Original Article
Ventricular septal defect in children and adolescents in Angola: Experience of a tertiary center
Comunicação interventricular em crianças e adolescentes em Angola: Experiência de um centro terciário
Read
6227
Timeswas read the article
1812
Total PDF
4415
Total HTML
Share statistics
array:24 [ "pii" => "S2174204914002293" "issn" => "21742049" "doi" => "10.1016/j.repce.2014.03.011" "estado" => "S300" "fechaPublicacion" => "2014-10-01" "aid" => "524" "copyright" => "Sociedade Portuguesa de Cardiologia" "copyrightAnyo" => "2014" "documento" => "article" "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "fla" "cita" => "Rev Port Cardiol. 2014;33:637-40" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 3090 "formatos" => array:3 [ "EPUB" => 162 "HTML" => 2371 "PDF" => 557 ] ] "Traduccion" => array:1 [ "en" => array:20 [ "pii" => "S0870255114002066" "issn" => "08702551" "doi" => "10.1016/j.repc.2014.03.012" "estado" => "S300" "fechaPublicacion" => "2014-10-01" "aid" => "524" "copyright" => "Sociedade Portuguesa de Cardiologia" "documento" => "article" "crossmark" => 0 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "fla" "cita" => "Rev Port Cardiol. 2014;33:637-40" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 4381 "formatos" => array:3 [ "EPUB" => 181 "HTML" => 3434 "PDF" => 766 ] ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>" "titulo" => "Ventricular septal defect in children and adolescents in Angola: Experience of a tertiary center" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "pt" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "637" "paginaFinal" => "640" ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Comunicação interventricular em crianças e adolescentes em Angola: Experiência de um centro terciário" ] ] "contieneResumen" => array:2 [ "en" => true "pt" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1074 "Ancho" => 1253 "Tamanyo" => 58947 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Distribution of the sample according to whether ventricular septal defect was associated with other congenital heart defects. CHD: congenital heart defect; VSD: ventricular septal defect.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Valdano Manuel, Humberto Morais, Ana Manuel, Bruna David, Sebastiana Gamboa" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Valdano" "apellidos" => "Manuel" ] 1 => array:2 [ "nombre" => "Humberto" "apellidos" => "Morais" ] 2 => array:2 [ "nombre" => "Ana" "apellidos" => "Manuel" ] 3 => array:2 [ "nombre" => "Bruna" "apellidos" => "David" ] 4 => array:2 [ "nombre" => "Sebastiana" "apellidos" => "Gamboa" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2174204914002293" "doi" => "10.1016/j.repce.2014.03.011" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204914002293?idApp=UINPBA00004E" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255114002066?idApp=UINPBA00004E" "url" => "/08702551/0000003300000010/v1_201410290045/S0870255114002066/v1_201410290045/en/main.assets" ] ] "itemSiguiente" => array:19 [ "pii" => "S2174204914002037" "issn" => "21742049" "doi" => "10.1016/j.repce.2014.04.003" "estado" => "S300" "fechaPublicacion" => "2014-10-01" "aid" => "514" "copyright" => "Sociedade Portuguesa de Cardiologia" "documento" => "article" "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "sco" "cita" => "Rev Port Cardiol. 2014;33:641-3" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 4153 "formatos" => array:3 [ "EPUB" => 188 "HTML" => 3181 "PDF" => 784 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Evidenced-Based Cardiology</span>" "titulo" => "Cochrane Corner: What is the clinical impact of oxygen therapy for acute myocardial infarction? Evaluation of a Cochrane systematic review" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "641" "paginaFinal" => "643" ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "<span class="elsevierStyleItalic">Cochrane Corner</span>: Qual é o impacto clínico da administracão de oxigénio em doentes com enfarte agudo do miocárdio? Avaliacão de uma revisão sistemática <span class="elsevierStyleItalic">Cochrane</span>" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 583 "Ancho" => 2923 "Tamanyo" => 152324 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Main results of the systematic review by Cabello et al.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> CI: confidence interval.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Daniel Caldeira, António Vaz-Carneiro, João Costa" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Daniel" "apellidos" => "Caldeira" ] 1 => array:2 [ "nombre" => "António" "apellidos" => "Vaz-Carneiro" ] 2 => array:2 [ "nombre" => "João" "apellidos" => "Costa" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "pt" => array:9 [ "pii" => "S0870255114001966" "doi" => "10.1016/j.repc.2014.04.002" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255114001966?idApp=UINPBA00004E" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204914002037?idApp=UINPBA00004E" "url" => "/21742049/0000003300000010/v1_201411060106/S2174204914002037/v1_201411060106/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S2174204914002281" "issn" => "21742049" "doi" => "10.1016/j.repce.2014.02.025" "estado" => "S300" "fechaPublicacion" => "2014-10-01" "aid" => "519" "copyright" => "Sociedade Portuguesa de Cardiologia" "documento" => "article" "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "fla" "cita" => "Rev Port Cardiol. 2014;33:629-36" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 4080 "formatos" => array:3 [ "EPUB" => 168 "HTML" => 3286 "PDF" => 626 ] ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>" "titulo" => "Role of cardiac multidetector computed tomography in the exclusion of ischemic etiology in heart failure patients" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "pt" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "629" "paginaFinal" => "636" ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Papel da tomografia computorizada cardíaca na exclusão de etiologia isquémica em pacientes com insuficiência cardíaca" ] ] "contieneResumen" => array:2 [ "en" => true "pt" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1965 "Ancho" => 2672 "Tamanyo" => 165147 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Cardiomyopathy etiology of the 100 HF patients who underwent CTA. CAD: coronary artery disease; CTA: multidetector computed tomography coronary angiography; ICA: invasive coronary angiography; MDCT: multidetector computed tomography.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Pedro A. Sousa, Nuno Bettencourt, Nuno Dias Ferreira, Mónica Carvalho, Daniel Leite, Wilson Ferreira, Ilídio de Jesus, Vasco Gama" "autores" => array:8 [ 0 => array:2 [ "nombre" => "Pedro A." "apellidos" => "Sousa" ] 1 => array:2 [ "nombre" => "Nuno" "apellidos" => "Bettencourt" ] 2 => array:2 [ "nombre" => "Nuno" "apellidos" => "Dias Ferreira" ] 3 => array:2 [ "nombre" => "Mónica" "apellidos" => "Carvalho" ] 4 => array:2 [ "nombre" => "Daniel" "apellidos" => "Leite" ] 5 => array:2 [ "nombre" => "Wilson" "apellidos" => "Ferreira" ] 6 => array:2 [ "nombre" => "Ilídio" "apellidos" => "de Jesus" ] 7 => array:2 [ "nombre" => "Vasco" "apellidos" => "Gama" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S0870255114002017" "doi" => "10.1016/j.repc.2014.02.028" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0870255114002017?idApp=UINPBA00004E" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204914002281?idApp=UINPBA00004E" "url" => "/21742049/0000003300000010/v1_201411060106/S2174204914002281/v1_201411060106/en/main.assets" ] "en" => array:20 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>" "titulo" => "Ventricular septal defect in children and adolescents in Angola: Experience of a tertiary center" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "637" "paginaFinal" => "640" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Valdano Manuel, Humberto Morais, Ana Manuel, Bruna David, Sebastiana Gamboa" "autores" => array:5 [ 0 => array:4 [ "nombre" => "Valdano" "apellidos" => "Manuel" "email" => array:1 [ 0 => "valdanympub@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Humberto" "apellidos" => "Morais" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "Ana" "apellidos" => "Manuel" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "Bruna" "apellidos" => "David" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 4 => array:3 [ "nombre" => "Sebastiana" "apellidos" => "Gamboa" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Cardio-Thoracic Center, Clínica Girassol, Luanda, Angola" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Cardiology Department, Hospital Militar Principal/Instituto Superior, Luanda, Angola" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Service of Pediatric Cardiology, Hospital Pediátrico David Bernardino, Luanda, Angola" "etiqueta" => "c" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Comunicação interventricular em crianças e adolescentes em Angola: Experiência de um centro terciário" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1074 "Ancho" => 1253 "Tamanyo" => 58947 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Distribution of the sample according to whether ventricular septal defect was associated with other congenital heart defects. CHD: congenital heart defect; VSD: ventricular septal defect.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Ventricular septal defect (VSD) is the most common congenital heart defect (CHD), affecting approximately 2–6/1000 live births.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,2</span></a> VSD results from a malfunction of cardiac development, possibly including a failure in the alignment or in the fusion of the atrioventricular cushions during the formation of the interventricular septum.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> The defects can be classified according to their location. Perimembranous defects are located in the membranous portion of the interventricular septum and muscular defects are located in the muscular portion of the trabecular septum or at its margins.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Perimembranous defect is more common, occurring in 70–80% of cases.<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4,5</span></a> VSDs can present in isolation or coexisting with other CHDs.</p><p id="par0010" class="elsevierStylePara elsevierViewall">In Africa VSD is also the most common CHD in childhood.<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6–9</span></a> In Angola, little is known of the prevalence of VSD, largely because few studies have been conducted.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> The authors of this study aim to characterize VSD in children and adolescents based on echocardiographic records from the pediatric cardiology service of the largest pediatric care center in Angola over a period of one year, from April 2010 to March 2011.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Methods</span><p id="par0015" class="elsevierStylePara elsevierViewall">The David Bernardino Pediatric Hospital is the largest pediatric cardiology and care center in Angola. It is a tertiary teaching and postgraduate hospital with 300 beds in 11 departments. The cardiology service has an echocardiography laboratory with teleconsultation links to the pediatric cardiology department of Coimbra Hospital in Portugal. Around the country many pediatrics patients have been referred to the hospital for assessment. Consecutive echocardiographic reports of 1267 patients over a period of one year (from April 2010 to March 2011) were retrospectively reviewed. Repeat scans were not included. All children and adolescents aged 0–18 years with a diagnosis of VSD with or without associated CHD were included. The diagnosis of VSD was made by clinical examination and confirmed by transthoracic echocardiography performed by three cardiologists of the institution. The echocardiogram was performed on a Medison SA 8000 system, using an F24AC transducer.</p><p id="par0020" class="elsevierStylePara elsevierViewall">The sample was divided into two groups, Group 1, isolated VSD; and Group 2, VSD associated with other CHDs.</p><p id="par0025" class="elsevierStylePara elsevierViewall">The variables studied were age (months), gender, type of VSD, other CHDs and associated genetic syndromes. The data were presented as absolute and relative frequencies.</p><p id="par0030" class="elsevierStylePara elsevierViewall">Descriptive statistics was used to determine mean, mode and standard deviation. The software used was Epi Info version 3.5.2.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Results</span><p id="par0035" class="elsevierStylePara elsevierViewall">Over a period of a year (April 2010–March 2011), 490 CHDs were diagnosed in children and adolescents (0–18 years of age), of which 283 (57.7%) were VSDs. <a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a> shows the division of the sample into groups: Group 1, isolated VSD (140; 49%); and Group 2, VSD associated with other CHDs (143; 51%). In Group 1, the mean age at diagnosis was 29 months (SD 36 months). The most frequent age (mode) at diagnosis was 24 months. There was no predominance of gender (ratio 1:1). The most common type of VSD was perimembranous (127; 91%) with 13 cases of muscular VSD (9%). In this group, five children (3.6%) had pulmonary hypertension. In Group 2, 113 (79%) had one, 27 (19%) had two and three (2%) had three other CHD associated with VSD (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>). In this group, 24 (17%) had VSD associated with a genetic syndrome; of these, 23 (96%) had trisomy 21 and one (4%) had Noonan syndrome (<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>). In Group 2, 50 (35%) of VSDs were associated with patent ductus arteriosus, 24 (16.8%) with pulmonary stenosis, eight (8.4%) with ostium primum atrial septal defect and seven (7.7%) with ostium secundum atrial septal defect (<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><elsevierMultimedia ident="tbl0015"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Discussion</span><p id="par0040" class="elsevierStylePara elsevierViewall">In the present study the incidence of CHDs was higher than is found in the literature, probably due to the fact that this center receives children and adolescents from all over the country. VSD was the most common CHD, as it is worldwide.<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4–13</span></a> The prevalence of VSDs found in this study was also high compared to published reports.<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6–14</span></a> More than half of VSDs were associated with other CHDs, which contrasts with the results of some authors.<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9,12</span></a> This difference may be explained by the exclusion of patients with conotruncal anomalies, atrioventricular septal defect and single ventricle. On the other hand, our results were similar to those of a study at Hospital Infantil Pequeno Principe in Brazil.<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> In cases of isolated VSD there was no gender predominance (ratio of 1:1), contrasting with the results of a study conducted in Enugu, Nigeria in which there was a predominance of males. The authors claimed this was due to Nigerian sociocultural practices.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> The age range of patients at diagnosis was wide (between six days and 18 years), which reflects the lack of a screening program and hence early diagnosis. Most VSDs were diagnosed at the age of 24 months (mode), which places Angola within the typical range of most developing countries.<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6–8</span></a> This result contrasts with those reported by other authors, who emphasize the need for diagnosis in the first year of life.<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9,12,13</span></a> Delay in diagnosis is directly proportional to a worse prognosis. Generally it is in the first year of life that the clinical manifestations of heart disease with left-to-right shunting appear, as in VSD, due to decreased pulmonary vascular resistance after birth and increased systemic resistance and right ventricular compliance, which causes the left-to-right shunt, leading to pulmonary hypertension and delay in development. The most frequent type of VSD in the isolated VSD group was perimembranous, which coincides with the results of other authors,<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4,14</span></a> but differs from those in a study at Cathay General Hospital (Taiwan) in which the authors found that 65% of VSDs were muscular.<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a> This may be an Asian characteristic. The percentage of association of VSD with other CHDs observed in this study is generally similar to the results of Glen et al.,<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a> although the association of VSD with two or three other CHDs was twice as common as in the literature. Regarding the type of CHD most commonly associated with VSD, our results differed from those of another study<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a> in which the most frequent associated CHD was pulmonary infundibular pulmonary stenosis, followed by aortic valve prolapse, pulmonary valve stenosis, ostium secundum atrial septal defect, patent ductus arteriosus and coarctation of the aorta. However, they resemble those of another African study (in Nigeria).<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> As in our series, in another study trisomy 21 was the most frequent genetic syndrome (3.5%).<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a></p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Conclusion</span><p id="par0045" class="elsevierStylePara elsevierViewall">The study demonstrated that VSD is the most common CHD in childhood. Delayed diagnosis is associated with worse prognosis. When VSD is detected we consider a detailed Doppler echocardiographic examination is required to exclude other CHDs associated with the VSD.</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Ethical disclosures</span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Protection of human and animal subjects</span><p id="par0050" class="elsevierStylePara elsevierViewall">The authors declare that no experiments were performed on humans or animals for this study.</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Confidentiality of data</span><p id="par0055" class="elsevierStylePara elsevierViewall">The authors declare that they have followed the protocols of their work center on the publication of patient data.</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Right to privacy and informed consent</span><p id="par0060" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appear in this article.</p></span></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Conflicts of interest</span><p id="par0070" class="elsevierStylePara elsevierViewall">The author has no conflicts of interest to declare.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:13 [ 0 => array:2 [ "identificador" => "xres380901" "titulo" => array:5 [ 0 => "Abstract" 1 => "Introduction and Objective" 2 => "Methods" 3 => "Results" 4 => "Conclusions" ] ] 1 => array:2 [ "identificador" => "xpalclavsec359719" "titulo" => "Keywords" ] 2 => array:2 [ "identificador" => "xres380900" "titulo" => array:5 [ 0 => "Resumo" 1 => "Introdução e objectivo" 2 => "Métodos" 3 => "Resultados" 4 => "Conclusões" ] ] 3 => array:2 [ "identificador" => "xpalclavsec359718" "titulo" => "Palavras-chave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Methods" ] 6 => array:2 [ "identificador" => "sec0015" "titulo" => "Results" ] 7 => array:2 [ "identificador" => "sec0020" "titulo" => "Discussion" ] 8 => array:2 [ "identificador" => "sec0025" "titulo" => "Conclusion" ] 9 => array:3 [ "identificador" => "sec0030" "titulo" => "Ethical disclosures" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0035" "titulo" => "Protection of human and animal subjects" ] 1 => array:2 [ "identificador" => "sec0040" "titulo" => "Confidentiality of data" ] 2 => array:2 [ "identificador" => "sec0045" "titulo" => "Right to privacy and informed consent" ] ] ] 10 => array:2 [ "identificador" => "sec0050" "titulo" => "Conflicts of interest" ] 11 => array:2 [ "identificador" => "xack100844" "titulo" => "Acknowledgments" ] 12 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2014-02-17" "fechaAceptado" => "2014-03-13" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec359719" "palabras" => array:3 [ 0 => "Congenital heart disease" 1 => "Ventricular septal defect" 2 => "Echocardiography" ] ] ] "pt" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palavras-chave" "identificador" => "xpalclavsec359718" "palabras" => array:3 [ 0 => "Cardiopatia congenital" 1 => "Comunicação interventricular" 2 => "Ecocardiografia" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0010">Introduction and Objective</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">This is the first study in Angola with the aim of characterizing ventricular septal defect (VSD) among children and adolescents.</p> <span class="elsevierStyleSectionTitle" id="sect0015">Methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A cross-sectional study based on echocardiographic records of the largest pediatric cardiology center in Angola included all children and adolescents (0 to 18 years old) with VSD between April 2010 and March 2011. The diagnosis was made by transthoracic and Doppler echocardiography with a Medison SA 8000 system. The sample was divided into two groups: Group 1, isolated VSD; and Group 2, VSD associated with other congenital heart defects (CHDs). Age, gender, type of VSD, associated CHDs and genetic syndromes were assessed.</p> <span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">A total of 490 CHDs were diagnosed, of which 283 were VSDs. In Group 1 (140, 49%) the mean age was 29±36 months. The most frequent age (mode) at diagnosis was 24 months. There was no predominance of gender (ratio 1:1). The majority (127, 91%) had perimembranous VSD. In Group 2 (143, 51%) 113 patients (79%) had one, 27 patients (19%) had two and three patients (2%) had three other CHDs. Trisomy 21 was the most common genetic syndrome (23, 96%).</p> <span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">The study shows that VSD is the most common CHD in childhood, the diagnosis is made late and almost half of VSDs are associated with other CHDs.</p>" ] "pt" => array:2 [ "titulo" => "Resumo" "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0035">Introdução e objectivo</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Esta é a primeira pesquisa em Angola com o objetivo de caracterizar a comunicação interventricular entre crianças e adolescentes.</p> <span class="elsevierStyleSectionTitle" id="sect0040">Métodos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Estudo transversal, com base nos registos ecocardigráficos do maior Hospital de Cardiologia Pediátrica em Angola (abril de 2010 para março de 2011). Todas as crianças e adolescentes (0 a 18 anos de idade) com comunicação interventricular foram incluídas. O diagnóstico foi feito por ecocardiografia transtorácica e Doppler com a máquina de Medison SA 8000. A amostra foi dividida em dois grupos: Grupo I – comunicação interventricular isolada e Grupo II – comunicação interventricular associada a outras cardiopatias congénitas. A Idade, o sexo, o tipo de defeito do septo, principais cardiopatias congénitas associadas e as síndromes genéticas foram avaliados.</p> <span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Houve 490 cardiopatias congénitas diagnosticadas, das quais 283 foram comunicação interventricular. No Grupo I (140, 49%) a idade média foi de 29<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>36 meses. A idade mais frequente (moda) ao diagnóstico foi de 24 meses. Não houve predomínio quanto ao género (1: 1). Neste grupo a maioria tinha comunicação interventricular perimembranosa (127, 91%). No Grupo II (143, 51%) 113 pacientes (79%) tinham uma, 27 (19%) tinham duas e três (2%) tinham três outras cardiopatias congénitas associadas a comunicação interventricular. A Trissomia do cromossomo 21 foi a síndrome genética mais comum (24, 96%).</p> <span class="elsevierStyleSectionTitle" id="sect0050">Conclusões</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">O estudo mostra que comunicação interventricular é a cardiopatia congénita mais comum em crianças pré-escolares.</p>" ] ] "multimedia" => array:4 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1074 "Ancho" => 1253 "Tamanyo" => 58947 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Distribution of the sample according to whether ventricular septal defect was associated with other congenital heart defects. CHD: congenital heart defect; VSD: ventricular septal defect.</p>" ] ] 1 => array:7 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">CHD: congenital heart defect.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Number of other associated CHDs \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">n (%) \t\t\t\t\t\t\n \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">One \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">113 (79) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Two \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">27 (19) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Three \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 (2) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Total \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">143 (100) \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab580169.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Associated congenital heart defects in patients with ventricular septal defect.</p>" ] ] 2 => array:7 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Genetic syndrome \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">n (%) \t\t\t\t\t\t\n \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Trisomy 21 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">23 (96) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Noonan syndrome \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 (4) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Total \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">24 (100) \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab580171.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Types of genetic syndrome associated with ventricular septal defect in Group 2.</p>" ] ] 3 => array:7 [ "identificador" => "tbl0015" "etiqueta" => "Table 3" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">AS: aortic stenosis; CAVD: common atrioventricular canal defect; CHD: congenital heart defect; CoA: coarctation of the aorta; DORV: double outlet right ventricle; OPASD: ostium primum atrial septal defect; OSASD: ostium secundum atrial septal defect; PA: pulmonary atresia; PDA: patent ductus arteriosus; PS: pulmonary stenosis; TA: tricuspid atresia; TGV: transposition of the great vessels; TOF: tetralogy of Fallot.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Type of CHD \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">n (%) \t\t\t\t\t\t\n \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">PDA \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">50 (35) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">PS \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">24 (16.8) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">OSASD \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">12 (8.4) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">OPASD \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">11 (7.7) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">OSASD + PDA \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8 (5.6) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">OPASD + PDA \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7 (4.9) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">TGV \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 (2.1) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">CoA \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 (2.1) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">PDA + DORV \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 (2.1) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">TA \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 (1.4) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">CAVD \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 (1.4) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">DORV \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 (1.4) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">PCA + PS \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 (1.4) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">DORV + OSASD \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 (1.4) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">TOF \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 (1.4) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">AS \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 (0.7) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Truncus arteriosus \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 (0.7) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">PDA + TGV + PS \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 (0.7) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">TGV + OPASD + PDA \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 (0.7) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">OPASD + PDA + PS \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 (0.7) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">PE + TA \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 (0.7) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">OPASD + TGV \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 (0.7) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">PS + DORV \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 (0.7) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">PS + AS \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 (0.7) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">OPASD + PDA \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 (0.7) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Total \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">143 (100) \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab580170.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Prevalence of other congenital heart defects in patients with ventricular septal defect.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:15 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Congenital heart disease among 815,569 children born between 1980 and 1990 and their 15 year survival: a prospective Bohemia survival study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M. Samanek" 1 => "M. Voriskova" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s002469900502" "Revista" => array:6 [ "tituloSerie" => "Pediatr Cardiol" "fecha" => "1999" "volumen" => "20" "paginaInicial" => "411" "paginaFinal" => "417" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10556387" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Ventricular septal defect" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M. Tynan" 1 => "R.H. Anderson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Paediatric Cardiology" "paginaInicial" => "983" "paginaFinal" => "1014" "serieFecha" => "2002" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Ventricular septal defect" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "D.J. Penny" 1 => "G.W. Vick 3rd." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0140-6736(10)61339-6" "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "2011" "volumen" => "377" "paginaInicial" => "1103" "paginaFinal" => "1112" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21349577" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prospective study of congenital heart disease in children" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "P. Wickramasinghe" 1 => "S.P. Lamabadusuriya" 2 => "S. Nerenthiran" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ceylon Med J" "fecha" => "2001" "volumen" => "46" "paginaInicial" => "96" "paginaFinal" => "98" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11732303" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical recognition of congenital heart disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J.K. Perloff" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:3 [ "fecha" => "2003" "editorial" => "Saunders" "editorialLocalizacion" => "Philadelphia, PA" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prevalence of congenital heart disease in black schoolchildren of Soweto, Johannesburg" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M.J. McLaren" 1 => "A.S. Lachman" 2 => "J.B. Barlow" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br Heart J" "fecha" => "1979" "volumen" => "41" "paginaInicial" => "554" "paginaFinal" => "558" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/465225" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Congenital heart disease in Zimbabwean children" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "C.H. Bannerman" 1 => "W. Mahalu" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Trop Paediatr" "fecha" => "1998" "volumen" => "18" "paginaInicial" => "5" "paginaFinal" => "12" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9691994" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Spectrum of congenital heart disease in a tropical environment: a echocardiography study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M.U. Sani" 1 => "M. Mukhtar-Yola" 2 => "K.M. Karaye" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Natl Med Assoc" "fecha" => "2007" "volumen" => "99" "paginaInicial" => "665" "paginaFinal" => "669" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17595936" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Ventricular septal defects at the University of Nigeria Teaching Hospital, Enugu: a review of echocardiogram records" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "E.C. Ejim" 1 => "S.O. Ike" 2 => "B.C. Anisiuba" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.trstmh.2008.06.016" "Revista" => array:6 [ "tituloSerie" => "Trans R Soc Trop Med Hyg" "fecha" => "2009" "volumen" => "103" "paginaInicial" => "159" "paginaFinal" => "161" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18675999" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Contribuição para o estudo das doenças cardíacas em crianças em Luanda (Angola)" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:1 [ 0 => "M.R. Monteiro" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Acta Méd Angolana" "fecha" => "1984" "volumen" => "3" "paginaInicial" => "41" "paginaFinal" => "56" ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Transcatheter closure of congenital ventricular septal defects: results of the European Registry" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "M. Carminati" 1 => "G. Butera" 2 => "M. Chessa" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/eurheartj/ehm314" "Revista" => array:6 [ "tituloSerie" => "Eur Heart J" "fecha" => "2007" "volumen" => "28" "paginaInicial" => "2361" "paginaFinal" => "2368" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17684082" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0060" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prevalence and development of additional cardiac abnormalities in 1448 patients with congenital ventricular septal defects" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S. Glen" 1 => "J. Burns" 2 => "P. Bloomfield" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/hrt.2003.025007" "Revista" => array:6 [ "tituloSerie" => "Heart" "fecha" => "2004" "volumen" => "90" "paginaInicial" => "1321" "paginaFinal" => "1325" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15486133" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0065" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Estudo Epidemiológico de Cardiopatias Congénitas na Infância e Adolescência. Análise em 4.538 Casos" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "N.I. Miyague" 1 => "S.M. Cardoso" 2 => "F. Meyer" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arq Bras Cardiol" "fecha" => "2003" "volumen" => "80" "paginaInicial" => "269" "paginaFinal" => "273" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12856270" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0070" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Ventricular septal defect and associated complications" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "T.A. Chaudhry" 1 => "M. Younas" 2 => "A. Baig" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "JPMA" "fecha" => "2011" "volumen" => "61" "paginaInicial" => "1001" "paginaFinal" => "1004" ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0075" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Spontaneous closure of ventricular septal defects in the first year of life" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "M.H. Lin" 1 => "N.-K. Wang" 2 => "K.-L. Hung" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Formos Med Assoc" "fecha" => "2001" "volumen" => "100" "paginaInicial" => "539" "paginaFinal" => "542" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11678004" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] "agradecimientos" => array:1 [ 0 => array:4 [ "identificador" => "xack100844" "titulo" => "Acknowledgments" "texto" => "<p id="par0065" class="elsevierStylePara elsevierViewall">We would like to thank Feliciano Chanana Paquissi for his valuable contribution.</p>" "vista" => "all" ] ] ] "idiomaDefecto" => "en" "url" => "/21742049/0000003300000010/v1_201411060106/S2174204914002293/v1_201411060106/en/main.assets" "Apartado" => array:4 [ "identificador" => "9917" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Original Articles" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/21742049/0000003300000010/v1_201411060106/S2174204914002293/v1_201411060106/en/main.pdf?idApp=UINPBA00004E&text.app=https://revportcardiol.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204914002293?idApp=UINPBA00004E" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 13 | 7 | 20 |
| 2024 October | 65 | 42 | 107 |
| 2024 September | 53 | 24 | 77 |
| 2024 August | 65 | 35 | 100 |
| 2024 July | 35 | 36 | 71 |
| 2024 June | 34 | 27 | 61 |
| 2024 May | 51 | 19 | 70 |
| 2024 April | 39 | 33 | 72 |
| 2024 March | 47 | 26 | 73 |
| 2024 February | 79 | 27 | 106 |
| 2024 January | 45 | 21 | 66 |
| 2023 December | 50 | 31 | 81 |
| 2023 November | 58 | 29 | 87 |
| 2023 October | 37 | 13 | 50 |
| 2023 September | 31 | 20 | 51 |
| 2023 August | 22 | 16 | 38 |
| 2023 July | 29 | 14 | 43 |
| 2023 June | 27 | 11 | 38 |
| 2023 May | 35 | 24 | 59 |
| 2023 April | 27 | 4 | 31 |
| 2023 March | 41 | 30 | 71 |
| 2023 February | 43 | 20 | 63 |
| 2023 January | 46 | 17 | 63 |
| 2022 December | 35 | 25 | 60 |
| 2022 November | 30 | 23 | 53 |
| 2022 October | 34 | 22 | 56 |
| 2022 September | 30 | 36 | 66 |
| 2022 August | 38 | 40 | 78 |
| 2022 July | 52 | 46 | 98 |
| 2022 June | 23 | 36 | 59 |
| 2022 May | 24 | 38 | 62 |
| 2022 April | 92 | 27 | 119 |
| 2022 March | 36 | 27 | 63 |
| 2022 February | 39 | 28 | 67 |
| 2022 January | 25 | 17 | 42 |
| 2021 December | 17 | 34 | 51 |
| 2021 November | 32 | 28 | 60 |
| 2021 October | 25 | 38 | 63 |
| 2021 September | 20 | 28 | 48 |
| 2021 August | 25 | 26 | 51 |
| 2021 July | 14 | 23 | 37 |
| 2021 June | 22 | 12 | 34 |
| 2021 May | 23 | 32 | 55 |
| 2021 April | 30 | 23 | 53 |
| 2021 March | 45 | 8 | 53 |
| 2021 February | 40 | 11 | 51 |
| 2021 January | 23 | 15 | 38 |
| 2020 December | 31 | 10 | 41 |
| 2020 November | 23 | 10 | 33 |
| 2020 October | 12 | 7 | 19 |
| 2020 September | 44 | 9 | 53 |
| 2020 August | 16 | 11 | 27 |
| 2020 July | 42 | 6 | 48 |
| 2020 June | 28 | 8 | 36 |
| 2020 May | 31 | 5 | 36 |
| 2020 April | 32 | 9 | 41 |
| 2020 March | 34 | 6 | 40 |
| 2020 February | 75 | 35 | 110 |
| 2020 January | 25 | 8 | 33 |
| 2019 December | 25 | 1 | 26 |
| 2019 November | 24 | 4 | 28 |
| 2019 October | 30 | 5 | 35 |
| 2019 September | 24 | 6 | 30 |
| 2019 August | 22 | 10 | 32 |
| 2019 July | 41 | 12 | 53 |
| 2019 June | 22 | 7 | 29 |
| 2019 May | 38 | 5 | 43 |
| 2019 April | 21 | 12 | 33 |
| 2019 March | 75 | 11 | 86 |
| 2019 February | 51 | 12 | 63 |
| 2019 January | 58 | 5 | 63 |
| 2018 December | 83 | 11 | 94 |
| 2018 November | 112 | 4 | 116 |
| 2018 October | 254 | 21 | 275 |
| 2018 September | 69 | 11 | 80 |
| 2018 August | 48 | 7 | 55 |
| 2018 July | 24 | 9 | 33 |
| 2018 June | 22 | 10 | 32 |
| 2018 May | 25 | 7 | 32 |
| 2018 April | 40 | 2 | 42 |
| 2018 March | 22 | 4 | 26 |
| 2018 February | 24 | 2 | 26 |
| 2018 January | 25 | 12 | 37 |
| 2017 December | 36 | 11 | 47 |
| 2017 November | 42 | 15 | 57 |
| 2017 October | 31 | 11 | 42 |
| 2017 September | 36 | 14 | 50 |
| 2017 August | 33 | 21 | 54 |
| 2017 July | 21 | 12 | 33 |
| 2017 June | 45 | 21 | 66 |
| 2017 May | 40 | 5 | 45 |
| 2017 April | 39 | 7 | 46 |
| 2017 March | 23 | 31 | 54 |
| 2017 February | 30 | 4 | 34 |
| 2017 January | 34 | 2 | 36 |
| 2016 December | 41 | 13 | 54 |
| 2016 November | 27 | 4 | 31 |
| 2016 October | 36 | 5 | 41 |
| 2016 September | 29 | 3 | 32 |
| 2016 August | 10 | 0 | 10 |
| 2016 July | 11 | 3 | 14 |
| 2016 June | 11 | 6 | 17 |
| 2016 May | 12 | 2 | 14 |
| 2016 April | 14 | 1 | 15 |
| 2016 March | 31 | 8 | 39 |
| 2016 February | 36 | 14 | 50 |
| 2016 January | 33 | 11 | 44 |
| 2015 December | 36 | 6 | 42 |
| 2015 November | 19 | 8 | 27 |
| 2015 October | 41 | 12 | 53 |
| 2015 September | 28 | 10 | 38 |
| 2015 August | 19 | 5 | 24 |
| 2015 July | 26 | 8 | 34 |
| 2015 June | 20 | 3 | 23 |
| 2015 May | 29 | 6 | 35 |
| 2015 April | 20 | 7 | 27 |
| 2015 March | 19 | 7 | 26 |
| 2015 February | 27 | 2 | 29 |
| 2015 January | 27 | 7 | 34 |
| 2014 December | 42 | 11 | 53 |
| 2014 November | 43 | 13 | 56 |
Show all
