers of increased risk of AKI&#46; Still&#44; measuring TOC and TAC in daily practice does not seem feasible&#46; The result of this study may however contribute to further investigation on the mechanisms of CIN and possibly lead to novel therapeutic options to prevent CIN&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">Currently&#44; hydration and possibly sodium bicarbonate&#47;N-acetylcysteine seem to be the best and only way to prevent CIN&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of interest</span><p id="par0080" class="elsevierStylePara elsevierViewall">The author has no conflicts of interest to declare&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:2 [
        0 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Conflicts of interest"
        ]
        1 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:15 [
            0 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Impact of renal insufficiency in patients undergoing primary angioplasty for acute myocardial infarction"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "H&#46;M&#46; Sadeghi"
                            1 => "G&#46;W&#46; Stone"
                            2 => "C&#46;L&#46; Grines"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/01.CIR. 0000103623.63687.21"
                      "Revista" => array:3 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "2003"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29752376"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Contrast-induced nephropathy in patients undergoing primary angioplasty for acute myocardial infarction"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "G&#46; Marenzi"
                            1 => "G&#46; Lauri"
                            2 => "E&#46; Assanelli"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jacc.2004.07.043"
                      "Revista" => array:3 [
                        "tituloSerie" => "J Am Coll Cardiol"
                        "fecha" => "2004"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27151352"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Incidence and prognostic importance of acute renal failure after percutaneous coronary intervention"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "C&#46;S&#46; Rihal"
                            1 => "S&#46;C&#46; Textor"
                            2 => "D&#46;E&#46; Grill"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/01.CIR. 0000016043.87291.33"
                      "Revista" => array:3 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "2002"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29752376"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pathophysiology of contrast-induced nephropathy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "P&#46;C&#46;Y&#46; Wong"
                            1 => "Z&#46; Li"
                            2 => "J&#46; Guo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ijcard.2011.06.115"
                      "Revista" => array:3 [
                        "tituloSerie" => "Int J Cardiol"
                        "fecha" => "2012"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21757243"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Contrast-induced kidney injury&#58; mechanisms&#44; risk factors&#44; and prevention"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "E&#46; Seeliger"
                            1 => "M&#46; Sendeski"
                            2 => "C&#46;S&#46; Rihal"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/eurheartj/ehr494"
                      "Revista" => array:3 [
                        "tituloSerie" => "Eur Heart J"
                        "fecha" => "2012"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27141094"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0105"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Acute kidney injury after primary angioplasty&#58; is contrast-induced nephropathy the culprit&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "O&#46; Caspi"
                            1 => "M&#46; Habib"
                            2 => "Y&#46; Cohen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/JAHA.117.005715"
                      "Revista" => array:2 [
                        "tituloSerie" => "J Am Heart Assoc"
                        "fecha" => "2017"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0110"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Predictive value of oxidant and antioxidant status for contrast-induced nephropathy after percutaneous coronary intervention for ST-segment elevation myocardial infarction"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "F&#46; Aksoy"
                            1 => "H&#46; Ayd&#305;n Ba&#351;"
                            2 => "A&#46; Ba&#287;c&#305;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.repc.2020.08.010"
                      "Revista" => array:3 [
                        "tituloSerie" => "Rev Port Cardiol"
                        "fecha" => "2021"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2631811"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0115"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A simple risk score for prediction of contrast-induced nephropathy after percutaneous coronary intervention&#58; development and initial validation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "R&#46; Mehran"
                            1 => "E&#46;D&#46; Aymong"
                            2 => "E&#46; Nikolsky"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jacc.2004.06.068"
                      "Revista" => array:3 [
                        "tituloSerie" => "J Am Coll Cardiol"
                        "fecha" => "2004"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27151352"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0120"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Oxygen free radicals and contrast nephropathy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "R&#46;E&#46; Katholi"
                            1 => "W&#46;T&#46; Woods"
                            2 => "G&#46;J&#46; Taylor"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1053/ajkd.1998.v32.pm9669426"
                      "Revista" => array:2 [
                        "tituloSerie" => "Am J Kidney Dis"
                        "fecha" => "1998"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0125"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Renal effects of N-acetylcysteine in patients at risk for contrast nephropathy&#58; decrease in oxidant stress-mediated renal tubular injury"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "L&#46;F&#46; Drager"
                            1 => "L&#46; Andrade"
                            2 => "J&#46;F&#46; Barros de Toledo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/ndt/gfh261"
                      "Revista" => array:3 [
                        "tituloSerie" => "Nephrol Dial Transplant"
                        "fecha" => "2004"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22773240"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0130"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prophylactic intravenous hydration to protect renal function from intravascular iodinated contrast material &#40;AMACING&#41;&#58; long-term results of a prospective&#44; randomised&#44; controlled trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "E&#46;C&#46; Nijssen"
                            1 => "P&#46;J&#46; Nelemans"
                            2 => "R&#46;J&#46; Rennenberg"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.eclinm.2018.10.007"
                      "Revista" => array:2 [
                        "tituloSerie" => "EClinicalMedicine"
                        "fecha" => "2018"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0135"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prevention of contrast media-associated nephropathy&#58; randomized comparison of 2 hydration regimens in 1620 patients undergoing coronary angioplasty"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "C&#46; Mueller"
                            1 => "G&#46; Buerkle"
                            2 => "H&#46;J&#46; Buettner"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/archinte.162.3.329"
                      "Revista" => array:3 [
                        "tituloSerie" => "Arch Intern Med"
                        "fecha" => "2002"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/13704490"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0140"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sodium bicarbonate vs sodium chloride for the prevention of contrast medium-induced nephropathy in patients undergoing coronary angiography&#58; a randomized trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "S&#46;S&#46; Brar"
                            1 => "A&#46;Y&#46;J&#46; Shen"
                            2 => "M&#46;B&#46; Jorgensen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/jama.300.9.1038"
                      "Revista" => array:2 [
                        "tituloSerie" => "JAMA - J Am Med Assoc"
                        "fecha" => "2008"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0145"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "RenalGuard system in high-risk patients for contrast-induced acute kidney injury"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "C&#46; Briguori"
                            1 => "G&#46; Visconti"
                            2 => "M&#46; Donahue"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ahj.2015.12.005"
                      "Revista" => array:3 [
                        "tituloSerie" => "Am Heart J"
                        "fecha" => "2016"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32866454"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0150"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prevention of radiographic-contrast-agent-induced reductions in renal function by acetylcysteine"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "M&#46; Tepel"
                            1 => "M&#46; van der Giet"
                            2 => "C&#46; Schwarzfeld"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/nejm200007203430304"
                      "Revista" => array:3 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2000"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32222134"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/21742049/0000004000000007/v1_202107150708/S2174204921001884/v1_202107150708/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "9917"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Original Articles"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/21742049/0000004000000007/v1_202107150708/S2174204921001884/v1_202107150708/en/main.pdf?idApp=UINPBA00004E&text.app=https://revportcardiol.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204921001884?idApp=UINPBA00004E"
]
Article information
ISSN: 21742049
Original language: English
The statistics are updated each day
Year/Month Html Pdf Total
2024 October 45 39 84
2024 September 43 32 75
2024 August 35 37 72
2024 July 26 30 56
2024 June 22 24 46
2024 May 38 23 61
2024 April 49 34 83
2024 March 26 25 51
2024 February 27 18 45
2024 January 41 31 72
2023 December 44 37 81
2023 November 58 48 106
2023 October 20 22 42
2023 September 24 27 51
2023 August 26 21 47
2023 July 22 8 30
2023 June 25 10 35
2023 May 36 33 69
2023 April 24 12 36
2023 March 46 25 71
2023 February 38 20 58
2023 January 19 26 45
2022 December 43 41 84
2022 November 36 41 77
2022 October 41 31 72
2022 September 22 26 48
2022 August 22 28 50
2022 July 29 46 75
2022 June 30 27 57
2022 May 30 30 60
2022 April 32 35 67
2022 March 35 56 91
2022 February 31 44 75
2022 January 27 34 61
2021 December 27 38 65
2021 November 45 35 80
2021 October 108 70 178
2021 September 52 30 82
2021 August 79 48 127
2021 July 42 52 94
Show all

Follow this link to access the full text of the article

Idiomas
Revista Portuguesa de Cardiologia (English edition)
en pt

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos

By checking that you are a health professional, you are stating that you are aware and accept that the Portuguese Journal of Cardiology (RPC) is the Data Controller that processes the personal information of users of its website, with its registered office at Campo Grande, n.º 28, 13.º, 1700-093 Lisbon, telephone 217 970 685 and 217 817 630, fax 217 931 095, and email revista@spc.pt. I declare for all purposes that the information provided herein is accurate and correct.