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who account for over 20&#37; of individuals in the European cardiac resynchronization therapy survey&#44; and for whom CRT is a class IIa recommendation&#44; level of evidence B&#44; since CRT is less beneficial in these patients&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a> Patients with AF undergoing CRT are generally older and have more comorbidities&#44; lower response rates and higher overall mortality compared with those in sinus rhythm&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">1&#44;3</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">The article by Marques et al&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">4</span></a> published in this issue of the <span class="elsevierStyleItalic">Journal</span> compares different LV pacing configurations in patients with permanent AF&#44; QRS &#62;120 ms &#40;not necessarily with criteria for complete left bundle branch block&#41; and ejection fraction &#40;EF&#41; &#60;40&#37; who had a CRT device implanted&#46; In a single assessment up to one month after implantation&#44; the authors determined the impact in the acute post-implantation phase of different pacing configurations on cardiac output &#40;analyzed by invasive arterial pressure measurement&#41;&#44; QRS duration and EF &#40;calculated by echocardiography&#41;&#46; They suggest that triple-site ventricular pacing &#40;Tri-V&#41; &#40;right ventricular &#91;RV&#93; apex and right ventricular outflow tract &#91;RVOT&#93; plus left ventricle&#41; produces better results in all three parameters than conventional biventricular &#40;Bi-V&#41; pacing &#40;RV apex or RVOT plus left ventricle&#41;&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">This was not a study of clinical response rate or reverse remodeling during follow-up&#44; but an analysis of the behavior of different variables in the acute phase &#40;up to one month post implantation&#41; that compared different configurations after 15 minutes of stable pacing&#46; Its focus on patients with permanent AF makes the study more interesting&#44; since other studies have shown less benefit in this patient group&#46; Tri-V pacing has been studied by other authors&#44; although all in relatively small samples and none exclusively of AF patients&#46; In a 2012 study with 43 patients&#44; Rogers et al&#46; showed that Tri-V pacing was associated with better clinical and echocardiographic results than Bi-V pacing in 12-month follow-up&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">5</span></a> All the study population had EF &#60;35&#37; and QRS duration &#8805;150 ms but only 14&#37; had AF&#46; The 20 patients treated by Tri-V pacing with RV&#44; high RV septum and LV leads had no better echocardiographic results than the Bi-V pacing group&#46; In a comparison study of 21 patients in sinus rhythm &#40;New York Heart Association class III or IV&#44; EF &#60;35&#37; and QRS &#62;120 ms&#41;&#44; Yoshida et al&#46;&#44; like Marques et al&#46;&#44; showed that in the acute phase&#44; Tri-V pacing &#40;RV apex and RVOT plus LV&#41; leads to significant QRS shortening and improvements in LV dP&#47;dt&#44; cardiac output&#44; ventricular synchrony on echocardiography and EF&#44; compared to Bi-V pacing&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">The possibility of more options in multi-site pacing configurations may help improve resynchronization therapy by producing a pattern of ventricular activation that is closer to physiological depolarization&#44; not only through more pacing sites&#44; but also by enabling optimization of VV interval programming according to the type of mechanical dyssynchrony observed&#46; In the study by Marques et al&#46;&#44; it would have been interesting to have analyzed dyssynchrony by the different types of echocardiography available &#40;septal flash or apical transverse motion&#44; tissue synchronization imaging&#44; tissue Doppler imaging&#44; radial strain&#44; and three-dimensional&#41;&#44; in order to provide some objective correlation between the observed hemodynamic benefits and the degree of ventricular dyssynchrony&#46; For example&#44; when the LV lead was connected to the atrial channel&#44; left pacing was always 25-40 ms earlier&#44; while if the RVOT lead was connected to the atrial channel pacing was always earlier at this site&#46; This possible limitation&#44; which results from the impossibility of simultaneous triple-site pacing&#44; could be tested in a detailed study of dyssynchrony&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">At a time of growing interest in multi-site and multi-point pacing for the treatment of CHF&#44; there have still been few studies on dual-site RV pacing with LV pacing&#46; Thus&#44; the article by Marques et al&#46; points to a viable alternative that is safe &#40;with no increase in procedural or fluoroscopy times&#41; and potentially beneficial in an important subgroup of CHF patients&#46; Although the study population was small&#44; it is also interesting to note that the results for the different parameters for Bi-V pacing with the lead in apical position or in the RVOT were similar&#46; Other ways in which this study differs from the experience of other groups include the lower percentage of patients with ischemic cardiomyopathy &#40;25&#37;&#41;&#44; the number who required atrioventricular node ablation &#40;6&#47;40&#44; 15&#37;&#41; and&#44; as pointed out by the authors&#44; the equipment used to measure cardiac output &#40;the FloTrac III&#8482; Vigileo&#8482; monitoring system&#44; Edwards Lifesciences&#44; Irvine&#44; CA&#44; USA&#41;&#44; which has not been evaluated in this context&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The need for viable solutions to the problem of non-responders to CRT is reason to pursue triple-site pacing&#44; which has the potential to improve patterns of electromechanical activation and thus ventricular performance&#46; Future studies will be necessary to determine if this modality brings benefits to all patients &#40;&#8220;one size fits all&#8221;&#41;&#44; or whether selection of the best Tri-V configuration should be individualized according to the type of dyssynchrony identified&#46; The TRIUMPH-CRT trial&#44; designed to compare optimized Tri-V pacing &#40;based on the left pre-ejection interval&#44; measured during implantation&#41; with standard Bi-V pacing in patients with severe systolic dysfunction and QRS &#62;150 ms&#44; without criteria for complete left bundle branch block&#44; will provide valuable information on this important subject&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">The relationship between electrocardiographic&#44; hemodynamic and echocardiographic findings in the acute phase and sustained clinical benefit will need to be demonstrated in randomized trials with larger populations and long-term follow-up&#46; In this context&#44; Marques et al&#46;&#8217;s study is a valid contribution to the search for viable options in the non-pharmacological treatment of CHF&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of interest</span><p id="par0045" class="elsevierStylePara elsevierViewall">The author has no conflicts of interest to declare&#46;</p></span></span>"
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Editorial comment
Triple-site pacing for cardiac resynchronization in atrial fibrillation – an opening onto different scenarios
Pacing multi-site para ressincronização cardíaca na fibrilhação auricular – uma janela com cenários diferentes
Mário Oliveiraa,b
a Laboratório de Pacing e Eletrofisiologia, Serviço de Cardiologia, Hospital de Santa Marta, Carnaxide, Portugal
b Instituto de Fisiologia, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal
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            "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Differences in cardiac output between Tri-V and Bi-V pacing &#40;A&#41;&#44; between Bi-V pacing and RVOT septal pacing&#44; and between RVOT septal pacing and RV apical pacing &#40;B&#41;&#46; Bi-V&#58; biventricular pacing&#59; LV&#58; left ventricular&#59; RV&#58; right ventricular&#59; RVOT&#58; right ventricular outflow tract&#59; Tri-V&#58; triple-site pacing&#46;</p>"
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    "titulo" => "Triple-site pacing for cardiac resynchronization in atrial fibrillation &#8211; an opening onto different scenarios"
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        "titulo" => "<span class="elsevierStyleItalic">Pacing multi</span>-<span class="elsevierStyleItalic">site</span> para ressincroniza&#231;&#227;o card&#237;aca na fibrilha&#231;&#227;o auricular &#8211; uma janela com cen&#225;rios diferentes"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Cardiac resynchronization therapy &#40;CRT&#41;&#44; whether or not combined with an implantable cardioverter-defibrillator&#44; is one of the most important innovations in the treatment of chronic heart failure &#40;CHF&#41;&#46; It is able to restore ventricular synchrony in patients with severe intraventricular conduction disturbances&#44; particularly complete left bundle branch block or QRS interval &#62;150 ms&#46; These conduction disorders&#44; found in a third of cases of severe CHF&#44; lead to mechanical dyssynchrony and systolic dysfunction&#44; and several large multicenter randomized trials have demonstrated that CRT improves functional class and quality of life and significantly reduces mortality and hospitalizations for CHF&#46; This treatment modality is increasingly studied and used in clinical practice&#44; with ever-growing numbers of specialists and reference centers&#44; and&#44; most importantly&#44; with many thousands of patients treated successfully worldwide&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">1&#44;2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Despite the consistently positive results of electromechanical resynchronization&#44; including improvements in hemodynamic parameters and increased cardiac output&#44; reverse remodeling and in a significant number of cases normalization of systolic function and left ventricular &#40;LV&#41; volumes&#44; several important questions remain to be answered&#46; One is how to improve the response rate to CRT &#40;even when selected in accordance with the international guidelines&#44; up to 30&#37; of patients do not respond&#41;&#46; Another is the question of the best pacing configuration &#40;biventricular or multi-site&#41;&#46; A third issue is how to improve CRT response in patients with CHF and atrial fibrillation &#40;AF&#41;&#44; who account for over 20&#37; of individuals in the European cardiac resynchronization therapy survey&#44; and for whom CRT is a class IIa recommendation&#44; level of evidence B&#44; since CRT is less beneficial in these patients&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a> Patients with AF undergoing CRT are generally older and have more comorbidities&#44; lower response rates and higher overall mortality compared with those in sinus rhythm&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">1&#44;3</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">The article by Marques et al&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">4</span></a> published in this issue of the <span class="elsevierStyleItalic">Journal</span> compares different LV pacing configurations in patients with permanent AF&#44; QRS &#62;120 ms &#40;not necessarily with criteria for complete left bundle branch block&#41; and ejection fraction &#40;EF&#41; &#60;40&#37; who had a CRT device implanted&#46; In a single assessment up to one month after implantation&#44; the authors determined the impact in the acute post-implantation phase of different pacing configurations on cardiac output &#40;analyzed by invasive arterial pressure measurement&#41;&#44; QRS duration and EF &#40;calculated by echocardiography&#41;&#46; They suggest that triple-site ventricular pacing &#40;Tri-V&#41; &#40;right ventricular &#91;RV&#93; apex and right ventricular outflow tract &#91;RVOT&#93; plus left ventricle&#41; produces better results in all three parameters than conventional biventricular &#40;Bi-V&#41; pacing &#40;RV apex or RVOT plus left ventricle&#41;&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">This was not a study of clinical response rate or reverse remodeling during follow-up&#44; but an analysis of the behavior of different variables in the acute phase &#40;up to one month post implantation&#41; that compared different configurations after 15 minutes of stable pacing&#46; Its focus on patients with permanent AF makes the study more interesting&#44; since other studies have shown less benefit in this patient group&#46; Tri-V pacing has been studied by other authors&#44; although all in relatively small samples and none exclusively of AF patients&#46; In a 2012 study with 43 patients&#44; Rogers et al&#46; showed that Tri-V pacing was associated with better clinical and echocardiographic results than Bi-V pacing in 12-month follow-up&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">5</span></a> All the study population had EF &#60;35&#37; and QRS duration &#8805;150 ms but only 14&#37; had AF&#46; The 20 patients treated by Tri-V pacing with RV&#44; high RV septum and LV leads had no better echocardiographic results than the Bi-V pacing group&#46; In a comparison study of 21 patients in sinus rhythm &#40;New York Heart Association class III or IV&#44; EF &#60;35&#37; and QRS &#62;120 ms&#41;&#44; Yoshida et al&#46;&#44; like Marques et al&#46;&#44; showed that in the acute phase&#44; Tri-V pacing &#40;RV apex and RVOT plus LV&#41; leads to significant QRS shortening and improvements in LV dP&#47;dt&#44; cardiac output&#44; ventricular synchrony on echocardiography and EF&#44; compared to Bi-V pacing&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">The possibility of more options in multi-site pacing configurations may help improve resynchronization therapy by producing a pattern of ventricular activation that is closer to physiological depolarization&#44; not only through more pacing sites&#44; but also by enabling optimization of VV interval programming according to the type of mechanical dyssynchrony observed&#46; In the study by Marques et al&#46;&#44; it would have been interesting to have analyzed dyssynchrony by the different types of echocardiography available &#40;septal flash or apical transverse motion&#44; tissue synchronization imaging&#44; tissue Doppler imaging&#44; radial strain&#44; and three-dimensional&#41;&#44; in order to provide some objective correlation between the observed hemodynamic benefits and the degree of ventricular dyssynchrony&#46; For example&#44; when the LV lead was connected to the atrial channel&#44; left pacing was always 25-40 ms earlier&#44; while if the RVOT lead was connected to the atrial channel pacing was always earlier at this site&#46; This possible limitation&#44; which results from the impossibility of simultaneous triple-site pacing&#44; could be tested in a detailed study of dyssynchrony&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">At a time of growing interest in multi-site and multi-point pacing for the treatment of CHF&#44; there have still been few studies on dual-site RV pacing with LV pacing&#46; Thus&#44; the article by Marques et al&#46; points to a viable alternative that is safe &#40;with no increase in procedural or fluoroscopy times&#41; and potentially beneficial in an important subgroup of CHF patients&#46; Although the study population was small&#44; it is also interesting to note that the results for the different parameters for Bi-V pacing with the lead in apical position or in the RVOT were similar&#46; Other ways in which this study differs from the experience of other groups include the lower percentage of patients with ischemic cardiomyopathy &#40;25&#37;&#41;&#44; the number who required atrioventricular node ablation &#40;6&#47;40&#44; 15&#37;&#41; and&#44; as pointed out by the authors&#44; the equipment used to measure cardiac output &#40;the FloTrac III&#8482; Vigileo&#8482; monitoring system&#44; Edwards Lifesciences&#44; Irvine&#44; CA&#44; USA&#41;&#44; which has not been evaluated in this context&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The need for viable solutions to the problem of non-responders to CRT is reason to pursue triple-site pacing&#44; which has the potential to improve patterns of electromechanical activation and thus ventricular performance&#46; Future studies will be necessary to determine if this modality brings benefits to all patients &#40;&#8220;one size fits all&#8221;&#41;&#44; or whether selection of the best Tri-V configuration should be individualized according to the type of dyssynchrony identified&#46; The TRIUMPH-CRT trial&#44; designed to compare optimized Tri-V pacing &#40;based on the left pre-ejection interval&#44; measured during implantation&#41; with standard Bi-V pacing in patients with severe systolic dysfunction and QRS &#62;150 ms&#44; without criteria for complete left bundle branch block&#44; will provide valuable information on this important subject&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">The relationship between electrocardiographic&#44; hemodynamic and echocardiographic findings in the acute phase and sustained clinical benefit will need to be demonstrated in randomized trials with larger populations and long-term follow-up&#46; In this context&#44; Marques et al&#46;&#8217;s study is a valid contribution to the search for viable options in the non-pharmacological treatment of CHF&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of interest</span><p id="par0045" class="elsevierStylePara elsevierViewall">The author has no conflicts of interest to declare&#46;</p></span></span>"
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Article information
ISSN: 21742049
Original language: English
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2022 November 36 27 63
2022 October 22 21 43
2022 September 13 16 29
2022 August 28 39 67
2022 July 25 35 60
2022 June 15 13 28
2022 May 16 32 48
2022 April 20 17 37
2022 March 14 26 40
2022 February 21 27 48
2022 January 17 27 44
2021 December 13 24 37
2021 November 37 31 68
2021 October 19 38 57
2021 September 19 30 49
2021 August 30 31 61
2021 July 12 23 35
2021 June 16 19 35
2021 May 26 41 67
2021 April 28 17 45
2021 March 54 32 86
2021 February 48 18 66
2021 January 18 9 27
2020 December 33 6 39
2020 November 25 14 39
2020 October 17 13 30
2020 September 59 14 73
2020 August 17 7 24
2020 July 48 17 65
2020 June 20 7 27
2020 May 41 10 51
2020 April 30 8 38
2020 March 42 13 55
2020 February 53 33 86
2020 January 31 4 35
2019 December 23 2 25
2019 November 28 11 39
2019 October 35 2 37
2019 September 30 9 39
2019 August 26 6 32
2019 July 45 12 57
2019 June 25 8 33
2019 May 39 5 44
2019 April 28 15 43
2019 March 15 10 25
2019 February 36 8 44
2019 January 16 7 23
2018 December 24 13 37
2018 November 92 8 100
2018 October 184 13 197
2018 September 73 15 88
2018 August 23 5 28
2018 July 19 2 21
2018 June 24 5 29
2018 May 48 4 52
2018 April 35 9 44
2018 March 68 5 73
2018 February 63 4 67
2018 January 48 11 59
2017 December 84 13 97
2017 November 50 17 67
2017 October 33 11 44
2017 September 32 16 48
2017 August 31 14 45
2017 July 26 13 39
2017 June 42 9 51
2017 May 31 6 37
2017 April 11 2 13
2017 March 23 50 73
2017 February 25 3 28
2017 January 36 0 36
2016 December 32 8 40
2016 November 23 3 26
2016 October 20 13 33
2016 September 30 5 35
2016 August 14 2 16
2016 July 48 13 61
2016 June 7 21 28
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Revista Portuguesa de Cardiologia (English edition)
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