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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Cardiogenic shock &#40;CS&#41; is defined as persistent hypotension &#40;systolic blood pressure &#60;90 mmHg&#41; secondary to myocardial dysfunction&#44; associated with signs of organ hypoperfusion&#46; CS may be present in 10&#37; of patients with ST-segment elevation myocardial infarction &#40;STEMI&#41; and is associated with 30-day mortality of about 50&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> In the majority of STEMI patients&#44; hemodynamic deterioration occurs after hospital admission&#44; which means that there may be room for preventive measures and highlights the importance of early recognition of those most likely to evolve to CS&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Scores such as Controlled Abciximab and Device Investigation to Lower Late Angioplasty Complications &#40;CADILLAC&#41;&#44; Thrombolysis in Myocardial Infarction &#40;TIMI&#41;&#44; the Global Registry of Acute Coronary Events &#40;GRACE&#41; and the Zwolle risk score are used to stratify patients and enable the adoption of different levels of clinical monitoring&#44; therapeutic care and post-discharge strategies&#46;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">3&#44;4</span></a> However&#44; the search for simpler and more accurate scores has continued&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">The shock index &#40;SI&#41; is defined as the ratio of heart rate to systolic blood pressure&#44; and was introduced in 1967 by Allgower and Burri to assess the degree of hypovolemia in hemorrhagic or infectious shock states&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a> The SI&#44; which is easy to calculate&#44; is an objective measure of cardiovascular performance and a marker for predicting the onset of hypotension&#46; Assessment of SI in the context of acute myocardial infarction was only used more recently&#44; and a first meta-analysis&#44; of eight studies enrolling 20<span class="elsevierStyleHsp" style=""></span>404 patients&#44; was published last year&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a> A high SI was associated with increased in-hospital mortality and higher risk of short- and long-term adverse outcomes compared to low SI&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">An important limitation of SI is the lack of information about systemic vascular resistance status&#46; Mean arterial pressure &#40;incorporating both systolic and diastolic blood pressure&#41; best represents tissue perfusion status&#46; The modified shock index &#40;MSI&#41;&#44; which is the ratio of heart rate to mean arterial pressure&#44; has been shown to be a better predictor of mortality than heart rate&#44; systolic blood pressure&#44; diastolic blood pressure and SI alone in trauma patients&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">7</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Shangguan et al&#46; were the first to assess the predictive value of MSI in the context of STEMI&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a> In a retrospective study of 160 consecutive patients&#44; they found that MSI &#8805;1&#46;4&#44; assessed in the emergency department&#44; was an independent factor for major adverse cardiac events and seven-day all-cause mortality&#44; with a stronger association than SI&#46; Yu et al&#46; retrospectively studied 1864 STEMI patients undergoing primary coronary angioplasty to assess whether admission age SI &#40;age multiplied by SI&#41; and MSI were useful clinical parameters to predict long-term prognosis&#44; with both showing good prognostic performance&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a> The cutoff value of MSI for the prediction of all-cause mortality was 0&#46;71&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">In this issue of the Journal&#44; Abreu et al&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a> assess the prognostic value of MSI to predict six-month mortality in a large retrospective observational study of 1158 STEMI patients without cardiogenic shock on admission&#46; They found that MSI &#8805;0&#46;93 was present in about a quarter of the patients and was associated with worse in-hospital clinical course&#46; Adverse events&#44; acute heart failure and cardiogenic shock were significantly more frequent in this subgroup&#46; MSI was also an independent predictor of overall six-month mortality&#46; The cutoff of 0&#46;93 identified by the authors is between those in the above studies&#44; which presumably reflects methodological differences&#44; such as population selection and the timing and method for assessing hemodynamic parameters&#46; However&#44; their approach of using MSI in patients with no shock at admission&#44; and assessing heart rate and blood pressure in the hemodynamic laboratory&#44; seems to be the most appropriate and practical way to apply this index in clinical practice&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Their study has limitations&#44; some of which are acknowledged by the authors&#44; including its single-center and retrospective design&#44; the lack of a control group to effectively test their hypothesis&#44; and the lack of comparison with other hemodynamic indices or risk scores&#46; Nevertheless&#44; the authors should be congratulated for their important contribution to an issue that is still poorly defined and that needs further investigation&#44; since a simple risk stratification of these patients remains an unmet clinical need&#46; They have paved the way for future studies that may validate this strategy&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of interest</span><p id="par0040" class="elsevierStylePara elsevierViewall">The author has no conflicts of interest to declare&#46;</p></span></span>"
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Cardiogenic shock in acute myocardial infarction: Stratify to prevent
Choque cardiogénico no enfarte agudo do miocárdio: estratificar para prevenir
António José Fiarresga
Serviço de Cardiologia, Hospital de Santa Marta, CHLC, Lisboa, Portugal
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Thrombolysis in Myocardial Infarction &#40;TIMI&#41;&#44; the Global Registry of Acute Coronary Events &#40;GRACE&#41; and the Zwolle risk score are used to stratify patients and enable the adoption of different levels of clinical monitoring&#44; therapeutic care and post-discharge strategies&#46;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">3&#44;4</span></a> However&#44; the search for simpler and more accurate scores has continued&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">The shock index &#40;SI&#41; is defined as the ratio of heart rate to systolic blood pressure&#44; and was introduced in 1967 by Allgower and Burri to assess the degree of hypovolemia in hemorrhagic or infectious shock states&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a> The SI&#44; which is easy to calculate&#44; is an objective measure of cardiovascular performance and a marker for predicting the onset of hypotension&#46; Assessment of SI in the context of acute myocardial infarction was only used more recently&#44; and a first meta-analysis&#44; of eight studies enrolling 20<span class="elsevierStyleHsp" style=""></span>404 patients&#44; was published last year&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a> A high SI was associated with increased in-hospital mortality and higher risk of short- and long-term adverse outcomes compared to low SI&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">An important limitation of SI is the lack of information about systemic vascular resistance status&#46; Mean arterial pressure &#40;incorporating both systolic and diastolic blood pressure&#41; best represents tissue perfusion status&#46; The modified shock index &#40;MSI&#41;&#44; which is the ratio of heart rate to mean arterial pressure&#44; has been shown to be a better predictor of mortality than heart rate&#44; systolic blood pressure&#44; diastolic blood pressure and SI alone in trauma patients&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">7</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Shangguan et al&#46; were the first to assess the predictive value of MSI in the context of STEMI&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a> In a retrospective study of 160 consecutive patients&#44; they found that MSI &#8805;1&#46;4&#44; assessed in the emergency department&#44; was an independent factor for major adverse cardiac events and seven-day all-cause mortality&#44; with a stronger association than SI&#46; Yu et al&#46; retrospectively studied 1864 STEMI patients undergoing primary coronary angioplasty to assess whether admission age SI &#40;age multiplied by SI&#41; and MSI were useful clinical parameters to predict long-term prognosis&#44; with both showing good prognostic performance&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a> The cutoff value of MSI for the prediction of all-cause mortality was 0&#46;71&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">In this issue of the Journal&#44; Abreu et al&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a> assess the prognostic value of MSI to predict six-month mortality in a large retrospective observational study of 1158 STEMI patients without cardiogenic shock on admission&#46; They found that MSI &#8805;0&#46;93 was present in about a quarter of the patients and was associated with worse in-hospital clinical course&#46; Adverse events&#44; acute heart failure and cardiogenic shock were significantly more frequent in this subgroup&#46; MSI was also an independent predictor of overall six-month mortality&#46; The cutoff of 0&#46;93 identified by the authors is between those in the above studies&#44; which presumably reflects methodological differences&#44; such as population selection and the timing and method for assessing hemodynamic parameters&#46; However&#44; their approach of using MSI in patients with no shock at admission&#44; and assessing heart rate and blood pressure in the hemodynamic laboratory&#44; seems to be the most appropriate and practical way to apply this index in clinical practice&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Their study has limitations&#44; some of which are acknowledged by the authors&#44; including its single-center and retrospective design&#44; the lack of a control group to effectively test their hypothesis&#44; and the lack of comparison with other hemodynamic indices or risk scores&#46; Nevertheless&#44; the authors should be congratulated for their important contribution to an issue that is still poorly defined and that needs further investigation&#44; since a simple risk stratification of these patients remains an unmet clinical need&#46; They have paved the way for future studies that may validate this strategy&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of interest</span><p id="par0040" class="elsevierStylePara elsevierViewall">The author has no conflicts of interest to declare&#46;</p></span></span>"
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