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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">We appreciate the interest of Josef Finsterer and Sinda Zarrouk-Mahjoub<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">1</span></a> in our recent original article entitled &#8220;Isolated left ventricular noncompaction causing refractory heart failure&#8221;&#44;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">2</span></a> and would like to thank them for their pertinent comments&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">First of all&#44; with regard to the concern about the patient&#39;s father&#44; we agree that it would be important to have information about his echocardiographic exams or even an autopsy study&#46; However&#44; his father had been treated from disease onset in another hospital and we did not have access to these exams&#46; Besides&#44; the family did not keep the father&#39;s previous exams&#44; so it was not possible to analyze them&#46; The family had been contacted and insisted he had no episodes of atrial fibrillation&#44; stroke&#44; cardioembolism&#44; arrhythmias or epilepsy&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Second&#44; concerning the index patient&#39;s seizures&#44; these occurred during use of high doses of vasoactive drugs&#44; which could have contributed to atrial fibrillation episodes &#40;recorded on ECG&#41;&#46; The seizures really occurred&#44; but only once &#40;with no previous episode in the patient&#39;s life&#41;&#44; and were considered to be a sign of low cardiac output &#40;LCO&#41; causing cerebral hypoxia due to cerebral hypoperfusion&#46; They were tonic-clonic&#44; lasted about two minutes&#44; and ceased after intravenous benzodiazepine administration&#59; at this time&#44; an electroencephalogram was not recorded&#46; She was then treated prophylactically with phenytoin&#46; An intracardiac thrombus 17 mm&#215;14 mm in size was detected in the left atrium&#44; as reported in the main article&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">1</span></a> Thrombocytopenia and hepatopathy developed previous to the seizures and were attributed to the use of prophylactic heparin and systemic inflammatory response syndrome &#40;SIRS&#41;&#44; in combination with congestive heart failure and LCO&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">It is important to note that after heart transplantation and hospital discharge&#44; the patient presented in outpatient care complaining of loss of consciousness&#44; not sudden&#44; but progressively and constantly&#46; Psychological and physical &#40;cerebral magnetic resonance imaging and EEG&#41; investigation revealed nothing&#46; She then underwent tilt testing&#59; a diagnosis was made of vasovagal syndrome and she was advised to make changes in her behavior in order to prevent syncope episodes&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Furthermore&#44; considering chromosomal defects&#44; we understand the role of genetics in this disease<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">3</span></a> and that it is inherited in at least 30-50&#37; of patients&#44; and several genes that cause left ventricular non-compaction &#40;LVNC&#41; have been identified&#46; These genes seem generally to encode sarcomere &#40;contractile apparatus&#41; or cytoskeletal proteins&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">4</span></a> However&#44; the patient was not investigated for gene mutations and it was presumed to be a congenital abnormality&#44; as reported&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The rest of her family were investigated by echocardiography and screened for similar myocardial changes but no evidence of myocardial hypertrabeculation&#47;non-compaction was found&#46; There were also no clinical or laboratory indications of neuromuscular disease in the index case or any of her relatives&#44; such as easy fatigability&#44; exercise intolerance&#44; muscle wasting or weakness&#44; myotonia or adverse reactions to general anesthesia&#46; We have not screened for chromosomal defects as this is not a routine procedure&#46; We understand the importance of these disorders particularly in acquired hypertrabeculation&#44; and that up to 80&#37; of patients with LVNC suffer from a neuromuscular disorder&#46;<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">5&#8211;7</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Concerning anatomopathology&#44; there were non-specific findings of hypertrophy and mild degeneration of myocardial fibers&#44; with no fibrosis or subendocardial fibroelastosis&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">The patient currently has no new symptoms of heart failure and has not developed LVNC in the transplanted heart&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">To summarize&#44; we believe that the genesis of isolated LVNC is still not completely understood&#59; further investigation of the disease and of patients is required&#44; and genetic studies in particular should be the aim of future research&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of interest</span><p id="par0050" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
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Letter to the Editor
Reply to the Letter to the Editor entitled “Acute heart failure from noncompaction requiring emergency heart transplantation”
Resposta à Carta ao Editor intitulada “Insuficiência cardíaca aguda associada a não compactação requerendo transplantação cardíaca emergente”
Rafael Alexandre Meneguz-Moreno
Corresponding author
rafael.meneguz@yahoo.com.br

Corresponding author.
, Marco Aurélio Finger, Carolina Casadei, João Manoel Rossi Neto
Seção Médica de Transplantes, Ambulatório de Disfunção Ventricular e Transplante Cardíaco, Instituto Dante Pazzanese de Cardiologia, Brazil
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">We appreciate the interest of Josef Finsterer and Sinda Zarrouk-Mahjoub<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">1</span></a> in our recent original article entitled &#8220;Isolated left ventricular noncompaction causing refractory heart failure&#8221;&#44;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">2</span></a> and would like to thank them for their pertinent comments&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">First of all&#44; with regard to the concern about the patient&#39;s father&#44; we agree that it would be important to have information about his echocardiographic exams or even an autopsy study&#46; However&#44; his father had been treated from disease onset in another hospital and we did not have access to these exams&#46; Besides&#44; the family did not keep the father&#39;s previous exams&#44; so it was not possible to analyze them&#46; The family had been contacted and insisted he had no episodes of atrial fibrillation&#44; stroke&#44; cardioembolism&#44; arrhythmias or epilepsy&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Second&#44; concerning the index patient&#39;s seizures&#44; these occurred during use of high doses of vasoactive drugs&#44; which could have contributed to atrial fibrillation episodes &#40;recorded on ECG&#41;&#46; The seizures really occurred&#44; but only once &#40;with no previous episode in the patient&#39;s life&#41;&#44; and were considered to be a sign of low cardiac output &#40;LCO&#41; causing cerebral hypoxia due to cerebral hypoperfusion&#46; They were tonic-clonic&#44; lasted about two minutes&#44; and ceased after intravenous benzodiazepine administration&#59; at this time&#44; an electroencephalogram was not recorded&#46; She was then treated prophylactically with phenytoin&#46; An intracardiac thrombus 17 mm&#215;14 mm in size was detected in the left atrium&#44; as reported in the main article&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">1</span></a> Thrombocytopenia and hepatopathy developed previous to the seizures and were attributed to the use of prophylactic heparin and systemic inflammatory response syndrome &#40;SIRS&#41;&#44; in combination with congestive heart failure and LCO&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">It is important to note that after heart transplantation and hospital discharge&#44; the patient presented in outpatient care complaining of loss of consciousness&#44; not sudden&#44; but progressively and constantly&#46; Psychological and physical &#40;cerebral magnetic resonance imaging and EEG&#41; investigation revealed nothing&#46; She then underwent tilt testing&#59; a diagnosis was made of vasovagal syndrome and she was advised to make changes in her behavior in order to prevent syncope episodes&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Furthermore&#44; considering chromosomal defects&#44; we understand the role of genetics in this disease<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">3</span></a> and that it is inherited in at least 30-50&#37; of patients&#44; and several genes that cause left ventricular non-compaction &#40;LVNC&#41; have been identified&#46; These genes seem generally to encode sarcomere &#40;contractile apparatus&#41; or cytoskeletal proteins&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">4</span></a> However&#44; the patient was not investigated for gene mutations and it was presumed to be a congenital abnormality&#44; as reported&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The rest of her family were investigated by echocardiography and screened for similar myocardial changes but no evidence of myocardial hypertrabeculation&#47;non-compaction was found&#46; There were also no clinical or laboratory indications of neuromuscular disease in the index case or any of her relatives&#44; such as easy fatigability&#44; exercise intolerance&#44; muscle wasting or weakness&#44; myotonia or adverse reactions to general anesthesia&#46; We have not screened for chromosomal defects as this is not a routine procedure&#46; We understand the importance of these disorders particularly in acquired hypertrabeculation&#44; and that up to 80&#37; of patients with LVNC suffer from a neuromuscular disorder&#46;<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">5&#8211;7</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Concerning anatomopathology&#44; there were non-specific findings of hypertrophy and mild degeneration of myocardial fibers&#44; with no fibrosis or subendocardial fibroelastosis&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">The patient currently has no new symptoms of heart failure and has not developed LVNC in the transplanted heart&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">To summarize&#44; we believe that the genesis of isolated LVNC is still not completely understood&#59; further investigation of the disease and of patients is required&#44; and genetic studies in particular should be the aim of future research&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of interest</span><p id="par0050" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
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ISSN: 21742049
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Revista Portuguesa de Cardiologia (English edition)
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