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No signs of hyperemia were detected; (D) right submaxillary gland with normal echostructure and echogenicity.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Eduardo Flores-Umanzor, Margarida Pujol-Lopez, Pedro Cepas, Guillem Caldentey, Xavier Freixa, Victoria Martin-Yuste, Marta Farrero, Rosario J. Perea, Matias Scuarcia, Monica Masotti" "autores" => array:10 [ 0 => array:2 [ "nombre" => "Eduardo" "apellidos" => "Flores-Umanzor" ] 1 => array:2 [ "nombre" => "Margarida" "apellidos" => "Pujol-Lopez" ] 2 => array:2 [ "nombre" => "Pedro" "apellidos" => "Cepas" ] 3 => array:2 [ "nombre" => "Guillem" "apellidos" => "Caldentey" ] 4 => array:2 [ "nombre" => "Xavier" "apellidos" => "Freixa" ] 5 => array:2 [ "nombre" => "Victoria" "apellidos" => "Martin-Yuste" ] 6 => array:2 [ "nombre" => "Marta" "apellidos" => "Farrero" ] 7 => array:2 [ "nombre" => "Rosario J." "apellidos" => "Perea" ] 8 => array:2 [ "nombre" => "Matias" "apellidos" => "Scuarcia" ] 9 => array:2 [ "nombre" => "Monica" "apellidos" => "Masotti" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2174204921001392" "doi" => "10.1016/j.repce.2021.06.004" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204921001392?idApp=UINPBA00004E" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255121001074?idApp=UINPBA00004E" "url" => "/08702551/0000004000000005/v1_202105010726/S0870255121001074/v1_202105010726/en/main.assets" ] ] "itemAnterior" => array:20 [ "pii" => "S2174204921001380" "issn" => "21742049" "doi" => "10.1016/j.repce.2020.11.023" "estado" => "S300" "fechaPublicacion" => "2021-05-01" "aid" => "1719" "copyright" => "Sociedade Portuguesa de Cardiologia" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "cor" "cita" => "Rev Port Cardiol. 2021;40:391-3" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>" "titulo" => "Cochrane Corner: Withdrawal of antihypertensive drugs in older people" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "391" "paginaFinal" => "393" ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Cochrane Corner: Descontinuação de fármacos anti-hipertensores em idosos" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 262 "Ancho" => 2508 "Tamanyo" => 74141 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Results of the meta-analysis showing the magnitude of blood pressure increase with discontinuation of antihypertensive medication.<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">1</span></a> CI: confidence interval; RCT: randomized controlled trial.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Filipa Reis, Mariana Alves, Daniel Caldeira" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Filipa" "apellidos" => "Reis" ] 1 => array:2 [ "nombre" => "Mariana" "apellidos" => "Alves" ] 2 => array:2 [ "nombre" => "Daniel" "apellidos" => "Caldeira" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S0870255121001128" "doi" => "10.1016/j.repc.2020.11.008" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255121001128?idApp=UINPBA00004E" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204921001380?idApp=UINPBA00004E" "url" => "/21742049/0000004000000005/v1_202106280555/S2174204921001380/v1_202106280555/en/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>" "titulo" => "A rare cause of non-infectious sialadenitis: Iodide-induced sialadenitis associated with coronary angiography" "tieneTextoCompleto" => true "saludo" => "To the Editor:" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "395" "paginaFinal" => "397" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Eduardo Flores-Umanzor, Margarida Pujol-Lopez, Pedro Cepas, Guillem Caldentey, Xavier Freixa, Victoria Martin-Yuste, Marta Farrero, Rosario J. Perea, Matias Scuarcia, Monica Masotti" "autores" => array:10 [ 0 => array:3 [ "nombre" => "Eduardo" "apellidos" => "Flores-Umanzor" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Margarida" "apellidos" => "Pujol-Lopez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "Pedro" "apellidos" => "Cepas" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "Guillem" "apellidos" => "Caldentey" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 4 => array:3 [ "nombre" => "Xavier" "apellidos" => "Freixa" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 5 => array:3 [ "nombre" => "Victoria" "apellidos" => "Martin-Yuste" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 6 => array:3 [ "nombre" => "Marta" "apellidos" => "Farrero" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 7 => array:3 [ "nombre" => "Rosario J." "apellidos" => "Perea" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 8 => array:3 [ "nombre" => "Matias" "apellidos" => "Scuarcia" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 9 => array:3 [ "nombre" => "Monica" "apellidos" => "Masotti" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Cardiology Department, Cardiovascular Institute, Hospital Clínic, University of Barcelona, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Radiology Department, Hospital Clínic, University of Barcelona, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Uma causa rara de sialadenite não infecciosa: sialadenite induzida por iodeto associada a coronariografia" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1564 "Ancho" => 1505 "Tamanyo" => 211331 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(A and B) Neck swelling predominantly on the right side secondary to acute enlargement of the right submandibular gland; (C and D) resolution of clinical picture of non-infectious right submandibular iodide-induced sialadenitis.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Sialadenitis is an extremely rare complication of procedures involving intravenous iodinated contrast medium. It was first described in 1956 by Sussman and Miller,<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">1</span></a> who coined the term ‘iodide mumps.’ To date, fewer than 10 cases of sialadenitis associated with coronary angiograms (CAs) have been described in the literature.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">2</span></a> The mechanism behind iodide-induced sialadenitis is not well understood and may be either idiosyncratic or related to toxic accumulation of iodide in the salivary glands. Two percent of the dose is excreted via the salivary glands and can affect them bilaterally or unilaterally.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">3</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">An 82-year-old man with no history of anaphylaxis and previous aortic valve replacement and a saphenous vein graft to the circumflex coronary artery was referred to our center for a scheduled outpatient CA to address progressive angina over recent months. Two previous CAs were performed without stenting, vascular, or anaphylactic complications. A drug-eluting stent was implanted in a severe lesion in the mid portion of the left descending coronary artery without immediate complications. Six hours post-procedure, the patient noticed bilateral neck swelling predominantly on the right side. Physical examination revealed enlargement and a slight tenderness of the right submandibular gland without airway compromise (<a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a>A and B). Intravenous antihistamine and corticoids were initiated. His medical chart revealed no current or recent use of angiotensin-converting enzyme inhibitors or angiotensin receptor blockers. A diagnosis of sialadenitis secondary to the use of iodinated contrast medium was assumed. Salivary gland ultrasound demonstrated homogenous inflammation of the right submandibular gland without dilated ducts and normal color velocity. These findings were compatible with non-infectious sialadenitis (<a class="elsevierStyleCrossRef" href="#fig0010">Figure 2</a>A-C).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">The corticoids and antihistamine were stopped, and the patient's clinical picture and echocardiographic abnormalities resolved after three days (<a class="elsevierStyleCrossRefs" href="#fig0005">Figures 1B and C and 2D</a>).</p><p id="par0020" class="elsevierStylePara elsevierViewall">Iodide sialadenitis is a rare late reaction to intravascular administration of iodine-containing contrast material leading to abnormal swelling of the salivary glands. In our case, it occurred within six hours of exposure to iodine contrast media.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">3</span></a> The risk for sialadenitis appears to be directly related to serum iodide levels, identifying renal insufficiency and large iodide loads as predisposing factors. However, in our case, the patient's renal function was normal. Although the reaction often recurs with subsequent contrast administrations, our patient was exposed to iodide contrast in two previous CAs without incident. Treatment of this condition is largely supportive, and most cases resolve in two to four days without treatment.<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">2,3</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Given the widespread use of imaging and interventional techniques that use iodinated contrast, including CAs, physicians should be aware of this condition.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Funding</span><p id="par0030" class="elsevierStylePara elsevierViewall">None.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Conflicts of interest</span><p id="par0035" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Funding" ] 1 => array:2 [ "identificador" => "sec0010" "titulo" => "Conflicts of interest" ] 2 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "multimedia" => array:2 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1564 "Ancho" => 1505 "Tamanyo" => 211331 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(A and B) Neck swelling predominantly on the right side secondary to acute enlargement of the right submandibular gland; (C and D) resolution of clinical picture of non-infectious right submandibular iodide-induced sialadenitis.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1130 "Ancho" => 1505 "Tamanyo" => 211735 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">(A-C) Right submaxillary gland increased in size, with diffuse alteration of the echostructure, globally hypoechoic, with markedly hypoechoic foci in its interior. No signs of hyperemia were detected; (D) right submaxillary gland with normal echostructure and echogenicity.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:3 [ 0 => array:3 [ "identificador" => "bib0020" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Iodide mumps after urography" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J. Miller" 1 => "R.M. Sussman" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM195608302550907" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "1956" "volumen" => "255" "paginaInicial" => "433" "paginaFinal" => "434" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/13358860" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0025" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Acute submandibular swelling complicating arteriography with iodide contrast. A case report and literature review" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "G. Zhang" 1 => "Y. Li" 2 => "R. Zhang" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Medicine (Balt)" "fecha" => "2015" "volumen" => "94" "paginaInicial" => "e1380" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0030" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Iodide mumps" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "M.A. Pérez-Valdivia" 1 => "López-Mendoza" 2 => "Toro-Prieto" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3265/Nefrologia.pre2014.Feb.12284" "Revista" => array:6 [ "tituloSerie" => "Nefrologia" "fecha" => "2014" "volumen" => "34" "paginaInicial" => "422" "paginaFinal" => "423" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24849065" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/21742049/0000004000000005/v1_202106280555/S2174204921001392/v1_202106280555/en/main.assets" "Apartado" => array:4 [ "identificador" => "29282" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Letters to the editor" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/21742049/0000004000000005/v1_202106280555/S2174204921001392/v1_202106280555/en/main.pdf?idApp=UINPBA00004E&text.app=https://revportcardiol.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204921001392?idApp=UINPBA00004E" ]
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