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    "titulo" => "Comment on &#8220;Surgical ablation of atrial fibrillation during mitral&#8208;valve surgery&#8221;"
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        "titulo" => "Coment&#225;rio a &#171;Abla&#231;&#227;o cir&#250;rgica de fibrilha&#231;&#227;o auricular&#44; durante cirurgia da v&#225;lvula mitral&#187;"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall"><elsevierMultimedia ident="tb0005"></elsevierMultimedia></p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Abstract</span><p id="par0015" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Background&#58;</span> Among patients undergoing mitral&#8208;valve surgery&#44; 30 to 50&#37; present with atrial fibrillation&#44; which is associated with reduced survival and increased risk of stroke&#46; Surgical ablation of atrial fibrillation has been widely adopted&#44; but evidence regarding its safety and effectiveness is limited&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Methods&#58;</span> We randomly assigned 260 patients with persistent or long&#8208;standing persistent atrial fibrillation who required mitral&#8208;valve surgery to undergo either surgical ablation &#40;ablation group&#41; or no ablation &#40;control group&#41; during the mitral&#8208;valve operation&#46; Patients in the ablation group underwent further randomization to pulmonary vein isolation or a biatrial maze procedure&#46; All patients underwent closure of the left atrial appendage&#46; The primary end point was freedom from atrial fibrillation at both 6 months and 12 months &#40;as assessed by means of 3&#8208;day Holter monitoring&#41;&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Results&#58;</span> More patients in the ablation group than in the control group were free from atrial fibrillation at both 6 and 12 months &#40;63&#46;2&#37; vs&#46; 29&#46;4&#37;&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#46; There was no significant difference in the rate of freedom from atrial fibrillation between patients who underwent pulmonar vein isolation and those who underwent the biatrial maze procedure &#40;61&#46;0&#37; and 66&#46;0&#37;&#44; respectively&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;60&#41;&#46; One&#8208;year mortality was 6&#46;8&#37; in the ablation group and 8&#46;7&#37; in the control group &#40;hazard ratio with ablation&#44; 0&#46;76&#59; 95&#37; confidence interval&#44; 0&#46;32 to 1&#46;84&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;55&#41;&#46; Ablation was associated with more implantations of a permanent pacemaker than was no ablation &#40;21&#46;5 vs&#46; 8&#46;1 per 100 patient&#8208;years&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;01&#41;&#46; There were no significant between&#8208;group differences in major cardiac or cerebrovascular adverse events&#44; overall serious adverse events&#44; or hospital readmissions&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Conclusions</span>&#58; The addition of atrial fibrillation ablation to mitral&#8208;valve surgery significantly increased the rate of freedom from atrial fibrillation at 1 year among patients with persistent or long&#8208;standing persistent atrial fibrillation&#44; but the risk of implantation of a permanent pacemaker was also increased&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Comment</span><p id="par0035" class="elsevierStylePara elsevierViewall">A fibrilha&#231;&#227;o auricular &#40;FA&#41; &#233; a arritmia mais prevalente na pr&#225;tica cl&#237;nica&#46; &#201; tamb&#233;m muito comum em doentes com doen&#231;a da v&#225;lvula mitral e &#233; sabido que a associa&#231;&#227;o das duas confere pior progn&#243;stico<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a>&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">A abla&#231;&#227;o percut&#226;nea de fibrilha&#231;&#227;o auricular&#44; com isolamento das veias pulmonares&#44; provou ser mais eficaz que a terap&#234;utica farmacol&#243;gica na manuten&#231;&#227;o de ritmo sinusal e&#44; atualmente&#44; &#233; uma indica&#231;&#227;o classe <span class="elsevierStyleSmallCaps">I</span> nas recomenda&#231;&#245;es da Sociedade Europeia de Cardiologia<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a>&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">A abla&#231;&#227;o cir&#250;rgica de fibrilha&#231;&#227;o auricular come&#231;ou na d&#233;cada de 90 do s&#233;culo <span class="elsevierStyleSmallCaps">XX</span>&#44; antes at&#233; da abla&#231;&#227;o percut&#226;nea&#44; e os avan&#231;os iniciais na &#250;ltima devem&#8208;se ao trabalho pioneiro de muitos cirurgi&#245;es&#46; A abla&#231;&#227;o cir&#250;rgica est&#225; tamb&#233;m presente nas recomenda&#231;&#245;es da Sociedade Europeia de Cardiologia&#44; sobretudo quando existe outra cirurgia card&#237;aca concomitante&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">N&#227;o &#233; claro qual a t&#233;cnica mais adequada para abla&#231;&#227;o cir&#250;rgica da fibrilha&#231;&#227;o auricular&#46; A cirurgia proposta inicialmente foi a cirurgia de MAZE&#44; pelo grupo do Prof&#46; Cox&#46; A cirurgia de MAZE consiste numa s&#233;rie de les&#245;es na aur&#237;cula esquerda e direita&#44; envolvendo as veias pulmonares&#44; a parede posterior e linhas para a v&#225;lvula mitral&#44; assim como les&#245;es lineares na aur&#237;cula direita&#46; Esta t&#233;cnica cir&#250;rgica veio a sofrer altera&#231;&#245;es ao longo dos anos &#40;tanto na localiza&#231;&#227;o das v&#225;rias linhas&#44; como na forma de fazer as les&#245;es &#8211; inicialmente les&#245;es cir&#250;rgicas&#44; efetuadas com bisturi&#47;sutura e&#44; atualmente&#44; energia de RF unipolar ou bipolar e crioenergia&#41;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a>&#46; Os resultados deste grupo mostraram uma elevada taxa de sucesso em v&#225;rias popula&#231;&#245;es de doentes&#44; tanto a curto como a longo prazo&#44; embora de forma n&#227;o reprodut&#237;vel quando a t&#233;cnica era efetuada por outros autores&#46; O isolamento cir&#250;rgico das veias pulmonares foi proposto pelo Prof&#46; Jo&#227;o Queir&#243;s e Melo&#44; a trabalhar no Hospital de Santa Cruz&#44; como uma forma de simplifica&#231;&#227;o da cirurgia de MAZE&#46; Os trabalhos iniciais deste grupo mostraram consistentemente taxas de sucesso mais baixas que as do grupo de Cox<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a>&#44; embora mais reprodut&#237;veis por outros&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">O presente estudo&#44; aleatorizado e multic&#234;ntrico&#44; pretende comparar tr&#234;s grupos de doentes com doen&#231;a mitral e fibrilha&#231;&#227;o auricular&#46; Todos os doentes tinham doen&#231;a mitral com indica&#231;&#227;o cir&#250;rgica e fibrilha&#231;&#227;o auricular persistente<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a>&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Foram inclu&#237;dos 260 doentes&#46; Os doentes eleg&#237;veis foram aleatorizados &#40;1&#58;1&#41; para efetuarem ou n&#227;o abla&#231;&#227;o cir&#250;rgica da FA&#44; no mesmo tempo operat&#243;rio da cirurgia mitral&#46; Os doentes do grupo da abla&#231;&#227;o foram aleatorizados para cirurgia de MAZE biauricular ou para isolamento das veias pulmonares&#46; A aleatoriza&#231;&#227;o para estes tr&#234;s grupos foi efetuada na fase anest&#233;sica&#44; ap&#243;s exclus&#227;o de trombos com ETE intraoperat&#243;rio&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Dos 260 doentes inclu&#237;dos&#44; 133 efetuaram cirurgia valvular com abla&#231;&#227;o &#40;67 isolamento de veias pulmonares e 66 MAZE biauricular&#41;&#46; Os restantes efetuaram apenas cirurgia valvular&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">Os grupos eram bem balanceados&#58; 45&#44;8&#37; dos doentes tinha FA persistente e os restantes FA persistente de longa dura&#231;&#227;o&#46; A maioria dos doentes &#40;55&#44;6&#37;&#41; fez plastia mitral&#46; O ap&#234;ndice auricular esquerdo foi excisado em todos os doentes&#46; A dura&#231;&#227;o da CEC foi cerca de 15 minutos maior no grupo da abla&#231;&#227;o&#46; Em 61&#44;4&#37; dos doentes&#44; foi efetuada cirurgia adicional&#44; al&#233;m da da v&#225;lvula mitral &#40;cirurgia de revasculariza&#231;&#227;o&#44; ou outra cirurgia valvular&#41;&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">O n&#250;mero de doentes em ritmo sinusal&#44; aos 6 e 12 meses&#44; no grupo da abla&#231;&#227;o era francamente superior ao do grupo controlo &#40;63&#44;2 <span class="elsevierStyleItalic">versus</span> 29&#44;4&#37;&#44; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#46; N&#227;o houve diferen&#231;a significativa na taxa de manuten&#231;&#227;o de ritmo sinusal para os dois tipos de cirurgia&#46; N&#227;o se encontraram diferen&#231;as entre grupos para o <span class="elsevierStyleItalic">endpoint</span> prim&#225;rio de seguran&#231;a &#40;morte&#44; hemorragia&#44; reinternamentos&#41;&#46; No entanto&#44; os doentes dos grupos da abla&#231;&#227;o tiveram mais frequentemente necessidade de implanta&#231;&#227;o de <span class="elsevierStyleItalic">pacemaker</span> definitivo&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">O presente estudo &#233; muito importante ao confirmar&#44; de forma inequ&#237;voca&#44; num ensaio cl&#237;nico&#44; multic&#234;ntrico e aleatorizado&#44; que existe vantagem na abla&#231;&#227;o cir&#250;rgica de FA concomitante a cirurgia da v&#225;lvula mitral&#46; N&#227;o se demonstraram diferen&#231;as nas taxas de manuten&#231;&#227;o de ritmo sinusal entre os dois tipos de cirurgia&#46; Existe um risco acrescido para os doentes da abla&#231;&#227;o que &#233; o de uma maior probabilidade de necessidade de implanta&#231;&#227;o de <span class="elsevierStyleItalic">pacemaker</span>&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">A limita&#231;&#227;o principal do estudo prende&#8208;se com o baixo n&#250;mero de doentes inclu&#237;dos e tamb&#233;m com o curto tempo de seguimento&#44; o que n&#227;o permitiu encontrar diferen&#231;as no que diz respeito a progn&#243;stico&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflicts of interest</span><p id="par0090" class="elsevierStylePara elsevierViewall">The author has no conflicts of interest to declare&#46;</p></span></span>"
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          "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0010" class="elsevierStylePara elsevierViewall">A&#46; Marc Gillinov&#44; Annetine C&#46; Gelijns&#44; Michael K&#46; Parides&#44; Joseph J&#46; DeRose&#44; Jr&#46;&#44; Alan J&#46; Moskowitz&#44; Pierre Voisine&#44; Gorav Ailawadi&#44; M&#46;D&#46;&#44; Denis Bouchard&#44; M&#46;D&#46;&#44; Peter K&#46; Smith&#44; Michael J&#46; Mack&#44; M&#46;D&#46;&#44; Michael A&#46; Acker&#44; M&#46;D&#46;&#44; John C&#46; Mullen&#44; Eric A&#46; Rose&#44; M&#46;D&#46;&#44; Helena L&#46; Chang&#44; M&#46;S&#46;&#44; John D&#46; Puskas&#44; Jean&#8208;Philippe Couderc&#44; Ph&#46;D&#46;&#44; Timothy J&#46; Gardner&#44; M&#46;D&#46;&#44; Robin Varghese&#44; Keith A&#46; Horvath&#44; Steven F&#46; Bolling&#44; Robert E&#46; Michler&#44; Nancy L&#46; Geller&#44; Deborah D&#46; Ascheim&#44; Marissa A&#46; Miller&#44; Emilia Bagiella&#44; Ellen G&#46; Moquete&#44; Paula Williams&#44; Wendy C&#46; Taddei&#8208;Peters&#44; Patrick T&#46; O&#8217;Gara&#44; Eugene H&#46; Blackstone and Michael Argenziano&#44; for the CTSN Investigators</p></span>"
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                      "titulo" => "Atrial fibrillation complicating the course of degenerative mitral regurgitation&#58; determinants and long&#8208;term outcome"
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                          "autores" => array:3 [
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                      "titulo" => "2012 focused update of the ESC Guidelines for the management of atrial fibrillation&#58; an update of the 2010 ESC Guidelines for the management of atrial fibrillation"
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                          "etal" => true
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                        "tituloSerie" => "Eur J Cardiothorac Surg&#46;"
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Recommended Article of the Month
Comment on “Surgical ablation of atrial fibrillation during mitral‐valve surgery”
Comentário a «Ablação cirúrgica de fibrilhação auricular, durante cirurgia da válvula mitral»
Diogo Magalhães Cavaco
Membro do Corpo Redatorial da Revista Portuguesa de Cardiologia
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    "titulo" => "Comment on &#8220;Surgical ablation of atrial fibrillation during mitral&#8208;valve surgery&#8221;"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall"><elsevierMultimedia ident="tb0005"></elsevierMultimedia></p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Abstract</span><p id="par0015" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Background&#58;</span> Among patients undergoing mitral&#8208;valve surgery&#44; 30 to 50&#37; present with atrial fibrillation&#44; which is associated with reduced survival and increased risk of stroke&#46; Surgical ablation of atrial fibrillation has been widely adopted&#44; but evidence regarding its safety and effectiveness is limited&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Methods&#58;</span> We randomly assigned 260 patients with persistent or long&#8208;standing persistent atrial fibrillation who required mitral&#8208;valve surgery to undergo either surgical ablation &#40;ablation group&#41; or no ablation &#40;control group&#41; during the mitral&#8208;valve operation&#46; Patients in the ablation group underwent further randomization to pulmonary vein isolation or a biatrial maze procedure&#46; All patients underwent closure of the left atrial appendage&#46; The primary end point was freedom from atrial fibrillation at both 6 months and 12 months &#40;as assessed by means of 3&#8208;day Holter monitoring&#41;&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Results&#58;</span> More patients in the ablation group than in the control group were free from atrial fibrillation at both 6 and 12 months &#40;63&#46;2&#37; vs&#46; 29&#46;4&#37;&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#46; There was no significant difference in the rate of freedom from atrial fibrillation between patients who underwent pulmonar vein isolation and those who underwent the biatrial maze procedure &#40;61&#46;0&#37; and 66&#46;0&#37;&#44; respectively&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;60&#41;&#46; One&#8208;year mortality was 6&#46;8&#37; in the ablation group and 8&#46;7&#37; in the control group &#40;hazard ratio with ablation&#44; 0&#46;76&#59; 95&#37; confidence interval&#44; 0&#46;32 to 1&#46;84&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;55&#41;&#46; Ablation was associated with more implantations of a permanent pacemaker than was no ablation &#40;21&#46;5 vs&#46; 8&#46;1 per 100 patient&#8208;years&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;01&#41;&#46; There were no significant between&#8208;group differences in major cardiac or cerebrovascular adverse events&#44; overall serious adverse events&#44; or hospital readmissions&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Conclusions</span>&#58; The addition of atrial fibrillation ablation to mitral&#8208;valve surgery significantly increased the rate of freedom from atrial fibrillation at 1 year among patients with persistent or long&#8208;standing persistent atrial fibrillation&#44; but the risk of implantation of a permanent pacemaker was also increased&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Comment</span><p id="par0035" class="elsevierStylePara elsevierViewall">A fibrilha&#231;&#227;o auricular &#40;FA&#41; &#233; a arritmia mais prevalente na pr&#225;tica cl&#237;nica&#46; &#201; tamb&#233;m muito comum em doentes com doen&#231;a da v&#225;lvula mitral e &#233; sabido que a associa&#231;&#227;o das duas confere pior progn&#243;stico<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a>&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">A abla&#231;&#227;o percut&#226;nea de fibrilha&#231;&#227;o auricular&#44; com isolamento das veias pulmonares&#44; provou ser mais eficaz que a terap&#234;utica farmacol&#243;gica na manuten&#231;&#227;o de ritmo sinusal e&#44; atualmente&#44; &#233; uma indica&#231;&#227;o classe <span class="elsevierStyleSmallCaps">I</span> nas recomenda&#231;&#245;es da Sociedade Europeia de Cardiologia<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a>&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">A abla&#231;&#227;o cir&#250;rgica de fibrilha&#231;&#227;o auricular come&#231;ou na d&#233;cada de 90 do s&#233;culo <span class="elsevierStyleSmallCaps">XX</span>&#44; antes at&#233; da abla&#231;&#227;o percut&#226;nea&#44; e os avan&#231;os iniciais na &#250;ltima devem&#8208;se ao trabalho pioneiro de muitos cirurgi&#245;es&#46; A abla&#231;&#227;o cir&#250;rgica est&#225; tamb&#233;m presente nas recomenda&#231;&#245;es da Sociedade Europeia de Cardiologia&#44; sobretudo quando existe outra cirurgia card&#237;aca concomitante&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">N&#227;o &#233; claro qual a t&#233;cnica mais adequada para abla&#231;&#227;o cir&#250;rgica da fibrilha&#231;&#227;o auricular&#46; A cirurgia proposta inicialmente foi a cirurgia de MAZE&#44; pelo grupo do Prof&#46; Cox&#46; A cirurgia de MAZE consiste numa s&#233;rie de les&#245;es na aur&#237;cula esquerda e direita&#44; envolvendo as veias pulmonares&#44; a parede posterior e linhas para a v&#225;lvula mitral&#44; assim como les&#245;es lineares na aur&#237;cula direita&#46; Esta t&#233;cnica cir&#250;rgica veio a sofrer altera&#231;&#245;es ao longo dos anos &#40;tanto na localiza&#231;&#227;o das v&#225;rias linhas&#44; como na forma de fazer as les&#245;es &#8211; inicialmente les&#245;es cir&#250;rgicas&#44; efetuadas com bisturi&#47;sutura e&#44; atualmente&#44; energia de RF unipolar ou bipolar e crioenergia&#41;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a>&#46; Os resultados deste grupo mostraram uma elevada taxa de sucesso em v&#225;rias popula&#231;&#245;es de doentes&#44; tanto a curto como a longo prazo&#44; embora de forma n&#227;o reprodut&#237;vel quando a t&#233;cnica era efetuada por outros autores&#46; O isolamento cir&#250;rgico das veias pulmonares foi proposto pelo Prof&#46; Jo&#227;o Queir&#243;s e Melo&#44; a trabalhar no Hospital de Santa Cruz&#44; como uma forma de simplifica&#231;&#227;o da cirurgia de MAZE&#46; Os trabalhos iniciais deste grupo mostraram consistentemente taxas de sucesso mais baixas que as do grupo de Cox<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a>&#44; embora mais reprodut&#237;veis por outros&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">O presente estudo&#44; aleatorizado e multic&#234;ntrico&#44; pretende comparar tr&#234;s grupos de doentes com doen&#231;a mitral e fibrilha&#231;&#227;o auricular&#46; Todos os doentes tinham doen&#231;a mitral com indica&#231;&#227;o cir&#250;rgica e fibrilha&#231;&#227;o auricular persistente<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a>&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Foram inclu&#237;dos 260 doentes&#46; Os doentes eleg&#237;veis foram aleatorizados &#40;1&#58;1&#41; para efetuarem ou n&#227;o abla&#231;&#227;o cir&#250;rgica da FA&#44; no mesmo tempo operat&#243;rio da cirurgia mitral&#46; Os doentes do grupo da abla&#231;&#227;o foram aleatorizados para cirurgia de MAZE biauricular ou para isolamento das veias pulmonares&#46; A aleatoriza&#231;&#227;o para estes tr&#234;s grupos foi efetuada na fase anest&#233;sica&#44; ap&#243;s exclus&#227;o de trombos com ETE intraoperat&#243;rio&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Dos 260 doentes inclu&#237;dos&#44; 133 efetuaram cirurgia valvular com abla&#231;&#227;o &#40;67 isolamento de veias pulmonares e 66 MAZE biauricular&#41;&#46; Os restantes efetuaram apenas cirurgia valvular&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">Os grupos eram bem balanceados&#58; 45&#44;8&#37; dos doentes tinha FA persistente e os restantes FA persistente de longa dura&#231;&#227;o&#46; A maioria dos doentes &#40;55&#44;6&#37;&#41; fez plastia mitral&#46; O ap&#234;ndice auricular esquerdo foi excisado em todos os doentes&#46; A dura&#231;&#227;o da CEC foi cerca de 15 minutos maior no grupo da abla&#231;&#227;o&#46; Em 61&#44;4&#37; dos doentes&#44; foi efetuada cirurgia adicional&#44; al&#233;m da da v&#225;lvula mitral &#40;cirurgia de revasculariza&#231;&#227;o&#44; ou outra cirurgia valvular&#41;&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">O n&#250;mero de doentes em ritmo sinusal&#44; aos 6 e 12 meses&#44; no grupo da abla&#231;&#227;o era francamente superior ao do grupo controlo &#40;63&#44;2 <span class="elsevierStyleItalic">versus</span> 29&#44;4&#37;&#44; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#46; N&#227;o houve diferen&#231;a significativa na taxa de manuten&#231;&#227;o de ritmo sinusal para os dois tipos de cirurgia&#46; N&#227;o se encontraram diferen&#231;as entre grupos para o <span class="elsevierStyleItalic">endpoint</span> prim&#225;rio de seguran&#231;a &#40;morte&#44; hemorragia&#44; reinternamentos&#41;&#46; No entanto&#44; os doentes dos grupos da abla&#231;&#227;o tiveram mais frequentemente necessidade de implanta&#231;&#227;o de <span class="elsevierStyleItalic">pacemaker</span> definitivo&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">O presente estudo &#233; muito importante ao confirmar&#44; de forma inequ&#237;voca&#44; num ensaio cl&#237;nico&#44; multic&#234;ntrico e aleatorizado&#44; que existe vantagem na abla&#231;&#227;o cir&#250;rgica de FA concomitante a cirurgia da v&#225;lvula mitral&#46; N&#227;o se demonstraram diferen&#231;as nas taxas de manuten&#231;&#227;o de ritmo sinusal entre os dois tipos de cirurgia&#46; Existe um risco acrescido para os doentes da abla&#231;&#227;o que &#233; o de uma maior probabilidade de necessidade de implanta&#231;&#227;o de <span class="elsevierStyleItalic">pacemaker</span>&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">A limita&#231;&#227;o principal do estudo prende&#8208;se com o baixo n&#250;mero de doentes inclu&#237;dos e tamb&#233;m com o curto tempo de seguimento&#44; o que n&#227;o permitiu encontrar diferen&#231;as no que diz respeito a progn&#243;stico&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflicts of interest</span><p id="par0090" class="elsevierStylePara elsevierViewall">The author has no conflicts of interest to declare&#46;</p></span></span>"
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ISSN: 21742049
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Idiomas
Revista Portuguesa de Cardiologia (English edition)
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