Original Article
Comparison of the presence of fragmented QRS complexes in the inferior versus the anterior leads for predicting coronary artery disease severity
Comparação da presença dos complexos QRS fragmentados nas derivações anteriores versus inferiores na predição da severidade da doença arterial coronária
a Department of Cardiology, Avrupa Medicine Center, Karabaglar, Izmir, Turkey
b Department of Cardiology, Gulhane Military Medical Academy, Haydarpasa Training Hospital, Istanbul, Turkey
c Department of Cardiology, Medifema Hospital, Torbali, Izmir, Turkey
d Department of Cardiology, DokuzEylul University Hospital, Balcova, Izmir, Turkey
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The diagnosis and assessment of CAD involves clinical evaluation, non-invasive tests and coronary angiography.<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">1</span></a> Despite improvements in non-invasive diagnostic methods, stress tests have limited sensitivity and specificity to predict CAD severity in many cases.<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">1–3</span></a> Hence, in addition to conventional risk factors, further risk stratifications may be useful to estimate CAD severity before coronary angiography. Fragmented QRS complexes (fQRS) are an electrocardiographic sign of heterogeneous ventricular conduction delay and are strongly correlated with myocardial fibrosis and ischemia.<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">4</span></a> fQRS has been defined as the presence of notching in the R or S waves in the absence of typical bundle branch block or an additional wave such as RSR’ pattern in the QRS complex (<120 ms) in two contiguous leads in one of the major coronary artery territories.<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">5</span></a> It is a predictor of adverse outcomes and mortality in patients with CAD, and CAD severity is a predictor of the presence of fQRS on electrocardiography (ECG).<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">4–6</span></a> The presence of fQRS increases the positive predictive value of positive stress tests and is associated with a higher incidence of significant CAD in patients undergoing coronary angiography.<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">7</span></a> However, little is known about the association between localization of fQRS on ECG and CAD severity in patients undergoing a first diagnostic coronary angiography.</p><p id="par0010" class="elsevierStylePara elsevierViewall">The SYNTAX score (SXscore) is a comprehensive angiographic scoring system based on lesion characteristics and coronary anatomy. It is a useful tool to determine the complexity and severity of CAD, and is also associated with prognosis.<a class="elsevierStyleCrossRefs" href="#bib0120"><span class="elsevierStyleSup">8–12</span></a> In this study, we aimed to investigate the association between localization of fQRS on ECG and CAD severity in patients undergoing a first diagnostic coronary angiography.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Methods</span><p id="par0015" class="elsevierStylePara elsevierViewall">Among patients referred for a first diagnostic coronary angiography for suspected CAD, 135 consecutive patients who had a narrow fQRS in the inferior or anterior leads on ECG were enrolled in the study. Patients with fQRS in both inferior and anterior leads, acute coronary syndromes, left ventricular hypertrophy, ejection fraction <50%, previous history of CAD or vascular disease, complete or incomplete bundle branch block, QRS duration ≥120 ms or severe valvular heart disease were excluded at baseline. All patients underwent coronary angiography following positive exercise treadmill test or myocardial perfusion scintigraphy. Patients’ characteristics including ECG, laboratory measurements and cardiovascular risk factors were evaluated and recorded before coronary angiography. Hypertension was defined as blood pressure >140/90 mmHg or treatment with antihypertensive medication, and diabetes was defined as at least two fasting plasma glucose measurements ≥126 mg/dl and/or two-hour plasma glucose ≥200 mg/dl or HbA1c ≥6.5% or receiving antidiabetic drugs. Dyslipidemia was defined as fasting serum total cholesterol >200 mg/dl, low-density lipoprotein (LDL) cholesterol >160 mg/dl, serum triglyceride (TG) >180 mg/dl, or the use of lipid-lowering drugs because of a history of dyslipidemia. Documented myocardial infarction in first-degree male relatives aged <55 years or in first-degree female relatives aged <65 years was accepted as a family history of premature CAD. Active smoking was defined as the current regular use of cigarettes.</p><p id="par0020" class="elsevierStylePara elsevierViewall">The study was approved by the local ethics committee and the study protocol complied with the Declaration of Helsinki.</p><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Electrocardiography and fQRS</span><p id="par0025" class="elsevierStylePara elsevierViewall">A 12-lead surface electrocardiogram was obtained from all patients on admission. fQRS was defined as the presence of notching in the R or S waves in the absence of typical bundle branch block or an additional wave such as RSR’ pattern in the QRS complex (<120 ms) in two contiguous leads in one of the major coronary artery territories<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">5</span></a> (<a class="elsevierStyleCrossRefs" href="#fig0005">Figures 1 and 2</a>).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">The patients were divided into two groups before coronary angiography according to the presence of fQRS in the inferior (group 1) or anterior leads (group 2).</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Angiographic analysis and coronary artery disease severity</span><p id="par0035" class="elsevierStylePara elsevierViewall">Coronary angiography was performed via a femoral or radial approach according to the standard Judkins technique. Coronary angiograms were evaluated by two experienced interventional cardiologists who were totally blinded to the study. Significant CAD was defined as ≥70% stenosis by quantitative angiography in ≥1 major coronary artery or ≥50% stenosis in the left main coronary artery. The presence of significant CAD, number of vessels with significant CAD, and SXscore were used to define CAD severity. Lesion severity was assessed in multiple projections in all patients. The SXscore was calculated for all coronary lesions with >50% stenosis in a >1.5 mm vessel, using the SXscore calculator (<a id="intr0005" class="elsevierStyleInterRef" href="http://www.syntaxscore.com/">www.syntaxscore.com</a>). An SXscore of >22 was defined as intermediate-high and ≤22 as low SXscore. All angiographic variables were assessed by two experienced interventional cardiologists who were blinded to the ECG findings and other procedural data. In cases of disagreement, the final decision was achieved by consensus.</p><p id="par0040" class="elsevierStylePara elsevierViewall">The two groups were compared regarding presence of significant CAD, multivessel disease (MVD) and SXscore.</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Statistical analysis</span><p id="par0045" class="elsevierStylePara elsevierViewall">Statistical analyses were performed using SPSS software version 15 (SPSS Inc., Chicago, Illinois). The variables were investigated using visual (histograms, probability plots) and analytical methods (Kolmogorov-Smirnov or Shapiro-Wilks tests) to determine whether they are normally distributed. Descriptive variables were presented using medians and interquartile range for non-normally distributed variables. Descriptive variables were presented using frequencies and proportions for ordinal variables. Since the continuous variables were not normally distributed, the Mann-Whitney U test was conducted to compare these parameters. The proportions of categorical variables were compared with the chi-square test or Fisher's exact test (when chi-square test assumptions did not hold due to low expected cell counts), where appropriate. A p-value of less than 0.05 was considered to show statistically significant results.</p></span></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Results</span><p id="par0050" class="elsevierStylePara elsevierViewall">Among 135 patients with fQRS, 86 (63.7%) had fQRS in the inferior leads (group 1) and 49 (36.3%) had fQRS in the anterior leads (group 2). The baseline demographic and laboratory characteristics of the two groups are presented in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>. There were no statistically significant differences between the groups concerning age, left ventricular ejection fraction, gender, hypertension, diabetes, dyslipidemia, cigarette smoking, family history or number of leads with fQRS. Coronary angiographic findings are shown in <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>. There was no significant difference between the groups regarding presence of significant CAD (47.7% vs. 51%, p=0.708). However, the incidence of patients with MVD was significantly higher in group 2 than in group 1 (10.5% vs. 28.6%, p=0.007). Comparing the groups in terms of CAD severity according to SXscore, median SXscore was significantly higher in group 2 than group 1 (6 [3,12] vs. 8 [4,24], p=0.047). Additionally, the incidence of patients with SXscore >22 was significantly higher in group 2 (3.5% vs. 20.4%, p=0.009).</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0010"></elsevierMultimedia></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Discussion</span><p id="par0055" class="elsevierStylePara elsevierViewall">The main finding of the present study is that the presence of fQRS in the anterior leads is associated with a higher incidence of MVD and higher SXscore levels compared to fQRS in the inferior leads in patients without known CAD or vascular disease undergoing a first diagnostic coronary angiography. This finding suggests that fQRS in the anterior leads may indicate more severe CAD than fQRS in the inferior leads. The presence of fQRS on ECG is a sign of myocardial fibrosis and scar and is associated with adverse outcomes and increased mortality in patients with CAD.<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">4,13</span></a> Additionally, it has been shown that the presence of fQRS on ECG is associated with a higher incidence of significant CAD compared to absence of fQRS in patients with chest pain considered to have an intermediate pretest likelihood of significant CAD and referred for diagnostic coronary angiography based on positive stress test.<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">7</span></a> However, little is known about the association between localization of fQRS and CAD severity in patients referred for diagnostic coronary angiography. In a population-based study, Terho et al.<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">14</span></a> demonstrated that the presence of fQRS on ECG is not an uncommon finding and reported that fQRS in both inferior and anterior leads was not associated with increased risk of mortality in subjects without known cardiac disease. Hence, the importance of fQRS and localization of fQRS in patients without known cardiovascular disease remains unclear. Our findings reveal that fQRS in the anterior leads is associated with more severe CAD than fQRS in the inferior leads, defined by MVD and SXscore, in patients undergoing a first diagnostic coronary angiography.</p><p id="par0060" class="elsevierStylePara elsevierViewall">Although the best modality to determine CAD severity, elective coronary angiography has a low diagnostic yield.<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">15</span></a> Only a third of patients without known disease who undergo elective coronary angiography have a diagnosis of obstructive CAD.<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">15,16</span></a> Therefore, better strategies for risk stratification are needed to inform decisions and to increase the diagnostic yield of coronary angiography. In our study, 47.7% of patients in group 1 and 51% of patients in group 2 had a diagnosis of obstructive CAD. Hence, the presence of fQRS seems to increase the diagnostic yield of coronary angiography. Also, we found that fQRS in the anterior leads are associated with more severe CAD than fQRS in the inferior leads. These findings also suggest that the presence of fQRS on ECG and localization of fQRS may be used for risk stratification in patients undergoing elective coronary angiography.</p><p id="par0065" class="elsevierStylePara elsevierViewall">Our study has several limitations. First, the study population was relatively small. However, we were still able to demonstrate a significant association between localization of fQRS on ECG and CAD severity. Second, there is a lack of data about coronary hemodynamics and microvascular dysfunction that may play a role in myocardial ischemia in patients who have a positive stress test.</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Conclusion</span><p id="par0070" class="elsevierStylePara elsevierViewall">fQRS is a simple and accessible non-invasive parameter that can be easily identified by routine ECG. Beyond its prognostic value in patients with CAD, it may be used to improve the diagnostic yield of elective coronary angiography in patients without known CAD or vascular disease. In particular, the presence of fQRS in the anterior leads may be used as an important marker of more severe CAD in patients undergoing a first diagnostic angiography.</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Ethical disclosures</span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Protection of human and animal subjects</span><p id="par0075" class="elsevierStylePara elsevierViewall">The authors declare that no experiments were performed on humans or animals for this study.</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Confidentiality of data</span><p id="par0080" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appear in this article.</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Right to privacy and informed consent</span><p id="par0085" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appear in this article.</p></span></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Conflicts of interest</span><p id="par0090" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:12 [ 0 => array:3 [ "identificador" => "xres805489" "titulo" => "Abstract" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Introduction" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Methods" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusion" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec803624" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres805490" "titulo" => "Resumo" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0025" "titulo" => "Introdução" ] 1 => array:2 [ "identificador" => "abst0030" "titulo" => "Métodos" ] 2 => array:2 [ "identificador" => "abst0035" "titulo" => "Resultados" ] 3 => array:2 [ "identificador" => "abst0040" "titulo" => "Conclusão" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec803625" "titulo" => "Palavras-chave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:3 [ "identificador" => "sec0010" "titulo" => "Methods" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0015" "titulo" => "Electrocardiography and fQRS" ] 1 => array:2 [ "identificador" => "sec0020" "titulo" => "Angiographic analysis and coronary artery disease severity" ] 2 => array:2 [ "identificador" => "sec0025" "titulo" => "Statistical analysis" ] ] ] 6 => array:2 [ "identificador" => "sec0030" "titulo" => "Results" ] 7 => array:2 [ "identificador" => "sec0035" "titulo" => "Discussion" ] 8 => array:2 [ "identificador" => "sec0040" "titulo" => "Conclusion" ] 9 => array:3 [ "identificador" => "sec0045" "titulo" => "Ethical disclosures" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0050" "titulo" => "Protection of human and animal subjects" ] 1 => array:2 [ "identificador" => "sec0055" "titulo" => "Confidentiality of data" ] 2 => array:2 [ "identificador" => "sec0060" "titulo" => "Right to privacy and informed consent" ] ] ] 10 => array:2 [ "identificador" => "sec0065" "titulo" => "Conflicts of interest" ] 11 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2016-04-19" "fechaAceptado" => "2016-07-13" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec803624" "palabras" => array:4 [ 0 => "Fragmented QRS" 1 => "Coronary artery disease" 2 => "Coronary angiography" 3 => "SYNTAX score" ] ] ] "pt" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palavras-chave" "identificador" => "xpalclavsec803625" "palabras" => array:4 [ 0 => "QRS fragmentado" 1 => "Doença arterial coronária" 2 => "Angiografia coronária" 3 => "<span class="elsevierStyleItalic">Score</span> SYNTAX" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:3 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Fragmented QRS complexes (fQRS) are a sign of myocardial scar and are associated with adverse outcomes and mortality in patients with coronary artery disease (CAD). However, little is known about the significance of fQRS or of their localization on electrocardiography (ECG) in patients without known CAD. We aimed to investigate the association between localization of fQRS on ECG and CAD severity in patients undergoing a first diagnostic coronary angiography.</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">We enrolled 135 consecutive patients who had a narrow fQRS on ECG and underwent a first diagnostic coronary angiography. Patients were divided into two groups based on localization of fQRS on ECG (group 1: fQRS in the inferior leads, group 2: fQRS in the anterior leads). The groups were compared regarding the presence of significant CAD, multivessel disease (MVD) and SYNTAX score (SXscore).</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Eighty-six (63.7%) patients had fQRS in the inferior leads and 49 (36.3%) had fQRS in the anterior leads. There was no statistically significant difference between the groups regarding presence of significant CAD (47.7% vs. 51%, p=0.708). However, the incidence of MVD was significantly higher in group 2 compared to group 1 (10.5% vs. 28.6%, p=0.007). The median SXscore (6 [3,12] vs. 8 [4,24], p=0.047), and incidence of patients with SXscore >22 were significantly higher in group 2 compared to group 1 (3.5% vs. 20.4%, p=0.009).</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusion</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">The presence of fQRS in the anterior leads may indicate more severe CAD compared to fQRS in the inferior leads in patients undergoing a first diagnostic coronary angiography.</p></span>" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Introduction" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Methods" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusion" ] ] ] "pt" => array:3 [ "titulo" => "Resumo" "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Introdução</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">O QRS fragmentado (QRSf) é um sinal de cicatriz miocárdica e está associado a resultados adversos e a mortalidade em doentes com doença coronária (DC). No entanto, não existem dados claros sobre o significado de QRSf e sobre a localização do QRSf no eletrocardiograma (ECG) em doentes com DC conhecida. Este artigo tem o objetivo de investigar a associação entre a localização do QRSf no ECG e a gravidade da DC em doentes submetidos a um primeiro diagnóstico por angiografia coronária.</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Métodos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Foram registados neste estudo 135 doentes consecutivos que apresentaram um QRSf estreito no ECG e foram submetidos a um primeiro diagnóstico por angiografia coronária. Os doentes foram divididos em dois grupos, com base na localização do QRSf no ECG (grupo 1: QRSf nas derivações inferiores; grupo 2: QRSf nas derivações anteriores). Foi feita a comparação entre os dois grupos atendendo à presença de DC significativa, doença multivasos (DMV) e <span class="elsevierStyleItalic">score</span> SYNTAX (<span class="elsevierStyleItalic">score</span> SX).</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Oitenta e seis (63,7%) doentes apresentaram QRSf nas derivações inferiores e 49 (36,3%) doentes nas derivações anteriores. Não se registou diferença estatística significativa entre os dois grupos relativamente à presença de DC significativa (47,7 <span class="elsevierStyleItalic">versus</span> 51%, p=0,708). No entanto, a incidência de doentes com DMV foi significativamente superior no grupo 2, quando comparado com o grupo 1 (10,5 <span class="elsevierStyleItalic">versus</span> 28,6%, p=0,007). O <span class="elsevierStyleItalic">score</span> SX médio (6 [3,12] <span class="elsevierStyleItalic">versus</span> 8 [4,24], p=0,047) e a incidência de doentes com <span class="elsevierStyleItalic">score</span> SX > 22 foram significativamente superiores no grupo 2, quando comparado com o grupo 1 (3,5 <span class="elsevierStyleItalic">versus</span> 20,4%, p=0,009).</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusão</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">A presença de QRSf nas derivações anteriores pode estimular mais a DC grave, quando comparado com o QRSf nas derivações inferiores dos doentes submetidos a primeiro diagnóstico por angiografia coronária.</p></span>" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0025" "titulo" => "Introdução" ] 1 => array:2 [ "identificador" => "abst0030" "titulo" => "Métodos" ] 2 => array:2 [ "identificador" => "abst0035" "titulo" => "Resultados" ] 3 => array:2 [ "identificador" => "abst0040" "titulo" => "Conclusão" ] ] ] ] "multimedia" => array:4 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 910 "Ancho" => 1601 "Tamanyo" => 302913 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">An example of fragmented QRS in the inferior leads.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 901 "Ancho" => 1601 "Tamanyo" => 299046 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">An example of fragmented QRS in the anterior leads.</p>" ] ] 2 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at1" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:3 [ "leyenda" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">CAD: coronary artery disease; HGB: hemoglobin; IQR: interquartile range; LDL: low-density lipoprotein cholesterol; LVEF: left ventricular ejection fraction; TG: triglycerides; WBC: white blood cell count.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">fQRS in inferior leads (n=86) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">fQRS in anterior leads (n=49) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">p \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Age, years (median [IQR])</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">50 [46,54] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">50 [46.5,53] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.599<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">LVEF, % (median [IQR])</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">62 [60,64] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">62 [60,64] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.655<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">No. of leads (median [IQR])</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2 [2,2] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2 [2,2] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.865<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">HGB, g/dl (median [IQR])</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">14.7 [13.9,15.3] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">14.6 [13.45,15.1] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.165<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Creatinine, mg/dl (median [IQR])</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.80 [0.67,0.90] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.80 [0.60,0.9] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.644<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">WBC, 10</span><span class="elsevierStyleSup"><span class="elsevierStyleItalic">3</span></span><span class="elsevierStyleItalic">/ml (median [IQR])</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">7.10 [6.80,7.95] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">7.20 [6.60-8.10] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.982<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">LDL, mg/dl (median [IQR])</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">98 [78,122] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">101 [88.50,121] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.168<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">TG, mg/dl (median [IQR])</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">122 [95.5,152] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">123 [99,144.5] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.674<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="4" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Gender</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.931<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Male, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">52 (60.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">30 (61.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Female, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">34 (39.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">19 (38.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="4" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Hypertensive, n (%)</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">28 (32.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">15 (30.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.815<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Diabetic, n (%)</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">26 (30.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">15 (30.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.963<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Family history of CAD, n (%)</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">26 (30.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">15 (30.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.963<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Smokers, n (%)</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">26 (30.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">16 (32.7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.770<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a> \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1351714.png" ] ] ] "notaPie" => array:2 [ 0 => array:3 [ "identificador" => "tblfn0005" "etiqueta" => "a" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Mann-Whitney U test.</p>" ] 1 => array:3 [ "identificador" => "tblfn0010" "etiqueta" => "b" "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Chi-square test.</p>" ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Baseline clinical and laboratory parameters of the two groups.</p>" ] ] 3 => array:8 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at2" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:3 [ "leyenda" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">CAD: coronary artery disease; IQR: interquartile range; SXscore: SYNTAX score.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">fQRS in inferior leads (n=86) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">fQRS in anterior leads (n=49) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">p \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Significant CAD, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">41 (47.7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">25 (51) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.708<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">a</span></a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Multivessel CAD, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">9 (10.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">14 (28.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.007<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">a</span></a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">SXscore >22, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3 (3.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">10 (20.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.009<a class="elsevierStyleCrossRef" href="#tblfn0020"><span class="elsevierStyleSup">b</span></a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">SXscore (median [IQR]) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">6 [3,12] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">8 [4,24] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.047<a class="elsevierStyleCrossRef" href="#tblfn0025"><span class="elsevierStyleSup">c</span></a> \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1351713.png" ] ] ] "notaPie" => array:3 [ 0 => array:3 [ "identificador" => "tblfn0015" "etiqueta" => "a" "nota" => "<p class="elsevierStyleNotepara" id="npar0015">Chi-square test.</p>" ] 1 => array:3 [ "identificador" => "tblfn0020" "etiqueta" => "b" "nota" => "<p class="elsevierStyleNotepara" id="npar0020">Fisher's exact test.</p>" ] 2 => array:3 [ "identificador" => "tblfn0025" "etiqueta" => "c" "nota" => "<p class="elsevierStyleNotepara" id="npar0025">Mann-Whitney U test.</p>" ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Comparison of angiographic findings in the two groups.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:16 [ 0 => array:3 [ "identificador" => "bib0085" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "2013 ESC guidelines on the management of stable coronary artery disease: the Task Force on the management of stable coronary artery disease of the European Society of Cardiology" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "G. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 5 | 4 | 9 |
| 2024 October | 49 | 31 | 80 |
| 2024 September | 48 | 31 | 79 |
| 2024 August | 58 | 39 | 97 |
| 2024 July | 46 | 28 | 74 |
| 2024 June | 61 | 26 | 87 |
| 2024 May | 52 | 25 | 77 |
| 2024 April | 89 | 35 | 124 |
| 2024 March | 64 | 21 | 85 |
| 2024 February | 43 | 19 | 62 |
| 2024 January | 36 | 23 | 59 |
| 2023 December | 25 | 30 | 55 |
| 2023 November | 40 | 27 | 67 |
| 2023 October | 23 | 14 | 37 |
| 2023 September | 24 | 26 | 50 |
| 2023 August | 30 | 15 | 45 |
| 2023 July | 50 | 8 | 58 |
| 2023 June | 37 | 11 | 48 |
| 2023 May | 46 | 20 | 66 |
| 2023 April | 31 | 1 | 32 |
| 2023 March | 39 | 27 | 66 |
| 2023 February | 40 | 22 | 62 |
| 2023 January | 27 | 21 | 48 |
| 2022 December | 58 | 20 | 78 |
| 2022 November | 48 | 17 | 65 |
| 2022 October | 68 | 20 | 88 |
| 2022 September | 66 | 35 | 101 |
| 2022 August | 60 | 25 | 85 |
| 2022 July | 99 | 34 | 133 |
| 2022 June | 78 | 23 | 101 |
| 2022 May | 65 | 27 | 92 |
| 2022 April | 74 | 33 | 107 |
| 2022 March | 39 | 30 | 69 |
| 2022 February | 43 | 34 | 77 |
| 2022 January | 54 | 19 | 73 |
| 2021 December | 36 | 30 | 66 |
| 2021 November | 52 | 35 | 87 |
| 2021 October | 51 | 49 | 100 |
| 2021 September | 27 | 22 | 49 |
| 2021 August | 48 | 32 | 80 |
| 2021 July | 35 | 22 | 57 |
| 2021 June | 30 | 21 | 51 |
| 2021 May | 54 | 41 | 95 |
| 2021 April | 111 | 57 | 168 |
| 2021 March | 82 | 24 | 106 |
| 2021 February | 69 | 19 | 88 |
| 2021 January | 73 | 16 | 89 |
| 2020 December | 59 | 15 | 74 |
| 2020 November | 51 | 20 | 71 |
| 2020 October | 43 | 16 | 59 |
| 2020 September | 97 | 23 | 120 |
| 2020 August | 63 | 8 | 71 |
| 2020 July | 58 | 15 | 73 |
| 2020 June | 77 | 17 | 94 |
| 2020 May | 69 | 12 | 81 |
| 2020 April | 70 | 12 | 82 |
| 2020 March | 46 | 9 | 55 |
| 2020 February | 114 | 13 | 127 |
| 2020 January | 54 | 6 | 60 |
| 2019 December | 39 | 3 | 42 |
| 2019 November | 60 | 11 | 71 |
| 2019 October | 49 | 4 | 53 |
| 2019 September | 36 | 9 | 45 |
| 2019 August | 35 | 10 | 45 |
| 2019 July | 28 | 9 | 37 |
| 2019 June | 22 | 13 | 35 |
| 2019 May | 42 | 12 | 54 |
| 2019 April | 20 | 19 | 39 |
| 2019 March | 45 | 6 | 51 |
| 2019 February | 92 | 8 | 100 |
| 2019 January | 31 | 9 | 40 |
| 2018 December | 44 | 9 | 53 |
| 2018 November | 90 | 14 | 104 |
| 2018 October | 109 | 16 | 125 |
| 2018 September | 32 | 11 | 43 |
| 2018 August | 21 | 9 | 30 |
| 2018 July | 22 | 2 | 24 |
| 2018 June | 25 | 8 | 33 |
| 2018 May | 33 | 12 | 45 |
| 2018 April | 43 | 11 | 54 |
| 2018 March | 37 | 4 | 41 |
| 2018 February | 17 | 4 | 21 |
| 2018 January | 33 | 6 | 39 |
| 2017 December | 24 | 9 | 33 |
| 2017 November | 36 | 18 | 54 |
| 2017 October | 19 | 9 | 28 |
| 2017 September | 27 | 13 | 40 |
| 2017 August | 30 | 10 | 40 |
| 2017 July | 25 | 12 | 37 |
| 2017 June | 44 | 23 | 67 |
| 2017 May | 42 | 12 | 54 |
| 2017 April | 33 | 12 | 45 |
| 2017 March | 68 | 44 | 112 |
| 2017 February | 9 | 6 | 15 |
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