Editorial comment
Compacting knowledge in left ventricular non-compaction
Compactar o conhecimento na não compactação ventricular esquerda
Multimodality Cardiac Imaging Department, Hospital da Luz, Lisbon, Portugal
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Additionally, it is sometimes doubted whether this entity really exists as a single disease.</p><p id="par0015" class="elsevierStylePara elsevierViewall">Though it has been thought to be a congenital heart disease resulting from incomplete morphogenesis of the endomyocardium, another theory argues that it is possible to acquire LVNC during life. Currently, it is recognized that physiological and pathophysiological processes associated with increased LV preload and afterload (including pregnancy, sports, chronic renal failure, sickle cell disease and heart valve disease) may lead to a cardiac morphology that also fulfills criteria for LVNC.<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">2</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">LVNC is classified as a genetic cardiomyopathy by the American Heart Association,<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">3</span></a> whereas the European Society of Cardiology includes LVNC in the group of unclassified cardiomyopathies.<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">4</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">However, the most important and debated point of controversy concerns LVNC diagnostic criteria. The most frequently used criteria are those of Jenni,<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">5</span></a> who proposed the following: (1) the existence of two layers, one thin and compacted (C) and the other noncompacted (NC), and a ratio of NC/C >2 when measured in end-systole in parasternal short-axis view; (2) absence of other structural cardiac anomalies; (3) numerous, excessively prominent trabeculations and deep intertrabecular recesses; and (4) intertrabecular spaces perfused by blood flow demonstrated by color Doppler. Chin et al.<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">6</span></a> suggest as a diagnostic criterion an X-to-Y ratio ≤0.5, where X is the distance between the epicardial surface and trough of a trabecular recess and Y is the distance from the epicardial surface to the peak of the trabeculation, as measured in images of the LV apex and free wall in end-diastole. Stöllberger et al.<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">7</span></a> propose as diagnostic criteria the existence of more than three trabeculations protruding from the LV wall, apical to the papillary muscles, visible in a single image plane, and intertrabecular spaces perfused from the ventricular cavity, visualized by color Doppler.</p><p id="par0030" class="elsevierStylePara elsevierViewall">Cardiac magnetic resonance (CMR), with its excellent spatial resolution and good visualization of the LV apex, also has an important role in diagnosing LVNC. Petersen et al.<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">8</span></a> suggested as a criterion an NC/C ratio of >2.3 in diastole. On the other hand, Jacquier et al.<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">9</span></a> calculated the LV trabecular mass using steady-state free precession short-axis views and proposed a cut-off of LV trabecular mass above 20% of the total LV mass as predictive of LVNC. More recently, Captur et al.<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">10</span></a> described a new CMR tool, fractal analysis, which summarizes global LV trabecular complexity as a continuous variable termed fractal dimension; a fractal dimension ≥1.3 gave the optimal prediction for patients with LVNC.</p><p id="par0035" class="elsevierStylePara elsevierViewall">The multiplicity of diagnostic criteria reflects the fact that none of them are fully satisfactory. In fact, in some cases we may be classifying as pathological a physiological adaptation to different load conditions. On the other hand, Kohli et al.<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">1</span></a> report that of 199 patients with LV systolic dysfunction, 23.6% met at least one of three echocardiographic definitions of LVNC, and suggest that the current criteria lack specificity. LV dilatation and the increased sphericity typical of dilated cardiomyopathy can make trabeculae more evident and in this way lead to overdiagnosis of LVNC.</p><p id="par0040" class="elsevierStylePara elsevierViewall">The broad clinical spectrum of disease ranges from asymptomatic patients, with no family history, normal LV ejection fraction, normal ECG, normal exercise capacity and excellent prognosis (in whom it is questionable if they really have LVNC) to the other extreme, of patients presenting with chronic heart failure, thromboembolic events, severe ventricular arrhythmias and sudden cardiac death.</p><p id="par0045" class="elsevierStylePara elsevierViewall">It is clear that an intense research effort is still needed to achieve a better understanding of the pathophysiology of LVNC, perhaps expanding knowledge of the disease to other cardiac chambers, such as the atria. A proper characterization of atrial mechanics could be important in detecting subclinical dysfunction in LVNC and also in differentiating between pathological and physiological conditions. Furthermore, as atrial enlargement and/or dysfunction are recognized outcome predictors in many heart diseases, it would be interesting to assess their prognostic power in LVNC.</p><p id="par0050" class="elsevierStylePara elsevierViewall">In this issue of the <span class="elsevierStyleItalic">Portuguese Journal of Cardiology</span>, Nemes et al.<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">11</span></a> studied right atrial (RA) deformation in LVNC patients with three-dimensional speckle tracking echocardiography (3D-STE). Although they identified atrial volume differences between LVNC patients and controls, they were unable to detect significant differences in RA deformation parameters between the two groups, suggesting that RA mechanics is preserved in LVNC.</p><p id="par0055" class="elsevierStylePara elsevierViewall">These results are in strong contrast to a previous study from the same group,<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">12</span></a> also with 3D-STE in LVNC patients but focusing on the left atrium (LA). In that study, the authors found (together with increased LA volumes and decreased LA emptying fractions) a significant reduction in LA deformation parameters in LVNC patients, showing significant deterioration in all the different components of LA function in LVNC.</p><p id="par0060" class="elsevierStylePara elsevierViewall">This work represents one more step towards a better understanding of LVNC, suggesting that RA dysfunction plays a minor role in LVNC and indicating that future investigation in this disease should remain focused mainly on the left heart chambers.</p><p id="par0065" class="elsevierStylePara elsevierViewall">To summarize, this paper is useful to compact knowledge in left ventricular non-compaction. Please, study the left heart in a left ventricular disease!</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of interest</span><p id="par0070" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Conflicts of interest" ] 1 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:12 [ 0 => array:3 [ "identificador" => "bib0065" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diagnosis of left-ventricular non-compaction in patients with left-ventricular systolic dysfunction: time for a reappraisal of diagnostic criteria?" 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| Year/Month | Html | Total | |
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| 2024 November | 4 | 6 | 10 |
| 2024 October | 25 | 25 | 50 |
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| 2023 August | 25 | 11 | 36 |
| 2023 July | 12 | 8 | 20 |
| 2023 June | 20 | 14 | 34 |
| 2023 May | 30 | 21 | 51 |
| 2023 April | 7 | 1 | 8 |
| 2023 March | 36 | 21 | 57 |
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| 2017 June | 33 | 6 | 39 |
| 2017 May | 28 | 12 | 40 |
| 2017 April | 22 | 5 | 27 |
| 2017 March | 29 | 6 | 35 |
| 2017 February | 27 | 17 | 44 |
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