Neutrophil-to-lymphocyte ratio predicts coronary artery lesion complexity and mortality after non-ST-segment elevation acute coronary syndrome | Revista Portuguesa de Cardiologia (English edition)

array:25 ["pii" => "S2174204915001610" "issn" => "21742049" "doi" => "10.1016/j.repce.2015.07.007" "estado" => "S300" "fechaPublicacion" => "2015-07-01" "aid" => "653" "copyright" => "Sociedade Portuguesa de Cardiologia" "copyrightAnyo" => "2014" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "fla" "cita" => "Rev Port Cardiol. 2015;34:465-71" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 3197 "formatos" => array:3 [ "EPUB" => 164 "HTML" => 2223 "PDF" => 810 ] ] "Traduccion" => array:1 [ "en" => array:20 [ "pii" => "S0870255115001511" "issn" => "08702551" "doi" => "10.1016/j.repc.2015.01.013" "estado" => "S300" "fechaPublicacion" => "2015-07-01" "aid" => "653" "copyright" => "Sociedade Portuguesa de Cardiologia" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "fla" "cita" => "Rev Port Cardiol. 2015;34:465-71" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 5216 "formatos" => array:3 [ "EPUB" => 192 "HTML" => 4353 "PDF" => 671 ] ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "Original Article" "titulo" => "Neutrophil-to-lymphocyte ratio predicts coronary artery lesion complexity and mortality after non-ST-segment elevation acute coronary syndrome" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "pt" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "465" "paginaFinal" => "471" ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Rácio neutrófilo-linfócito prevê a complexidade da lesão arterial coronária e a mortalidade após o enfarte do miocárdio sem elevação do segmento ST" ] ] "contieneResumen" => array:2 [ "en" => true "pt" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1234 "Ancho" => 1666 "Tamanyo" => 137193 ] ] "descripcion" => array:1 [ "en" => "Study flow diagram. NLR: neutrophil-to-lymphocyte ratio." ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Korhan Soylu, Ömer Gedikli, Göksel Dagasan, Ertan Aydin, Gökhan Aksan, Gökay Nar, Sinan İnci, Özcan Yilmaz" "autores" => array:8 [ 0 => array:2 [ "nombre" => "Korhan" "apellidos" => "Soylu" ] 1 => array:2 [ "nombre" => "Ömer" "apellidos" => "Gedikli" ] 2 => array:2 [ "nombre" => "Göksel" "apellidos" => "Dagasan" ] 3 => array:2 [ "nombre" => "Ertan" "apellidos" => "Aydin" ] 4 => array:2 [ "nombre" => "Gökhan" "apellidos" => "Aksan" ] 5 => array:2 [ "nombre" => "Gökay" "apellidos" => "Nar" ] 6 => array:2 [ "nombre" => "Sinan" "apellidos" => "İnci" ] 7 => array:2 [ "nombre" => "Özcan" "apellidos" => "Yilmaz" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2174204915001610" "doi" => "10.1016/j.repce.2015.07.007" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204915001610?idApp=UINPBA00004E" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255115001511?idApp=UINPBA00004E" "url" => "/08702551/0000003400000078/v1_201507290010/S0870255115001511/v1_201507290010/en/main.assets" ] ] "itemSiguiente" => array:20 [ "pii" => "S2174204915001622" "issn" => "21742049" "doi" => "10.1016/j.repce.2015.07.008" "estado" => "S300" "fechaPublicacion" => "2015-07-01" "aid" => "652" "copyright" => "Sociedade Portuguesa de Cardiologia" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "fla" "cita" => "Rev Port Cardiol. 2015;34:473-8" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 3396 "formatos" => array:3 [ "EPUB" => 176 "HTML" => 2625 "PDF" => 595 ] ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "Original Article" "titulo" => "Prognostic value of plasma neutrophil gelatinase-associated lipocalin in patients with heart failure" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "pt" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "473" "paginaFinal" => "478" ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Valor prognóstico da lipocalina associada a gelatinase de neutrófilos em pacientes com insuficiência cardíaca" ] ] "contieneResumen" => array:2 [ "en" => true "pt" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0020" "etiqueta" => "Figure 4" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr4.jpeg" "Alto" => 630 "Ancho" => 944 "Tamanyo" => 62069 ] ] "descripcion" => array:1 [ "en" => "Receiver operating characteristic curve analysis of neutrophil gelatinase-associated lipocalin and estimated glomerular filtration rate for predicting cardiovascular mortality, heart failure hospitalization or emergency department visit for heart failure. AUC: area under the curve; eGFR: estimated glomerular filtration rate; NGAL: neutrophil gelatinase-associated lipocalin." ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Humberto Villacorta, Rochele Alberto Martins Santos, Marcelle Alves Baco Marroig, Guilherme Pinella Guedes Pereira, Analucia Rampazzo Xavier, Salim Kanaan" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Humberto" "apellidos" => "Villacorta" ] 1 => array:2 [ "nombre" => "Rochele Alberto" "apellidos" => "Martins Santos" ] 2 => array:2 [ "nombre" => "Marcelle Alves" "apellidos" => "Baco Marroig" ] 3 => array:2 [ "nombre" => "Guilherme Pinella" "apellidos" => "Guedes Pereira" ] 4 => array:2 [ "nombre" => "Analucia Rampazzo" "apellidos" => "Xavier" ] 5 => array:2 [ "nombre" => "Salim" "apellidos" => "Kanaan" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S087025511500150X" "doi" => "10.1016/j.repc.2015.02.003" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S087025511500150X?idApp=UINPBA00004E" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204915001622?idApp=UINPBA00004E" "url" => "/21742049/0000003400000078/v1_201508050210/S2174204915001622/v1_201508050210/en/main.assets" ] "itemAnterior" => array:20 [ "pii" => "S2174204915001609" "issn" => "21742049" "doi" => "10.1016/j.repce.2015.07.006" "estado" => "S300" "fechaPublicacion" => "2015-07-01" "aid" => "651" "copyright" => "Sociedade Portuguesa de Cardiologia" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "fla" "cita" => "Rev Port Cardiol. 2015;34:457-63" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 3235 "formatos" => array:3 [ "EPUB" => 201 "HTML" => 2494 "PDF" => 540 ] ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "Original Article" "titulo" => "Clinical characteristics and prognosis of heart failure in elderly patients" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "pt" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "457" "paginaFinal" => "463" ] ] "contieneResumen" => array:2 [ "en" => true "pt" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 850 "Ancho" => 992 "Tamanyo" => 54356 ] ] "descripcion" => array:1 [ "en" => "Follow-up survival curve for patients with heart failure with preserved ejection fraction and heart failure with reduced ejection fraction." ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Lucía Martínez-Braña, Lara Mateo-Mosquera, María Bermúdez-Ramos, María de los Ángeles Valcárcel García, Lorena Fernández Hernández, Álvaro Hermida Ameijeiras, Francisco Luis Lado Lado" "autores" => array:7 [ 0 => array:2 [ "nombre" => "Lucía" "apellidos" => "Martínez-Braña" ] 1 => array:2 [ "nombre" => "Lara" "apellidos" => "Mateo-Mosquera" ] 2 => array:2 [ "nombre" => "María" "apellidos" => "Bermúdez-Ramos" ] 3 => array:2 [ "nombre" => "María de los Ángeles" "apellidos" => "Valcárcel García" ] 4 => array:2 [ "nombre" => "Lorena" "apellidos" => "Fernández Hernández" ] 5 => array:2 [ "nombre" => "Álvaro" "apellidos" => "Hermida Ameijeiras" ] 6 => array:2 [ "nombre" => "Francisco Luis" "apellidos" => "Lado Lado" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S0870255115001493" "doi" => "10.1016/j.repc.2015.02.002" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255115001493?idApp=UINPBA00004E" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204915001609?idApp=UINPBA00004E" "url" => "/21742049/0000003400000078/v1_201508050210/S2174204915001609/v1_201508050210/en/main.assets" ] "en" => array:19 [ "idiomaDefecto" => true "cabecera" => "Original Article" "titulo" => "Neutrophil-to-lymphocyte ratio predicts coronary artery lesion complexity and mortality after non-ST-segment elevation acute coronary syndrome" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "465" "paginaFinal" => "471" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Korhan Soylu, Ömer Gedikli, Göksel Dagasan, Ertan Aydin, Gökhan Aksan, Gökay Nar, Sinan İnci, Özcan Yilmaz" "autores" => array:8 [ 0 => array:4 [ "nombre" => "Korhan" "apellidos" => "Soylu" "email" => array:1 [ 0 => "korhansoylu@yahoo.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Ömer" "apellidos" => "Gedikli" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "b" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "Göksel" "apellidos" => "Dagasan" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "Ertan" "apellidos" => "Aydin" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0005" ] ] ] 4 => array:3 [ "nombre" => "Gökhan" "apellidos" => "Aksan" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "c" "identificador" => "aff0015" ] ] ] 5 => array:3 [ "nombre" => "Gökay" "apellidos" => "Nar" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "d" "identificador" => "aff0020" ] ] ] 6 => array:3 [ "nombre" => "Sinan" "apellidos" => "İnci" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "d" "identificador" => "aff0020" ] ] ] 7 => array:3 [ "nombre" => "Özcan" "apellidos" => "Yilmaz" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:4 [ 0 => array:3 [ "entidad" => "Department of Cardiology, Ondokuz Mayis University, Faculty of Medicine, Samsun, Turkey" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Department of Cardiology, Artvin State Hospital, Artvin, Turkey" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Department of Cardiology, Gazi State Hospital, Samsun, Turkey" "etiqueta" => "c" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Department of Cardiology, Aksaray State Hospital, Aksaray, Turkey" "etiqueta" => "d" "identificador" => "aff0020" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Rácio neutrófilo-linfócito prevê a complexidade da lesão arterial coronária e a mortalidade após o enfarte do miocárdio sem elevação do segmento ST" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0020" "etiqueta" => "Figure 4" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr4.jpeg" "Alto" => 807 "Ancho" => 964 "Tamanyo" => 51163 ] ] "descripcion" => array:1 [ "en" => "Receiver operating characteristic curve analysis of neutrophil-to-lymphocyte ratio (area under the curve=0.857) and GRACE risk score (area under the curve=0.926) for in-hospital mortality. NLR: neutrophil-to-lymphocyte ratio." ] ] ] "textoCompleto" => "IntroductionThe content and intensity of treatment, and the need for intervention, are closely linked to disease severity in the treatment of patients with coronary artery disease (CAD). Clinical and angiographic risk scores have been developed to aid decision-making. Current guidelines recommend the GRACE and SYNTAX risk scoring systems for patients diagnosed with non-ST-elevation acute coronary syndrome (NSTE-ACS).<a class="elsevierStyleCrossRefs" href="#bib0170">1,2</a> The GRACE risk score includes parameters such as ECG changes, initial cardiac markers, and serum creatinine, in addition to clinical characteristics such as age, heart rate, systolic blood pressure, and degree of heart failure.<a class="elsevierStyleCrossRef" href="#bib0180">3</a> The SYNTAX risk score grades the severity and complexity of lesions on coronary angiography.<a class="elsevierStyleCrossRef" href="#bib0175">2</a> It also has an important role in decisions as to whether to perform percutaneous coronary intervention.Several studies have shown the role of inflammation in the pathophysiology of atherosclerosis,<a class="elsevierStyleCrossRefs" href="#bib0185">4,5</a> and inflammatory mediators such as C-reactive protein (CRP) can be used for risk stratification in CAD.<a class="elsevierStyleCrossRef" href="#bib0185">4</a> The neutrophil-to-lymphocyte ratio (NLR) is a new marker recently shown to be effective in CAD and certain non-cardiac diseases. Previous studies have demonstrated that NLR is associated with adverse events in stable coronary disease,<a class="elsevierStyleCrossRef" href="#bib0195">6</a> long-term mortality in patients with ST-segment elevation myocardial infarction (STEMI),<a class="elsevierStyleCrossRef" href="#bib0200">7</a> and in-hospital and six-month mortality in acute coronary syndrome.<a class="elsevierStyleCrossRef" href="#bib0205">8</a> NLR has also been shown to be a predictor of poor prognosis in patients with NSTE-ACS.<a class="elsevierStyleCrossRef" href="#bib0210">9</a> However, the association between NLR and clinical risk scores, and whether it is a determinant of lesion complexity, particularly in CAD, have not been investigated. In the present study, we aimed to investigate the importance of NLR in terms of hospital mortality, and its association with currently used risk scores in patients with NSTE-ACS.MethodsStudy populationIn this study, patients admitted to the cardiology clinic at Ondokuz Mayis University with NSTE-ACS between January 2006 and January 2012 were retrospectively assessed. The inclusion criterion was the NSTE-ACS diagnosis code in the electronic patient database. The medical history of all patients with the NSTE-ACS diagnosis code was obtained and assessed by the investigators. Exclusion criteria included inconclusive NSTE-ACS diagnosis according to medical records, hematological disease, autoimmune disease, infectious or inflammatory disease, severe renal disease (glomerular filtration rate <30 ml/min/1.73 m2), severe liver disease, and ongoing treatment with immunosuppressive agents.Definition of non-ST-elevation acute coronary syndromeNSTE-ACS was defined as the presence of T-wave inversion or ST-segment depression and/or positive troponin I in the absence of electrocardiographic (ECG) ST elevation in patients presenting with angina or equivalent. Positive troponin was defined as troponin I >0.1 ng/ml.Coronary angiographyCoronary angiography was performed using standard techniques. Selective cine angiographic images of the coronaries were recorded with a digital angiographic system (ACOM.PC, Siemens AG, Germany).Risk scoringFor the SYNTAX score,<a class="elsevierStyleCrossRef" href="#bib0215">10</a> the severity of coronary atherosclerotic lesions was assessed with at least three projections in all patients. The score for each patient was calculated by a team of two experienced cardiologists who scored all coronary lesions with ≥50% stenosis in vessels ≥1.5 mm. The online SYNTAX score calculation tool was used (<a href="http://www.syntaxscore.com/">http://www.SYNTAXscore.com</a>).The principle of the GRACE risk score has been described elsewhere.<a class="elsevierStyleCrossRef" href="#bib0180">3</a> The variables used in the calculation of the score include age, heart rate, systolic blood pressure, baseline creatinine level, history of congestive heart failure, in-hospital percutaneous coronary intervention, history of myocardial infarction, ST-segment depression on admission electrocardiography (ECG), and elevated cardiac markers. In the present study, we used a single measurement of serum cardiac troponin I, considering 0.06 ng/ml to be an elevated cardiac marker. ST-segment depression was defined as ST segment >0.5 mV below the isoelectric line in any ECG lead.Laboratory parametersVenous blood samples, obtained from the patients within an hour of admission to the emergency room, were used for the laboratory analyses. Biochemical parameters were measured using an Abbott Architect c8000 analyzer (Abbott Laboratories, USA) with commercial kits. Total blood cell counts and subtypes were analyzed using an automated blood cell counter (Abbott Laboratories, USA). NLR values were calculated as the ratio of neutrophil to lymphocyte count obtained from the same blood sample. Patients were divided into tertiles according to NLR values (NLR <2.6, NLR=2.6–4.5, and NLR >4.5).Follow-upClinical records of the patients over the course of hospitalization were reviewed and all-cause mortality before hospital discharge was recorded as in-hospital mortality.Statistical analysisThe dataset was analyzed using SPSS version 15. The normal distribution of the data was tested using the Kolmogorov-Smirnov test and non-normally distributed data were transformed. One-way ANOVA was used for the comparison of multiple groups. Categorical data were compared using the chi-square test or Fisher's exact test, as appropriate. Correlation between data was tested with Pearson's correlation analysis. Logistic regression analysis was used to test the significance of the data on mortality. Variables were eliminated by forward selection. NLR and the GRACE score criteria were selected as the potential variables for logistic regression analysis, excepting cardiac arrest on admission, which was not assessed because there were no patients with this parameter. Continuous data were expressed as mean ± SD (standard deviation) and categorical data were expressed as percentages. A p value of <0.05 was accepted as statistically significant. Bonferroni's correction was performed when statistical comparisons of the three groups were made as <0.016.ResultsFor the present study, records were analyzed of 2135 patients admitted to the coronary intensive care unit, of whom 418 patients were admitted with an NSTE-ACS diagnosis code. On the basis of patients’ records, 33 patients with an inconclusive diagnosis, 11 with hematological disease, 21 with infectious and inflammatory disease, 14 with severe renal disease, four with severe liver disease, and 18 with missing data were excluded from the study (<a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a>). As a result, a total of 317 patients were included in the study. Following clinical assessment, 276 (86.8%) patients underwent coronary angiography.<elsevierMultimedia ident="fig0005"></elsevierMultimedia>Demographic, clinical, and laboratory characteristics of the patients are presented in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>. The patients in the group with high NLR were older and had higher serum glucose levels, lower hemoglobin, lower ejection fraction, higher heart rate, higher Killip class, more ST-segment changes, and higher troponin and creatinine levels.<elsevierMultimedia ident="tbl0005"></elsevierMultimedia>GRACE risk score was significantly higher in the high NLR group than in those with moderate or low NLR (161.5±40.3, 130.5±32.3 and 123.9±34.3, respectively, p<0.001). Similarly, SYNTAX score was significantly higher in the group with high NLR (20.4±10.1, 15.5±10.5 and 13.4±7.8, respectively, p=0.003). Moreover, both GRACE risk score (r=0.457, p<0.001) and SYNTAX score (r=0.253, p=0.001) showed a significant positive correlation with NLR (<a class="elsevierStyleCrossRefs" href="#fig0010">Figures 2 and 3</a>). Analysis of the NLR subgroups revealed a correlation between NLR, GRACE and SYNTAX scores only in the high NLR group (r=0.483, p<0.001, and r=0.495, p=0.001, respectively).<elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia>The high NLR group had higher in-hospital mortality than both the low and the moderate NLR groups (35.8%, 7.5% and 1.9%, p<0.001). Receiver operating characteristic (ROC) analysis showed that NLR >4.5 had 75% specificity and 75% sensitivity for in-hospital mortality (<a class="elsevierStyleCrossRef" href="#fig0020">Figure 4</a>), with a positive predictive value of 79.2% and a negative predictive value of 95.3% (area under the curve [AUC]=0.857). On the other hand, ROC analysis showed that a GRACE score >140 had 61% specificity and 92.2% sensitivity for in-hospital mortality, with a positive predictive value of 91.6% and a negative predictive value of 97.7% (AUC=0.926). ROC analysis showed that a CRP value of 36.7 had 78.6% specificity and 70.9% sensitivity for in-hospital mortality, with a positive predictive value of 0.79% and a negative predictive value of 96.9% (AUC=0.815). Furthermore, multivariate regression analysis showed that NLR was an independent predictor of in-hospital mortality (OR: 1.182; 95% confidence interval [CI]: 1.042–1.340; p=0.009). Additionally, NLR >4.5 had higher odds ratios for in-hospital mortality (OR: 11.457; 95% CI: 5.415–24.229; p<0.001). Other independent variables were age, Killip class, and troponin I value (<a class="elsevierStyleCrossRef" href="#tbl0025">Table 2</a>).<elsevierMultimedia ident="fig0020"></elsevierMultimedia><elsevierMultimedia ident="tbl0025"></elsevierMultimedia>DiscussionIn this study, we found higher GRACE and SYNTAX risk scores and in-hospital mortality in patients with high NLR values. In addition, NLR correlated with GRACE and SYNTAX scores. The present study is the first to demonstrate an association between coronary artery lesion complexity and NLR in patients with NSTE-ACS.An association between cardiovascular disease and NLR has been shown in previous studies.<a class="elsevierStyleCrossRefs" href="#bib0195">6–9</a> Increased NLR has been found to be associated with increased mortality,<a class="elsevierStyleCrossRef" href="#bib0220">11</a> no-reflow,<a class="elsevierStyleCrossRef" href="#bib0225">12</a> coronary ectasia,<a class="elsevierStyleCrossRef" href="#bib0230">13</a> and coronary collateral circulation<a class="elsevierStyleCrossRef" href="#bib0235">14</a> in various subgroups with CAD. This is an unsurprising result, given the increased inflammatory response seen during the clinical presentation of CAD as well as in its pathophysiology. The role of neutrophils during the atherosclerotic process is well known<a class="elsevierStyleCrossRef" href="#bib0185">4</a>; in particular, proteolytic enzymes released by neutrophils and myeloperoxidase activation, as well as acid phosphatase and free oxygen radicals, have been found to be involved in this process.<a class="elsevierStyleCrossRefs" href="#bib0240">15–17</a> Furthermore, Sonmez et al. found an association between NLR and coronary artery lesion complexity in patients with stable CAD and STEMI,<a class="elsevierStyleCrossRef" href="#bib0255">18</a> and Oncel et al. demonstrated an association between GRACE score and NLR in patients with STEMI.<a class="elsevierStyleCrossRef" href="#bib0260">19</a> In the present study, we have shown this association in patients with NSTE-ACS.Neutrophil infiltration during acute coronary events is associated with impaired microvascular perfusion and expansion of the infarct area, as well as with increased risk of no-reflow in primary angioplasty among patients with STEMI,<a class="elsevierStyleCrossRef" href="#bib0225">12</a> and increased NLR has been suggested as a predictor of increased thrombus load.<a class="elsevierStyleCrossRef" href="#bib0265">20</a> Furthermore, acute coronary syndrome (ACS)-associated decreased lymphocyte levels have been reported to suppress immune response, and may be a predictor of mechanical complications,<a class="elsevierStyleCrossRef" href="#bib0270">21</a> as well as being associated with adverse events and cardiac failure in patients with ACS.<a class="elsevierStyleCrossRefs" href="#bib0275">22,23</a> In this regard, NLR is associated with increased inflammation as well as inadequate immune response. The present study shows significantly higher in-hospital mortality in the groups with increased NLR. Furthermore, patients with high NLR also suffer from more severely depressed left ventricular function. On ROC analysis, NLR with a threshold of 4.5 has a high positive and negative predictive value. However, the higher negative predictive value is particularly important; considering that NLR is a non-specific marker, low NLR may be interpreted as a good predictor of good prognosis and survival, which may be more useful than the positive role of increased NLR. Sawant et al.<a class="elsevierStyleCrossRef" href="#bib0285">24</a> have shown an association of NLR and CRP with post-revascularization prognosis in patients with ST-elevation ACS.The GRACE risk score is a scoring method based on criteria also recommended by current guidelines. It is a good indicator of in-hospital and subsequent prognosis.<a class="elsevierStyleCrossRef" href="#bib0290">25</a> Inflammatory markers such as CRP and dickkopf-1 have been associated with GRACE score in patients with ACS.<a class="elsevierStyleCrossRefs" href="#bib0295">26,27</a> Also in our study, higher CRP values were observed in the high NLR group. The present study shows that the GRACE risk score has high positive and negative predictive values, and also correlates well with NLR. An earlier study also demonstrated a significant correlation between NLR and GRACE risk score in patients with STEMI.<a class="elsevierStyleCrossRef" href="#bib0260">19</a> The GRACE risk score includes a series of clinical and laboratory criteria, and the comparison of its ROC curve against the ROC curve of NLR indicates that NLR may be a simple and valuable marker of early survival. In the present study, higher specificity was determined for an NLR value of 4.5 as compared to a GRACE risk score of 140. This might be particularly helpful in identifying patients with low GRACE risk score who are likely to have poor prognosis.The SYNTAX score provides information on the severity of CAD as well as the complexity of lesions. It is thus important in terms of eligibility of patients for percutaneous intervention.<a class="elsevierStyleCrossRef" href="#bib0305">28</a> Altun et al.<a class="elsevierStyleCrossRef" href="#bib0310">29</a> found a significant association between SYNTAX score and NLR in patients presenting with acute MI. Furthermore, Sonmez et al.<a class="elsevierStyleCrossRef" href="#bib0315">30</a> demonstrated a correlation between NLR and SYNTAX score in patients with stable CAD, while Sahin et al.<a class="elsevierStyleCrossRef" href="#bib0255">18</a> showed an association between SYNTAX score and NLR in patients with STEMI. However, the present study is the first to demonstrate an association between NLR and SYNTAX score in isolated patients with NSTE-ACS. This is most likely related to the sensitivity of coronary lesions and myocardial damage. Histopathological studies have shown increased neutrophils in unstable and ruptured plaques,<a class="elsevierStyleCrossRefs" href="#bib0320">31,32</a> while increased neutrophils are thought to impair microvascular circulation, leading to infarct expansion after reperfusion.<a class="elsevierStyleCrossRef" href="#bib0325">32</a>In the present study, a strong correlation between NLR with GRACE and SYNTAX scores has been demonstrated, particularly in the high NLR group. Therefore, in addition to the relation of low and moderate NLR values with low morbidity, it may be assumed that a high NLR would be associated with increased morbidity and a higher atherosclerotic plaque burden.Study limitationsAlthough a total of 2135 patients admitted to the coronary intensive care unit were screened in the present study, only 418 (19.6%) of them were coded with the diagnosis of NST-ACS. Our study demonstrates an association between NLR and in-hospital mortality, though its role in post-discharge survival and other adverse events could not be assessed due to insufficient retrospective data. Furthermore, since there were a limited number of patients with CRP values in our database, CRP could not be included in the multivariate regression analysis.ConclusionIn our study, NLR, a new marker, was tested in a large group of patients, and increased NLR was associated with short-term survival in patients with NSTE-ACS. In addition, NLR was found to be correlated with clinical and angiographic risk scores. These results support the relation of low NLR with improved short-term survival and of increased NLR with massive atherosclerotic burden and inflammation.Ethical disclosuresProtection of human and animal subjectsThe authors declare that the procedures followed were in accordance with the regulations of the relevant clinical research ethics committee and with those of the Code of Ethics of the World Medical Association (Declaration of Helsinki).Confidentiality of dataThe authors declare that they have followed the protocols of their work center on the publication of patient data.Right to privacy and informed consentThe authors have obtained the written informed consent of the patients or subjects mentioned in the article. The corresponding author is in possession of this document.Conflicts of interestThe authors have no conflicts of interest to declare." "textoCompletoSecciones" => array:1 [ "secciones" => array:13 [ 0 => array:3 [ "identificador" => "xres538925" "titulo" => "Abstract" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Objective" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Methods" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusion" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec558594" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres538924" "titulo" => "Resumo" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0025" "titulo" => "Objetivos" ] 1 => array:2 [ "identificador" => "abst0030" "titulo" => "Métodos" ] 2 => array:2 [ "identificador" => "abst0035" "titulo" => "Resultados" ] 3 => array:2 [ "identificador" => "abst0040" "titulo" => "Conclusão" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec558593" "titulo" => "Palavras-chave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:3 [ "identificador" => "sec0010" "titulo" => "Methods" "secciones" => array:7 [ 0 => array:2 [ "identificador" => "sec0015" "titulo" => "Study population" ] 1 => array:2 [ "identificador" => "sec0020" "titulo" => "Definition of non-ST-elevation acute coronary syndrome" ] 2 => array:2 [ "identificador" => "sec0025" "titulo" => "Coronary angiography" ] 3 => array:2 [ "identificador" => "sec0030" "titulo" => "Risk scoring" ] 4 => array:2 [ "identificador" => "sec0035" "titulo" => "Laboratory parameters" ] 5 => array:2 [ "identificador" => "sec0040" "titulo" => "Follow-up" ] 6 => array:2 [ "identificador" => "sec0045" "titulo" => "Statistical analysis" ] ] ] 6 => array:2 [ "identificador" => "sec0050" "titulo" => "Results" ] 7 => array:2 [ "identificador" => "sec0055" "titulo" => "Discussion" ] 8 => array:2 [ "identificador" => "sec0060" "titulo" => "Study limitations" ] 9 => array:2 [ "identificador" => "sec0065" "titulo" => "Conclusion" ] 10 => array:3 [ "identificador" => "sec0070" "titulo" => "Ethical disclosures" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0075" "titulo" => "Protection of human and animal subjects" ] 1 => array:2 [ "identificador" => "sec0080" "titulo" => "Confidentiality of data" ] 2 => array:2 [ "identificador" => "sec0085" "titulo" => "Right to privacy and informed consent" ] ] ] 11 => array:2 [ "identificador" => "sec0090" "titulo" => "Conflicts of interest" ] 12 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2014-08-13" "fechaAceptado" => "2015-01-12" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec558594" "palabras" => array:4 [ 0 => "Non-ST-segment acute coronary syndrome" 1 => "Neutrophil-to-lymphocyte ratio" 2 => "SYNTAX score" 3 => "GRACE score" ] ] ] "pt" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palavras-chave" "identificador" => "xpalclavsec558593" "palabras" => array:4 [ 0 => "Síndrome coronária aguda sem elevação do segmento ST" 1 => "Rácio neutrófilo/linfócito" 2 => "Score SYNTAX" 3 => "Score GRACE" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:3 [ "titulo" => "Abstract" "resumen" => "ObjectiveInflammatory mechanisms are known to play an important role in coronary artery disease. The present study aimed to investigate the importance of the neutrophil-to-lymphocyte ratio (NLR) in terms of in-hospital mortality and its association with currently used risk scores in patients with non-ST-elevation acute coronary syndrome (NSTE-ACS). MethodsThree hundred and seventeen patients with NSTE-ACS were included. The patients were divided into tertiles according to their NLR values (NLR <2.6, NLR=2.6–4.5, and NLR >4.5). Clinical and angiographic risk was evaluated by the SYNTAX and GRACE risk scores. ResultsThe GRACE risk score was significantly higher in the group with high NLR values compared to those with moderate or low NLR (161.5±40.3, 130.5±32.3, and 123.9±34.3, respectively, p<0.001). Similarly, the SYNTAX score was significantly higher in the group with high NLR values (20.4±10.1, 15.5±10.5, and 13.4±7.8, respectively, p=0.003). Moreover, both GRACE (r=0.457, p<0.001) and SYNTAX scores (r=0.253, p=0.001) showed a significant positive correlation with NLR. ConclusionNLR has been found to be correlated with clinical and angiographic risk scores. Low NLR might be a good predictor for low in-hospital mortality and simple coronary anatomy in NSTE-ACS patients." "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Objective" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Methods" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusion" ] ] ] "pt" => array:3 [ "titulo" => "Resumo" "resumen" => "ObjetivosSabe-se que os mecanismos inflamatórios têm um papel importante na doença arterial coronária. O presente estudo visa investigar a importância do rácio neutrófilo/linfócito (RNL) relativamente à mortalidade hospitalar e à sua associação com os scores de risco atuais em doentes com síndromes coronárias agudas sem elevação do segmento-ST (SCA-NSTE). MétodosForam incluídos 317 doentes com SCA-NSTE. Os doentes foram divididos em tercis de acordo com os seus valores de RNL (RNL < 2,6, RNL = 2,6-4,5 e RNL > 4,5). Os scores de risco clínicos e angiográficos foram avaliados pelos métodos de risco SYNTAX e GRACE. ResultadosO score de risco GRACE foi significativamente mais elevado no grupo com valores RNL elevados comparado com os grupos com RNL moderado ou baixo (161,5 ± 40,3, 130,5 ± 32,3 e 123,9 ± 34,3, respetivamente, p<0,001). Do mesmo modo, o score SYNTAX foi significativamente superior no grupo com valores RNL elevados (20,4 ± 10,1, 15,5 ± 10,5 e 13,4 ± 7,8, respetivamente, p=0,003). Por outro lado, tanto o score de risco GRACE (r=0,457, p<0,001) como o score SYNTAX (r=0,253, p=0,001) mostraram uma correlação positiva significativa com RNL. ConclusãoVerificou-se que o RNL está correlacionado com os scores de risco clínicos e angiográficos. Um RNL baixo pode ser um bom fator preditor de mortalidade intra-hospitalar e de anatomia coronária simples em doentes com enfarte do miocárdio sem elevação do segmento ST." "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0025" "titulo" => "Objetivos" ] 1 => array:2 [ "identificador" => "abst0030" "titulo" => "Métodos" ] 2 => array:2 [ "identificador" => "abst0035" "titulo" => "Resultados" ] 3 => array:2 [ "identificador" => "abst0040" "titulo" => "Conclusão" ] ] ] ] "multimedia" => array:6 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 742 "Ancho" => 1000 "Tamanyo" => 96520 ] ] "descripcion" => array:1 [ "en" => "Study flow diagram. NLR: neutrophil-to-lymphocyte ratio." ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 883 "Ancho" => 992 "Tamanyo" => 94792 ] ] "descripcion" => array:1 [ "en" => "Correlation of neutrophil-to-lymphocyte ratio with GRACE risk score." ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 788 "Ancho" => 995 "Tamanyo" => 78772 ] ] "descripcion" => array:1 [ "en" => "Correlation of neutrophil-to-lymphocyte ratio with SYNTAX score." ] ] 3 => array:7 [ "identificador" => "fig0020" "etiqueta" => "Figure 4" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr4.jpeg" "Alto" => 807 "Ancho" => 964 "Tamanyo" => 51163 ] ] "descripcion" => array:1 [ "en" => "Receiver operating characteristic curve analysis of neutrophil-to-lymphocyte ratio (area under the curve=0.857) and GRACE risk score (area under the curve=0.926) for in-hospital mortality. NLR: neutrophil-to-lymphocyte ratio." ] ] 4 => array:7 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:3 [ "leyenda" => "CABG: coronary artery bypass grafting; CRP: C-reactive protein; HDL: high-density lipoprotein; hs-CRP: high-sensitivity C-reactive protein; LDL: low-density lipoprotein; NLR: neutrophil-to-lymphocyte ratio; PCI: percutaneous coronary intervention; SBP: systolic blood pressure." "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Low NLR (<2.6), n=105 \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Medium NLR (2.6–4.5), n=106 \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">High NLR (>4.5), n=106 \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">p \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Age, years \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">62.8±11.3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">60.9±13.6<a class="elsevierStyleCrossRef" href="#tblfn0015">c</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">67.6±12.5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Gender, male (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">76 (72.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">78 (73.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">83 (79.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.578 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Hypertension (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">45 (42.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">39 (36.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">52 (49.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.196 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Diabetes (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">24 (22.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">21 (19.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">38 (35.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.019 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">hs-CRP (mg/l) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">38.9±51.0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">44.7±60.6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">80.3±17.9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.423 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Serum glucose (mg/dl) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">157.1±89.9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">143.5±68.7<a class="elsevierStyleCrossRef" href="#tblfn0015">c</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">171.0±83.5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.017 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Total cholesterol (mg/dl) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">182.8±48.5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">188.2±41.5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">169.9±44.6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.027 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">LDL cholesterol (mg/dl) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">116.9±47.7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">115.9±33.3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">104.3±36.2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.075 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">HDL cholesterol (mg/dl) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">37.6±10.2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">37.6±9.6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">36.3±11.7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.287 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Triglycerides (mg/dl) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">167.5±104.5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">170.9±103.6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">146.5±83.6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.167 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Hemoglobin (g/l) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">13.7±1.7<a class="elsevierStyleCrossRef" href="#tblfn0010">b</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">13.9±1.7<a class="elsevierStyleCrossRef" href="#tblfn0015">c</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">12.7±2.4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Ejection fraction (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">55.6±9.0<a class="elsevierStyleCrossRef" href="#tblfn0005">a</a>,<a class="elsevierStyleCrossRef" href="#tblfn0010">b</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">49.4±11.6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">47.5±13.8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Heart rate \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">74.9±15.2<a class="elsevierStyleCrossRef" href="#tblfn0010">b</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">79.2±16.1<a class="elsevierStyleCrossRef" href="#tblfn0015">c</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">86.6±17.9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">SBP (mmHg) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">152.3±37.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">147.5±31.3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">141.0±33.6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.059 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="5" align="left" valign="top"></td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="5" align="left" valign="top">Killip class</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">I \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">99 (94.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">96 (90.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">66 (62.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">II \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">6 (5.7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">8 (7.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">26 (24.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">III \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1 (0.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">13 (12.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">IV \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1 (0.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1 (0.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.607 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="5" align="left" valign="top"></td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">ST-segment deviation \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">76 (72.4)<a class="elsevierStyleCrossRef" href="#tblfn0005">a</a>,<a class="elsevierStyleCrossRef" href="#tblfn0010">b</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">92 (86.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">94 (88.7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.003 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Elevated cardiac markers \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">80 (76.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">90 (84.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">95 (89.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.028 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Troponin I (ng/ml) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">10.1±16.9<a class="elsevierStyleCrossRef" href="#tblfn0005">a</a>,<a class="elsevierStyleCrossRef" href="#tblfn0010">b</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">19.7±27.9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">29.2±31.5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Creatinine (mg/dl) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1.04±0.83<a class="elsevierStyleCrossRef" href="#tblfn0010">b</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1.5±2.5<a class="elsevierStyleCrossRef" href="#tblfn0015">c</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">2.05±2.6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">GRACE risk score \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">123.9±34.3<a class="elsevierStyleCrossRef" href="#tblfn0010">b</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">130.5±32.3<a class="elsevierStyleCrossRef" href="#tblfn0015">c</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">161.5±40.3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">SYNTAX score (n=276) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">13.4±7.8<a class="elsevierStyleCrossRef" href="#tblfn0010">b</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">15.5±10.5<a class="elsevierStyleCrossRef" href="#tblfn0015">c</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">20.4±10.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.003 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">CRP (mg/l) (n=146) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">42.4±63.2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">51.1±83.7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">96.8±165.5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.045 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">NLR \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1.89±0.44<a class="elsevierStyleCrossRef" href="#tblfn0005">a</a>,<a class="elsevierStyleCrossRef" href="#tblfn0010">b</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">3.53±0.54<a class="elsevierStyleCrossRef" href="#tblfn0015">c</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">8.63±4.39 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab866173.png" ] ] ] "notaPie" => array:3 [ 0 => array:3 [ "identificador" => "tblfn0005" "etiqueta" => "a" "nota" => "p<0.016 between low and medium NLR groups." ] 1 => array:3 [ "identificador" => "tblfn0010" "etiqueta" => "b" "nota" => "p<0.016 between low and high NLR groups." ] 2 => array:3 [ "identificador" => "tblfn0015" "etiqueta" => "c" "nota" => "p<0.016 between medium and high NLR groups." ] ] ] "descripcion" => array:1 [ "en" => "Baseline characteristics of the study population." ] ] 5 => array:7 [ "identificador" => "tbl0025" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "CI: confidence interval; NLR: neutrophil-to-lymphocyte ratio; OR: odds ratio; SBP: systolic blood pressure." "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="left" valign="top" scope="col">Variable \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " colspan="3" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Univariate logistic regression</th><th class="td" title="table-head " colspan="3" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Multivariate logistic regression</th></tr><tr title="table-row"><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">OR \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">95% CI \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">p \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">OR \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">95% CI \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">p \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">NLR \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.183 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.030–1.359 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.017 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.182 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.042–1.340 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.009 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Age (years) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.114 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.055–1.176 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.115 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.057–1.175 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Heart rate (bpm) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.999 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.971–1.029 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.971 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">SBP (mmHg) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.001 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.985–1.017 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.879 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Creatinine (mg/dl) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.012 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.847–1.209 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.899 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Killip class \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">29.005 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">9.287–90.587 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">29.794 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">9.871–89.931 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Troponin I \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.018 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.001–1.036 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.042 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.019 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.002–1.036 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.024 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">ST-segment deviation \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.556 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.161–15.012 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.702 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab866174.png" ] ] ] ] "descripcion" => array:1 [ "en" => "Effects of different variables on in-hospital mortality in multivariate logistic regression analysis." ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:32 [ 0 => array:3 [ "identificador" => "bib0170" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "2012 ACCF/AHA focused update of the guideline for the management of patients with unstable angina/non-ST-elevation myocardial infarction (updating the 2007 guideline and replacing the 2011 focused update): a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "H. Jneid" 1 => "J.L. Anderson" 2 => "R.S. Wright" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jacc.2012.06.004" "Revista" => array:6 [ "tituloSerie" => "J Am Coll Cardiol" "fecha" => "2012" "volumen" => "60" "paginaInicial" => "645" "paginaFinal" => "681" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22809746" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0175" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: The Task Force for the management of acute coronary syndromes (ACS) in patients presenting without persistent ST-segment elevation of the European Society of Cardiology (ESC)" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "C.W. Hamm" 1 => "J.P. Bassand" 2 => "S. Agewall" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/eurheartj/ehr236" "Revista" => array:6 [ "tituloSerie" => "Eur Heart J" "fecha" => "2011" "volumen" => "32" "paginaInicial" => "2999" "paginaFinal" => "3054" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21873419" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0180" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prediction of risk of death and myocardial infarction in the six months after presentation with acute coronary syndrome: prospective multinational observational study (GRACE)" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "K.A. Fox" 1 => "O.H. Dabbous" 2 => "R.J. Goldberg" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/bmj.38985.646481.55" "Revista" => array:5 [ "tituloSerie" => "BMJ" "fecha" => "2006" "volumen" => "333" "paginaInicial" => "1091" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17032691" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0185" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Inflammation and atherosclerosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "P. Libby" 1 => "P.M. Ridker" 2 => "A. Maseri" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Circulation" "fecha" => "2002" "volumen" => "105" "paginaInicial" => "1135" "paginaFinal" => "1143" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11877368" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0190" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The role of inflammation, humoral and cell mediated autoimmunity in the pathogenesis of atherosclerosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "I.A. Pereira" 1 => "E.F. Borba" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "2008/37/smw-12287" "Revista" => array:7 [ "tituloSerie" => "Swiss Med Wkly" "fecha" => "2008" "volumen" => "138" "paginaInicial" => "534" "paginaFinal" => "539" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18803034" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S1885585714003314" "estado" => "S300" "issn" => "18855857" ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0195" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Association between neutrophil to lymphocyte ratio and severity of coronary artery disease" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "H. Kaya" 1 => "F. Ertaş" 2 => "Y. İslamoğlu" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1177/1076029612452116" "Revista" => array:7 [ "tituloSerie" => "Clin Appl Thromb Hemost" "fecha" => "2014" "volumen" => "20" "paginaInicial" => "50" "paginaFinal" => "54" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22790659" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S1885585714003910" "estado" => "S300" "issn" => "18855857" ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0200" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Usefulness of the neutrophil to lymphocyte ratio in predicting long-term mortality in ST segment elevation myocardial infarction" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "J. Núñez" 1 => "E. Núñez" 2 => "V. Bodí" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.amjcard.2007.11.004" "Revista" => array:6 [ "tituloSerie" => "Am J Cardiol" "fecha" => "2008" "volumen" => "101" "paginaInicial" => "747" "paginaFinal" => "752" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18328833" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0205" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Association between admission neutrophil to lymphocyte ratio and outcomes in patients with acute coronary syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "U.U. Tamhane" 1 => "S. Aneja" 2 => "D. Montgomery" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.amjcard.2008.05.006" "Revista" => array:6 [ "tituloSerie" => "Am J Cardiol" "fecha" => "2008" "volumen" => "102" "paginaInicial" => "653" "paginaFinal" => "657" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18773982" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0210" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Predictive value of neutrophil to lymphocyte ratio in clinical outcomes of non-ST elevation myocardial infarction and unstable angina pectoris: a 3-year follow-up" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "M. Gul" 1 => "H. Uyarel" 2 => "M. Ergelen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1177/1076029612465669" "Revista" => array:6 [ "tituloSerie" => "Clin Appl Thromb Hemost" "fecha" => "2014" "volumen" => "20" "paginaInicial" => "378" "paginaFinal" => "384" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23144177" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0215" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "SYNTAX Working Group. SYNTAX score calculator. Available at: <a href="http://www.syntaxscore.com/">http://www.SYNTAXscore.com</a> [accessed 15.01.11]" ] ] ] 10 => array:3 [ "identificador" => "bib0220" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Usefulness of neutrophil to lymphocyte ratio in predicting short- and long-term mortality after non-ST-elevation myocardial infarction" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "B. Azab" 1 => "M. Zaher" 2 => "K.F. Weiserbs" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.amjcard.2010.03.062" "Revista" => array:6 [ "tituloSerie" => "Am J Cardiol" "fecha" => "2010" "volumen" => "106" "paginaInicial" => "470" "paginaFinal" => "476" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20691303" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0225" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The relationship of coronary flow to neutrophil/lymphocyte ratio in patients undergoing primary percutaneous coronary intervention" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "K. Soylu" 1 => "S. Yuksel" 2 => "O. Gulel" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3978/j.issn.2072-1439.2013.05.13" "Revista" => array:6 [ "tituloSerie" => "J Thorac Dis" "fecha" => "2013" "volumen" => "5" "paginaInicial" => "258" "paginaFinal" => "264" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23825756" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0230" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Neutrophil-to-lymphocyte ratio is associated with severity of coronary artery ectasia" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "B. Sarli" 1 => "A.O. Baktir" 2 => "H. Saglam" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1177/0003319713488932" "Revista" => array:6 [ "tituloSerie" => "Angiology" "fecha" => "2014" "volumen" => "65" "paginaInicial" => "147" "paginaFinal" => "151" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23657176" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0235" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The relationship between neutrophil to lymphocyte ratio and coronary collateral circulation" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "O.K. Uysal" 1 => "C. Turkoglu" 2 => "D.Y. Sahin" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1177/1076029613503399" "Revista" => array:6 [ "tituloSerie" => "Clin Appl Thromb Hemost" "fecha" => "2013" "volumen" => "21" "paginaInicial" => "329" "paginaFinal" => "333" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24027113" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0240" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Role of neutrophils in myocardial ischemia and reperfusion" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "P.R. Hansen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Circulation" "fecha" => "1995" "volumen" => "91" "paginaInicial" => "1872" "paginaFinal" => "1885" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7882499" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0245" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Neutrophil function in ischemic heart disease" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "J. Mehta" 1 => "J. Dinerman" 2 => "P. Mehta" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Circulation" "fecha" => "1989" "volumen" => "79" "paginaInicial" => "549" "paginaFinal" => "556" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2537159" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0250" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pro-inflammatory cytokines in acute coronary syndromes: from bench to bedside" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "D. Tousoulis" 1 => "C. Antoniades" 2 => "N. Koumallos" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.cytogfr.2006.04.003" "Revista" => array:6 [ "tituloSerie" => "Cytokine Growth Factor Rev" "fecha" => "2006" "volumen" => "17" "paginaInicial" => "225" "paginaFinal" => "233" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16750416" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0255" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Neutrophil to lymphocyte ratio is associated with the severity of coronary artery disease in patients with ST-segment elevation myocardial infarction" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "D.Y. Sahin" 1 => "Z. Elbasan" 2 => "M. Gür" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1177/0003319712453305" "Revista" => array:6 [ "tituloSerie" => "Angiology" "fecha" => "2013" "volumen" => "64" "paginaInicial" => "423" "paginaFinal" => "429" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22802534" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0260" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Relation of neutrophil-to-lymphocyte ratio with GRACE risk score to in-hospital cardiac events in patients with ST-segment elevated myocardial infarction" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "R.C. Oncel" 1 => "M. Ucar" 2 => "M.S. Karakas" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1177/1076029613505763" "Revista" => array:6 [ "tituloSerie" => "Clin Appl Thromb Hemost" "fecha" => "2015" "volumen" => "21" "paginaInicial" => "383" "paginaFinal" => "388" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24078555" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0265" "etiqueta" => "20" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "White blood cell subtypes and neutrophil-lymphocyte ratio in prediction of coronary thrombus formation in non-ST-segment elevated acute coronary syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "M. Yilmaz" 1 => "E. Tenekecioglu" 2 => "B. Arslan" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1177/1076029613507337" "Revista" => array:6 [ "tituloSerie" => "Clin Appl Thromb Hemost" "fecha" => "2015" "volumen" => "21" "paginaInicial" => "446" "paginaFinal" => "452" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24203350" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0270" "etiqueta" => "21" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mechanical complications after myocardial infarction reliably predicted using C-reactive protein levels and lymphocytopenia" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "A. Widmer" 1 => "A.Z. Linka" 2 => "C.H. Attenhofer Jost" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "68448" "Revista" => array:6 [ "tituloSerie" => "Cardiology" "fecha" => "2003" "volumen" => "99" "paginaInicial" => "25" "paginaFinal" => "31" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12589119" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib0275" "etiqueta" => "22" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Usefulness of the lymphocyte concentration as a prognostic marker in coronary artery disease" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "S.R. Ommen" 1 => "R.J. Gibbons" 2 => "D.O. Hodge" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Cardiol" "fecha" => "1997" "volumen" => "79" "paginaInicial" => "812" "paginaFinal" => "824" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9070569" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib0280" "etiqueta" => "23" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Predictive power of the relative lymphocyte concentration in patients with advanced heart failure" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "S.R. Ommen" 1 => "D.O. Hodge" 2 => "R.J. Rodeheffer" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Circulation" "fecha" => "1998" "volumen" => "97" "paginaInicial" => "19" "paginaFinal" => "22" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9443426" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib0285" "etiqueta" => "24" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Neutrophil to lymphocyte ratio predicts short- and long-term mortality following revascularization therapy for ST elevation myocardial infarction" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "A.C. Sawant" 1 => "P. Adhikari" 2 => "S.R. Narra" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.5603/CJ.a2013.0148" "Revista" => array:6 [ "tituloSerie" => "Cardiol J" "fecha" => "2014" "volumen" => "21" "paginaInicial" => "500" "paginaFinal" => "508" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24142685" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib0290" "etiqueta" => "25" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "TIMI, PURSUIT, and GRACE risk scores: sustained prognostic value and interaction with revascularization in NSTE-ACS" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "P. de Araújo Gonçalves" 1 => "J. Ferreira" 2 => "C. Aguiar" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/eurheartj/ehi187" "Revista" => array:6 [ "tituloSerie" => "Eur Heart J" "fecha" => "2005" "volumen" => "26" "paginaInicial" => "865" "paginaFinal" => "872" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15764619" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib0295" "etiqueta" => "26" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dickkopf-1 as a novel predictor is associated with risk stratification by GRACE risk scores for predictive value in patients with acute coronary syndrome: a retrospective research" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "L. Wang" 1 => "X.B. Hu" 2 => "W. Zhang" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1371/journal.pone.0054731" "Revista" => array:5 [ "tituloSerie" => "PLOS ONE" "fecha" => "2013" "volumen" => "8" "paginaInicial" => "e54731" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23359112" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib0300" "etiqueta" => "27" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Inflammatory response and C-reactive protein value in patient with acute coronary syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "L. Kubková" 1 => "J. Spinar" 2 => "M. Pávková Goldbergová" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Vnitr Lek" "fecha" => "2013" "volumen" => "59" "paginaInicial" => "981" "paginaFinal" => "988" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24279442" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib0305" "etiqueta" => "28" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The SYNTAX score: an angiographic tool grading the complexity of coronary artery disease" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "G. Sianos" 1 => "M.A. Morel" 2 => "A.P. Kappetein" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eurointervention" "fecha" => "2005" "volumen" => "1" "paginaInicial" => "219" "paginaFinal" => "227" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19758907" "web" => "Medline" ] ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib0310" "etiqueta" => "29" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The relationship between high-sensitive troponin T, neutrophil lymphocyte ratio and SYNTAX score" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "B. Altun" 1 => "H. Turkon" 2 => "H. Tasolar" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3109/00365513.2013.860619" "Revista" => array:6 [ "tituloSerie" => "Scand J Clin Lab Invest" "fecha" => "2014" "volumen" => "74" "paginaInicial" => "108" "paginaFinal" => "115" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24304492" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib0315" "etiqueta" => "30" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Relation of neutrophil-to-lymphocyte ratio with the presence and complexity of coronary artery disease: an observational study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "O. Sönmez" 1 => "G. Ertaş" 2 => "A. Bacaksız" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.5152/akd.2013.188" "Revista" => array:6 [ "tituloSerie" => "Anadolu Kardiyol Derg" "fecha" => "2013" "volumen" => "13" "paginaInicial" => "662" "paginaFinal" => "667" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23912788" "web" => "Medline" ] ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib0320" "etiqueta" => "31" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "High neutrophil numbers in human carotid atherosclerotic plaques are associated with characteristics of rupture-prone lesions" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M.G. Ionita" 1 => "P. van den Borne" 2 => "L.M. Catanzariti" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1161/ATVBAHA.110.209296" "Revista" => array:6 [ "tituloSerie" => "Arterioscler Thromb Vasc Biol" "fecha" => "2010" "volumen" => "30" "paginaInicial" => "1842" "paginaFinal" => "1848" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20595650" "web" => "Medline" ] ] ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib0325" "etiqueta" => "32" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Neutrophil infiltration of culprit lesions in acute coronary syndromes" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "T. Naruko" 1 => "M. Ueda" 2 => "K. Haze" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Circulation" "fecha" => "2002" "volumen" => "106" "paginaInicial" => "2894" "paginaFinal" => "2900" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12460868" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/21742049/0000003400000078/v1_201508050210/S2174204915001610/v1_201508050210/en/main.assets" "Apartado" => array:4 [ "identificador" => "9917" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Original Articles" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/21742049/0000003400000078/v1_201508050210/S2174204915001610/v1_201508050210/en/main.pdf?idApp=UINPBA00004E&text.app=https://revportcardiol.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204915001610?idApp=UINPBA00004E"]

Statistics

Original Article

Neutrophil-to-lymphocyte ratio predicts coronary artery lesion complexity and mortality after non-ST-segment elevation acute coronary syndrome

Rácio neutrófilo-linfócito prevê a complexidade da lesão arterial coronária e a mortalidade após o enfarte do miocárdio sem elevação do segmento ST

Korhan Soylua,

Corresponding author

korhansoylu@yahoo.com

Corresponding author.

, Ömer Gediklib, Göksel Dagasana, Ertan Aydina, Gökhan Aksanc, Gökay Nard, Sinan İncid, Özcan Yilmaza

a Department of Cardiology, Ondokuz Mayis University, Faculty of Medicine, Samsun, Turkey

b Department of Cardiology, Artvin State Hospital, Artvin, Turkey

c Department of Cardiology, Gazi State Hospital, Samsun, Turkey

d Department of Cardiology, Aksaray State Hospital, Aksaray, Turkey

Read

6919

Times
was read the article

2123

Total PDF

4796

Total HTML

Share statistics

 array:25 [
  "pii" => "S2174204915001610"
  "issn" => "21742049"
  "doi" => "10.1016/j.repce.2015.07.007"
  "estado" => "S300"
  "fechaPublicacion" => "2015-07-01"
  "aid" => "653"
  "copyright" => "Sociedade Portuguesa de Cardiologia"
  "copyrightAnyo" => "2014"
  "documento" => "article"
  "crossmark" => 1
  "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
  "subdocumento" => "fla"
  "cita" => "Rev Port Cardiol. 2015;34:465-71"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 3197
    "formatos" => array:3 [
      "EPUB" => 164
      "HTML" => 2223
      "PDF" => 810
    ]
  ]
  "Traduccion" => array:1 [
    "en" => array:20 [
      "pii" => "S0870255115001511"
      "issn" => "08702551"
      "doi" => "10.1016/j.repc.2015.01.013"
      "estado" => "S300"
      "fechaPublicacion" => "2015-07-01"
      "aid" => "653"
      "copyright" => "Sociedade Portuguesa de Cardiologia"
      "documento" => "article"
      "crossmark" => 1
      "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
      "subdocumento" => "fla"
      "cita" => "Rev Port Cardiol. 2015;34:465-71"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 5216
        "formatos" => array:3 [
          "EPUB" => 192
          "HTML" => 4353
          "PDF" => 671
        ]
      ]
      "en" => array:13 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>"
        "titulo" => "Neutrophil-to-lymphocyte ratio predicts coronary artery lesion complexity and mortality after non-ST-segment elevation acute coronary syndrome"
        "tienePdf" => "en"
        "tieneTextoCompleto" => "en"
        "tieneResumen" => array:2 [
          0 => "en"
          1 => "pt"
        ]
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "465"
            "paginaFinal" => "471"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "pt" => array:1 [
            "titulo" => "R&#225;cio neutr&#243;filo-linf&#243;cito prev&#234; a complexidade da les&#227;o arterial coron&#225;ria e a mortalidade ap&#243;s o enfarte do mioc&#225;rdio sem eleva&#231;&#227;o do segmento ST"
          ]
        ]
        "contieneResumen" => array:2 [
          "en" => true
          "pt" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "en" => true
        ]
        "contienePdf" => array:1 [
          "en" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0005"
            "etiqueta" => "Figure 1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr1.jpeg"
                "Alto" => 1234
                "Ancho" => 1666
                "Tamanyo" => 137193
              ]
            ]
            "descripcion" => array:1 [
              "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Study flow diagram&#46; NLR&#58; neutrophil-to-lymphocyte ratio&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Korhan Soylu, &#214;mer Gedikli, G&#246;ksel Dagasan, Ertan Aydin, G&#246;khan Aksan, G&#246;kay Nar, Sinan &#304;nci, &#214;zcan Yilmaz"
            "autores" => array:8 [
              0 => array:2 [
                "nombre" => "Korhan"
                "apellidos" => "Soylu"
              ]
              1 => array:2 [
                "nombre" => "&#214;mer"
                "apellidos" => "Gedikli"
              ]
              2 => array:2 [
                "nombre" => "G&#246;ksel"
                "apellidos" => "Dagasan"
              ]
              3 => array:2 [
                "nombre" => "Ertan"
                "apellidos" => "Aydin"
              ]
              4 => array:2 [
                "nombre" => "G&#246;khan"
                "apellidos" => "Aksan"
              ]
              5 => array:2 [
                "nombre" => "G&#246;kay"
                "apellidos" => "Nar"
              ]
              6 => array:2 [
                "nombre" => "Sinan"
                "apellidos" => "&#304;nci"
              ]
              7 => array:2 [
                "nombre" => "&#214;zcan"
                "apellidos" => "Yilmaz"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "en"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S2174204915001610"
          "doi" => "10.1016/j.repce.2015.07.007"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204915001610?idApp=UINPBA00004E"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255115001511?idApp=UINPBA00004E"
      "url" => "/08702551/0000003400000078/v1_201507290010/S0870255115001511/v1_201507290010/en/main.assets"
    ]
  ]
  "itemSiguiente" => array:20 [
    "pii" => "S2174204915001622"
    "issn" => "21742049"
    "doi" => "10.1016/j.repce.2015.07.008"
    "estado" => "S300"
    "fechaPublicacion" => "2015-07-01"
    "aid" => "652"
    "copyright" => "Sociedade Portuguesa de Cardiologia"
    "documento" => "article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "fla"
    "cita" => "Rev Port Cardiol. 2015;34:473-8"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 3396
      "formatos" => array:3 [
        "EPUB" => 176
        "HTML" => 2625
        "PDF" => 595
      ]
    ]
    "en" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>"
      "titulo" => "Prognostic value of plasma neutrophil gelatinase-associated lipocalin in patients with heart failure"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "pt"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "473"
          "paginaFinal" => "478"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "pt" => array:1 [
          "titulo" => "Valor progn&#243;stico da lipocalina associada a gelatinase de neutr&#243;filos em pacientes com insufici&#234;ncia card&#237;aca"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "pt" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0020"
          "etiqueta" => "Figure 4"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr4.jpeg"
              "Alto" => 630
              "Ancho" => 944
              "Tamanyo" => 62069
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Receiver operating characteristic curve analysis of neutrophil gelatinase-associated lipocalin and estimated glomerular filtration rate for predicting cardiovascular mortality&#44; heart failure hospitalization or emergency department visit for heart failure&#46; AUC&#58; area under the curve&#59; eGFR&#58; estimated glomerular filtration rate&#59; NGAL&#58; neutrophil gelatinase-associated lipocalin&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Humberto Villacorta, Rochele Alberto Martins Santos, Marcelle Alves Baco Marroig, Guilherme Pinella Guedes Pereira, Analucia Rampazzo Xavier, Salim Kanaan"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "Humberto"
              "apellidos" => "Villacorta"
            ]
            1 => array:2 [
              "nombre" => "Rochele Alberto"
              "apellidos" => "Martins Santos"
            ]
            2 => array:2 [
              "nombre" => "Marcelle Alves"
              "apellidos" => "Baco Marroig"
            ]
            3 => array:2 [
              "nombre" => "Guilherme Pinella"
              "apellidos" => "Guedes Pereira"
            ]
            4 => array:2 [
              "nombre" => "Analucia Rampazzo"
              "apellidos" => "Xavier"
            ]
            5 => array:2 [
              "nombre" => "Salim"
              "apellidos" => "Kanaan"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S087025511500150X"
        "doi" => "10.1016/j.repc.2015.02.003"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S087025511500150X?idApp=UINPBA00004E"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204915001622?idApp=UINPBA00004E"
    "url" => "/21742049/0000003400000078/v1_201508050210/S2174204915001622/v1_201508050210/en/main.assets"
  ]
  "itemAnterior" => array:20 [
    "pii" => "S2174204915001609"
    "issn" => "21742049"
    "doi" => "10.1016/j.repce.2015.07.006"
    "estado" => "S300"
    "fechaPublicacion" => "2015-07-01"
    "aid" => "651"
    "copyright" => "Sociedade Portuguesa de Cardiologia"
    "documento" => "article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "fla"
    "cita" => "Rev Port Cardiol. 2015;34:457-63"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 3235
      "formatos" => array:3 [
        "EPUB" => 201
        "HTML" => 2494
        "PDF" => 540
      ]
    ]
    "en" => array:12 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>"
      "titulo" => "Clinical characteristics and prognosis of heart failure in elderly patients"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "pt"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "457"
          "paginaFinal" => "463"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "pt" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 850
              "Ancho" => 992
              "Tamanyo" => 54356
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Follow-up survival curve for patients with heart failure with preserved ejection fraction and heart failure with reduced ejection fraction&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Luc&#237;a Mart&#237;nez-Bra&#241;a, Lara Mateo-Mosquera, Mar&#237;a Berm&#250;dez-Ramos, Mar&#237;a de los &#193;ngeles Valc&#225;rcel Garc&#237;a, Lorena Fern&#225;ndez Hern&#225;ndez, &#193;lvaro Hermida Ameijeiras, Francisco Luis Lado Lado"
          "autores" => array:7 [
            0 => array:2 [
              "nombre" => "Luc&#237;a"
              "apellidos" => "Mart&#237;nez-Bra&#241;a"
            ]
            1 => array:2 [
              "nombre" => "Lara"
              "apellidos" => "Mateo-Mosquera"
            ]
            2 => array:2 [
              "nombre" => "Mar&#237;a"
              "apellidos" => "Berm&#250;dez-Ramos"
            ]
            3 => array:2 [
              "nombre" => "Mar&#237;a de los &#193;ngeles"
              "apellidos" => "Valc&#225;rcel Garc&#237;a"
            ]
            4 => array:2 [
              "nombre" => "Lorena"
              "apellidos" => "Fern&#225;ndez Hern&#225;ndez"
            ]
            5 => array:2 [
              "nombre" => "&#193;lvaro"
              "apellidos" => "Hermida Ameijeiras"
            ]
            6 => array:2 [
              "nombre" => "Francisco Luis"
              "apellidos" => "Lado Lado"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S0870255115001493"
        "doi" => "10.1016/j.repc.2015.02.002"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255115001493?idApp=UINPBA00004E"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204915001609?idApp=UINPBA00004E"
    "url" => "/21742049/0000003400000078/v1_201508050210/S2174204915001609/v1_201508050210/en/main.assets"
  ]
  "en" => array:19 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>"
    "titulo" => "Neutrophil-to-lymphocyte ratio predicts coronary artery lesion complexity and mortality after non-ST-segment elevation acute coronary syndrome"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "465"
        "paginaFinal" => "471"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Korhan Soylu, &#214;mer Gedikli, G&#246;ksel Dagasan, Ertan Aydin, G&#246;khan Aksan, G&#246;kay Nar, Sinan &#304;nci, &#214;zcan Yilmaz"
        "autores" => array:8 [
          0 => array:4 [
            "nombre" => "Korhan"
            "apellidos" => "Soylu"
            "email" => array:1 [
              0 => "korhansoylu&#64;yahoo&#46;com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "&#214;mer"
            "apellidos" => "Gedikli"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "G&#246;ksel"
            "apellidos" => "Dagasan"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Ertan"
            "apellidos" => "Aydin"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "G&#246;khan"
            "apellidos" => "Aksan"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
          5 => array:3 [
            "nombre" => "G&#246;kay"
            "apellidos" => "Nar"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">d</span>"
                "identificador" => "aff0020"
              ]
            ]
          ]
          6 => array:3 [
            "nombre" => "Sinan"
            "apellidos" => "&#304;nci"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">d</span>"
                "identificador" => "aff0020"
              ]
            ]
          ]
          7 => array:3 [
            "nombre" => "&#214;zcan"
            "apellidos" => "Yilmaz"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:4 [
          0 => array:3 [
            "entidad" => "Department of Cardiology&#44; Ondokuz Mayis University&#44; Faculty of Medicine&#44; Samsun&#44; Turkey"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Department of Cardiology&#44; Artvin State Hospital&#44; Artvin&#44; Turkey"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Department of Cardiology&#44; Gazi State Hospital&#44; Samsun&#44; Turkey"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
          3 => array:3 [
            "entidad" => "Department of Cardiology&#44; Aksaray State Hospital&#44; Aksaray&#44; Turkey"
            "etiqueta" => "d"
            "identificador" => "aff0020"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "pt" => array:1 [
        "titulo" => "R&#225;cio neutr&#243;filo-linf&#243;cito prev&#234; a complexidade da les&#227;o arterial coron&#225;ria e a mortalidade ap&#243;s o enfarte do mioc&#225;rdio sem eleva&#231;&#227;o do segmento ST"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0020"
        "etiqueta" => "Figure 4"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr4.jpeg"
            "Alto" => 807
            "Ancho" => 964
            "Tamanyo" => 51163
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Receiver operating characteristic curve analysis of neutrophil-to-lymphocyte ratio &#40;area under the curve&#61;0&#46;857&#41; and GRACE risk score &#40;area under the curve&#61;0&#46;926&#41; for in-hospital mortality&#46; NLR&#58; neutrophil-to-lymphocyte ratio&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">The content and intensity of treatment&#44; and the need for intervention&#44; are closely linked to disease severity in the treatment of patients with coronary artery disease &#40;CAD&#41;&#46; Clinical and angiographic risk scores have been developed to aid decision-making&#46; Current guidelines recommend the GRACE and SYNTAX risk scoring systems for patients diagnosed with non-ST-elevation acute coronary syndrome &#40;NSTE-ACS&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0170"><span class="elsevierStyleSup">1&#44;2</span></a> The GRACE risk score includes parameters such as ECG changes&#44; initial cardiac markers&#44; and serum creatinine&#44; in addition to clinical characteristics such as age&#44; heart rate&#44; systolic blood pressure&#44; and degree of heart failure&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">3</span></a> The SYNTAX risk score grades the severity and complexity of lesions on coronary angiography&#46;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">2</span></a> It also has an important role in decisions as to whether to perform percutaneous coronary intervention&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Several studies have shown the role of inflammation in the pathophysiology of atherosclerosis&#44;<a class="elsevierStyleCrossRefs" href="#bib0185"><span class="elsevierStyleSup">4&#44;5</span></a> and inflammatory mediators such as C-reactive protein &#40;CRP&#41; can be used for risk stratification in CAD&#46;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">4</span></a> The neutrophil-to-lymphocyte ratio &#40;NLR&#41; is a new marker recently shown to be effective in CAD and certain non-cardiac diseases&#46; Previous studies have demonstrated that NLR is associated with adverse events in stable coronary disease&#44;<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">6</span></a> long-term mortality in patients with ST-segment elevation myocardial infarction &#40;STEMI&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">7</span></a> and in-hospital and six-month mortality in acute coronary syndrome&#46;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">8</span></a> NLR has also been shown to be a predictor of poor prognosis in patients with NSTE-ACS&#46;<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">9</span></a> However&#44; the association between NLR and clinical risk scores&#44; and whether it is a determinant of lesion complexity&#44; particularly in CAD&#44; have not been investigated&#46; In the present study&#44; we aimed to investigate the importance of NLR in terms of hospital mortality&#44; and its association with currently used risk scores in patients with NSTE-ACS&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Methods</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Study population</span><p id="par0015" class="elsevierStylePara elsevierViewall">In this study&#44; patients admitted to the cardiology clinic at Ondokuz Mayis University with NSTE-ACS between January 2006 and January 2012 were retrospectively assessed&#46; The inclusion criterion was the NSTE-ACS diagnosis code in the electronic patient database&#46; The medical history of all patients with the NSTE-ACS diagnosis code was obtained and assessed by the investigators&#46; Exclusion criteria included inconclusive NSTE-ACS diagnosis according to medical records&#44; hematological disease&#44; autoimmune disease&#44; infectious or inflammatory disease&#44; severe renal disease &#40;glomerular filtration rate &#60;30 ml&#47;min&#47;1&#46;73 m<span class="elsevierStyleSup">2</span>&#41;&#44; severe liver disease&#44; and ongoing treatment with immunosuppressive agents&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Definition of non-ST-elevation acute coronary syndrome</span><p id="par0020" class="elsevierStylePara elsevierViewall">NSTE-ACS was defined as the presence of T-wave inversion or ST-segment depression and&#47;or positive troponin I in the absence of electrocardiographic &#40;ECG&#41; ST elevation in patients presenting with angina or equivalent&#46; Positive troponin was defined as troponin I &#62;0&#46;1 ng&#47;ml&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Coronary angiography</span><p id="par0025" class="elsevierStylePara elsevierViewall">Coronary angiography was performed using standard techniques&#46; Selective cine angiographic images of the coronaries were recorded with a digital angiographic system &#40;ACOM&#46;PC&#44; Siemens AG&#44; Germany&#41;&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Risk scoring</span><p id="par0030" class="elsevierStylePara elsevierViewall">For the SYNTAX score&#44;<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">10</span></a> the severity of coronary atherosclerotic lesions was assessed with at least three projections in all patients&#46; The score for each patient was calculated by a team of two experienced cardiologists who scored all coronary lesions with &#8805;50&#37; stenosis in vessels &#8805;1&#46;5 mm&#46; The online SYNTAX score calculation tool was used &#40;<a href="http://www.syntaxscore.com/">http&#58;&#47;&#47;www&#46;SYNTAXscore&#46;com</a>&#41;&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The principle of the GRACE risk score has been described elsewhere&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">3</span></a> The variables used in the calculation of the score include age&#44; heart rate&#44; systolic blood pressure&#44; baseline creatinine level&#44; history of congestive heart failure&#44; in-hospital percutaneous coronary intervention&#44; history of myocardial infarction&#44; ST-segment depression on admission electrocardiography &#40;ECG&#41;&#44; and elevated cardiac markers&#46; In the present study&#44; we used a single measurement of serum cardiac troponin I&#44; considering 0&#46;06 ng&#47;ml to be an elevated cardiac marker&#46; ST-segment depression was defined as ST segment &#62;0&#46;5 mV below the isoelectric line in any ECG lead&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Laboratory parameters</span><p id="par0040" class="elsevierStylePara elsevierViewall">Venous blood samples&#44; obtained from the patients within an hour of admission to the emergency room&#44; were used for the laboratory analyses&#46; Biochemical parameters were measured using an Abbott Architect c8000 analyzer &#40;Abbott Laboratories&#44; USA&#41; with commercial kits&#46; Total blood cell counts and subtypes were analyzed using an automated blood cell counter &#40;Abbott Laboratories&#44; USA&#41;&#46; NLR values were calculated as the ratio of neutrophil to lymphocyte count obtained from the same blood sample&#46; Patients were divided into tertiles according to NLR values &#40;NLR &#60;2&#46;6&#44; NLR&#61;2&#46;6&#8211;4&#46;5&#44; and NLR &#62;4&#46;5&#41;&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Follow-up</span><p id="par0045" class="elsevierStylePara elsevierViewall">Clinical records of the patients over the course of hospitalization were reviewed and all-cause mortality before hospital discharge was recorded as in-hospital mortality&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Statistical analysis</span><p id="par0050" class="elsevierStylePara elsevierViewall">The dataset was analyzed using SPSS version 15&#46; The normal distribution of the data was tested using the Kolmogorov-Smirnov test and non-normally distributed data were transformed&#46; One-way ANOVA was used for the comparison of multiple groups&#46; Categorical data were compared using the chi-square test or Fisher&#39;s exact test&#44; as appropriate&#46; Correlation between data was tested with Pearson&#39;s correlation analysis&#46; Logistic regression analysis was used to test the significance of the data on mortality&#46; Variables were eliminated by forward selection&#46; NLR and the GRACE score criteria were selected as the potential variables for logistic regression analysis&#44; excepting cardiac arrest on admission&#44; which was not assessed because there were no patients with this parameter&#46; Continuous data were expressed as mean &#177; SD &#40;standard deviation&#41; and categorical data were expressed as percentages&#46; A p value of &#60;0&#46;05 was accepted as statistically significant&#46; Bonferroni&#39;s correction was performed when statistical comparisons of the three groups were made as &#60;0&#46;016&#46;</p></span></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Results</span><p id="par0055" class="elsevierStylePara elsevierViewall">For the present study&#44; records were analyzed of 2135 patients admitted to the coronary intensive care unit&#44; of whom 418 patients were admitted with an NSTE-ACS diagnosis code&#46; On the basis of patients&#8217; records&#44; 33 patients with an inconclusive diagnosis&#44; 11 with hematological disease&#44; 21 with infectious and inflammatory disease&#44; 14 with severe renal disease&#44; four with severe liver disease&#44; and 18 with missing data were excluded from the study &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a>&#41;&#46; As a result&#44; a total of 317 patients were included in the study&#46; Following clinical assessment&#44; 276 &#40;86&#46;8&#37;&#41; patients underwent coronary angiography&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0060" class="elsevierStylePara elsevierViewall">Demographic&#44; clinical&#44; and laboratory characteristics of the patients are presented in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46; The patients in the group with high NLR were older and had higher serum glucose levels&#44; lower hemoglobin&#44; lower ejection fraction&#44; higher heart rate&#44; higher Killip class&#44; more ST-segment changes&#44; and higher troponin and creatinine levels&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0065" class="elsevierStylePara elsevierViewall">GRACE risk score was significantly higher in the high NLR group than in those with moderate or low NLR &#40;161&#46;5&#177;40&#46;3&#44; 130&#46;5&#177;32&#46;3 and 123&#46;9&#177;34&#46;3&#44; respectively&#44; p&#60;0&#46;001&#41;&#46; Similarly&#44; SYNTAX score was significantly higher in the group with high NLR &#40;20&#46;4&#177;10&#46;1&#44; 15&#46;5&#177;10&#46;5 and 13&#46;4&#177;7&#46;8&#44; respectively&#44; p&#61;0&#46;003&#41;&#46; Moreover&#44; both GRACE risk score &#40;r&#61;0&#46;457&#44; p&#60;0&#46;001&#41; and SYNTAX score &#40;r&#61;0&#46;253&#44; p&#61;0&#46;001&#41; showed a significant positive correlation with NLR &#40;<a class="elsevierStyleCrossRefs" href="#fig0010">Figures 2 and 3</a>&#41;&#46; Analysis of the NLR subgroups revealed a correlation between NLR&#44; GRACE and SYNTAX scores only in the high NLR group &#40;r&#61;0&#46;483&#44; p&#60;0&#46;001&#44; and r&#61;0&#46;495&#44; p&#61;0&#46;001&#44; respectively&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0070" class="elsevierStylePara elsevierViewall">The high NLR group had higher in-hospital mortality than both the low and the moderate NLR groups &#40;35&#46;8&#37;&#44; 7&#46;5&#37; and 1&#46;9&#37;&#44; p&#60;0&#46;001&#41;&#46; Receiver operating characteristic &#40;ROC&#41; analysis showed that NLR &#62;4&#46;5 had 75&#37; specificity and 75&#37; sensitivity for in-hospital mortality &#40;<a class="elsevierStyleCrossRef" href="#fig0020">Figure 4</a>&#41;&#44; with a positive predictive value of 79&#46;2&#37; and a negative predictive value of 95&#46;3&#37; &#40;area under the curve &#91;AUC&#93;&#61;0&#46;857&#41;&#46; On the other hand&#44; ROC analysis showed that a GRACE score &#62;140 had 61&#37; specificity and 92&#46;2&#37; sensitivity for in-hospital mortality&#44; with a positive predictive value of 91&#46;6&#37; and a negative predictive value of 97&#46;7&#37; &#40;AUC&#61;0&#46;926&#41;&#46; ROC analysis showed that a CRP value of 36&#46;7 had 78&#46;6&#37; specificity and 70&#46;9&#37; sensitivity for in-hospital mortality&#44; with a positive predictive value of 0&#46;79&#37; and a negative predictive value of 96&#46;9&#37; &#40;AUC&#61;0&#46;815&#41;&#46; Furthermore&#44; multivariate regression analysis showed that NLR was an independent predictor of in-hospital mortality &#40;OR&#58; 1&#46;182&#59; 95&#37; confidence interval &#91;CI&#93;&#58; 1&#46;042&#8211;1&#46;340&#59; p&#61;0&#46;009&#41;&#46; Additionally&#44; NLR &#62;4&#46;5 had higher odds ratios for in-hospital mortality &#40;OR&#58; 11&#46;457&#59; 95&#37; CI&#58; 5&#46;415&#8211;24&#46;229&#59; p&#60;0&#46;001&#41;&#46; Other independent variables were age&#44; Killip class&#44; and troponin I value &#40;<a class="elsevierStyleCrossRef" href="#tbl0025">Table 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0020"></elsevierMultimedia><elsevierMultimedia ident="tbl0025"></elsevierMultimedia></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Discussion</span><p id="par0075" class="elsevierStylePara elsevierViewall">In this study&#44; we found higher GRACE and SYNTAX risk scores and in-hospital mortality in patients with high NLR values&#46; In addition&#44; NLR correlated with GRACE and SYNTAX scores&#46; The present study is the first to demonstrate an association between coronary artery lesion complexity and NLR in patients with NSTE-ACS&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">An association between cardiovascular disease and NLR has been shown in previous studies&#46;<a class="elsevierStyleCrossRefs" href="#bib0195"><span class="elsevierStyleSup">6&#8211;9</span></a> Increased NLR has been found to be associated with increased mortality&#44;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">11</span></a> no-reflow&#44;<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">12</span></a> coronary ectasia&#44;<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">13</span></a> and coronary collateral circulation<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">14</span></a> in various subgroups with CAD&#46; This is an unsurprising result&#44; given the increased inflammatory response seen during the clinical presentation of CAD as well as in its pathophysiology&#46; The role of neutrophils during the atherosclerotic process is well known<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">4</span></a>&#59; in particular&#44; proteolytic enzymes released by neutrophils and myeloperoxidase activation&#44; as well as acid phosphatase and free oxygen radicals&#44; have been found to be involved in this process&#46;<a class="elsevierStyleCrossRefs" href="#bib0240"><span class="elsevierStyleSup">15&#8211;17</span></a> Furthermore&#44; Sonmez et al&#46; found an association between NLR and coronary artery lesion complexity in patients with stable CAD and STEMI&#44;<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">18</span></a> and Oncel et al&#46; demonstrated an association between GRACE score and NLR in patients with STEMI&#46;<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">19</span></a> In the present study&#44; we have shown this association in patients with NSTE-ACS&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">Neutrophil infiltration during acute coronary events is associated with impaired microvascular perfusion and expansion of the infarct area&#44; as well as with increased risk of no-reflow in primary angioplasty among patients with STEMI&#44;<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">12</span></a> and increased NLR has been suggested as a predictor of increased thrombus load&#46;<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">20</span></a> Furthermore&#44; acute coronary syndrome &#40;ACS&#41;-associated decreased lymphocyte levels have been reported to suppress immune response&#44; and may be a predictor of mechanical complications&#44;<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">21</span></a> as well as being associated with adverse events and cardiac failure in patients with ACS&#46;<a class="elsevierStyleCrossRefs" href="#bib0275"><span class="elsevierStyleSup">22&#44;23</span></a> In this regard&#44; NLR is associated with increased inflammation as well as inadequate immune response&#46; The present study shows significantly higher in-hospital mortality in the groups with increased NLR&#46; Furthermore&#44; patients with high NLR also suffer from more severely depressed left ventricular function&#46; On ROC analysis&#44; NLR with a threshold of 4&#46;5 has a high positive and negative predictive value&#46; However&#44; the higher negative predictive value is particularly important&#59; considering that NLR is a non-specific marker&#44; low NLR may be interpreted as a good predictor of good prognosis and survival&#44; which may be more useful than the positive role of increased NLR&#46; Sawant et al&#46;<a class="elsevierStyleCrossRef" href="#bib0285"><span class="elsevierStyleSup">24</span></a> have shown an association of NLR and CRP with post-revascularization prognosis in patients with ST-elevation ACS&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">The GRACE risk score is a scoring method based on criteria also recommended by current guidelines&#46; It is a good indicator of in-hospital and subsequent prognosis&#46;<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">25</span></a> Inflammatory markers such as CRP and dickkopf-1 have been associated with GRACE score in patients with ACS&#46;<a class="elsevierStyleCrossRefs" href="#bib0295"><span class="elsevierStyleSup">26&#44;27</span></a> Also in our study&#44; higher CRP values were observed in the high NLR group&#46; The present study shows that the GRACE risk score has high positive and negative predictive values&#44; and also correlates well with NLR&#46; An earlier study also demonstrated a significant correlation between NLR and GRACE risk score in patients with STEMI&#46;<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">19</span></a> The GRACE risk score includes a series of clinical and laboratory criteria&#44; and the comparison of its ROC curve against the ROC curve of NLR indicates that NLR may be a simple and valuable marker of early survival&#46; In the present study&#44; higher specificity was determined for an NLR value of 4&#46;5 as compared to a GRACE risk score of 140&#46; This might be particularly helpful in identifying patients with low GRACE risk score who are likely to have poor prognosis&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">The SYNTAX score provides information on the severity of CAD as well as the complexity of lesions&#46; It is thus important in terms of eligibility of patients for percutaneous intervention&#46;<a class="elsevierStyleCrossRef" href="#bib0305"><span class="elsevierStyleSup">28</span></a> Altun et al&#46;<a class="elsevierStyleCrossRef" href="#bib0310"><span class="elsevierStyleSup">29</span></a> found a significant association between SYNTAX score and NLR in patients presenting with acute MI&#46; Furthermore&#44; Sonmez et al&#46;<a class="elsevierStyleCrossRef" href="#bib0315"><span class="elsevierStyleSup">30</span></a> demonstrated a correlation between NLR and SYNTAX score in patients with stable CAD&#44; while Sahin et al&#46;<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">18</span></a> showed an association between SYNTAX score and NLR in patients with STEMI&#46; However&#44; the present study is the first to demonstrate an association between NLR and SYNTAX score in isolated patients with NSTE-ACS&#46; This is most likely related to the sensitivity of coronary lesions and myocardial damage&#46; Histopathological studies have shown increased neutrophils in unstable and ruptured plaques&#44;<a class="elsevierStyleCrossRefs" href="#bib0320"><span class="elsevierStyleSup">31&#44;32</span></a> while increased neutrophils are thought to impair microvascular circulation&#44; leading to infarct expansion after reperfusion&#46;<a class="elsevierStyleCrossRef" href="#bib0325"><span class="elsevierStyleSup">32</span></a></p><p id="par0100" class="elsevierStylePara elsevierViewall">In the present study&#44; a strong correlation between NLR with GRACE and SYNTAX scores has been demonstrated&#44; particularly in the high NLR group&#46; Therefore&#44; in addition to the relation of low and moderate NLR values with low morbidity&#44; it may be assumed that a high NLR would be associated with increased morbidity and a higher atherosclerotic plaque burden&#46;</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Study limitations</span><p id="par0105" class="elsevierStylePara elsevierViewall">Although a total of 2135 patients admitted to the coronary intensive care unit were screened in the present study&#44; only 418 &#40;19&#46;6&#37;&#41; of them were coded with the diagnosis of NST-ACS&#46; Our study demonstrates an association between NLR and in-hospital mortality&#44; though its role in post-discharge survival and other adverse events could not be assessed due to insufficient retrospective data&#46; Furthermore&#44; since there were a limited number of patients with CRP values in our database&#44; CRP could not be included in the multivariate regression analysis&#46;</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Conclusion</span><p id="par0110" class="elsevierStylePara elsevierViewall">In our study&#44; NLR&#44; a new marker&#44; was tested in a large group of patients&#44; and increased NLR was associated with short-term survival in patients with NSTE-ACS&#46; In addition&#44; NLR was found to be correlated with clinical and angiographic risk scores&#46; These results support the relation of low NLR with improved short-term survival and of increased NLR with massive atherosclerotic burden and inflammation&#46;</p></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Ethical disclosures</span><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0135">Protection of human and animal subjects</span><p id="par0120" class="elsevierStylePara elsevierViewall">The authors declare that the procedures followed were in accordance with the regulations of the relevant clinical research ethics committee and with those of the Code of Ethics of the World Medical Association &#40;Declaration of Helsinki&#41;&#46;</p></span><span id="sec0080" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0140">Confidentiality of data</span><p id="par0125" class="elsevierStylePara elsevierViewall">The authors declare that they have followed the protocols of their work center on the publication of patient data&#46;</p></span><span id="sec0085" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0145">Right to privacy and informed consent</span><p id="par0130" class="elsevierStylePara elsevierViewall">The authors have obtained the written informed consent of the patients or subjects mentioned in the article&#46; The corresponding author is in possession of this document&#46;</p></span></span><span id="sec0090" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0150">Conflicts of interest</span><p id="par0135" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:13 [
        0 => array:3 [
          "identificador" => "xres538925"
          "titulo" => "Abstract"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "abst0005"
              "titulo" => "Objective"
            ]
            1 => array:2 [
              "identificador" => "abst0010"
              "titulo" => "Methods"
            ]
            2 => array:2 [
              "identificador" => "abst0015"
              "titulo" => "Results"
            ]
            3 => array:2 [
              "identificador" => "abst0020"
              "titulo" => "Conclusion"
            ]
          ]
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec558594"
          "titulo" => "Keywords"
        ]
        2 => array:3 [
          "identificador" => "xres538924"
          "titulo" => "Resumo"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "abst0025"
              "titulo" => "Objetivos"
            ]
            1 => array:2 [
              "identificador" => "abst0030"
              "titulo" => "M&#233;todos"
            ]
            2 => array:2 [
              "identificador" => "abst0035"
              "titulo" => "Resultados"
            ]
            3 => array:2 [
              "identificador" => "abst0040"
              "titulo" => "Conclus&#227;o"
            ]
          ]
        ]
        3 => array:2 [
          "identificador" => "xpalclavsec558593"
          "titulo" => "Palavras-chave"
        ]
        4 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introduction"
        ]
        5 => array:3 [
          "identificador" => "sec0010"
          "titulo" => "Methods"
          "secciones" => array:7 [
            0 => array:2 [
              "identificador" => "sec0015"
              "titulo" => "Study population"
            ]
            1 => array:2 [
              "identificador" => "sec0020"
              "titulo" => "Definition of non-ST-elevation acute coronary syndrome"
            ]
            2 => array:2 [
              "identificador" => "sec0025"
              "titulo" => "Coronary angiography"
            ]
            3 => array:2 [
              "identificador" => "sec0030"
              "titulo" => "Risk scoring"
            ]
            4 => array:2 [
              "identificador" => "sec0035"
              "titulo" => "Laboratory parameters"
            ]
            5 => array:2 [
              "identificador" => "sec0040"
              "titulo" => "Follow-up"
            ]
            6 => array:2 [
              "identificador" => "sec0045"
              "titulo" => "Statistical analysis"
            ]
          ]
        ]
        6 => array:2 [
          "identificador" => "sec0050"
          "titulo" => "Results"
        ]
        7 => array:2 [
          "identificador" => "sec0055"
          "titulo" => "Discussion"
        ]
        8 => array:2 [
          "identificador" => "sec0060"
          "titulo" => "Study limitations"
        ]
        9 => array:2 [
          "identificador" => "sec0065"
          "titulo" => "Conclusion"
        ]
        10 => array:3 [
          "identificador" => "sec0070"
          "titulo" => "Ethical disclosures"
          "secciones" => array:3 [
            0 => array:2 [
              "identificador" => "sec0075"
              "titulo" => "Protection of human and animal subjects"
            ]
            1 => array:2 [
              "identificador" => "sec0080"
              "titulo" => "Confidentiality of data"
            ]
            2 => array:2 [
              "identificador" => "sec0085"
              "titulo" => "Right to privacy and informed consent"
            ]
          ]
        ]
        11 => array:2 [
          "identificador" => "sec0090"
          "titulo" => "Conflicts of interest"
        ]
        12 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2014-08-13"
    "fechaAceptado" => "2015-01-12"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec558594"
          "palabras" => array:4 [
            0 => "Non-ST-segment acute coronary syndrome"
            1 => "Neutrophil-to-lymphocyte ratio"
            2 => "SYNTAX score"
            3 => "GRACE score"
          ]
        ]
      ]
      "pt" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palavras-chave"
          "identificador" => "xpalclavsec558593"
          "palabras" => array:4 [
            0 => "S&#237;ndrome coron&#225;ria aguda sem eleva&#231;&#227;o do segmento ST"
            1 => "R&#225;cio neutr&#243;filo&#47;linf&#243;cito"
            2 => "<span class="elsevierStyleItalic">Score</span> SYNTAX"
            3 => "<span class="elsevierStyleItalic">Score</span> GRACE"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Objective</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Inflammatory mechanisms are known to play an important role in coronary artery disease&#46; The present study aimed to investigate the importance of the neutrophil-to-lymphocyte ratio &#40;NLR&#41; in terms of in-hospital mortality and its association with currently used risk scores in patients with non-ST-elevation acute coronary syndrome &#40;NSTE-ACS&#41;&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Three hundred and seventeen patients with NSTE-ACS were included&#46; The patients were divided into tertiles according to their NLR values &#40;NLR &#60;2&#46;6&#44; NLR&#61;2&#46;6&#8211;4&#46;5&#44; and NLR &#62;4&#46;5&#41;&#46; Clinical and angiographic risk was evaluated by the SYNTAX and GRACE risk scores&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">The GRACE risk score was significantly higher in the group with high NLR values compared to those with moderate or low NLR &#40;161&#46;5&#177;40&#46;3&#44; 130&#46;5&#177;32&#46;3&#44; and 123&#46;9&#177;34&#46;3&#44; respectively&#44; p&#60;0&#46;001&#41;&#46; Similarly&#44; the SYNTAX score was significantly higher in the group with high NLR values &#40;20&#46;4&#177;10&#46;1&#44; 15&#46;5&#177;10&#46;5&#44; and 13&#46;4&#177;7&#46;8&#44; respectively&#44; p&#61;0&#46;003&#41;&#46; Moreover&#44; both GRACE &#40;r&#61;0&#46;457&#44; p&#60;0&#46;001&#41; and SYNTAX scores &#40;r&#61;0&#46;253&#44; p&#61;0&#46;001&#41; showed a significant positive correlation with NLR&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusion</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">NLR has been found to be correlated with clinical and angiographic risk scores&#46; Low NLR might be a good predictor for low in-hospital mortality and simple coronary anatomy in NSTE-ACS patients&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Objective"
          ]
          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Methods"
          ]
          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Results"
          ]
          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Conclusion"
          ]
        ]
      ]
      "pt" => array:3 [
        "titulo" => "Resumo"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Objetivos</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Sabe-se que os mecanismos inflamat&#243;rios t&#234;m um papel importante na doen&#231;a arterial coron&#225;ria&#46; O presente estudo visa investigar a import&#226;ncia do r&#225;cio neutr&#243;filo&#47;linf&#243;cito &#40;RNL&#41; relativamente &#224; mortalidade hospitalar e &#224; sua associa&#231;&#227;o com os <span class="elsevierStyleItalic">scores</span> de risco atuais em doentes com s&#237;ndromes coron&#225;rias agudas sem eleva&#231;&#227;o do segmento-ST &#40;SCA-NSTE&#41;&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">M&#233;todos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Foram inclu&#237;dos 317 doentes com SCA-NSTE&#46; Os doentes foram divididos em tercis de acordo com os seus valores de RNL &#40;RNL &#60; 2&#44;6&#44; RNL &#61; 2&#44;6-4&#44;5 e RNL &#62; 4&#44;5&#41;&#46; Os <span class="elsevierStyleItalic">scores</span> de risco cl&#237;nicos e angiogr&#225;ficos foram avaliados pelos m&#233;todos de risco SYNTAX e GRACE&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">O <span class="elsevierStyleItalic">score</span> de risco GRACE foi significativamente mais elevado no grupo com valores RNL elevados comparado com os grupos com RNL moderado ou baixo &#40;161&#44;5 &#177; 40&#44;3&#44; 130&#44;5 &#177; 32&#44;3 e 123&#44;9 &#177; 34&#44;3&#44; respetivamente&#44; p&#60;0&#44;001&#41;&#46; Do mesmo modo&#44; o <span class="elsevierStyleItalic">score</span> SYNTAX foi significativamente superior no grupo com valores RNL elevados &#40;20&#44;4 &#177; 10&#44;1&#44; 15&#44;5 &#177; 10&#44;5 e 13&#44;4 &#177; 7&#44;8&#44; respetivamente&#44; p&#61;0&#44;003&#41;&#46; Por outro lado&#44; tanto o <span class="elsevierStyleItalic">score</span> de risco GRACE &#40;r&#61;0&#44;457&#44; p&#60;0&#44;001&#41; como o <span class="elsevierStyleItalic">score</span> SYNTAX &#40;r&#61;0&#44;253&#44; p&#61;0&#44;001&#41; mostraram uma correla&#231;&#227;o positiva significativa com RNL&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclus&#227;o</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Verificou-se que o RNL est&#225; correlacionado com os <span class="elsevierStyleItalic">scores</span> de risco cl&#237;nicos e angiogr&#225;ficos&#46; Um RNL baixo pode ser um bom fator preditor de mortalidade intra-hospitalar e de anatomia coron&#225;ria simples em doentes com enfarte do mioc&#225;rdio sem eleva&#231;&#227;o do segmento ST&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Objetivos"
          ]
          1 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "M&#233;todos"
          ]
          2 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Resultados"
          ]
          3 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Conclus&#227;o"
          ]
        ]
      ]
    ]
    "multimedia" => array:6 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 742
            "Ancho" => 1000
            "Tamanyo" => 96520
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Study flow diagram&#46; NLR&#58; neutrophil-to-lymphocyte ratio&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 883
            "Ancho" => 992
            "Tamanyo" => 94792
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Correlation of neutrophil-to-lymphocyte ratio with GRACE risk score&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "fig0015"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 788
            "Ancho" => 995
            "Tamanyo" => 78772
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Correlation of neutrophil-to-lymphocyte ratio with SYNTAX score&#46;</p>"
        ]
      ]
      3 => array:7 [
        "identificador" => "fig0020"
        "etiqueta" => "Figure 4"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr4.jpeg"
            "Alto" => 807
            "Ancho" => 964
            "Tamanyo" => 51163
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Receiver operating characteristic curve analysis of neutrophil-to-lymphocyte ratio &#40;area under the curve&#61;0&#46;857&#41; and GRACE risk score &#40;area under the curve&#61;0&#46;926&#41; for in-hospital mortality&#46; NLR&#58; neutrophil-to-lymphocyte ratio&#46;</p>"
        ]
      ]
      4 => array:7 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:3 [
          "leyenda" => "<p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">CABG&#58; coronary artery bypass grafting&#59; CRP&#58; C-reactive protein&#59; HDL&#58; high-density lipoprotein&#59; hs-CRP&#58; high-sensitivity C-reactive protein&#59; LDL&#58; low-density lipoprotein&#59; NLR&#58; neutrophil-to-lymphocyte ratio&#59; PCI&#58; percutaneous coronary intervention&#59; SBP&#58; systolic blood pressure&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Low NLR &#40;&#60;2&#46;6&#41;&#44; n&#61;105&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Medium NLR &#40;2&#46;6&#8211;4&#46;5&#41;&#44; n&#61;106&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">High NLR &#40;&#62;4&#46;5&#41;&#44; n&#61;106&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Age&#44; years</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">62&#46;8&#177;11&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">60&#46;9&#177;13&#46;6<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">c</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">67&#46;6&#177;12&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Gender&#44; male &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">76 &#40;72&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">78 &#40;73&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">83 &#40;79&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;578&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Hypertension &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">45 &#40;42&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">39 &#40;36&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">52 &#40;49&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;196&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Diabetes &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">24 &#40;22&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">21 &#40;19&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">38 &#40;35&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;019&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">hs-CRP &#40;mg&#47;l&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">38&#46;9&#177;51&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">44&#46;7&#177;60&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">80&#46;3&#177;17&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;423&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Serum glucose &#40;mg&#47;dl&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">157&#46;1&#177;89&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">143&#46;5&#177;68&#46;7<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">c</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">171&#46;0&#177;83&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;017&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Total cholesterol &#40;mg&#47;dl&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">182&#46;8&#177;48&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">188&#46;2&#177;41&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">169&#46;9&#177;44&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;027&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">LDL cholesterol &#40;mg&#47;dl&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">116&#46;9&#177;47&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">115&#46;9&#177;33&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">104&#46;3&#177;36&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;075&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">HDL cholesterol &#40;mg&#47;dl&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">37&#46;6&#177;10&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">37&#46;6&#177;9&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">36&#46;3&#177;11&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;287&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Triglycerides &#40;mg&#47;dl&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">167&#46;5&#177;104&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">170&#46;9&#177;103&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">146&#46;5&#177;83&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;167&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Hemoglobin &#40;g&#47;l&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">13&#46;7&#177;1&#46;7<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">13&#46;9&#177;1&#46;7<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">c</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">12&#46;7&#177;2&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Ejection fraction &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">55&#46;6&#177;9&#46;0<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a><span class="elsevierStyleSup">&#44;</span><a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">49&#46;4&#177;11&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">47&#46;5&#177;13&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Heart rate</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">74&#46;9&#177;15&#46;2<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">79&#46;2&#177;16&#46;1<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">c</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">86&#46;6&#177;17&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">SBP &#40;mmHg&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">152&#46;3&#177;37&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">147&#46;5&#177;31&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">141&#46;0&#177;33&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;059&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="5" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="5" align="left" valign="top"><span class="elsevierStyleItalic">Killip class</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>I&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">99 &#40;94&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">96 &#40;90&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">66 &#40;62&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>II&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">6 &#40;5&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">8 &#40;7&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">26 &#40;24&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>III&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1 &#40;0&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">13 &#40;12&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>IV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1 &#40;0&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1 &#40;0&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;607&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="5" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">ST-segment deviation</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">76 &#40;72&#46;4&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a><span class="elsevierStyleSup">&#44;</span><a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">92 &#40;86&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">94 &#40;88&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;003&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Elevated cardiac markers</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">80 &#40;76&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">90 &#40;84&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">95 &#40;89&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;028&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Troponin I &#40;ng&#47;ml&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">10&#46;1&#177;16&#46;9<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a><span class="elsevierStyleSup">&#44;</span><a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">19&#46;7&#177;27&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">29&#46;2&#177;31&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Creatinine &#40;mg&#47;dl&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;04&#177;0&#46;83<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;5&#177;2&#46;5<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">c</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#46;05&#177;2&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">GRACE risk score</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">123&#46;9&#177;34&#46;3<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">130&#46;5&#177;32&#46;3<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">c</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">161&#46;5&#177;40&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">SYNTAX score &#40;n&#61;276&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">13&#46;4&#177;7&#46;8<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">15&#46;5&#177;10&#46;5<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">c</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">20&#46;4&#177;10&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;003&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">CRP &#40;mg&#47;l&#41; &#40;n&#61;146&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">42&#46;4&#177;63&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">51&#46;1&#177;83&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">96&#46;8&#177;165&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;045&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">NLR</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;89&#177;0&#46;44<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a><span class="elsevierStyleSup">&#44;</span><a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&#46;53&#177;0&#46;54<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">c</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">8&#46;63&#177;4&#46;39&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab866173.png"
              ]
            ]
          ]
          "notaPie" => array:3 [
            0 => array:3 [
              "identificador" => "tblfn0005"
              "etiqueta" => "a"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0005">p&#60;0&#46;016 between low and medium NLR groups&#46;</p>"
            ]
            1 => array:3 [
              "identificador" => "tblfn0010"
              "etiqueta" => "b"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0010">p&#60;0&#46;016 between low and high NLR groups&#46;</p>"
            ]
            2 => array:3 [
              "identificador" => "tblfn0015"
              "etiqueta" => "c"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0015">p&#60;0&#46;016 between medium and high NLR groups&#46;</p>"
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Baseline characteristics of the study population&#46;</p>"
        ]
      ]
      5 => array:7 [
        "identificador" => "tbl0025"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0105" class="elsevierStyleSimplePara elsevierViewall">CI&#58; confidence interval&#59; NLR&#58; neutrophil-to-lymphocyte ratio&#59; OR&#58; odds ratio&#59; SBP&#58; systolic blood pressure&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col">Variable&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " colspan="3" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Univariate logistic regression</th><th class="td" title="table-head  " colspan="3" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Multivariate logistic regression</th></tr><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">OR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">95&#37; CI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">OR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">95&#37; CI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">NLR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;183&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;030&#8211;1&#46;359&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;017&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;182&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;042&#8211;1&#46;340&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;009&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Age &#40;years&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;114&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;055&#8211;1&#46;176&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;115&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;057&#8211;1&#46;175&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Heart rate &#40;bpm&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;999&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;971&#8211;1&#46;029&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;971&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">SBP &#40;mmHg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;985&#8211;1&#46;017&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;879&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Creatinine &#40;mg&#47;dl&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;012&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;847&#8211;1&#46;209&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;899&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Killip class&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">29&#46;005&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9&#46;287&#8211;90&#46;587&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">29&#46;794&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9&#46;871&#8211;89&#46;931&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Troponin I&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;018&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;001&#8211;1&#46;036&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;042&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;019&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;002&#8211;1&#46;036&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;024&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">ST-segment deviation&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;556&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;161&#8211;15&#46;012&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;702&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab866174.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0090" class="elsevierStyleSimplePara elsevierViewall">Effects of different variables on in-hospital mortality in multivariate logistic regression analysis&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:32 [
            0 => array:3 [
              "identificador" => "bib0170"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "2012 ACCF&#47;AHA focused update of the guideline for the management of patients with unstable angina&#47;non-ST-elevation myocardial infarction &#40;updating the 2007 guideline and replacing the 2011 focused update&#41;&#58; a report of the American College of Cardiology Foundation&#47;American Heart Association Task Force on Practice Guidelines"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "H&#46; Jneid"
                            1 => "J&#46;L&#46; Anderson"
                            2 => "R&#46;S&#46; Wright"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jacc.2012.06.004"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Coll Cardiol"
                        "fecha" => "2012"
                        "volumen" => "60"
                        "paginaInicial" => "645"
                        "paginaFinal" => "681"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22809746"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0175"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation&#58; The Task Force for the management of acute coronary syndromes &#40;ACS&#41; in patients presenting without persistent ST-segment elevation of the European Society of Cardiology &#40;ESC&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "C&#46;W&#46; Hamm"
                            1 => "J&#46;P&#46; Bassand"
                            2 => "S&#46; Agewall"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/eurheartj/ehr236"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Heart J"
                        "fecha" => "2011"
                        "volumen" => "32"
                        "paginaInicial" => "2999"
                        "paginaFinal" => "3054"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21873419"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0180"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prediction of risk of death and myocardial infarction in the six months after presentation with acute coronary syndrome&#58; prospective multinational observational study &#40;GRACE&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "K&#46;A&#46; Fox"
                            1 => "O&#46;H&#46; Dabbous"
                            2 => "R&#46;J&#46; Goldberg"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/bmj.38985.646481.55"
                      "Revista" => array:5 [
                        "tituloSerie" => "BMJ"
                        "fecha" => "2006"
                        "volumen" => "333"
                        "paginaInicial" => "1091"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17032691"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0185"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Inflammation and atherosclerosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "P&#46; Libby"
                            1 => "P&#46;M&#46; Ridker"
                            2 => "A&#46; Maseri"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "2002"
                        "volumen" => "105"
                        "paginaInicial" => "1135"
                        "paginaFinal" => "1143"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11877368"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0190"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The role of inflammation&#44; humoral and cell mediated autoimmunity in the pathogenesis of atherosclerosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "I&#46;A&#46; Pereira"
                            1 => "E&#46;F&#46; Borba"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "2008/37/smw-12287"
                      "Revista" => array:7 [
                        "tituloSerie" => "Swiss Med Wkly"
                        "fecha" => "2008"
                        "volumen" => "138"
                        "paginaInicial" => "534"
                        "paginaFinal" => "539"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18803034"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S1885585714003314"
                          "estado" => "S300"
                          "issn" => "18855857"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0195"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Association between neutrophil to lymphocyte ratio and severity of coronary artery disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "H&#46; Kaya"
                            1 => "F&#46; Erta&#351;"
                            2 => "Y&#46; &#304;slamo&#287;lu"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1177/1076029612452116"
                      "Revista" => array:7 [
                        "tituloSerie" => "Clin Appl Thromb Hemost"
                        "fecha" => "2014"
                        "volumen" => "20"
                        "paginaInicial" => "50"
                        "paginaFinal" => "54"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22790659"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S1885585714003910"
                          "estado" => "S300"
                          "issn" => "18855857"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0200"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Usefulness of the neutrophil to lymphocyte ratio in predicting long-term mortality in ST segment elevation myocardial infarction"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "J&#46; N&#250;&#241;ez"
                            1 => "E&#46; N&#250;&#241;ez"
                            2 => "V&#46; Bod&#237;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.amjcard.2007.11.004"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Cardiol"
                        "fecha" => "2008"
                        "volumen" => "101"
                        "paginaInicial" => "747"
                        "paginaFinal" => "752"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18328833"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0205"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Association between admission neutrophil to lymphocyte ratio and outcomes in patients with acute coronary syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "U&#46;U&#46; Tamhane"
                            1 => "S&#46; Aneja"
                            2 => "D&#46; Montgomery"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.amjcard.2008.05.006"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Cardiol"
                        "fecha" => "2008"
                        "volumen" => "102"
                        "paginaInicial" => "653"
                        "paginaFinal" => "657"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18773982"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0210"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Predictive value of neutrophil to lymphocyte ratio in clinical outcomes of non-ST elevation myocardial infarction and unstable angina pectoris&#58; a 3-year follow-up"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "M&#46; Gul"
                            1 => "H&#46; Uyarel"
                            2 => "M&#46; Ergelen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1177/1076029612465669"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Appl Thromb Hemost"
                        "fecha" => "2014"
                        "volumen" => "20"
                        "paginaInicial" => "378"
                        "paginaFinal" => "384"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23144177"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0215"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "SYNTAX Working Group&#46; SYNTAX score calculator&#46; Available at&#58; <a href="http://www.syntaxscore.com/">http&#58;&#47;&#47;www&#46;SYNTAXscore&#46;com</a> &#91;accessed 15&#46;01&#46;11&#93;"
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0220"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Usefulness of neutrophil to lymphocyte ratio in predicting short- and long-term mortality after non-ST-elevation myocardial infarction"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "B&#46; Azab"
                            1 => "M&#46; Zaher"
                            2 => "K&#46;F&#46; Weiserbs"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.amjcard.2010.03.062"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Cardiol"
                        "fecha" => "2010"
                        "volumen" => "106"
                        "paginaInicial" => "470"
                        "paginaFinal" => "476"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20691303"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0225"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The relationship of coronary flow to neutrophil&#47;lymphocyte ratio in patients undergoing primary percutaneous coronary intervention"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "K&#46; Soylu"
                            1 => "S&#46; Yuksel"
                            2 => "O&#46; Gulel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3978/j.issn.2072-1439.2013.05.13"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Thorac Dis"
                        "fecha" => "2013"
                        "volumen" => "5"
                        "paginaInicial" => "258"
                        "paginaFinal" => "264"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23825756"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0230"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Neutrophil-to-lymphocyte ratio is associated with severity of coronary artery ectasia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "B&#46; Sarli"
                            1 => "A&#46;O&#46; Baktir"
                            2 => "H&#46; Saglam"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1177/0003319713488932"
                      "Revista" => array:6 [
                        "tituloSerie" => "Angiology"
                        "fecha" => "2014"
                        "volumen" => "65"
                        "paginaInicial" => "147"
                        "paginaFinal" => "151"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23657176"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0235"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The relationship between neutrophil to lymphocyte ratio and coronary collateral circulation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "O&#46;K&#46; Uysal"
                            1 => "C&#46; Turkoglu"
                            2 => "D&#46;Y&#46; Sahin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1177/1076029613503399"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Appl Thromb Hemost"
                        "fecha" => "2013"
                        "volumen" => "21"
                        "paginaInicial" => "329"
                        "paginaFinal" => "333"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24027113"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0240"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Role of neutrophils in myocardial ischemia and reperfusion"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "P&#46;R&#46; Hansen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "1995"
                        "volumen" => "91"
                        "paginaInicial" => "1872"
                        "paginaFinal" => "1885"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7882499"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0245"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Neutrophil function in ischemic heart disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "J&#46; Mehta"
                            1 => "J&#46; Dinerman"
                            2 => "P&#46; Mehta"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "1989"
                        "volumen" => "79"
                        "paginaInicial" => "549"
                        "paginaFinal" => "556"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2537159"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0250"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pro-inflammatory cytokines in acute coronary syndromes&#58; from bench to bedside"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "D&#46; Tousoulis"
                            1 => "C&#46; Antoniades"
                            2 => "N&#46; Koumallos"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.cytogfr.2006.04.003"
                      "Revista" => array:6 [
                        "tituloSerie" => "Cytokine Growth Factor Rev"
                        "fecha" => "2006"
                        "volumen" => "17"
                        "paginaInicial" => "225"
                        "paginaFinal" => "233"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16750416"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0255"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Neutrophil to lymphocyte ratio is associated with the severity of coronary artery disease in patients with ST-segment elevation myocardial infarction"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "D&#46;Y&#46; Sahin"
                            1 => "Z&#46; Elbasan"
                            2 => "M&#46; G&#252;r"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1177/0003319712453305"
                      "Revista" => array:6 [
                        "tituloSerie" => "Angiology"
                        "fecha" => "2013"
                        "volumen" => "64"
                        "paginaInicial" => "423"
                        "paginaFinal" => "429"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22802534"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0260"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Relation of neutrophil-to-lymphocyte ratio with GRACE risk score to in-hospital cardiac events in patients with ST-segment elevated myocardial infarction"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "R&#46;C&#46; Oncel"
                            1 => "M&#46; Ucar"
                            2 => "M&#46;S&#46; Karakas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1177/1076029613505763"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Appl Thromb Hemost"
                        "fecha" => "2015"
                        "volumen" => "21"
                        "paginaInicial" => "383"
                        "paginaFinal" => "388"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24078555"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0265"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "White blood cell subtypes and neutrophil-lymphocyte ratio in prediction of coronary thrombus formation in non-ST-segment elevated acute coronary syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "M&#46; Yilmaz"
                            1 => "E&#46; Tenekecioglu"
                            2 => "B&#46; Arslan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1177/1076029613507337"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Appl Thromb Hemost"
                        "fecha" => "2015"
                        "volumen" => "21"
                        "paginaInicial" => "446"
                        "paginaFinal" => "452"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24203350"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0270"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mechanical complications after myocardial infarction reliably predicted using C-reactive protein levels and lymphocytopenia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "A&#46; Widmer"
                            1 => "A&#46;Z&#46; Linka"
                            2 => "C&#46;H&#46; Attenhofer Jost"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "68448"
                      "Revista" => array:6 [
                        "tituloSerie" => "Cardiology"
                        "fecha" => "2003"
                        "volumen" => "99"
                        "paginaInicial" => "25"
                        "paginaFinal" => "31"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12589119"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0275"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Usefulness of the lymphocyte concentration as a prognostic marker in coronary artery disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "S&#46;R&#46; Ommen"
                            1 => "R&#46;J&#46; Gibbons"
                            2 => "D&#46;O&#46; Hodge"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Cardiol"
                        "fecha" => "1997"
                        "volumen" => "79"
                        "paginaInicial" => "812"
                        "paginaFinal" => "824"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9070569"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0280"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Predictive power of the relative lymphocyte concentration in patients with advanced heart failure"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "S&#46;R&#46; Ommen"
                            1 => "D&#46;O&#46; Hodge"
                            2 => "R&#46;J&#46; Rodeheffer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "1998"
                        "volumen" => "97"
                        "paginaInicial" => "19"
                        "paginaFinal" => "22"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9443426"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib0285"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Neutrophil to lymphocyte ratio predicts short- and long-term mortality following revascularization therapy for ST elevation myocardial infarction"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "A&#46;C&#46; Sawant"
                            1 => "P&#46; Adhikari"
                            2 => "S&#46;R&#46; Narra"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.5603/CJ.a2013.0148"
                      "Revista" => array:6 [
                        "tituloSerie" => "Cardiol J"
                        "fecha" => "2014"
                        "volumen" => "21"
                        "paginaInicial" => "500"
                        "paginaFinal" => "508"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24142685"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib0290"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "TIMI&#44; PURSUIT&#44; and GRACE risk scores&#58; sustained prognostic value and interaction with revascularization in NSTE-ACS"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "P&#46; de Ara&#250;jo Gon&#231;alves"
                            1 => "J&#46; Ferreira"
                            2 => "C&#46; Aguiar"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/eurheartj/ehi187"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Heart J"
                        "fecha" => "2005"
                        "volumen" => "26"
                        "paginaInicial" => "865"
                        "paginaFinal" => "872"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15764619"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib0295"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Dickkopf-1 as a novel predictor is associated with risk stratification by GRACE risk scores for predictive value in patients with acute coronary syndrome&#58; a retrospective research"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "L&#46; Wang"
                            1 => "X&#46;B&#46; Hu"
                            2 => "W&#46; Zhang"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1371/journal.pone.0054731"
                      "Revista" => array:5 [
                        "tituloSerie" => "PLOS ONE"
                        "fecha" => "2013"
                        "volumen" => "8"
                        "paginaInicial" => "e54731"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23359112"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib0300"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Inflammatory response and C-reactive protein value in patient with acute coronary syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "L&#46; Kubkov&#225;"
                            1 => "J&#46; Spinar"
                            2 => "M&#46; P&#225;vkov&#225; Goldbergov&#225;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Vnitr Lek"
                        "fecha" => "2013"
                        "volumen" => "59"
                        "paginaInicial" => "981"
                        "paginaFinal" => "988"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24279442"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib0305"
              "etiqueta" => "28"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The SYNTAX score&#58; an angiographic tool grading the complexity of coronary artery disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "G&#46; Sianos"
                            1 => "M&#46;A&#46; Morel"
                            2 => "A&#46;P&#46; Kappetein"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Eurointervention"
                        "fecha" => "2005"
                        "volumen" => "1"
                        "paginaInicial" => "219"
                        "paginaFinal" => "227"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19758907"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib0310"
              "etiqueta" => "29"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The relationship between high-sensitive troponin T&#44; neutrophil lymphocyte ratio and SYNTAX score"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "B&#46; Altun"
                            1 => "H&#46; Turkon"
                            2 => "H&#46; Tasolar"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3109/00365513.2013.860619"
                      "Revista" => array:6 [
                        "tituloSerie" => "Scand J Clin Lab Invest"
                        "fecha" => "2014"
                        "volumen" => "74"
                        "paginaInicial" => "108"
                        "paginaFinal" => "115"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24304492"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib0315"
              "etiqueta" => "30"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Relation of neutrophil-to-lymphocyte ratio with the presence and complexity of coronary artery disease&#58; an observational study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "O&#46; S&#246;nmez"
                            1 => "G&#46; Erta&#351;"
                            2 => "A&#46; Bacaks&#305;z"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.5152/akd.2013.188"
                      "Revista" => array:6 [
                        "tituloSerie" => "Anadolu Kardiyol Derg"
                        "fecha" => "2013"
                        "volumen" => "13"
                        "paginaInicial" => "662"
                        "paginaFinal" => "667"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23912788"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            30 => array:3 [
              "identificador" => "bib0320"
              "etiqueta" => "31"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "High neutrophil numbers in human carotid atherosclerotic plaques are associated with characteristics of rupture-prone lesions"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46;G&#46; Ionita"
                            1 => "P&#46; van den Borne"
                            2 => "L&#46;M&#46; Catanzariti"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/ATVBAHA.110.209296"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arterioscler Thromb Vasc Biol"
                        "fecha" => "2010"
                        "volumen" => "30"
                        "paginaInicial" => "1842"
                        "paginaFinal" => "1848"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20595650"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            31 => array:3 [
              "identificador" => "bib0325"
              "etiqueta" => "32"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Neutrophil infiltration of culprit lesions in acute coronary syndromes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "T&#46; Naruko"
                            1 => "M&#46; Ueda"
                            2 => "K&#46; Haze"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "2002"
                        "volumen" => "106"
                        "paginaInicial" => "2894"
                        "paginaFinal" => "2900"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12460868"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/21742049/0000003400000078/v1_201508050210/S2174204915001610/v1_201508050210/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "9917"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Original Articles"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/21742049/0000003400000078/v1_201508050210/S2174204915001610/v1_201508050210/en/main.pdf?idApp=UINPBA00004E&text.app=https://revportcardiol.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204915001610?idApp=UINPBA00004E"
]

Article information

ISSN: 21742049
Original language: English

DOI:10.1016/j.repce.2015.07.007

The statistics are updated each day

Year/Month	Html	Pdf	Total

2024 November	4	5	9
2024 October	33	23	56
2024 September	33	18	51
2024 August	42	26	68
2024 July	41	25	66
2024 June	30	21	51
2024 May	61	23	84
2024 April	78	23	101
2024 March	75	21	96
2024 February	59	24	83
2024 January	34	25	59
2023 December	25	23	48
2023 November	28	21	49
2023 October	21	13	34
2023 September	20	20	40
2023 August	32	18	50
2023 July	25	18	43
2023 June	30	12	42
2023 May	45	33	78
2023 April	24	8	32
2023 March	39	23	62
2023 February	35	20	55
2023 January	26	20	46
2022 December	44	20	64
2022 November	56	19	75
2022 October	73	19	92
2022 September	77	27	104
2022 August	82	20	102
2022 July	80	35	115
2022 June	46	21	67
2022 May	62	39	101
2022 April	62	24	86
2022 March	48	32	80
2022 February	31	25	56
2022 January	38	35	73
2021 December	27	32	59
2021 November	33	39	72
2021 October	46	38	84
2021 September	35	37	72
2021 August	36	26	62
2021 July	44	29	73
2021 June	42	19	61
2021 May	34	28	62
2021 April	43	45	88
2021 March	57	22	79
2021 February	61	18	79
2021 January	49	18	67
2020 December	62	15	77
2020 November	49	11	60
2020 October	33	17	50
2020 September	67	32	99
2020 August	41	14	55
2020 July	44	10	54
2020 June	58	16	74
2020 May	64	18	82
2020 April	42	17	59
2020 March	47	17	64
2020 February	102	49	151
2020 January	45	19	64
2019 December	55	3	58
2019 November	43	11	54
2019 October	40	4	44
2019 September	49	14	63
2019 August	30	7	37
2019 July	39	8	47
2019 June	28	8	36
2019 May	31	10	41
2019 April	19	20	39
2019 March	39	9	48
2019 February	47	7	54
2019 January	24	7	31
2018 December	44	7	51
2018 November	168	11	179
2018 October	361	11	372
2018 September	57	17	74
2018 August	25	11	36
2018 July	28	10	38
2018 June	25	12	37
2018 May	30	9	39
2018 April	42	26	68
2018 March	39	15	54
2018 February	28	7	35
2018 January	24	15	39
2017 December	35	17	52
2017 November	32	16	48
2017 October	23	14	37
2017 September	27	14	41
2017 August	31	24	55
2017 July	26	15	41
2017 June	50	23	73
2017 May	33	37	70
2017 April	34	31	65
2017 March	26	41	67
2017 February	20	5	25
2017 January	41	4	45
2016 December	39	11	50
2016 November	16	7	23
2016 October	24	14	38
2016 September	18	8	26
2016 August	14	3	17
2016 July	12	6	18
2016 June	10	29	39
2016 May	12	3	15
2016 April	14	15	29
2016 March	17	19	36
2016 February	37	21	58
2016 January	32	23	55
2015 December	26	24	50
2015 November	28	22	50
2015 October	36	24	60
2015 September	39	16	55
2015 August	29	13	42

Show all

Indexed in:

Follow us:

Statistics

Indexed in:

Follow us:

Statistics

Subscribe to our newsletter