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procedures&#44; either isolated or with bypass grafting&#44; were performed in 2015&#46; This corresponds to a BAV&#47;SAVR ratio of 1&#58;6&#44; while the ratio in many other European countries is 1&#58;15&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">9</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">The pressure on heart teams involved in TAVR has grown as they have had to adapt to an enormous increase in numbers of patients&#44; many of whom do not have a primary indication for TAVR&#46; The major issues to be addressed at present are&#58;<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">1&#46;</span><p id="par0020" class="elsevierStylePara elsevierViewall">Implementation of a fast track protocol&#44; through which clinical assessment and the main diagnostic exams &#40;cardiological and surgical consultations&#44; laboratory tests&#44; cardiac computed tomography&#44; transthoracic and possibly transesophageal echocardiography&#44; catheterization and possible angioplasty&#41; can be performed in two or three sessions&#59;</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">2&#46;</span><p id="par0025" class="elsevierStylePara elsevierViewall">The indications for BAV in the latest guidelines of the European Society of Cardiology and the American College of Cardiology&#47;American Heart Association on valvular heart disease &#40;class IIb recommendation&#41; do not reflect improved outcomes in the TAVR era&#46;<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">7&#44;8</span></a> Given that many of the associated complications may recur when initial BAV is followed by TAVR&#44; the situations in which it is acceptable to subject a patient to the increased risk of BAV must be carefully considered&#58;<ul class="elsevierStyleList" id="lis0010"><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">&#40;a&#41;</span><p id="par0030" class="elsevierStylePara elsevierViewall">BAV is only acceptable as a palliative measure to relieve severe symptoms &#40;on compassionate grounds&#41;&#44; or as a bridge to definitive treatment&#44; due to a severe comorbidity&#44; which may be temporary or have an uncertain prognosis&#44; and&#47;or the patient has an expected survival of less than a year &#40;typically due to cancer or an urgent intervention that does not allow for dual antiplatelet therapy&#44; or to enable very elderly patients with other significant and irreversible disease to be discharged home&#41;&#59;</p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">&#40;b&#41;</span><p id="par0035" class="elsevierStylePara elsevierViewall">all other indications for BAV should be carefully weighed&#44; particularly those related to access to prompt treatment&#44; which there is an obligation to provide&#44; or if there are doubts concerning the benefit of TAVR as noninvasive methods can be used for the same purpose &#40;most commonly to treat left ventricular dysfunction and&#47;or severe mitral regurgitation&#41;&#59;</p></li></ul></p></li><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">3&#46;</span><p id="par0040" class="elsevierStylePara elsevierViewall">Prompt and appropriate action in the event of complications&#58; once the indication has been established&#44; survival is 1-3 years in symptomatic patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">2&#44;10&#44;11</span></a> Whatever the therapeutic option&#44; however arbitrary the decision may be&#44; the procedure should be performed within two weeks to two months&#44; depending on severity&#46; In the case of BAV&#44; since this is a palliative procedure the possibility of clinical instability or complications that can be treated by TAVR &#8211; typically severe aortic regurgitation or stroke &#8211; must be borne in mind&#44; and the heart team must be prepared to proceed with TAVR &#40;an appropriate device being readied&#41; and&#47;or bailout surgery&#44; as in TAVR&#46;</p></li></ul></p><p id="par0045" class="elsevierStylePara elsevierViewall">The article by Francisco et al&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">12</span></a> published in this issue of the <span class="elsevierStyleItalic">Journal</span> provides valuable information that enables the importance of BAV to be judged in the light of the above considerations&#46; The study&#44; a retrospective analysis of the experience of a high-volume TAVR center in patients who had undergone BAV&#44; concludes that the procedure led to significant improvement in most patients&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">The study&#39;s principal merit is that it is the first to analyze a Portuguese experience in the TAVR era&#46; It is based on a single-center observational registry of 23 patients treated between January 2005 and October 2013&#44; and compares outcomes with larger previous series of 45-473 individuals&#46; Patients were followed for around nine months and the results were analyzed retrospectively&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">The most frequent indication for BAV was as a bridge to definitive treatment &#40;43&#37; of cases&#41;&#44; unlike most other series&#44; in which the main indication was palliative&#44; with only 18&#37; as a bridge&#46; Except for a higher prevalence of diabetes&#44; this cohort is generally less complex than others&#44; both demographically and clinically&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">3</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">In terms of technical details&#44; the article does not specify how balloon size was determined or how rapid pacing was performed&#44; particularly by what access route or the rate achieved&#44; since a sustained pressure fall is crucial for stable balloon positioning&#46; Undersizing the balloon by 1-2 mm allows for a less aggressive approach&#44; which&#44; together with smaller introducers and vascular closure devices&#44; appears to be responsible for the reduced rate of complications seen nowadays&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">2&#44;3</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">There was no periprocedural mortality or severe aortic regurgitation&#46; There was one in-hospital death due to stroke &#40;4&#46;3&#37;&#41; and the rate of major vascular complications was 8&#46;6&#37;&#59; it should be borne in mind that three refractory patients under mechanical ventilation were successfully extubated&#46; The favorable course at nine months of the patients treated definitively by TAVR attests to the effectiveness of the stratification process and the reasonable outcomes now achieved with the technique&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">In conclusion&#44; the study by Francisco et al&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">12</span></a> is significant for its analysis of the current risk associated with BAV in Portuguese patients in the TAVR era&#46; Prediction of the risk of palliative treatment is important and heart teams should be organized in such a way as to provide a rapid response to patients with indication for TAVR&#44; thus avoiding BAV as a palliative procedure for those awaiting definitive treatment by TAVR or SAVR&#44; since complications remain significant despite the experienced gained&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of interest</span><p id="par0075" class="elsevierStylePara elsevierViewall">The author has no conflicts of interest to declare&#46;</p></span></span>"
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Balloon aortic valvuloplasty in the transcatheter aortic valve replacement era: A challenge to organization of the heart team
Valvuloplastia aórtica de balão na era das válvulas aórticas percutâneas. Um desafio à dimensão organizativa dos programas multidisciplinares
Rui Campante Telesa,b
a Unidade de Intervenção Cardiovascular (UNICARV), Hospital de Santa Cruz, CHLO, Carnaxide, Portugal
b Centro de Estudos de Doenças Crónicas (CEDOC), NOVA Medical School, Lisboa, Portugal
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transthoracic and possibly transesophageal echocardiography&#44; catheterization and possible angioplasty&#41; can be performed in two or three sessions&#59;</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">2&#46;</span><p id="par0025" class="elsevierStylePara elsevierViewall">The indications for BAV in the latest guidelines of the European Society of Cardiology and the American College of Cardiology&#47;American Heart Association on valvular heart disease &#40;class IIb recommendation&#41; do not reflect improved outcomes in the TAVR era&#46;<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">7&#44;8</span></a> Given that many of the associated complications may recur when initial BAV is followed by TAVR&#44; the situations in which it is acceptable to subject a patient to the increased risk of BAV must be carefully considered&#58;<ul class="elsevierStyleList" id="lis0010"><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">&#40;a&#41;</span><p id="par0030" class="elsevierStylePara elsevierViewall">BAV is only acceptable as a palliative measure to relieve severe symptoms &#40;on compassionate grounds&#41;&#44; or as a bridge to definitive treatment&#44; due to a severe comorbidity&#44; which may be temporary or have an uncertain prognosis&#44; and&#47;or the patient has an expected survival of less than a year &#40;typically due to cancer or an urgent intervention that does not allow for dual antiplatelet therapy&#44; or to enable very elderly patients with other significant and irreversible disease to be discharged home&#41;&#59;</p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">&#40;b&#41;</span><p id="par0035" class="elsevierStylePara elsevierViewall">all other indications for BAV should be carefully weighed&#44; particularly those related to access to prompt treatment&#44; which there is an obligation to provide&#44; or if there are doubts concerning the benefit of TAVR as noninvasive methods can be used for the same purpose &#40;most commonly to treat left ventricular dysfunction and&#47;or severe mitral regurgitation&#41;&#59;</p></li></ul></p></li><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">3&#46;</span><p id="par0040" class="elsevierStylePara elsevierViewall">Prompt and appropriate action in the event of complications&#58; once the indication has been established&#44; survival is 1-3 years in symptomatic patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">2&#44;10&#44;11</span></a> Whatever the therapeutic option&#44; however arbitrary the decision may be&#44; the procedure should be performed within two weeks to two months&#44; depending on severity&#46; In the case of BAV&#44; since this is a palliative procedure the possibility of clinical instability or complications that can be treated by TAVR &#8211; typically severe aortic regurgitation or stroke &#8211; must be borne in mind&#44; and the heart team must be prepared to proceed with TAVR &#40;an appropriate device being readied&#41; and&#47;or bailout surgery&#44; as in TAVR&#46;</p></li></ul></p><p id="par0045" class="elsevierStylePara elsevierViewall">The article by Francisco et al&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">12</span></a> published in this issue of the <span class="elsevierStyleItalic">Journal</span> provides valuable information that enables the importance of BAV to be judged in the light of the above considerations&#46; The study&#44; a retrospective analysis of the experience of a high-volume TAVR center in patients who had undergone BAV&#44; concludes that the procedure led to significant improvement in most patients&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">The study&#39;s principal merit is that it is the first to analyze a Portuguese experience in the TAVR era&#46; It is based on a single-center observational registry of 23 patients treated between January 2005 and October 2013&#44; and compares outcomes with larger previous series of 45-473 individuals&#46; Patients were followed for around nine months and the results were analyzed retrospectively&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">The most frequent indication for BAV was as a bridge to definitive treatment &#40;43&#37; of cases&#41;&#44; unlike most other series&#44; in which the main indication was palliative&#44; with only 18&#37; as a bridge&#46; Except for a higher prevalence of diabetes&#44; this cohort is generally less complex than others&#44; both demographically and clinically&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">3</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">In terms of technical details&#44; the article does not specify how balloon size was determined or how rapid pacing was performed&#44; particularly by what access route or the rate achieved&#44; since a sustained pressure fall is crucial for stable balloon positioning&#46; Undersizing the balloon by 1-2 mm allows for a less aggressive approach&#44; which&#44; together with smaller introducers and vascular closure devices&#44; appears to be responsible for the reduced rate of complications seen nowadays&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">2&#44;3</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">There was no periprocedural mortality or severe aortic regurgitation&#46; There was one in-hospital death due to stroke &#40;4&#46;3&#37;&#41; and the rate of major vascular complications was 8&#46;6&#37;&#59; it should be borne in mind that three refractory patients under mechanical ventilation were successfully extubated&#46; The favorable course at nine months of the patients treated definitively by TAVR attests to the effectiveness of the stratification process and the reasonable outcomes now achieved with the technique&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">In conclusion&#44; the study by Francisco et al&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">12</span></a> is significant for its analysis of the current risk associated with BAV in Portuguese patients in the TAVR era&#46; Prediction of the risk of palliative treatment is important and heart teams should be organized in such a way as to provide a rapid response to patients with indication for TAVR&#44; thus avoiding BAV as a palliative procedure for those awaiting definitive treatment by TAVR or SAVR&#44; since complications remain significant despite the experienced gained&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of interest</span><p id="par0075" class="elsevierStylePara elsevierViewall">The author has no conflicts of interest to declare&#46;</p></span></span>"
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Article information
ISSN: 21742049
Original language: English
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2018 February 37 5 42
2018 January 25 6 31
2017 December 50 15 65
2017 November 53 11 64
2017 October 35 14 49
2017 September 29 8 37
2017 August 33 14 47
2017 July 30 13 43
2017 June 55 16 71
2017 May 112 32 144
2017 April 169 18 187
2017 March 0 1 1
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Revista Portuguesa de Cardiologia (English edition)
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