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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">The various forms of amyloidosis are characterized by the extracellular deposition of amyloid substances&#46; These consist of insoluble&#44; non-functional fibrils derived from different precursor proteins that accumulate in characteristic conformations&#46; Amyloid infiltration into organs causes them to fail&#44; and cardiac amyloidosis is a major cause of death&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">The common denominator of both hereditary and acquired forms of amyloidosis is prolonged exposure to an abnormal protein or to excessive quantities of a normal protein&#46; More than 30 amyloid precursor proteins are known&#44;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">2</span></a> the most common being immunoglobulin light chain&#44; wild-type transthyretin&#44; and mutant forms of transthyretin&#44; apolipoprotein A1 and fibrinogen alpha chain&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">3</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Mutant variants of transthyretin are the cause of the most common type of autosomal dominant hereditary systemic amyloidosis&#44; familial amyloid polyneuropathy &#40;FAP&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">4</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Transthyretin is a plasma transport protein mainly synthesized by the liver&#46; FAP is the result of mutations in <span class="elsevierStyleItalic">TTR</span>&#44; the gene that codes for transthyretin&#44; with the Val30Met mutation being responsible for 50&#37; of cases&#46; Clinically&#44; FAP is characterized by sensory&#44; motor and autonomic neuropathy&#44; gastrointestinal alterations&#44; and heart and renal failure that can rapidly lead to death&#46; The phenotype varies according to geographic origin of the mutation&#44; age of onset&#44; and gender&#46;<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">4&#44;5</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">The first cases of FAP were described by Corino de Andrade in northern Portugal &#40;Vila do Conde and P&#243;voa do Varzim&#41; in 1952&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">6</span></a> Its prevalence in the endemic areas of Portugal and Sweden ranges between 1&#47;1000 and 1&#47;10<span class="elsevierStyleHsp" style=""></span>000 individuals&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">4</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Effective treatment requires an accurate diagnosis based on histopathology and genetics&#46; Imaging studies such as echocardiography&#44; magnetic resonance and scintigraphy aid assessment of the extent and severity of involvement of different organs and enable stratification of associated risk&#46;<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">4&#44;5</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Liver transplantation has made it possible to slow the progression of the disease&#44; and recently there have been promising reports of drugs&#44; including tafamidis and diflunisal&#44; that appear to stabilize transthyretin&#46;<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">4&#44;5</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">The article by Coutinho et al&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">7</span></a> in this issue of the <span class="elsevierStyleItalic">Journal</span> analyzes the use of MIBG scintigraphy to assess cardiac sympathetic denervation and how it is affected by liver transplantation in FAP patients&#46; Their work is of particular interest due to the high prevalence of the disease in some regions of Portugal&#46; It is a prospective observational study of 232 carriers of the Val30Met mutation who underwent annual clinical assessment and serial <span class="elsevierStyleSup">123</span>I-MIBG scans&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleSup">123</span>I-MIBG scintigraphy provides information on cardiac autonomic neuropathy&#44; but its role in clinical practice is as yet unclear&#46; <span class="elsevierStyleSup">123</span>I-MIBG is an analog of norepinephrine and behaves similarly&#59; when injected peripherally it is taken up by presynaptic nerve endings at concentrations that are dependent on the release and uptake of norepinephrine and thus on the integrity of the autonomic nervous system&#46; The heart-to-mediastinum ratio is a measure of relative uptake of the radioisotope in the heart and mediastinum and is lower in cases of sympathetic denervation&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">8</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">Coutinho et al&#46; report that decreased heart-to-mediastinum ratio was associated with risk of death&#44; and that this ratio stabilized during a median follow-up of 4&#46;5 years in 70 patients who underwent liver transplantation&#46; They conclude that sympathetic denervation is common in this variant of FAP and that MIBG scintigraphy is useful for risk stratification in these patients&#46; Their results suggest that liver transplantation halted progression of sympathetic denervation&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleSup">123</span>I-MIBG scintigraphy is used to study cardiac denervation in various conditions including ischemic heart disease&#44; heart failure&#44; arrhythmias and sudden death&#59; risk of the latter has been shown to be associated with sympathetic denervation assessed by <span class="elsevierStyleSup">123</span>I-MIBG scintigraphy in certain contexts&#46;<a class="elsevierStyleCrossRefs" href="#bib0150"><span class="elsevierStyleSup">8&#44;9</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">There are few studies in the literature on the use of <span class="elsevierStyleSup">123</span>I-MIBG scintigraphy in FAP&#46; One of the first was a case report in Japan in 1995&#46;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">10</span></a> In 1999 a study by Delahaye et al&#46; published in the <span class="elsevierStyleItalic">European Journal of Nuclear Medicine</span> concluded that <span class="elsevierStyleSup">123</span>I-MIBG scintigraphy was of value for assessing cardiac sympathetic denervation in FAP&#44;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">11</span></a> and in 2006&#44; in a study of 31 patients&#44; the same group reported that liver transplantation helped stabilize denervation and that patients with worsened neurological status after transplantation were those who had had the most severe denervation before surgery&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">12</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">Coutinho et al&#46;&#8217;s group have already published two articles on <span class="elsevierStyleSup">123</span>I-MIBG scintigraphy in FAP&#58; a study of 34 patients in the <span class="elsevierStyleItalic">Journal</span> in 2004 that demonstrated a high incidence of cardiac denervation in FAP type I&#44;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">13</span></a> and another of 143 patients in <span class="elsevierStyleItalic">Circulation&#58; Cardiovascular Imaging</span> in 2013&#44; in which they concluded that sympathetic denervation as assessed by <span class="elsevierStyleSup">123</span>I-MIBG scintigraphy was a prognostic marker in FAP patients&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">14</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">The article under discussion<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">7</span></a> is thus part of a research line they have followed for some years and that now covers a substantial population of FAP patients assessed by <span class="elsevierStyleSup">123</span>I-MIBG scintigraphy&#46; They have related the findings with prognosis and conclude that sympathetic denervation does in fact stabilize following liver transplantation&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of interest</span><p id="par0075" class="elsevierStylePara elsevierViewall">The author has no conflicts of interest to declare&#46;</p></span></span>"
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            0 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Systemic amyloidosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46;D&#46; Wechalekar"
                            1 => "J&#46;D&#46; Gillmore"
                            2 => "P&#46;N&#46; Hawkins"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0140-6736(15)01274-X"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "2016"
                        "volumen" => "387"
                        "paginaInicial" => "2641"
                        "paginaFinal" => "2654"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26719234"
                            "web" => "Medline"
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                    ]
                  ]
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              ]
            ]
            1 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Nomenclature 2014&#58; amyloid fibril proteins and clinical classification of the amyloidosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "J&#46;D&#46; Sipe"
                            1 => "M&#46;D&#46; Benson"
                            2 => "J&#46;N&#46; Buxbaum"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3109/13506129.2014.964858"
                      "Revista" => array:6 [
                        "tituloSerie" => "Amyloid"
                        "fecha" => "2014"
                        "volumen" => "21"
                        "paginaInicial" => "221"
                        "paginaFinal" => "224"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25263598"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Amyloidosis&#58; pathogenesis and new therapeutic options"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "G&#46; Merlini"
                            1 => "D&#46;C&#46; Seldin"
                            2 => "M&#46;A&#46; Gertz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1200/JCO.2010.32.2271"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Oncol"
                        "fecha" => "2011"
                        "volumen" => "29"
                        "paginaInicial" => "1924"
                        "paginaFinal" => "1933"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21483018"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sixty years of transthyretin familial amyloid polyneuropathy &#40;TTR-FAP&#41; in Europe&#58; where are we now&#63; A European network approach to defining the epidemiology and management patterns for TTR-FAP"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "Y&#46; Parman"
                            1 => "D&#46; Adams"
                            2 => "L&#46; Obici"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/WCO.0000000000000288"
                      "Revista" => array:7 [
                        "tituloSerie" => "Curr Opin Neurol"
                        "fecha" => "2016"
                        "volumen" => "29"
                        "numero" => "Suppl"
                        "paginaInicial" => "S3"
                        "paginaFinal" => "S13"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26734951"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Recent advances in transthyretin amyloidosis therapy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M&#46; Ueda"
                            1 => "Y&#46; Ando"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/2047-9158-3-19"
                      "Revista" => array:5 [
                        "tituloSerie" => "Transl Neurodegener"
                        "fecha" => "2014"
                        "volumen" => "3"
                        "paginaInicial" => "19"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25228988"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0140"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A peculiar form of peripheral neuropathy&#59; familiar atypical generalized amyloidosis with special involvement of the peripheral nerves"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "C&#46; Andrade"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Brain"
                        "fecha" => "1952"
                        "volumen" => "75"
                        "paginaInicial" => "408"
                        "paginaFinal" => "427"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12978172"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0145"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Progress&#227;o da desnerva&#231;&#227;o simp&#225;tica card&#237;aca avaliada por cintigrafia com MIBG-I123 na polineuropatia amiloid&#243;tica familiar e o impacto da transplanta&#231;&#227;o hep&#225;tica"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "C&#46;J&#46;A&#46; Coutinho"
                            1 => "N&#46; Cortez-Dias"
                            2 => "G&#46; Cantinho"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.repc.2016.08.010"
                      "Revista" => array:6 [
                        "tituloSerie" => "Rev Port Cardiol"
                        "fecha" => "2017"
                        "volumen" => "36"
                        "paginaInicial" => "333"
                        "paginaFinal" => "340"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28479268"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0150"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Iodine-123-metaiodobenzylguanidine scintigraphy in risk stratification of sudden death in heart failure"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46;I&#46; Martins da Silva"
                            1 => "M&#46;J&#46; Vidigal Ferreira"
                            2 => "A&#46;P&#46; Mor&#227;o Moreira"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.repc.2012.11.003"
                      "Revista" => array:6 [
                        "tituloSerie" => "Rev Port Cardiol"
                        "fecha" => "2013"
                        "volumen" => "32"
                        "paginaInicial" => "509"
                        "paginaFinal" => "516"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23731734"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0155"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Myocardial iodine-123 meta-iodobenzylguanidine imaging and cardiac events in heart failure&#46; Results of the prospective ADMIRE-HF &#40;AdreView Myocardial Imaging for Risk Evaluation in Heart Failure&#41; study"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "A&#46;F&#46; Jacobson"
                            1 => "R&#46; Senior"
                            2 => "M&#46;D&#46; Cerqueira"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jacc.2010.01.014"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Coll Cardiol"
                        "fecha" => "2010"
                        "volumen" => "55"
                        "paginaInicial" => "2212"
                        "paginaFinal" => "2221"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20188504"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0160"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cardiac sympathetic denervation in transthyretin-related familial amyloidotic polyneuropathy&#58; detection with iodine-123-MIBG"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "T&#46; Nakata"
                            1 => "K&#46; Shimamoto"
                            2 => "S&#46; Yonekura"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Nucl Med"
                        "fecha" => "1995"
                        "volumen" => "36"
                        "paginaInicial" => "1040"
                        "paginaFinal" => "1042"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7769425"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0120"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cardiac sympathetic denervation in familial amyloid polyneuropathy assessed by iodine-123 metaiodobenzylguanidine scintigraphy and heart rate variability"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "N&#46; Delahaye"
                            1 => "S&#46; Dinanian"
                            2 => "M&#46;S&#46; Slama"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Nucl Med"
                        "fecha" => "1999"
                        "volumen" => "26"
                        "paginaInicial" => "416"
                        "paginaFinal" => "424"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10199949"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0125"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Impact of liver transplantation on cardiac autonomic denervation in familial amyloid polyneuropathy"
                      "autores" => array:1 [
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                          "etal" => true
                          "autores" => array:3 [
                            0 => "N&#46; Delahaye"
                            1 => "F&#46; Rouzet"
                            2 => "L&#46; Sarda"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Medicine &#40;Baltimore&#41;"
                        "fecha" => "2006"
                        "volumen" => "85"
                        "paginaInicial" => "229"
                        "paginaFinal" => "238"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0130"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Early detection of sympathetic myocardial denervation in patients with familial amyloid polyneuropathy type I"
                      "autores" => array:1 [
                        0 => array:2 [
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                          "autores" => array:3 [
                            0 => "C&#46;A&#46; Coutinho"
                            1 => "I&#46; Concei&#231;&#227;o"
                            2 => "A&#46; Almeida"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Rev Port Cardiol"
                        "fecha" => "2004"
                        "volumen" => "23"
                        "paginaInicial" => "201"
                        "paginaFinal" => "211"
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