Editorial comment
Biomarkers in pulmonary hypertension: An ongoing quest for better outcomes
Biomarcadores na hipertensão pulmonar: uma busca contínua por melhores resultados
Maria Graça Castro
Serviço de Cardiologia, Hospitais da Universidade de Coimbra Centro, Hospitalar e Universitário de Coimbra, Coimbra, Portugal
Read
4059
Timeswas read the article
1442
Total PDF
2617
Total HTML
Share statistics
array:25 [ "pii" => "S2174204917300302" "issn" => "21742049" "doi" => "10.1016/j.repce.2017.02.006" "estado" => "S300" "fechaPublicacion" => "2017-02-01" "aid" => "942" "copyright" => "Sociedade Portuguesa de Cardiologia" "copyrightAnyo" => "2016" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "dis" "cita" => "Rev Port Cardiol. 2017;36:127-8" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1509 "formatos" => array:3 [ "EPUB" => 145 "HTML" => 1011 "PDF" => 353 ] ] "Traduccion" => array:1 [ "en" => array:20 [ "pii" => "S0870255116304309" "issn" => "08702551" "doi" => "10.1016/j.repc.2016.12.005" "estado" => "S300" "fechaPublicacion" => "2017-02-01" "aid" => "942" "copyright" => "Sociedade Portuguesa de Cardiologia" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "dis" "cita" => "Rev Port Cardiol. 2017;36:127-8" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2073 "formatos" => array:3 [ "EPUB" => 173 "HTML" => 1396 "PDF" => 504 ] ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Editorial comment</span>" "titulo" => "Biomarkers in pulmonary hypertension: An ongoing quest for better outcomes" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "127" "paginaFinal" => "128" ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Biomarcadores na hipertensão pulmonar: uma busca contínua por melhores resultados" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Maria Graça Castro" "autores" => array:1 [ 0 => array:2 [ "nombre" => "Maria Graça" "apellidos" => "Castro" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2174204917300302" "doi" => "10.1016/j.repce.2017.02.006" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204917300302?idApp=UINPBA00004E" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255116304309?idApp=UINPBA00004E" "url" => "/08702551/0000003600000002/v1_201702090011/S0870255116304309/v1_201702090011/en/main.assets" ] ] "itemSiguiente" => array:19 [ "pii" => "S2174204916302677" "issn" => "21742049" "doi" => "10.1016/j.repce.2016.12.002" "estado" => "S300" "fechaPublicacion" => "2017-02-01" "aid" => "898" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "ssu" "cita" => "Rev Port Cardiol. 2017;36:129-39" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2480 "formatos" => array:3 [ "EPUB" => 183 "HTML" => 1788 "PDF" => 509 ] ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Review article</span>" "titulo" => "Cost-effectiveness of ambulatory blood pressure monitoring in the management of hypertension" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "pt" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "129" "paginaFinal" => "139" ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Custo-efetividade da monitorização ambulatória da pressão arterial na abordagem da hipertensão arterial" ] ] "contieneResumen" => array:2 [ "en" => true "pt" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Diogo Costa, Ricardo Peixoto Lima" "autores" => array:2 [ 0 => array:2 [ "nombre" => "Diogo" "apellidos" => "Costa" ] 1 => array:2 [ "nombre" => "Ricardo" "apellidos" => "Peixoto Lima" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "pt" => array:9 [ "pii" => "S0870255116302281" "doi" => "10.1016/j.repc.2016.09.007" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255116302281?idApp=UINPBA00004E" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204916302677?idApp=UINPBA00004E" "url" => "/21742049/0000003600000002/v1_201702240018/S2174204916302677/v1_201702240018/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S2174204916302665" "issn" => "21742049" "doi" => "10.1016/j.repce.2016.12.001" "estado" => "S300" "fechaPublicacion" => "2017-02-01" "aid" => "888" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "fla" "cita" => "Rev Port Cardiol. 2017;36:111-25" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2808 "formatos" => array:3 [ "EPUB" => 161 "HTML" => 2127 "PDF" => 520 ] ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>" "titulo" => "Prognostic stratification in pulmonary hypertension: A multi-biomarker approach" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "pt" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "111" "paginaFinal" => "125" ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Estratificação prognóstica na hipertensão pulmonar: valor acrescido da abordagem multibiomarcadores" ] ] "contieneResumen" => array:2 [ "en" => true "pt" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 3021 "Ancho" => 2799 "Tamanyo" => 436844 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Mortality according to tertile distribution of serum biomarker levels. CI: confidence interval; MR-proANP: mid-regional pro-atrial natriuretic peptide; NS: non-significant; NT-proBNP: N-terminal pro-brain natriuretic peptide; sST2: soluble ST2.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Rui Plácido, Nuno Cortez-Dias, Susana Robalo Martins, Ana G. Almeida, Carina Calisto, Susana Gonçalves, Malha Sadoune, António Nunes Diogo, Alexandre Mebazaa, Fausto J. Pinto" "autores" => array:10 [ 0 => array:2 [ "nombre" => "Rui" "apellidos" => "Plácido" ] 1 => array:2 [ "nombre" => "Nuno" "apellidos" => "Cortez-Dias" ] 2 => array:2 [ "nombre" => "Susana" "apellidos" => "Robalo Martins" ] 3 => array:2 [ "nombre" => "Ana G." "apellidos" => "Almeida" ] 4 => array:2 [ "nombre" => "Carina" "apellidos" => "Calisto" ] 5 => array:2 [ "nombre" => "Susana" "apellidos" => "Gonçalves" ] 6 => array:2 [ "nombre" => "Malha" "apellidos" => "Sadoune" ] 7 => array:2 [ "nombre" => "António" "apellidos" => "Nunes Diogo" ] 8 => array:2 [ "nombre" => "Alexandre" "apellidos" => "Mebazaa" ] 9 => array:2 [ "nombre" => "Fausto J." "apellidos" => "Pinto" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "pt" => array:9 [ "pii" => "S0870255116302153" "doi" => "10.1016/j.repc.2016.08.005" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255116302153?idApp=UINPBA00004E" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204916302665?idApp=UINPBA00004E" "url" => "/21742049/0000003600000002/v1_201702240018/S2174204916302665/v1_201702240018/en/main.assets" ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Editorial comment</span>" "titulo" => "Biomarkers in pulmonary hypertension: An ongoing quest for better outcomes" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "127" "paginaFinal" => "128" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "Maria Graça Castro" "autores" => array:1 [ 0 => array:3 [ "nombre" => "Maria Graça" "apellidos" => "Castro" "email" => array:1 [ 0 => "castro2406@gmail.com" ] ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Serviço de Cardiologia, Hospitais da Universidade de Coimbra Centro, Hospitalar e Universitário de Coimbra, Coimbra, Portugal" "identificador" => "aff0005" ] ] ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Biomarcadores na hipertensão pulmonar: uma busca contínua por melhores resultados" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Pulmonary hypertension (PH) is a rare disease that still carries a poor prognosis in spite of recent advances in management and the availability of new therapies. With current best practice, survival at one and five years is 90% and 65%, respectively.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Risk stratification plays a central role in disease management, guiding treatment strategies. At present it relies on a panel of indicators derived from clinical, exercise and hemodynamic evaluation.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a> Although this assessment is of recognized value, it is complex and sometimes subjective and inaccurate.</p><p id="par0015" class="elsevierStylePara elsevierViewall">The development of new biomarkers has the potential to improve risk stratification. In order to be clinically useful, biomarkers must be reliable surrogates of meaningful clinical endpoints like mortality and must fully capture the net effect of treatment on clinical outcomes. Moreover, a valuable biomarker must be easy to measure and interpret, inexpensive, and provide independent information on prognosis.</p><p id="par0020" class="elsevierStylePara elsevierViewall">In order to address this problem, various compounds have been studied in recent years and there is intense investigation of novel biomarkers.<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">3,4</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Potential biomarkers for PH can generally be categorized based on their association with cardiac dysfunction, vascular and endothelial dysfunction, collagen metabolism, systemic inflammation and oxidative stress, and non-cardiopulmonary organ dysfunction.</p><p id="par0030" class="elsevierStylePara elsevierViewall">At present only two biomarkers, brain natriuretic peptide (BNP) and its N-terminal prohormone fragment (NT-proBNP), are recommended in clinical guidelines for risk stratification and follow-up in PH.<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">2,5</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">In this issue of the <span class="elsevierStyleItalic">Journal</span>, Plácido et al.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a> analyze the role of novel biomarkers in PH and compare them to conventional NT-proBNP measurement and echocardiographic parameters. Based on their findings they propose a score that combines several biomarkers and has greater prognostic value than any of them separately.</p><p id="par0040" class="elsevierStylePara elsevierViewall">This prospective observational study has the merit of analyzing several biomarkers in this population that have been more extensively studied in left heart failure.</p><p id="par0045" class="elsevierStylePara elsevierViewall">Interestingly, the authors identify different temporal relationships between the biomarkers and the endpoints of mortality and death or hospitalization, suggesting that different pathogenic processes might play different roles according to disease states.</p><p id="par0050" class="elsevierStylePara elsevierViewall">The findings of this study are in line with increasing evidence that a multiple biomarker approach could be superior to using only one biomarker.</p><p id="par0055" class="elsevierStylePara elsevierViewall">Although promising, the proposed multi-biomarker score needs further investigation and prospective validation in larger populations before it can be used in routine practice.</p><p id="par0060" class="elsevierStylePara elsevierViewall">The development of valid new biomarkers will increase our knowledge of the basic pathologic mechanisms behind vascular pulmonary disease, as well as contributing to early diagnosis and differentiation of PH from other diseases and improving risk assessment before and during treatment. In the best scenario they might even help in individualizing prevention and treatment.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of interest</span><p id="par0065" class="elsevierStylePara elsevierViewall">The author has no conflicts of interest to declare.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Conflicts of interest" ] 1 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:6 [ 0 => array:3 [ "identificador" => "bib0035" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Five-year outcomes of patients enrolled in the REVEAL Registry" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "H.W. Farber" 1 => "D.P. Miller" 2 => "A.D. Poms" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1378/chest.15-0300" "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2015" "volumen" => "148" "paginaInicial" => "1043" "paginaFinal" => "1054" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26066077" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0040" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Guidelines for the diagnosis and treatment of pulmonary hypertension: the Task Force for the diagnosis and treatment of pulmonary hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS), endorsed by the International Society for Heart and Lung Transplantation (ISHLT)" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "N. Galiè" 1 => "M.M. Hoeper" 2 => "M. Humbert" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/eurheartj/ehp297" "Revista" => array:7 [ "tituloSerie" => "Eur Heart J" "fecha" => "2009" "volumen" => "30" "paginaInicial" => "2493" "paginaFinal" => "2537" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19713419" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0168822713003859" "estado" => "S300" "issn" => "01688227" ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0045" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Treatment-related biomarkers in pulmonary hypertension" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "A.C. Swaminathan" 1 => "A.C. Dusek" 2 => "T.J. McMahon" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1165/rcmb.2014-0438TR" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Cell Mol Biol" "fecha" => "2015" "volumen" => "52" "paginaInicial" => "663" "paginaFinal" => "673" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25611885" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0050" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Novel biomarkers for pulmonary arterial hypertension" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "A. Anwar" 1 => "G. Ruffenach" 2 => "A. Mahajan" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/s12931-016-0396-6" "Revista" => array:5 [ "tituloSerie" => "Respir Res" "fecha" => "2016" "volumen" => "17" "paginaInicial" => "88" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27439993" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0055" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Guidelines for the management of pulmonary hypertension patients" "autores" => array:1 [ 0 => array:3 [ "colaboracion" => "Pulmonary Vascular Disease Study Group of the Portuguese Society of Internal Medicine; Pulmonary Hypertension Study Group of the Portuguese Society of Cardiology; Portuguese Societies of Pulmonology and Paediatric Cardiology" "etal" => true "autores" => array:3 [ 0 => "A. Reis" 1 => "N. Rocha" 2 => "R. Barros" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Rev Port Cardiol" "fecha" => "2010" "volumen" => "29" "paginaInicial" => "253" "paginaFinal" => "289" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20545252" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0060" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Estratificação prognóstica na hipertensão pulmonar: valor acrescido de abordagem multi-biomarcadores" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "R. Plácido" 1 => "N. Cortez-Dias" 2 => "S. Martins" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.repc.2016.08.005" "Revista" => array:6 [ "tituloSerie" => "Rev Port Cardiol" "fecha" => "2017" "volumen" => "36" "paginaInicial" => "111" "paginaFinal" => "125" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28117181" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/21742049/0000003600000002/v1_201702240018/S2174204917300302/v1_201702240018/en/main.assets" "Apartado" => array:4 [ "identificador" => "9917" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Original Articles" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/21742049/0000003600000002/v1_201702240018/S2174204917300302/v1_201702240018/en/main.pdf?idApp=UINPBA00004E&text.app=https://revportcardiol.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204917300302?idApp=UINPBA00004E" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 8 | 4 | 12 |
| 2024 October | 53 | 27 | 80 |
| 2024 September | 34 | 24 | 58 |
| 2024 August | 45 | 26 | 71 |
| 2024 July | 30 | 26 | 56 |
| 2024 June | 29 | 17 | 46 |
| 2024 May | 39 | 13 | 52 |
| 2024 April | 24 | 24 | 48 |
| 2024 March | 24 | 12 | 36 |
| 2024 February | 26 | 18 | 44 |
| 2024 January | 26 | 23 | 49 |
| 2023 December | 17 | 29 | 46 |
| 2023 November | 29 | 28 | 57 |
| 2023 October | 14 | 12 | 26 |
| 2023 September | 16 | 18 | 34 |
| 2023 August | 21 | 21 | 42 |
| 2023 July | 29 | 10 | 39 |
| 2023 June | 31 | 10 | 41 |
| 2023 May | 31 | 24 | 55 |
| 2023 April | 11 | 2 | 13 |
| 2023 March | 24 | 20 | 44 |
| 2023 February | 21 | 17 | 38 |
| 2023 January | 16 | 12 | 28 |
| 2022 December | 25 | 16 | 41 |
| 2022 November | 22 | 19 | 41 |
| 2022 October | 26 | 18 | 44 |
| 2022 September | 15 | 18 | 33 |
| 2022 August | 15 | 16 | 31 |
| 2022 July | 24 | 23 | 47 |
| 2022 June | 14 | 17 | 31 |
| 2022 May | 16 | 18 | 34 |
| 2022 April | 23 | 26 | 49 |
| 2022 March | 15 | 26 | 41 |
| 2022 February | 20 | 26 | 46 |
| 2022 January | 30 | 24 | 54 |
| 2021 December | 35 | 19 | 54 |
| 2021 November | 37 | 30 | 67 |
| 2021 October | 55 | 37 | 92 |
| 2021 September | 25 | 26 | 51 |
| 2021 August | 20 | 31 | 51 |
| 2021 July | 17 | 25 | 42 |
| 2021 June | 29 | 9 | 38 |
| 2021 May | 32 | 35 | 67 |
| 2021 April | 41 | 43 | 84 |
| 2021 March | 71 | 24 | 95 |
| 2021 February | 64 | 23 | 87 |
| 2021 January | 47 | 11 | 58 |
| 2020 December | 25 | 7 | 32 |
| 2020 November | 32 | 18 | 50 |
| 2020 October | 14 | 17 | 31 |
| 2020 September | 36 | 10 | 46 |
| 2020 August | 15 | 10 | 25 |
| 2020 July | 45 | 8 | 53 |
| 2020 June | 24 | 11 | 35 |
| 2020 May | 31 | 6 | 37 |
| 2020 April | 20 | 12 | 32 |
| 2020 March | 44 | 8 | 52 |
| 2020 February | 43 | 18 | 61 |
| 2020 January | 23 | 11 | 34 |
| 2019 December | 18 | 3 | 21 |
| 2019 November | 29 | 6 | 35 |
| 2019 October | 20 | 6 | 26 |
| 2019 September | 16 | 8 | 24 |
| 2019 August | 19 | 4 | 23 |
| 2019 July | 23 | 13 | 36 |
| 2019 June | 15 | 11 | 26 |
| 2019 May | 27 | 11 | 38 |
| 2019 April | 20 | 15 | 35 |
| 2019 March | 11 | 13 | 24 |
| 2019 February | 24 | 15 | 39 |
| 2019 January | 16 | 6 | 22 |
| 2018 December | 26 | 11 | 37 |
| 2018 November | 40 | 7 | 47 |
| 2018 October | 60 | 13 | 73 |
| 2018 September | 28 | 12 | 40 |
| 2018 August | 20 | 2 | 22 |
| 2018 July | 20 | 4 | 24 |
| 2018 June | 28 | 7 | 35 |
| 2018 May | 42 | 4 | 46 |
| 2018 April | 49 | 9 | 58 |
| 2018 March | 39 | 8 | 47 |
| 2018 February | 20 | 9 | 29 |
| 2018 January | 40 | 4 | 44 |
| 2017 December | 31 | 7 | 38 |
| 2017 November | 22 | 7 | 29 |
| 2017 October | 33 | 15 | 48 |
| 2017 September | 26 | 11 | 37 |
| 2017 August | 27 | 8 | 35 |
| 2017 July | 16 | 5 | 21 |
| 2017 June | 38 | 21 | 59 |
| 2017 May | 36 | 10 | 46 |
| 2017 April | 14 | 13 | 27 |
| 2017 March | 47 | 20 | 67 |
| 2017 February | 9 | 11 | 20 |
Show all
