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Adaptado de: Unverzagt et al.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">1</span></a>. BIA: balão intra‐aórtico; DAV: dispositivos de assistência ventricular; HR: <span class="elsevierStyleItalic">hazard ratio</span>; IC 95%: intervalo de confiança de 95%; RCT: ensaios clínicos controlados e aleatorizados.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Daniel Caldeira, Hélder Pereira, João Costa, António Vaz‐Carneiro" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Daniel" "apellidos" => "Caldeira" ] 1 => array:2 [ "nombre" => "Hélder" "apellidos" => "Pereira" ] 2 => array:2 [ "nombre" => "João" "apellidos" => "Costa" ] 3 => array:2 [ "nombre" => "António" "apellidos" => "Vaz‐Carneiro" ] ] ] ] ] "idiomaDefecto" => "pt" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2174204916000635" "doi" => "10.1016/j.repce.2015.09.018" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204916000635?idApp=UINPBA00004E" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S087025511500325X?idApp=UINPBA00004E" "url" => "/08702551/0000003500000004/v1_201604010041/S087025511500325X/v1_201604010041/pt/main.assets" ] ] "itemSiguiente" => array:20 [ "pii" => "S2174204916300034" "issn" => "21742049" "doi" => "10.1016/j.repce.2015.09.020" "estado" => "S300" "fechaPublicacion" => "2016-04-01" "aid" => "791" "copyright" => "Sociedade Portuguesa de Cardiologia" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "crp" "cita" => "Rev Port Cardiol. 2016;35:233.e1-3" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2762 "formatos" => array:3 [ "EPUB" => 165 "HTML" => 2030 "PDF" => 567 ] ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case report</span>" "titulo" => "Intracardiac thrombus and Murphy's law: Reflections on a clinical dilemma" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "pt" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "233.e1" "paginaFinal" => "233.e3" ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Trombos intracardíacos e a lei de Murphy: reflexão sobre um dilema clínico" ] ] "contieneResumen" => array:2 [ "en" => true "pt" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1941 "Ancho" => 2668 "Tamanyo" => 573578 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">(A) Transthoracic echocardiogram, apical 4-chamber view in diastole, showing apical LV thrombus; (B) transthoracic echocardiogram, apical 4-chamber view in systole, showing the thrombus protruding into the LV cavity; (C) transthoracic echocardiogram, apical 3-chamber view, showing the LV and LA thrombi; (D) cerebral computed tomography, displaying a large cerebral infarct; (E–G) abdominal computed tomography with contrast, showing splenic (E) and renal (F) infarcts and almost total occlusion of the infrarenal abdominal aorta (G). 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"referencia" => array:4 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] 3 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Hélder" "apellidos" => "Pereira" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 2 => array:3 [ "nombre" => "João" "apellidos" => "Costa" "referencia" => array:4 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] 3 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">e</span>" "identificador" => "aff0025" ] ] ] 3 => array:3 [ "nombre" => "António" "apellidos" => "Vaz-Carneiro" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">e</span>" "identificador" => "aff0025" ] ] ] ] "afiliaciones" => array:5 [ 0 => array:3 [ "entidad" => "Laboratório de Farmacologia Clínica e Terapêutica, Faculdade Medicina, Universidade de Lisboa, Lisboa, Portugal" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Unidade de Farmacologia Clínica, Instituto de Medicina Molecular, Lisboa, Portugal" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Serviço de Cardiologia, Hospital Garcia de Orta, Almada, Portugal" "etiqueta" => "c" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Centro de Estudos de Medicina Baseada na Evidência, Faculdade Medicina, Universidade de Lisboa, Lisboa, Portugal" "etiqueta" => "d" "identificador" => "aff0020" ] 4 => array:3 [ "entidad" => "Centro Colaborador Português da Rede Cochrane Iberoamericana, Portugal" "etiqueta" => "e" "identificador" => "aff0025" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 500 "Ancho" => 3257 "Tamanyo" => 113292 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">30-day mortality with IABP (adapted from Unverzagt et al.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">1</span></a>). CI: confidence interval; HR: hazard ratio; IABP: intra-aortic balloon pump counterpulsation; RCTs: randomized controlled trials; VADs: ventricular assist devices.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall"><elsevierMultimedia ident="tb0005"></elsevierMultimedia></p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Clinical question</span><p id="par0015" class="elsevierStylePara elsevierViewall">What is the impact of intra-aortic balloon pump counterpulsation (IABP) in patients with cardiogenic shock following acute myocardial infarction (MI)?</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Objectives</span><p id="par0020" class="elsevierStylePara elsevierViewall">To evaluate the efficacy and safety of IABP versus non-IABP treatment in patients with MI complicated by cardiogenic shock.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Description of review</span><p id="par0025" class="elsevierStylePara elsevierViewall">A systematic review was performed of all randomized controlled trials (RCTs) of patients with MI complicated by cardiogenic shock<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">1</span></a> that assessed the use of IABP compared to non-IABP treatment including other ventricular assist devices.</p><p id="par0030" class="elsevierStylePara elsevierViewall">Searches of the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE, LILACS, IndMed, KoreaMed, and registers of ongoing trials were performed in October 2013.</p><p id="par0035" class="elsevierStylePara elsevierViewall">Data were pooled in meta-analyses. Hazard ratios (HR) with 95% confidence intervals (CI) were used to express time-related variables such as time to event and dichotomous variables were expressed as odds ratios (OR) with 95% CI.</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Results</span><p id="par0040" class="elsevierStylePara elsevierViewall">Seven trials were included, with a total of 790 patients (406 in the intervention groups and 384 in the control groups). Four trials compared IABP to standard therapy and three to other left ventricular assist devices (two with the TandemHeart<span class="elsevierStyleSup">®</span> and one with the Impella<span class="elsevierStyleSup">®</span>).</p><p id="par0045" class="elsevierStylePara elsevierViewall">None of the trials were blinded to treatment allocation. All patients were revascularized, 95% by primary angioplasty and 5% by fibrinolysis. Mean time of IABP support was 59 hours.</p><p id="par0050" class="elsevierStylePara elsevierViewall">The proportion of fatal events at 30 days was around 40%. Aggregate analysis of the trials provided no evidence for a beneficial effect of IABP on mortality 30 days after the index event (HR 0.95; 95% CI 0.76–1.19) (<a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a>). Six-month mortality was also similar to other treatment strategies (OR 0.96; 95% CI 0.71–1.30).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0055" class="elsevierStylePara elsevierViewall">During hospitalization, 15 (4.12%) out of 364 patients from the intervention groups suffered severe adverse events (reinfarction or stroke), compared to five (1.38%) out of 363 from the control groups.</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Conclusions</span><p id="par0060" class="elsevierStylePara elsevierViewall">Available evidence, based on RCTs, does not support the systematic use of IABP in patients with cardiogenic shock secondary to MI to improve survival.</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Comment</span><p id="par0065" class="elsevierStylePara elsevierViewall">Cardiogenic shock is a complication of MI in 5–7% of cases and is associated with high mortality.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">2</span></a> There is little evidence concerning treatment of this extremely serious condition; only coronary revascularization has been shown to reduce mortality significantly at six months.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">3</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">The physiological basis for inflation of an IABP in the thoracic aorta in diastole is that it will improve certain hemodynamic parameters that affect prognosis, particularly by enhancing coronary flow, reducing afterload and increasing the cardiac index. As with any medical intervention, its systematic use must be based on methodologically robust studies. In this review, IABP did not reduce mortality in either the short or long term in the pooled analysis of RCTs.<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">1,4</span></a> With regard to the adverse events most often associated with IABP (stroke, peripheral ischemic vascular complications, bleeding and sepsis), the most robust study (IABP-SHOCK II) showed no significant differences between IABP and medical therapy.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">5</span></a></p><p id="par0075" class="elsevierStylePara elsevierViewall">It should be borne in mind that the overall assessment of the impact of IABP in this systematic review is limited by certain factors, including the lack of blinding to treatment allocation, the inclusion of trials with small study populations and high crossover rates, and the inclusion of patients with IABP at randomization.</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Clinical implications</span><p id="par0080" class="elsevierStylePara elsevierViewall">The European Society of Cardiology guidelines for the management of MI with ST-segment elevation state that IABP may be considered (class of recommendation IIb, level of evidence B) in patients with MI complicated by cardiogenic shock, while other ventricular assist devices have the same class of recommendation (IIb) but a lower level of evidence (C).<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">6</span></a></p><p id="par0085" class="elsevierStylePara elsevierViewall">The American College of Cardiology Foundation/American Heart Association guidelines for the management of heart failure give class of recommendation IIa, level of evidence B, for ventricular assist devices in patients with MI and cardiogenic shock refractory to medical therapy.<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">7</span></a></p><p id="par0090" class="elsevierStylePara elsevierViewall">IABP thus has only a secondary role in the treatment of MI-related cardiogenic shock, and its routine use is not recommended, since the intervention does not lead to clear benefits.</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Ethical disclosures</span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Protection of human and animal subjects</span><p id="par0095" class="elsevierStylePara elsevierViewall">The authors declare that no experiments were performed on humans or animals for this study.</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Confidentiality of data</span><p id="par0100" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appear in this article.</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Right to privacy and informed consent</span><p id="par0105" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appear in this article.</p></span></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Conflicts of interest</span><p id="par0110" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:14 [ 0 => array:3 [ "identificador" => "xres821805" "titulo" => "Abstract" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0005" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec818753" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres821806" "titulo" => "Resumo" "secciones" => array:1 [ 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=> "Right to privacy and informed consent" ] ] ] 12 => array:2 [ "identificador" => "sec0060" "titulo" => "Conflicts of interest" ] 13 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2015-07-10" "fechaAceptado" => "2015-09-13" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec818753" "palabras" => array:4 [ 0 => "Cardiogenic shock" 1 => "Myocardial infarction" 2 => "Intra-aortic balloon pump" 3 => "Left ventricular assist device" ] ] ] "pt" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palavras-chave" "identificador" => "xpalclavsec818752" "palabras" => array:4 [ 0 => "Choque cardiogénico" 1 => "Enfarte agudo do miocárdio" 2 => "Balão intra-aórtico" 3 => "Dispositivo de assistência ventricular" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Improvement of hemodynamic parameters is the rationale for the use of intra-aortic balloon pump counterpulsation (IABP) in patients with cardiogenic shock following acute myocardial infarction (MI). This Cochrane systematic review evaluated the impact of this intervention in reducing mortality. Seven randomized controlled trials with a total of 790 patients were included (four using medical therapy as a comparator, and three comparing IABP with other ventricular assist devices). IABP did not reduce mortality in either the short or long term. Therefore, the systematic use of IABP in patients with cardiogenic shock following MI cannot be recommended.</p></span>" ] "pt" => array:2 [ "titulo" => "Resumo" "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">A melhoria de parâmetros hemodinâmicos justifica o uso do balão intra-aórtico (BIA) em doentes com enfarte agudo do miocárdio (EAM) complicado por choque cardiogénico. Esta revisão sistemática da <span class="elsevierStyleItalic">Cochrane</span> avaliou o potencial impacto desta intervenção na mortalidade. Foram avaliados sete ensaios clínicos aleatorizados e controlados com um total de 790 doentes (quatro estudos utilizando a terapêutica médica como comparador e três estudos compararam o BIA com outros dispositivos de assistência ventricular). O uso de BIA não reduziu significativamente a mortalidade a curto ou a longo prazo nos doentes com EAM e choque cardiogénico. Não existe evidência que suporte o seu uso sistemático nestes doentes.</p></span>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Caldeira D, Pereira H, Costa J, Vaz-Carneiro A. <span class="elsevierStyleItalic">Cochrane Corner</span>: uso do balão intra-aórtico em doentes com enfarte agudo do miocárdio complicado com choque cardiogénico. Rev Port Cardiol. 2016;35:229–231.</p>" ] ] "multimedia" => array:2 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 500 "Ancho" => 3257 "Tamanyo" => 113292 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">30-day mortality with IABP (adapted from Unverzagt et al.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">1</span></a>). CI: confidence interval; HR: hazard ratio; IABP: intra-aortic balloon pump counterpulsation; RCTs: randomized controlled trials; VADs: ventricular assist devices.</p>" ] ] 1 => array:5 [ "identificador" => "tb0005" "tipo" => "MULTIMEDIATEXTO" "mostrarFloat" => false "mostrarDisplay" => true "texto" => array:1 [ "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0010" class="elsevierStylePara elsevierViewall">Unverzagt S, Buerke M, de Waha A, Haerting J, Pietzner D, Seyfarth M, Thiele H, Werdan K, Zeymer U, Prondzinsky R. Intra-aortic balloon pump counterpulsation (IABP) for myocardial infarction complicated by cardiogenic shock. Cochrane Database of Systematic Reviews 2015, Issue 3. Art. No.: CD007398. <span class="elsevierStyleInterRef" id="intr0010" href="doi:10.1002/14651858.CD007398.pub3">doi:10.1002/14651858.CD007398.pub3</span>.</p></span>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:7 [ 0 => array:3 [ "identificador" => "bib0040" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Intra-aortic balloon pump counterpulsation (IABP) for myocardial infarction complicated by cardiogenic shock" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "S. Unverzagt" 1 => "M. 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