Editorial comment
D-dimers in the identification of vascular risk: A good tool or just another one?
D-dímeros na identificação do risco vascular: uma boa ferramenta ou apenas mais uma?
Henrique Cyrne Carvalho
Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, Portugal
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At the cut-off value of >0.610 cm, sensitivity and specificity of MPV were 76% and 73%, respectively (AUC=0.843, 95% CI, 0.751-0.935). AUC: area under the curve, CI: confidence interval.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Emrah Erdal, Mehmet İnanir, Gülbahar Ustaoglu, İsa Sincer" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Emrah" "apellidos" => "Erdal" ] 1 => array:2 [ "nombre" => "Mehmet" "apellidos" => "İnanir" ] 2 => array:2 [ "nombre" => "Gülbahar" "apellidos" => "Ustaoglu" ] 3 => array:2 [ "nombre" => "İsa" "apellidos" => "Sincer" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204920304323?idApp=UINPBA00004E" "url" => "/21742049/0000003900000012/v1_202012240833/S2174204920304323/v1_202012240833/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S2174204920304116" "issn" => "21742049" "doi" => "10.1016/j.repce.2020.08.002" "estado" => "S300" "fechaPublicacion" => "2020-12-01" "aid" => "1623" "copyright" => "Sociedade Portuguesa de Cardiologia" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "fla" "cita" => "Rev Port Cardiol. 2020;39:687-93" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>" "titulo" => "D-dimers are associated with coronary artery disease severity assessed using Syntax and Syntax II scores in patients with ST elevation myocardial infarction" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "pt" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "687" "paginaFinal" => "693" ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Os D-dímeros associam-se à gravidade da doença coronária avaliada pelos <span class="elsevierStyleItalic">scores</span> Syntax e Syntax II em doentes com enfarte do miocárdio com elevação do segmento ST" ] ] "contieneResumen" => array:2 [ "en" => true "pt" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1575 "Ancho" => 1571 "Tamanyo" => 123735 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">D-dimers to predict CAD severity based on receiver operating characteristic curve analysis.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Caner Türkoğlu, Hazar Harbalıoğlu, Taner Şeker, Ahmet Oytun Baykan, Onur Kadir Uysal" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Caner" "apellidos" => "Türkoğlu" ] 1 => array:2 [ "nombre" => "Hazar" "apellidos" => "Harbalıoğlu" ] 2 => array:2 [ "nombre" => "Taner" "apellidos" => "Şeker" ] 3 => array:2 [ "nombre" => "Ahmet Oytun" "apellidos" => "Baykan" ] 4 => array:2 [ "nombre" => "Onur Kadir" "apellidos" => "Uysal" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204920304116?idApp=UINPBA00004E" "url" => "/21742049/0000003900000012/v1_202012240833/S2174204920304116/v1_202012240833/en/main.assets" ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Editorial comment</span>" "titulo" => "D-dimers in the identification of vascular risk: A good tool or just another one?" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "695" "paginaFinal" => "696" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "Henrique Cyrne Carvalho" "autores" => array:1 [ 0 => array:3 [ "nombre" => "Henrique Cyrne" "apellidos" => "Carvalho" "email" => array:1 [ 0 => "henriquecyrnecarvalh2@gmail.com" ] ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, Portugal" "identificador" => "aff0005" ] ] ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "D-dímeros na identificação do risco vascular: uma boa ferramenta ou apenas mais uma?" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">The need for an increasingly thorough risk assessment after percutaneous coronary treatment for acute coronary syndrome (ACS) has led investigators to search for biological and clinical markers that act as specific predictors of severity, better identifying patients at greater risk and who should, therefore, be candidates for more aggressive pharmacological therapy.</p><p id="par0010" class="elsevierStylePara elsevierViewall">Despite the high efficacy of preventive treatments defined in clinical guidelines at managing vascular risk, many patients present a clinical condition with a very high probability of major ischemic events. This “residual risk” is particularly relevant in patients with severe symptomatic atherothrombosis.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">1</span></a> Previously this status was not included in decisions on establishing long-term treatment guidelines, whereas now it is recognized and identified as a differentiating factor when establishing prognosis.</p><p id="par0015" class="elsevierStylePara elsevierViewall">There is, therefore, a clear need for markers that can identify the probability of recurrent manifestations of cardiovascular disease in its most varied forms of clinical presentation, identifying patients at greater atherothrombotic risk, redefining prognosis and orienting with differentiated therapies.</p><p id="par0020" class="elsevierStylePara elsevierViewall">Alongside classic myocardial lesion markers, D-dimers have recently been presented as candidates for profiling ACS,<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">2</span></a> and for stratifying short and long-term risk.<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">3–5</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">D-dimers are produced by the breakdown of fibrin and are markers of hypercoagulability and thrombotic events.<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">6</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Many studies have confirmed the association between high D-dimer value and increased long-term mortality in patients with stable coronary disease,<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">7</span></a> acute coronary syndromes<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">8</span></a> and ST-elevated myocardial infarction (STEMI).<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">9</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">The observation that elevated D-dimers are of clinical interest in the identification of conditions as different as complementary, such as the differential diagnosis in ACS between infarction and unstable angina,<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">2</span></a> to risk stratification associated with STEMI<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">10</span></a> patients or other ACSs,<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">4</span></a> has drawn attention to the potentially major role these markers may play in the definition of therapeutic strategies. Elevated baseline levels are associated with cardiovascular mortality and increased non-cardiovascular mortality in clinical follow-up windows, from the hospital phase up until at least 16 years after ACS.<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">6</span></a> A high rate of infarction and stroke has also been recorded within six months of an index percutaneous coronary intervention (PCI) event.<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">10</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">The use of this marker together with the remaining vascular risk factors to define populations at risk requiring close monitoring and suitable therapeutic measures seems clear, as D-dimers have been identified as a long-term marker of mortality and major complications in hospital and within six months following a PCI. The goal of these measures is to control ischemic and residual risk. Based on the results and study conditions of the ATLAS ACS 2 – TIMI 51 Trial (ClinicalTrials.gov number, NCT00809965), the use of the so-called “vascular dose” of rivaroxaban 2.5 mg bid (anti-factor Xa action) in this elevated risk group would make sense.<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">11</span></a> This study assessed a population of more than 15 000 patients with stable coronary artery disease (CAD) seven days after PCI in ACS. The indicated dose of rivaroxaban reduced the composite endpoint comprised of cardiovascular death, infarction or stroke, mainly at the expense of a reduction in mortality in patients with a high vascular risk score. It is therefore more pertinent to propose coagulation in the pathophysiological mechanism, which associated with platelet aggregation, defines events that lead to cardiovascular death.</p><p id="par0045" class="elsevierStylePara elsevierViewall">Studies have performed to obtain optimized information on the association of other risk markers with D-dimers to identify patients at greater risk of clinical recurrence of CAD manifestations. They then associated them with clinical risk scores (Grace)<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">3</span></a> and morphological risk, based on the severity of the coronary disease (Syntax score).<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">4</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">Elevated baseline D-dimers upon arrival at hospital in patients with ACSs, who had undergone PCI, was identified as an independent predictor of hospital mortality. Use in combination with the Grace Score has to led improved prognosis performance, compared to the isolated use of this score.<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">3</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">With respect to the complexity of coronary anatomy, increased D-dimer values were associated with the severity of coronary disease, represented by high Syntax Score values in patients with STEMI, successfully revascularized in a primary angioplasty. Elevated D-dimers were also linked to more serious intracoronary thrombotic content (thrombotic burden) and a more frequent occurrence of acute occlusion with complete interruption of the coronary flow during primary angioplasty (bailout),<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">4</span></a> which is associated with worse prognosis.</p><p id="par0060" class="elsevierStylePara elsevierViewall">It appears to be clear that the baseline D-dimer levels, in the context of several types of CAD presentation, are associated independently with clinical and morphological markers of severity, which have themselves already been identified as negative prognostic factors. The association between elevated D-dimers and other prognosis markers reinforces the identification of patients who are at a higher risk of mortality and have a worse prognosis.</p><p id="par0065" class="elsevierStylePara elsevierViewall">However, the identification of D-dimers as markers of long term risk is not limited to vascular risk, as demonstrated by the LIPID Study.<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">6</span></a> It involved almost 8000 patients with follow-up over 16 years and demonstrated the association between elevated levels of D-dimers and a significant and independent rise in mortality with an identified cause (cardiovascular and neoplastic), in addition to non-cardiovascular and non-neoplastic mortality.</p><p id="par0070" class="elsevierStylePara elsevierViewall">It is therefore evident that a variable of increased cardiovascular risk is also associated with other causes of mortality, supporting the notion that this marker's lack of specificity identifies a population that presents comparatively higher mortality, justifying more highly differentiated clinical follow-up guidelines that favor a tighter control of overall risk stratification.</p><p id="par0075" class="elsevierStylePara elsevierViewall">Only the future will tell us to what extent current evidence can condition new approaches effectively in this complex group of patients with elevated vascular risk before and after the first clinical manifestation of the disease.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of interest</span><p id="par0080" class="elsevierStylePara elsevierViewall">The author has no conflicts of interest to declare.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Conflicts of interest" ] 1 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:11 [ 0 => array:3 [ "identificador" => "bib0060" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Three-year follow-up event rates in the international REduction of Atherothrombosis for Continued Health" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "M.J. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 3 | 3 | 6 |
| 2024 October | 43 | 29 | 72 |
| 2024 September | 35 | 26 | 61 |
| 2024 August | 54 | 27 | 81 |
| 2024 July | 40 | 33 | 73 |
| 2024 June | 29 | 23 | 52 |
| 2024 May | 27 | 16 | 43 |
| 2024 April | 25 | 28 | 53 |
| 2024 March | 23 | 20 | 43 |
| 2024 February | 30 | 15 | 45 |
| 2024 January | 29 | 23 | 52 |
| 2023 December | 17 | 28 | 45 |
| 2023 November | 32 | 30 | 62 |
| 2023 October | 22 | 18 | 40 |
| 2023 September | 20 | 25 | 45 |
| 2023 August | 17 | 14 | 31 |
| 2023 July | 17 | 10 | 27 |
| 2023 June | 21 | 15 | 36 |
| 2023 May | 30 | 32 | 62 |
| 2023 April | 21 | 6 | 27 |
| 2023 March | 45 | 24 | 69 |
| 2023 February | 22 | 13 | 35 |
| 2023 January | 30 | 17 | 47 |
| 2022 December | 42 | 14 | 56 |
| 2022 November | 43 | 31 | 74 |
| 2022 October | 38 | 21 | 59 |
| 2022 September | 25 | 35 | 60 |
| 2022 August | 23 | 28 | 51 |
| 2022 July | 44 | 41 | 85 |
| 2022 June | 25 | 28 | 53 |
| 2022 May | 17 | 23 | 40 |
| 2022 April | 30 | 25 | 55 |
| 2022 March | 25 | 53 | 78 |
| 2022 February | 18 | 38 | 56 |
| 2022 January | 15 | 22 | 37 |
| 2021 December | 18 | 32 | 50 |
| 2021 November | 20 | 32 | 52 |
| 2021 October | 29 | 41 | 70 |
| 2021 September | 18 | 28 | 46 |
| 2021 August | 24 | 35 | 59 |
| 2021 July | 14 | 26 | 40 |
| 2021 June | 25 | 28 | 53 |
| 2021 May | 33 | 48 | 81 |
| 2021 April | 74 | 71 | 145 |
| 2021 March | 41 | 24 | 65 |
| 2021 February | 61 | 31 | 92 |
| 2021 January | 56 | 29 | 85 |
| 2020 December | 22 | 6 | 28 |
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