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which left atrial &#40;LA&#41; size and LA volume index are not&#46;<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">1&#44;9</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Increased left ventricular &#40;LV&#41; mass index is associated with prolonged interatrial conduction time and LA electromechanical coupling interval&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">1</span></a> The severity of LV hypertrophy appears to be one of the factors associated with the onset of AF&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">It has been demonstrated that pharmacological treatment that reduces blood pressure &#40;BP&#41; and hence LV mass makes AF less likely to occur&#46;<a class="elsevierStyleCrossRefs" href="#bib0180"><span class="elsevierStyleSup">10&#8211;12</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Data from the Framingham Heart Study show a relation between LA size as determined by echocardiography and systolic BP and pulse pressure &#40;PP&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">13</span></a> At the same time&#44; 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ischemic heart disease&#44; valve disease&#44; congenital heart defects and heart failure&#46;<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">17</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">In hypertensive patients&#44; P-wave dispersion may help identify LV hypertrophy and LV diastolic dysfunction&#44; both of which lead to morphological and hemodynamic alterations in the left atrium that increase the risk of AF&#46; Raised intra-atrial pressures and ischemia promote atrial remodeling&#44; with disorganization of myocardial fibers and fibrosis&#44; dilatation and electrical instability&#46;<a class="elsevierStyleCrossRefs" href="#bib0215"><span class="elsevierStyleSup">17&#44;18</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Among the factors tending to increase P-wave dispersion and atrial fibrosis is elevation of angiotensin II and catecholamines&#46;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">18</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">Treatment targeting the renin-angiotensin-aldosterone system &#40;RAAS&#41; with perindopril in hypertensives led to a decrease in P-wave dispersion&#44;<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">17</span></a> an effect also seen in a similar study using quinapril&#46;<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">17</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">In hypertensive patients&#44; increased P-wave dispersion and maximum P-wave duration reflect instability and heterogeneity of atrial conduction&#44; which may be a result of the morphological and hemodynamic alterations undergone by the left atrium as a consequence of hypertension&#46;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">18</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">Heart failure with reduced LV ejection fraction &#40;LVEF&#41; predisposes to the onset of AF&#46; In a study of patients with non-ischemic dilated cardiomyopathy&#44; P-wave dispersion was much higher than in the control group&#46;<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">19</span></a> This increased P-wave dispersion may be explained by hemodynamic variations resulting from LV dysfunction and associated neurohormonal activation affecting the left atrium&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Camsari et al&#46; found a significant correlation between P-wave dispersion and LVEF in patients with heart failure&#46; Both sympathetic activity and the RAAS are stimulated in heart failure&#44; and this influences P-wave duration and dispersion&#44; both of which were reduced following treatment with metoprolol in their study&#46;<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">20</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">For patients with symptomatic heart failure despite optimized drug treatment&#44; in sinus rhythm and with LVEF &#8804;35&#37;&#44; QRS &#8805;130 ms and complete left bundle branch block&#44; cardiac resynchronization therapy &#40;CRT&#41; improves LV function and reduces neurohormonal activation&#46; It has also been shown to contribute to reverse atrial remodeling and thus to improvement in atrial function&#46;<a class="elsevierStyleCrossRefs" href="#bib0235"><span class="elsevierStyleSup">21&#44;22</span></a></p><p id="par0075" class="elsevierStylePara elsevierViewall">In a study of 46 patients with heart failure with reduced LVEF&#44; after three months of CRT&#44; maximum P-wave duration&#44; P-wave dispersion and LA diameter were decreased and LVEF was increased&#46;<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">22</span></a> Maximum P-wave duration and P-wave dispersion were positively correlated with reduction in LA diameter and negatively correlated with improvement in LVEF&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">P-wave terminal force in lead V1 &#40;PTFV1&#41; is the product of the amplitude and duration of the terminal negative phase of the P wave in lead V1 in mm&#215;ms&#46; It is a marker of cardiovascular prognosis and there is evidence that when increased it indicates increased risk of AF&#46;<a class="elsevierStyleCrossRefs" href="#bib0245"><span class="elsevierStyleSup">23&#44;24</span></a> Abnormal PTFV1&#44; defined as &#8805;40 mm&#215;ms&#44; was shown to be an independent predictor of cardiac death or hospitalization for heart failure in patients with prior myocardial infarction&#44;<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">23</span></a> while another study&#44; in patients with increased LV mass&#44; showed that PTFV1 &#8805;40 mm&#215;ms was associated with increased risk for ischemic stroke&#46;<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">25</span></a></p><p id="par0085" class="elsevierStylePara elsevierViewall">In their study published in this issue of the <span class="elsevierStyleItalic">Journal</span>&#44; &#199;imen et al&#46; examine early changes in atrial conduction times and P-wave dispersion in 157 patients with essential hypertension&#44; no significant cardiac structural alterations&#44; and elevated PP &#40;&#8805;60 mmHg&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">26</span></a> Atrial electromechanical delay &#40;EMD&#41; was assessed by tissue Doppler echocardiography and P-wave dispersion by electrocardiography&#46; The authors show that elevated PP was associated with increased atrial EMD and P-wave dispersion&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">Detection of early alterations&#44; by non-invasive and easily accessible means&#44; that could help prevent structural and electrical remodeling and thus reduce the risk of AF is of the utmost importance&#46; The study by &#199;imen et al&#46; in this issue is another contribution to this goal&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of interest</span><p id="par0095" class="elsevierStylePara elsevierViewall">The author has no conflicts of interest to declare&#46;</p></span></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Menezes Falc&#227;o L&#46; Predisposi&#231;&#227;o para remodelagem auricular na hipertens&#227;o arterial - dete&#231;&#227;o precoce por meios n&#227;o invasivos&#46; Rev Port Cardiol&#46; 2017&#59;36&#58;461&#8211;463&#46;</p>"
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      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:26 [
            0 => array:3 [
              "identificador" => "bib0135"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Early changes in atrial electromechanical coupling in patients with hypertension&#58; assessment by tissue Doppler imaging"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "B&#46;K&#46; Avci"
                            1 => "O&#46; Gulmez"
                            2 => "G&#46; Donmez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Chin Med J &#40;Engl&#41;"
                        "fecha" => "2016"
                        "volumen" => "129"
                        "paginaInicial" => "1311"
                        "paginaFinal" => "1315"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0140"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Alterations of cardiac structure in patients with isolated office&#44; ambulatory&#44; or home hypertension&#58; data from the general population &#40;Pressione Arteriose Monitorate E Loro Associazioni &#91;PAMELA&#93; Study&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "R&#46; Sega"
                            1 => "G&#46; Trocino"
                            2 => "A&#46; Lanzarotti"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "2001"
                        "volumen" => "104"
                        "paginaInicial" => "1385"
                        "paginaFinal" => "1392"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11560854"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0145"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Atrial tissue Doppler imaging for prediction of new-onset atrial fibrillation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "C&#46;B&#46; De Vos"
                            1 => "B&#46; Weijs"
                            2 => "H&#46;J&#46; Crijns"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/hrt.2008.148528"
                      "Revista" => array:6 [
                        "tituloSerie" => "Heart"
                        "fecha" => "2009"
                        "volumen" => "95"
                        "paginaInicial" => "835"
                        "paginaFinal" => "840"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19074923"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0150"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Atrial fibrillation as an independent risk factor for stroke&#58; the Framingham Study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "P&#46;A&#46; Wolf"
                            1 => "R&#46;D&#46; Abbott"
                            2 => "W&#46;B&#46; Kannel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Stroke"
                        "fecha" => "1991"
                        "volumen" => "22"
                        "paginaInicial" => "983"
                        "paginaFinal" => "988"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1866765"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0155"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The epidemiology of atrial fibrillation in elderly persons&#58; the tip of the iceberg"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "A&#46;S&#46; Go"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Am J Geriatr Cardiol"
                        "fecha" => "2005"
                        "volumen" => "14"
                        "paginaInicial" => "56"
                        "paginaFinal" => "61"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15785146"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S1081120615008443"
                          "estado" => "S300"
                          "issn" => "10811206"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0160"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Impact of atrial fibrillation on the risk of death&#58; the Framingham Heart Study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "E&#46;J&#46; Benjamin"
                            1 => "P&#46;A&#46; Wolf"
                            2 => "R&#46;B&#46; d&#8217;Agostino"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "1998"
                        "volumen" => "98"
                        "paginaInicial" => "946"
                        "paginaFinal" => "952"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9737513"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0165"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Assessment of atrial electromechanical coupling and influential factors in nonrheumatic paroxysmal atrial fibrillation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "Q&#46;Q&#46; Cui"
                            1 => "W&#46; Zhang"
                            2 => "H&#46; Wang"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/clc.20162"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Cardiol"
                        "fecha" => "2008"
                        "volumen" => "31"
                        "paginaInicial" => "74"
                        "paginaFinal" => "78"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18257022"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0170"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Doppler tissue analysis of atrial electromechanical coupling in paroxysmal atrial fibrillation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "W&#46; Omi"
                            1 => "H&#46; Nagai"
                            2 => "M&#46; Takamura"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.echo.2004.08.029"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Soc Echocardiogr"
                        "fecha" => "2005"
                        "volumen" => "18"
                        "paginaInicial" => "39"
                        "paginaFinal" => "44"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15637487"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0175"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Evaluation of atrial conduction time by P wave dispersion and tissue Doppler echocardiography in prehypertensive patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "N&#46; Ermis"
                            1 => "N&#46; A&#231;ikg&#246;z"
                            2 => "E&#46; Yasar"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Turk Kardiyol Dern Ars"
                        "fecha" => "2010"
                        "volumen" => "38"
                        "paginaInicial" => "525"
                        "paginaFinal" => "530"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21248451"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0180"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Regression of electrocardiographic left ventricular hypertrophy decreased incidence of new-onset atrial fibrillation in patients with hypertension"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "P&#46;M&#46; Okin"
                            1 => "K&#46; Wachtell"
                            2 => "R&#46;B&#46; Devereux"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/jama.296.10.1242"
                      "Revista" => array:6 [
                        "tituloSerie" => "JAMA"
                        "fecha" => "2006"
                        "volumen" => "296"
                        "paginaInicial" => "1242"
                        "paginaFinal" => "1248"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16968848"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0185"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The left atrium&#44; atrial fibrillation&#44; and the risk of stroke in hypertensive patients with left ventricular hypertrophy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "K&#46; Wachtell"
                            1 => "R&#46;B&#46; Devereux"
                            2 => "P&#46;A&#46; Lyle"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1177/1753944708093846"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ther Adv Cardiovasc Dis"
                        "fecha" => "2008"
                        "volumen" => "2"
                        "paginaInicial" => "507"
                        "paginaFinal" => "513"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19124445"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0190"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prevalence of paroxysmal atrial fibrillation depending on the regression of left ventricular hypertrophy in arterial hypertension"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "M&#46;G&#46; Hennersdorf"
                            1 => "P&#46;O&#46; Schueller"
                            2 => "S&#46; Steiner"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1291/hypres.30.535"
                      "Revista" => array:6 [
                        "tituloSerie" => "Hypertens Res"
                        "fecha" => "2007"
                        "volumen" => "30"
                        "paginaInicial" => "535"
                        "paginaFinal" => "540"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17664857"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0195"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Influence of blood pressure on left atrial size&#46; The Framingham Heart Study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "S&#46;M&#46; Vaziri"
                            1 => "M&#46;G&#46; Larson"
                            2 => "M&#46;S&#46; Lauer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Hypertension"
                        "fecha" => "1995"
                        "volumen" => "25"
                        "paginaInicial" => "1155"
                        "paginaFinal" => "1160"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7768556"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0200"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Association of pulse pressure with new-onset atrial fibrillation in patients with hypertension and left ventricular hypertrophy&#58; the Losartan Intervention For Endpoint &#40;LIFE&#41; reduction in hypertension study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "A&#46;C&#46;K&#46; Larstorp"
                            1 => "I&#46; Ariansen"
                            2 => "K&#46; Gjesdal"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/HYPERTENSIONAHA.112.195032"
                      "Revista" => array:6 [
                        "tituloSerie" => "Hypertension"
                        "fecha" => "2012"
                        "volumen" => "60"
                        "paginaInicial" => "347"
                        "paginaFinal" => "353"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22753219"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0205"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pulse pressure risk of new-onset atrial fibrillation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "G&#46;F&#46; Mitchell"
                            1 => "R&#46;S&#46; Vasan"
                            2 => "M&#46;J&#46; Keyes"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/jama.297.7.709"
                      "Revista" => array:6 [
                        "tituloSerie" => "JAMA"
                        "fecha" => "2007"
                        "volumen" => "297"
                        "paginaInicial" => "709"
                        "paginaFinal" => "715"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17312290"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0210"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Relation of systolic&#44; diastolic&#44; and pulse pressures and aortic distensibility with atrial fibrillation &#40;from the Multi-Ethnic Study of Atherosclerosis&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "N&#46;S&#46; Roetker"
                            1 => "L&#46;Y&#46; Chen"
                            2 => "S&#46;R&#46; Heckbert"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.amjcard.2014.05.041"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Cardiol"
                        "fecha" => "2014"
                        "volumen" => "114"
                        "paginaInicial" => "587"
                        "paginaFinal" => "592"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24996553"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0215"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "P-wave dispersion&#58; what we know till now&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "S&#46; Okutucu"
                            1 => "K&#46; Aytemir"
                            2 => "A&#46; Oto"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
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Early detection by non-invasive methods of predisposition to atrial remodeling in hypertension
Predisposição para remodelagem auricular na hipertensão arterial - deteção precoce por meios não invasivos
Luiz Menezes Falcão
Faculdade de Medicina de Lisboa, Hospital de Santa Maria/Centro Hospitalar Lisboa Norte, Lisboa, Portugal
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    "titulo" => "Early detection by non-invasive methods of predisposition to atrial remodeling in hypertension"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Hypertension &#40;persistently high blood pressure levels&#41; is one of the main cardiovascular risk factors&#46; It causes pressure overload that leads to the structural and electrical alterations known as atrial remodeling&#46;<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">1&#44;2</span></a> The consequences are seen at various levels&#44; especially in increased risk for atrial fibrillation &#40;AF&#41;&#44; which worsens with increasing age&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">3</span></a> AF has a significant impact on cardiac output and is associated with a 4-5-fold higher risk of cardioembolic ischemic stroke&#44;<a class="elsevierStyleCrossRefs" href="#bib0150"><span class="elsevierStyleSup">4&#44;5</span></a> as well as a considerably higher risk of death&#46;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">6</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Interatrial electromechanical delay and prolonged total atrial activation time have been linked to a higher incidence of AF&#46;<a class="elsevierStyleCrossRefs" href="#bib0145"><span class="elsevierStyleSup">3&#44;7&#44;8</span></a> Increased atrial conduction time is an indication of structural and electrical remodeling&#44; which left atrial &#40;LA&#41; size and LA volume index are not&#46;<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">1&#44;9</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Increased left ventricular &#40;LV&#41; mass index is associated with prolonged interatrial conduction time and LA electromechanical coupling interval&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">1</span></a> The severity of LV hypertrophy appears to be one of the factors associated with the onset of AF&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">It has been demonstrated that pharmacological treatment that reduces blood pressure &#40;BP&#41; and hence LV mass makes AF less likely to occur&#46;<a class="elsevierStyleCrossRefs" href="#bib0180"><span class="elsevierStyleSup">10&#8211;12</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Data from the Framingham Heart Study show a relation between LA size as determined by echocardiography and systolic BP and pulse pressure &#40;PP&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">13</span></a> At the same time&#44; there is evidence of a link between higher PP and increased incidence of AF in hypertension&#46;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">14</span></a> PP has been shown to be a better predictor of AF risk than mean arterial pressure or aortic distensibility&#46;<a class="elsevierStyleCrossRefs" href="#bib0205"><span class="elsevierStyleSup">15&#44;16</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">There is a good correlation between P-wave duration obtained in a single surface electrocardiographic &#40;ECG&#41; lead and the maximum duration of atrial electrograms&#59; it also correlates with inter- and intra-atrial conduction times&#46;<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">17</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">P-wave dispersion&#44; the difference between maximum and minimum P-wave duration recorded in multiple ECG leads in sinus rhythm&#44; has been studied as an indicator of AF risk in populations with and without cardiovascular disease and in conditions including hypertension&#44; ischemic heart disease&#44; valve disease&#44; congenital heart defects and heart failure&#46;<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">17</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">In hypertensive patients&#44; P-wave dispersion may help identify LV hypertrophy and LV diastolic dysfunction&#44; both of which lead to morphological and hemodynamic alterations in the left atrium that increase the risk of AF&#46; Raised intra-atrial pressures and ischemia promote atrial remodeling&#44; with disorganization of myocardial fibers and fibrosis&#44; dilatation and electrical instability&#46;<a class="elsevierStyleCrossRefs" href="#bib0215"><span class="elsevierStyleSup">17&#44;18</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Among the factors tending to increase P-wave dispersion and atrial fibrosis is elevation of angiotensin II and catecholamines&#46;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">18</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">Treatment targeting the renin-angiotensin-aldosterone system &#40;RAAS&#41; with perindopril in hypertensives led to a decrease in P-wave dispersion&#44;<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">17</span></a> an effect also seen in a similar study using quinapril&#46;<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">17</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">In hypertensive patients&#44; increased P-wave dispersion and maximum P-wave duration reflect instability and heterogeneity of atrial conduction&#44; which may be a result of the morphological and hemodynamic alterations undergone by the left atrium as a consequence of hypertension&#46;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">18</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">Heart failure with reduced LV ejection fraction &#40;LVEF&#41; predisposes to the onset of AF&#46; In a study of patients with non-ischemic dilated cardiomyopathy&#44; P-wave dispersion was much higher than in the control group&#46;<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">19</span></a> This increased P-wave dispersion may be explained by hemodynamic variations resulting from LV dysfunction and associated neurohormonal activation affecting the left atrium&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Camsari et al&#46; found a significant correlation between P-wave dispersion and LVEF in patients with heart failure&#46; Both sympathetic activity and the RAAS are stimulated in heart failure&#44; and this influences P-wave duration and dispersion&#44; both of which were reduced following treatment with metoprolol in their study&#46;<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">20</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">For patients with symptomatic heart failure despite optimized drug treatment&#44; in sinus rhythm and with LVEF &#8804;35&#37;&#44; QRS &#8805;130 ms and complete left bundle branch block&#44; cardiac resynchronization therapy &#40;CRT&#41; improves LV function and reduces neurohormonal activation&#46; It has also been shown to contribute to reverse atrial remodeling and thus to improvement in atrial function&#46;<a class="elsevierStyleCrossRefs" href="#bib0235"><span class="elsevierStyleSup">21&#44;22</span></a></p><p id="par0075" class="elsevierStylePara elsevierViewall">In a study of 46 patients with heart failure with reduced LVEF&#44; after three months of CRT&#44; maximum P-wave duration&#44; P-wave dispersion and LA diameter were decreased and LVEF was increased&#46;<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">22</span></a> Maximum P-wave duration and P-wave dispersion were positively correlated with reduction in LA diameter and negatively correlated with improvement in LVEF&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">P-wave terminal force in lead V1 &#40;PTFV1&#41; is the product of the amplitude and duration of the terminal negative phase of the P wave in lead V1 in mm&#215;ms&#46; It is a marker of cardiovascular prognosis and there is evidence that when increased it indicates increased risk of AF&#46;<a class="elsevierStyleCrossRefs" href="#bib0245"><span class="elsevierStyleSup">23&#44;24</span></a> Abnormal PTFV1&#44; defined as &#8805;40 mm&#215;ms&#44; was shown to be an independent predictor of cardiac death or hospitalization for heart failure in patients with prior myocardial infarction&#44;<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">23</span></a> while another study&#44; in patients with increased LV mass&#44; showed that PTFV1 &#8805;40 mm&#215;ms was associated with increased risk for ischemic stroke&#46;<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">25</span></a></p><p id="par0085" class="elsevierStylePara elsevierViewall">In their study published in this issue of the <span class="elsevierStyleItalic">Journal</span>&#44; &#199;imen et al&#46; examine early changes in atrial conduction times and P-wave dispersion in 157 patients with essential hypertension&#44; no significant cardiac structural alterations&#44; and elevated PP &#40;&#8805;60 mmHg&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">26</span></a> Atrial electromechanical delay &#40;EMD&#41; was assessed by tissue Doppler echocardiography and P-wave dispersion by electrocardiography&#46; The authors show that elevated PP was associated with increased atrial EMD and P-wave dispersion&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">Detection of early alterations&#44; by non-invasive and easily accessible means&#44; that could help prevent structural and electrical remodeling and thus reduce the risk of AF is of the utmost importance&#46; The study by &#199;imen et al&#46; in this issue is another contribution to this goal&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of interest</span><p id="par0095" class="elsevierStylePara elsevierViewall">The author has no conflicts of interest to declare&#46;</p></span></span>"
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              "etiqueta" => "1"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Early changes in atrial electromechanical coupling in patients with hypertension&#58; assessment by tissue Doppler imaging"
                      "autores" => array:1 [
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                          "autores" => array:3 [
                            0 => "B&#46;K&#46; Avci"
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                            2 => "G&#46; Donmez"
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                  "host" => array:1 [
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                        "tituloSerie" => "Chin Med J &#40;Engl&#41;"
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                        "volumen" => "129"
                        "paginaInicial" => "1311"
                        "paginaFinal" => "1315"
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              "identificador" => "bib0140"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Alterations of cardiac structure in patients with isolated office&#44; ambulatory&#44; or home hypertension&#58; data from the general population &#40;Pressione Arteriose Monitorate E Loro Associazioni &#91;PAMELA&#93; Study&#41;"
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                          "autores" => array:3 [
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                            1 => "G&#46; Trocino"
                            2 => "A&#46; Lanzarotti"
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                        ]
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                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
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                        "tituloSerie" => "Circulation"
                        "fecha" => "2001"
                        "volumen" => "104"
                        "paginaInicial" => "1385"
                        "paginaFinal" => "1392"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11560854"
                            "web" => "Medline"
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                  ]
                ]
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              "identificador" => "bib0145"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
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                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/hrt.2008.148528"
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                        "tituloSerie" => "Heart"
                        "fecha" => "2009"
                        "volumen" => "95"
                        "paginaInicial" => "835"
                        "paginaFinal" => "840"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19074923"
                            "web" => "Medline"
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                      ]
                    ]
                  ]
                ]
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              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Atrial fibrillation as an independent risk factor for stroke&#58; the Framingham Study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "P&#46;A&#46; Wolf"
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                    ]
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                  "host" => array:1 [
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                        "tituloSerie" => "Stroke"
                        "fecha" => "1991"
                        "volumen" => "22"
                        "paginaInicial" => "983"
                        "paginaFinal" => "988"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1866765"
                            "web" => "Medline"
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                0 => array:2 [
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                        "tituloSerie" => "Am J Geriatr Cardiol"
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                        "paginaInicial" => "56"
                        "paginaFinal" => "61"
                        "link" => array:1 [
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                        "fecha" => "1998"
                        "volumen" => "98"
                        "paginaInicial" => "946"
                        "paginaFinal" => "952"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9737513"
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                      "doi" => "10.1002/clc.20162"
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                        "tituloSerie" => "Clin Cardiol"
                        "fecha" => "2008"
                        "volumen" => "31"
                        "paginaInicial" => "74"
                        "paginaFinal" => "78"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18257022"
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                      "doi" => "10.1016/j.echo.2004.08.029"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Soc Echocardiogr"
                        "fecha" => "2005"
                        "volumen" => "18"
                        "paginaInicial" => "39"
                        "paginaFinal" => "44"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15637487"
                            "web" => "Medline"
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                      "titulo" => "Evaluation of atrial conduction time by P wave dispersion and tissue Doppler echocardiography in prehypertensive patients"
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                          "etal" => true
                          "autores" => array:3 [
                            0 => "N&#46; Ermis"
                            1 => "N&#46; A&#231;ikg&#246;z"
                            2 => "E&#46; Yasar"
                          ]
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                      ]
                    ]
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                  "host" => array:1 [
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                      "Revista" => array:6 [
                        "tituloSerie" => "Turk Kardiyol Dern Ars"
                        "fecha" => "2010"
                        "volumen" => "38"
                        "paginaInicial" => "525"
                        "paginaFinal" => "530"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21248451"
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                          ]
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              "identificador" => "bib0180"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Regression of electrocardiographic left ventricular hypertrophy decreased incidence of new-onset atrial fibrillation in patients with hypertension"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "P&#46;M&#46; Okin"
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                            2 => "R&#46;B&#46; Devereux"
                          ]
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                      ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/jama.296.10.1242"
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                        "tituloSerie" => "JAMA"
                        "fecha" => "2006"
                        "volumen" => "296"
                        "paginaInicial" => "1242"
                        "paginaFinal" => "1248"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16968848"
                            "web" => "Medline"
                          ]
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                      ]
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                ]
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              "identificador" => "bib0185"
              "etiqueta" => "11"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The left atrium&#44; atrial fibrillation&#44; and the risk of stroke in hypertensive patients with left ventricular hypertrophy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
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                            2 => "P&#46;A&#46; Lyle"
                          ]
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                    ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1177/1753944708093846"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ther Adv Cardiovasc Dis"
                        "fecha" => "2008"
                        "volumen" => "2"
                        "paginaInicial" => "507"
                        "paginaFinal" => "513"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19124445"
                            "web" => "Medline"
                          ]
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                ]
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              "identificador" => "bib0190"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prevalence of paroxysmal atrial fibrillation depending on the regression of left ventricular hypertrophy in arterial hypertension"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
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                            2 => "S&#46; Steiner"
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                    ]
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                    0 => array:2 [
                      "doi" => "10.1291/hypres.30.535"
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                        "tituloSerie" => "Hypertens Res"
                        "fecha" => "2007"
                        "volumen" => "30"
                        "paginaInicial" => "535"
                        "paginaFinal" => "540"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17664857"
                            "web" => "Medline"
                          ]
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              "identificador" => "bib0195"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Influence of blood pressure on left atrial size&#46; The Framingham Heart Study"
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                          "etal" => true
                          "autores" => array:3 [
                            0 => "S&#46;M&#46; Vaziri"
                            1 => "M&#46;G&#46; Larson"
                            2 => "M&#46;S&#46; Lauer"
                          ]
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                    ]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Hypertension"
                        "fecha" => "1995"
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                        "paginaInicial" => "1155"
                        "paginaFinal" => "1160"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7768556"
                            "web" => "Medline"
                          ]
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Association of pulse pressure with new-onset atrial fibrillation in patients with hypertension and left ventricular hypertrophy&#58; the Losartan Intervention For Endpoint &#40;LIFE&#41; reduction in hypertension study"
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                        0 => array:2 [
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                          "autores" => array:3 [
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                            2 => "K&#46; Gjesdal"
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                      "doi" => "10.1161/HYPERTENSIONAHA.112.195032"
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                        "tituloSerie" => "Hypertension"
                        "fecha" => "2012"
                        "volumen" => "60"
                        "paginaInicial" => "347"
                        "paginaFinal" => "353"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22753219"
                            "web" => "Medline"
                          ]
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                    0 => array:2 [
                      "titulo" => "Pulse pressure risk of new-onset atrial fibrillation"
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                          "etal" => true
                          "autores" => array:3 [
                            0 => "G&#46;F&#46; Mitchell"
                            1 => "R&#46;S&#46; Vasan"
                            2 => "M&#46;J&#46; Keyes"
                          ]
                        ]
                      ]
                    ]
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                    0 => array:2 [
                      "doi" => "10.1001/jama.297.7.709"
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                        "tituloSerie" => "JAMA"
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                        "volumen" => "297"
                        "paginaInicial" => "709"
                        "paginaFinal" => "715"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17312290"
                            "web" => "Medline"
                          ]
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              "identificador" => "bib0210"
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                      "titulo" => "Relation of systolic&#44; diastolic&#44; and pulse pressures and aortic distensibility with atrial fibrillation &#40;from the Multi-Ethnic Study of Atherosclerosis&#41;"
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                          "etal" => true
                          "autores" => array:3 [
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                        "tituloSerie" => "Am J Cardiol"
                        "fecha" => "2014"
                        "volumen" => "114"
                        "paginaInicial" => "587"
                        "paginaFinal" => "592"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24996553"
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                      "titulo" => "P-wave dispersion&#58; what we know till now&#63;"
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                            0 => "S&#46; Okutucu"
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                      ]
                    ]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J R Soc Med Cardiovasc Dis"
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                        "volumen" => "5"
                        "paginaInicial" => "1"
                        "paginaFinal" => "9"
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                      "titulo" => "Are maximum P wave duration and P wave dispersion a marker of target organ damage in the hypertensive population&#63;"
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                          "autores" => array:3 [
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                            2 => "M&#46; Yavuzkir"
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                      "doi" => "10.1007/s00392-007-0587-8"
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                        "tituloSerie" => "Clin Res Cardiol"
                        "fecha" => "2008"
                        "volumen" => "97"
                        "paginaInicial" => "98"
                        "paginaFinal" => "104"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17938849"
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              "identificador" => "bib0225"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "P-wave duration and P-wave dispersion in patients with dilated cardiomyopathy"
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                    0 => array:2 [
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                        "tituloSerie" => "Eur J Heart Fail"
                        "fecha" => "2004"
                        "volumen" => "6"
                        "paginaInicial" => "567"
                        "paginaFinal" => "569"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15302004"
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                        "paginaInicial" => "111"
                        "paginaFinal" => "116"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12764693"
                            "web" => "Medline"
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                    0 => array:2 [
                      "titulo" => "Improvement of atrial function and atrial reverse remodeling after cardiac resynchronization therapy for heart failure"
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                        "link" => array:1 [
                          0 => array:2 [
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                        "tituloSerie" => "Heart Vessels"
                        "fecha" => "2013"
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                        "paginaFinal" => "695"
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Article information
ISSN: 21742049
Original language: English
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Idiomas
Revista Portuguesa de Cardiologia (English edition)
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