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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">As a health economist&#44; with a particular interest in the economic evaluation of drugs&#44; I was pleased to read the article &#8220;Cost-effectiveness of rivaroxaban for stroke prevention in atrial fibrillation in the Portuguese setting&#8221; by Morais et al&#46; in volume 33&#44; issue 9&#44; of the <span class="elsevierStyleItalic">Journal</span>&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">It is increasingly clear that as well as the criteria of efficacy&#44; safety and quality that are required for market authorization&#44; the cost-effectiveness of a drug should also be taken into consideration&#46; This is essential to ensure the best use of resources and thus better health outcomes&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Of course&#44; this objective can only be fully achieved if the medical community has access to studies published in journals of recognized scientific quality and prestige&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">However&#44; despite improvements over the last 15 years&#44; a significant proportion of the medical community lacks the necessary tools to perform a critical analysis of a study&#39;s results or to identify factors that could affect them&#46; It is thus essential that at least the main parameters used in a particular study should be explained in a transparent fashion&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">As the lead author of the article &#8220;Economic evaluation of dabigatran for stroke prevention in patients with non-valvular atrial fibrillation&#8221;&#44; published in volume 32&#44; issue 7&#8211;8&#44; of the <span class="elsevierStyleItalic">Journal</span>&#44;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">2</span></a> I carried out a careful analysis of the results presented by Morais et al&#46; Comparison between the two studies showed that the differences stem from the different financial costs assigned to monitoring patients under warfarin&#46; As readers will naturally compare the two articles&#44; I consider it essential that the authors of the cost-effectiveness study of rivaroxaban clearly specify this parameter&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">I would also like to point out that there appears to be an error in Table 4 &#40;&#8220;Cost-effectiveness results of base-case analysis&#8221;&#41; of the article by Morais et al&#46; In this table&#44; the authors report the total costs for both drugs and separate costs for drug acquisition&#44; drug administration&#44; and event treatment&#46; However&#44; the sum of the latter does not equal the total&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Ethical disclosures</span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Protection of human and animal subjects</span><p id="par0035" class="elsevierStylePara elsevierViewall">The authors declare that no experiments were performed on humans or animals for this investigation&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Confidentiality of data</span><p id="par0040" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appears in this article&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Right to privacy and informed consent</span><p id="par0045" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appears in this article&#46;</p></span></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conflicts of interest</span><p id="par0050" class="elsevierStylePara elsevierViewall">The author has no conflicts of interest to declare&#46;</p></span></span>"
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Letter to the Editor
Comment on “Cost-effectiveness of rivaroxaban for stroke prevention in atrial fibrillation in the Portuguese setting”
Comentário a estudo de custo-efetividade de rivaroxabano para prevenção de acidente vascular cerebral em doentes com fibrilhação auricular em Portugal
Luís Silva Miguel
Centro de Investigação Sobre Economia Portuguesa, Instituto Superior de Economia e Gestão, Lisboa, Portugal
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">As a health economist&#44; with a particular interest in the economic evaluation of drugs&#44; I was pleased to read the article &#8220;Cost-effectiveness of rivaroxaban for stroke prevention in atrial fibrillation in the Portuguese setting&#8221; by Morais et al&#46; in volume 33&#44; issue 9&#44; of the <span class="elsevierStyleItalic">Journal</span>&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">It is increasingly clear that as well as the criteria of efficacy&#44; safety and quality that are required for market authorization&#44; the cost-effectiveness of a drug should also be taken into consideration&#46; This is essential to ensure the best use of resources and thus better health outcomes&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Of course&#44; this objective can only be fully achieved if the medical community has access to studies published in journals of recognized scientific quality and prestige&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">However&#44; despite improvements over the last 15 years&#44; a significant proportion of the medical community lacks the necessary tools to perform a critical analysis of a study&#39;s results or to identify factors that could affect them&#46; It is thus essential that at least the main parameters used in a particular study should be explained in a transparent fashion&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">As the lead author of the article &#8220;Economic evaluation of dabigatran for stroke prevention in patients with non-valvular atrial fibrillation&#8221;&#44; published in volume 32&#44; issue 7&#8211;8&#44; of the <span class="elsevierStyleItalic">Journal</span>&#44;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">2</span></a> I carried out a careful analysis of the results presented by Morais et al&#46; Comparison between the two studies showed that the differences stem from the different financial costs assigned to monitoring patients under warfarin&#46; As readers will naturally compare the two articles&#44; I consider it essential that the authors of the cost-effectiveness study of rivaroxaban clearly specify this parameter&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">I would also like to point out that there appears to be an error in Table 4 &#40;&#8220;Cost-effectiveness results of base-case analysis&#8221;&#41; of the article by Morais et al&#46; In this table&#44; the authors report the total costs for both drugs and separate costs for drug acquisition&#44; drug administration&#44; and event treatment&#46; However&#44; the sum of the latter does not equal the total&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Ethical disclosures</span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Protection of human and animal subjects</span><p id="par0035" class="elsevierStylePara elsevierViewall">The authors declare that no experiments were performed on humans or animals for this investigation&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Confidentiality of data</span><p id="par0040" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appears in this article&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Right to privacy and informed consent</span><p id="par0045" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appears in this article&#46;</p></span></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conflicts of interest</span><p id="par0050" class="elsevierStylePara elsevierViewall">The author has no conflicts of interest to declare&#46;</p></span></span>"
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                      "titulo" => "Avalia&#231;&#227;o econ&#243;mica do dabigatrano na preven&#231;&#227;o de acidentes vasculares cerebrais isqu&#233;micos em doentes com fibrilha&#231;&#227;o auricular n&#227;o valvular"
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Article information
ISSN: 21742049
Original language: English
DOI:10.1016/j.repce.2015.09.006
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