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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Heart failure &#40;HF&#41; has an overall population prevalence of approximately 1&#8211;3&#37;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> and projections show that by 2030&#44; its prevalence will increase 25&#37; from 2013 estimates&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Despite advances in the therapeutic management of chronic heart failure &#40;CHF&#41; and consequent improvement in survival over time&#44;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> the death rate remains high&#44; with an averaged overall 5-year mortality rate of 50&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Left ventricular systolic function &#40;LVSF&#41; is a strong outcome predictor with a major impact on the medical decisions&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Consequently&#44; LVSF should be quantified by a sensitive&#44; accurate and reproducible method&#46; Left ventricular ejection fraction &#40;LVEF&#41; is the most widely used parameter for the global assessment of LVSF&#46; However&#44; its measurement by two-dimensional &#40;2D&#41; echocardiography&#44; has several disadvantages&#58; it is based on geometric assumptions&#44; depends on accurate tracing of endocardial borders and has significant interobserver and intraobserver variability&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> On the other hand&#44; left ventricular &#40;LV&#41; global longitudinal strain &#40;GLS&#41; is an accurate and sensitive measure of myocardium deformation&#44; allowing the angle-independent quantification of myocardial function in 2D&#44; based on the LV active shortening in the longitudinal direction&#44; which is more reproducible than LVEF and does not rely on geometrical assumptions&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7&#44;8</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Some authors have suggested that GLS is useful in the prediction of cardiovascular &#40;CV&#41; events&#44; in various heart diseases and clinical conditions&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9&#8211;11</span></a> Nahum et al<span class="elsevierStyleItalic">&#46;</span><a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> showed that in CHF patients&#44; GLS determined by speckle-tracking is superior to LVEF in identifying patients with poor clinical outcome&#46; However&#44; its ability to assess disease severity in CHF is still poorly addressed&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The Seattle Heart Failure Model Score &#40;SHFM&#41; is a validated multimarker risk assessment tool developed to predict prognosis in patients with CHF&#44; which was derived from a cohort of 1125 HF patients and was prospectively validated in five additional outpatient cohorts including 9942 HF patients&#46; It provides an accurate estimation of 1-&#44; 2-&#44; and 5-year survival&#44; as well as of life expectancy using commonly obtained clinical&#44; laboratory and therapeutic &#40;pharmacologic and device&#41; information&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">The purpose of this study was to evaluate the LV GLS association with clinical and prognostic indicators in patients with CHF and systolic dysfunction&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Methods</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Population study</span><p id="par0035" class="elsevierStylePara elsevierViewall">The present study consisted of a cross-sectional analysis of clinical and echocardiographic data from ambulatory CHF patients&#44; followed in an outpatient &#8220;Heart Failure&#44; Cardiomyopathy and Pre-Transplant&#8221; Clinic&#44; included consecutively&#44; <span class="elsevierStyleBold">between</span> September and November 2012&#46; Eligible patients were CHF ambulatory patients&#44; with EF &#60;45&#37; under optimal medical therapy <span class="elsevierStyleBold">for</span> at least three months&#46; Exclusion criteria included recent acute coronary syndrome&#44; myocardial revascularization in the last three months&#44; recent or planned cardiac surgery within six months&#44; significant primary valvular disease&#44; recent onset cardiomyopathy &#40;&#60;6 months&#41;&#44; early stage of potentially reversible LV dysfunction &#40;&#60;6 months&#41; and the presence of concomitant serious illness&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Patients in atrial fibrillation &#40;AF&#41; were not excluded from the study&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Patient demographic&#44; clinical information and laboratory data were collected during the clinical visit at the time of the echocardiographic study&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">SHFM application</span><p id="par0050" class="elsevierStylePara elsevierViewall">Application of the SHFM was performed in all patients&#44; using the online module&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a> There were no missing covariates for score calculation&#46; Estimated SHFM-predicted life expectancy was used as the prognostic status indicator&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Echocardiographic analysis</span><p id="par0055" class="elsevierStylePara elsevierViewall">A standardized complete echocardiographic examination was performed using a commercially available Vivid 7 system &#40;GE Vingmed&#44; Horton&#44; Norway&#41;&#44; with a M4S &#40;2&#46;5-MHz&#41; probe&#46; All data were stored digitally for off-line analysis on Echo-Pac PC software &#40;V8&#46;1 GE&#44; Horton Norway&#41;&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Standard echocardiographic techniques were used to obtain two-dimensional &#40;2D&#41; and Doppler measurements in accordance with European Association of Echocardiography guidelines&#46;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">13&#44;14</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">LV volumes and LVEF were calculated by the biplane Simpson&#39;s method from apical 4- and 2-chamber views&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">Peak tricuspid annular systolic velocity &#40;S&#8242;&#41;&#44; by tissue Doppler imaging &#40;TDI&#41; was used to assess right ventricle systolic function &#40;RVSF&#41;&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">The ratio of early transmitral velocity &#40;E wave by conventional pulsed Doppler&#41; to tissue Doppler mitral annular early diastolic velocity &#40;e&#8242; by TDI&#41; was used to assess LV end-diastolic pressure &#40;LVEDP&#41;&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">LV longitudinal strain analysis</span><p id="par0080" class="elsevierStylePara elsevierViewall">GLS was assessed in the 18 LV segments from the three standard apical views &#40;4-chamber&#44; 2-chamber&#44; 3-chamber&#41;&#44; using a speckle tracking software&#46; For strain processing&#44; the peak of the R wave on the electrocardiogram was used as the reference time point for end-diastole&#46; The endocardial border was traced manually in the end-diastolic frame&#46; The software subsequently and automatically traced the borders in the other frames&#46; Segments which failed to track were manually adjusted by the operator&#46; Any segments which subsequently failed to track were excluded from the analysis&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">In AF patients&#44; cine loops were analyzed to determine which index beat should be used to GLS calculation&#46; The speckle tracking software was able to successfully and appropriately track the frame-to-frame movement of LV segments if cardiac cycle of the index beat was &#62;500 ms and if the preceding and pre preceding intervals of the index beat were of nearly equal duration &#40;&#60;60 ms&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a></p><p id="par0090" class="elsevierStylePara elsevierViewall">GLS was obtained only in the case of adequate tracking quality &#8805;5 of the six segments per view&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">Graphical displays of deformation parameters for each segment were then generated automatically&#46; GLS was obtained by averaging the peak strain values from the 18 regional longitudinal strain curves&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Reproducibility</span><p id="par0100" class="elsevierStylePara elsevierViewall">Fifteen patients were randomly selected for evaluation of the interobserver variability of GLS measurement by two independent observers&#46; To get the intraobsever variability&#44; the same measurement was repeated three to six months apart&#46; Reproducibility was expressed as the mean absolute difference&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Statistical analysis</span><p id="par0105" class="elsevierStylePara elsevierViewall">Continuous variables with normal distribution were expressed as mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD and skewed variables as median and quartiles&#46; Categorical variables were expressed as percentages&#46; The comparison of continuous variables was performed by an independent sample <span class="elsevierStyleItalic">t</span> test&#46; For categorical variables&#44; the chi-square test was used&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">A Pearson correlation analysis was used to evaluate the strength of the association between continuous variables&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">A logistic regression model was used for multivariate analysis to investigate which prognostic factors identified using univariate analysis were independently associated with a lower survival &#40;&#60;10 years of life expectancy derived from SHFM&#41;&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">Receiver-operating characteristic &#40;ROC&#41; curve analysis was used to determine optimal cutoff value of continuous variable&#46; The best cutoff value was defined as the point with the highest sum of sensitivity and specificity&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">Two-tailed p-values &#60;0&#46;05 were considered statistically significant&#46; Statistical analysis was performed using SPSS Statistics version 19&#46;0 &#40;SPSS Inc&#46;&#44; Chicago&#44; Illinois&#41;&#46;</p></span></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Results</span><p id="par0130" class="elsevierStylePara elsevierViewall">Of the 62 patients included&#44; adequate echocardiographic tracking quality of the LV segments&#44; allowing appropriate GLS analysis&#44; was feasible in 54 &#40;87&#37;&#41; patients &#40;54&#46;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>12&#46;1 years&#44; 79&#46;1&#37; men&#41;&#44; which constituted the final patient population&#46; Three of the eight excluded patients had AF&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">The clinical and echocardiographic characteristics of the overall patient population are summarized in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Patient population</span><p id="par0140" class="elsevierStylePara elsevierViewall">Dyslipidemia&#44; hypertension&#44; and diabetes were present in 43 &#40;80&#37;&#41;&#44; 23 &#40;43&#37;&#41; and 16 &#40;30&#37;&#41; patients&#44; respectively&#46; Ischemic etiology was present in 30&#37; and 59&#37; of the patients were in NYHA functional class II&#46; Median BNP level was relatively low&#58; 186&#46;3 &#91;P<span class="elsevierStyleInf">25-75</span> 55&#46;9&#8211;560&#46;1&#93; pg&#47;ml&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">Most patients were treated with beta-blockers &#40;94&#37;&#41; and angiotensin converting enzyme inhibitors or angiotensin-receptor blockers &#40;94&#37;&#41;&#46; Diuretics&#44; spironolactone and statins were also frequently used in this patient population &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">In addition&#44; 11 &#40;20&#37;&#41; patients had an implantable cardioverter defibrillator &#40;ICD&#41; device and 6 &#40;11&#37;&#41; had a cardiac resynchronization therapy defibrillator &#40;CRT-D&#41; device&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Baseline echocardiography</span><p id="par0155" class="elsevierStylePara elsevierViewall">End diastolic and systolic volumes averaged 116&#46;0<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>40&#46;25 ml&#47;m<span class="elsevierStyleSup">2</span> and 86&#46;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>38&#46;56 ml&#47;m<span class="elsevierStyleSup">2</span>&#44; respectively&#46; Mean LVEF was 27&#46;0<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>8&#46;8&#37; and E&#47;e&#8242; ratio averaged 12&#46;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#46;4&#46; RVSD was observed in 11&#37; of the patients and mean peak systolic velocity of the tricuspid annulus by tissue Doppler imaging &#40;RV S&#8242; TDI&#41; averaged 11&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#46;3 cm&#47;s&#46;</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">LV longitudinal strain analysis</span><p id="par0160" class="elsevierStylePara elsevierViewall">The mean GLS was &#8722;10&#46;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#46;1&#37;&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">GLS was found to be highly associated with various clinical and echocardiographic variables&#59; relevant correlations are summarized in <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0170" class="elsevierStylePara elsevierViewall">GLS was significantly related to NYHA functional class &#40;r&#61;0&#46;41&#44; p&#61;0&#46;002&#41; and BNP levels &#40;r&#61;0&#46;47&#44; p&#61;0&#46;001&#41;&#46;</p><p id="par0175" class="elsevierStylePara elsevierViewall">GLS presented a good correlation with LV end-diastolic volume index &#40;r&#61;0&#46;60&#44; p&#60;0&#46;001&#41;&#44; LV end-systolic volume index &#40;r&#61;0&#46;68&#44; p&#60;0&#46;001&#41; and with LVEF &#40;r&#61;-0&#46;69&#44; p&#60;0&#46;001&#41;&#46;</p><p id="par0180" class="elsevierStylePara elsevierViewall">The magnitude of GLS showed a moderate correlation with RVSF assessed by TDI-derived peak systolic tricuspid velocity &#40;r&#61;&#8722;0&#46;32&#44; p&#61;0&#46;031&#41; and <span class="elsevierStyleBold">LV filling pressure</span>&#44; assessed by E&#47;e&#8242; ratio &#40;r&#61;0&#46;35&#44; p&#61;0&#46;014&#41; and LA maximal volume index &#40;r&#61;0&#46;57&#44; p&#60;0&#46;001&#41;&#46;</p><p id="par0185" class="elsevierStylePara elsevierViewall">Finally&#44; a significant correlation was found between GLS and SHFM prognostic estimates for life expectancy &#40;r&#61;&#8722;0&#46;41&#44; p&#61;0&#46;002&#41;&#46;</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Predictors of worse prognosis</span><p id="par0190" class="elsevierStylePara elsevierViewall">Univariate analysis using a logistic regression model &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#41; showed that GLS predicted a life expectancy &#60;10 years&#44; derived from SHFM &#40;OR 1&#46;544&#44; p&#61;0&#46;008&#41;&#46; Other relevant variables found to be significantly associated to a worse survival included BNP levels &#40;OR 1&#46;001&#44; p&#61;0&#46;013&#41;&#44; E&#47;e&#8242; ratio &#40;OR 1&#46;241&#44; p&#61;0&#46;012&#41; and LA maximal volume &#40;OR 1&#46;071&#44; p&#61;0&#46;021&#41;&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0195" class="elsevierStylePara elsevierViewall">In a multivariate analysis adjusted to E&#47;e&#8242; ratio and BNP &#40;significant variables not contributing to the SHFM&#41;&#44; GLS remained a significant independent predictor of survival &#40;OR 2&#46;614&#44; 95&#37; CI&#58; 1&#46;010&#8211;6&#46;763&#44; p&#61;0&#46;048&#41;&#46;</p><p id="par0200" class="elsevierStylePara elsevierViewall">The area under the receiver operating characteristic curve &#40;AUC&#41; for GLS to predict a life expectancy &#60;10 years was highly relevant &#40;AUC&#58; 0&#46;802 &#91;0&#46;653&#8211;0&#46;951&#93;&#41; and a GLS cut-off &#62;&#8722;9&#46;5&#37; identified patients with poor prognosis &#40;80&#37; sensitivity&#44; 65&#37; specificity&#44; p&#61;0&#46;003&#41; &#8211; <a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a>&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0115" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Reproducibility</span><p id="par0205" class="elsevierStylePara elsevierViewall">The intraobserver and interobserver mean difference for GLS measurement were 0&#46;47<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;40 and 0&#46;86<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;56&#44; respectively&#46;</p></span></span><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0135">Discussion</span><p id="par0210" class="elsevierStylePara elsevierViewall">Myocardial function assessment significantly influences therapeutic decision making&#44; including devices implantation&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> In daily practice&#44; myocardial function is based on LVEF by echocardiography using the Simpson biplane model&#46; However&#44; this method has several limitations&#58; it is based on geometric assumptions and depends on image quality&#44; on load conditions and on the experience of the operator&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> In addition&#44; LVEF lacks sensitivity to accurately identify myocardial contractility impairment&#46;<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">16&#8211;18</span></a> In the present study&#44; global systolic LV myocardial function was determined with 2D speckle tracking strain analysis&#44; which is feasible&#44; reproducible&#44; angle independent and does not rely on geometry assumptions&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> 2D-echocardiographic TDI is also available to LVSF assessment&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a> However&#44; some limitations should be noted&#58; it is angle dependent and it appears more noised and less robust compared to speckle tracking modality&#46;</p><p id="par0215" class="elsevierStylePara elsevierViewall">The characteristics of this study population are partly different from other groups of CHF patients&#44; as our patients are younger and we present a high number of CHF patients with non-ischemic etiology&#44; like familial dilated cardiomyopathies&#46; This can be explained by the specific purposes of the outpatient clinic that receives potential candidates for cardiac transplantation&#46;</p><p id="par0220" class="elsevierStylePara elsevierViewall">NYHA functional class and BNP levels were significantly correlated with GLS&#46; Donal et al&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a> shown an important association between GLS and functional capacity&#44; assessed by cardiopulmonary exercise testing performance&#46; Yoneyama et al&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a> had also found a close correlation between longitudinal LV strain and BNP levels&#46; The apparent clinical stability and the exclusively outpatient setting probably contributed to the relatively low NYHA functional class and BNP levels for a CHF population with depressed LVEF&#46;</p><p id="par0225" class="elsevierStylePara elsevierViewall">The good correlation found in the current evaluation between GLS and LVEF is consistent with the scientific literature&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8&#44;22</span></a></p><p id="par0230" class="elsevierStylePara elsevierViewall">Furthermore&#44; a variety of echocardiographic parameters have been suggested to estimate LV filling pressure in CHF&#46; The E&#47;e&#8242; ratio is the most frequently used parameter for this purpose and&#44; along with E-wave deceleration time &#40;DT&#41;&#44; has become central in this evaluation&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">23</span></a></p><p id="par0235" class="elsevierStylePara elsevierViewall">LA maximal volume index is gaining incremental relevance and has been recognized as a reflection of severity and chronicity of diastolic dysfunction and as an independent predictor of mortality&#44; both CV as well as all-cause&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a> New studies are focusing in the role of LA function and LA strain in diastolic function evaluation and prognostic information&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">25</span></a> In this analysis&#44; a lower magnitude of GLS was associated with worsening LV diastolic function&#44; assessed by E&#47;e&#8242; ratio and LA maximal volume index&#46;</p><p id="par0240" class="elsevierStylePara elsevierViewall">Previous reports have already shown that GLS is a sensitive measure of LV mechanics and is a good predictor of CV events&#44; in various heart diseases and clinical conditions&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9&#8211;11</span></a> This study showed that GLS is highly associated to disease severity status and is an independent predictor of survival&#44; according to the integrated assessment provided by SHFM&#46; This model simultaneously weights a large number of clinical&#44; laboratory and therapeutics variables with established prognostic impact&#46; This is the first study that relates a myocardial deformation marker with a prognostic indicator derived by a multivariable risk assessment tool&#46; The SHFM integrated approach is highly advantageous and provides feasibility and accuracy to investigations&#46; For example&#44; because CHF etiology &#40;ischemic versus non ischemic&#41; corresponds to a SHFM integrated parameter&#44; additional population stratification is redundant&#44; since CHF etiology clinical impact has been already taken into account in the SHFM survival results&#46;</p><p id="par0245" class="elsevierStylePara elsevierViewall">LV GLS by speckle tracking seems to have a good ability to stratify HF patients prognosis&#46; In this study&#44; LV GLS &#62;&#8722;9&#46;5&#37; indicated an increased risk of worse outcome&#46; These results may have clinical and practical impact as these patients often require a more aggressive medical treatment and monitoring&#46; Thus&#44; LV function assessment by speckle tracking-derived GLS should be encouraged in clinical practice&#46;</p><p id="par0250" class="elsevierStylePara elsevierViewall">Nonetheless&#44; intrinsic limitations of speckle tracking should be considered and include&#58; frame rate dependency&#44; potential errors in epicardial or endocardial border tracing due to suboptimal image quality&#44; and need for an appropriate learning curve to achieve adequate experience in using analysis softwares&#46; Because of beat-to-beat variation in AF patients&#44; LV GLS calculation may be more difficult to estimate&#46; Besides this&#44; lack of standardization with intermachine variability and frequent software upgrades&#44; resulting in different and changing references values are also limiting characteristics of speckle-tracking software&#46;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">26</span></a></p><p id="par0255" class="elsevierStylePara elsevierViewall">It is important to note that this validated multivariate model application provides a prognostic status approximation and does not replace the clinical and prognostic relevance of the information derived from a real long-term follow-up of the patients&#46; Future robust prospective long-term follow-up investigations should confirm these study results and provide further insight into the impact of myocardial deformation assessment on medical decisions&#44; regarding device implantations or cardiac transplant proposal&#46; Additional investigations might also explore the presence of other relevant clinical associations in CHF patients&#44; such as any relation between echocardiographic GLS and quality of life&#46;</p><span id="sec0080" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0140">Limitations</span><p id="par0260" class="elsevierStylePara elsevierViewall">All conclusions are supported by a developed prognostic model and not on the real evolution and follow-up of a CHF population&#46; Nevertheless&#44; SHFM is a widely validated model for predicting survival and assessing disease severity in outpatients with CHF&#44; based on multiple clinical variables known to have prognostic impact in CHF patients&#46;</p><p id="par0265" class="elsevierStylePara elsevierViewall">Speckle tracking 2D strain is highly dependent on image quality and the inherent limitation therein&#46; In addition&#44; radial and circumferential strains were not explored&#46; However&#44; longitudinal deformation is a particular marker of subendocardial function&#44; which is frequently the first layer to be affected when myocardial function deteriorates&#46; Thus&#44; longitudinal deformation appears to be a more sensitive marker of cardiac function compared to radial or circumferential strain&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a></p><p id="par0270" class="elsevierStylePara elsevierViewall">Finally&#44; our conclusions apply to CHF outpatients and should not be extrapolated for hospitalized patients or acute heart failure patients&#46;</p></span></span><span id="sec0085" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0145">Conclusions</span><p id="par0275" class="elsevierStylePara elsevierViewall">2D-echocardiographic LV GLS&#44; determined by speckle-tracking&#44; was significantly correlated with clinical and echocardiographic parameters of recognized prognostic value&#44; in patients with CHF and systolic dysfunction&#46; GLS was strongly associated to a higher severity disease status and predicted a lower prognostic estimate for life expectancy&#46;</p><p id="par0280" class="elsevierStylePara elsevierViewall">Future longitudinal studies are required to confirm the potential prognostic value of GLS measurements in the CHF population&#46;</p></span><span id="sec0095" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0150">Ethical disclosures</span><span id="sec0100" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0155">Protection of human and animal subjects</span><p id="par0290" class="elsevierStylePara elsevierViewall">The authors declare that no experiments were performed on humans or animals for this study&#46;</p></span><span id="sec0105" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0160">Confidentiality of data</span><p id="par0295" class="elsevierStylePara elsevierViewall">The authors declare that they have followed the protocols of their work center on the publication of patient data</p></span><span id="sec0110" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0165">Right to privacy and informed consent</span><p id="par0300" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appear in this article</p></span></span><span id="sec0090" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0170">Conflicts of interest</span><p id="par0285" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
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      "secciones" => array:12 [
        0 => array:2 [
          "identificador" => "xres381498"
          "titulo" => array:5 [
            0 => "Abstract"
            1 => "Introduction and objective"
            2 => "Methods"
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              "identificador" => "sec0015"
              "titulo" => "Population study"
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            1 => array:2 [
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              "titulo" => "SHFM application"
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            2 => array:2 [
              "identificador" => "sec0025"
              "titulo" => "Echocardiographic analysis"
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            3 => array:2 [
              "identificador" => "sec0030"
              "titulo" => "LV longitudinal strain analysis"
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            1 => array:2 [
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              "titulo" => "Baseline echocardiography"
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              "titulo" => "LV longitudinal strain analysis"
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            3 => array:2 [
              "identificador" => "sec0065"
              "titulo" => "Predictors of worse prognosis"
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              "identificador" => "sec0115"
              "titulo" => "Reproducibility"
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          "titulo" => "Ethical disclosures"
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            0 => array:2 [
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              "titulo" => "Protection of human and animal subjects"
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              "titulo" => "Confidentiality of data"
            ]
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              "identificador" => "sec0110"
              "titulo" => "Right to privacy and informed consent"
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          "identificador" => "sec0090"
          "titulo" => "Conflicts of interest"
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        11 => array:1 [
          "titulo" => "References"
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    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2013-09-16"
    "fechaAceptado" => "2014-01-02"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec360309"
          "palabras" => array:3 [
            0 => "Heart failure"
            1 => "Longitudinal strain"
            2 => "Prognosis"
          ]
        ]
      ]
      "pt" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palavras-chave"
          "identificador" => "xpalclavsec360310"
          "palabras" => array:3 [
            0 => "Insufici&#234;ncia card&#237;aca"
            1 => "<span class="elsevierStyleItalic">Strain</span> longitudinal global"
            2 => "Progn&#243;stico"
          ]
        ]
      ]
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    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0010">Introduction and objective</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">The prognostic value of myocardium deformation measurements in chronic heart failure &#40;CHF&#41; is still poorly addressed&#46; The purpose of this study was to evaluate the correlation of left ventricular &#40;LV&#41; global longitudinal strain &#40;GLS&#41; with clinical and prognostic indicators in patients with CHF and systolic dysfunction&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0015">Methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Ambulatory patients with CHF and LV ejection fraction &#40;LVEF&#41; &#60;45&#37; were studied by two-dimensional and Doppler transthoracic echocardiogram with assessment of GLS&#46; An indication of prognostic status was obtained by the Seattle Heart Failure Model &#40;SHFM&#41; prognostic estimates for life expectancy&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">We included 54 CHF patients &#40;mean age 55<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>12 years&#59; 80&#37; male&#41;&#46; GLS was significantly correlated with NYHA functional class &#40;r&#61;0&#46;41&#44; p&#61;0&#46;002&#41;&#44; BNP levels &#40;r&#61;0&#46;47&#44; p&#61;0&#46;001&#41;&#44; LVEF &#40;r&#61;&#8722;0&#46;69&#44; p&#60;0&#46;001&#41; and <span class="elsevierStyleBold">LV end-diastolic pressure</span>&#44; assessed by E&#47;e&#8217; ratio &#40;r&#61;0&#46;35&#44; p&#60;0&#46;014&#41; and left atrial maximal volume index &#40;r&#61;0&#46;57&#44; p&#60;0&#46;001&#41;&#46; A significant correlation was found between GLS and SHFM prognostic estimates for life expectancy &#40;r&#61;&#8722;0&#46;41&#44; p&#61;0&#46;002&#41;&#46; The multivariate logistic regression analysis showed that GLS independently predicted an estimated life expectancy &#60;10 years &#40;OR 2&#46;614 &#91;95&#37; CI 1&#46;010&#8211;6&#46;763&#93;&#41;&#46; The corresponding area under the ROC curve was 0&#46;802 &#40;0&#46;653&#8211;0&#46;951&#41; and the best obtained threshold was &#8722;9&#46;5 &#40;80&#37; sensitivity&#44; 65&#37; specificity&#44; p&#61;0&#46;003&#41;&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">GLS was strongly associated with a higher disease severity status and predicted a lower prognostic estimate for life expectancy&#46;</p>"
      ]
      "pt" => array:2 [
        "titulo" => "Resumo"
        "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0035">Introdu&#231;&#227;o e objetivo</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">O valor progn&#243;stico das medidas de deforma&#231;&#227;o mioc&#225;rdica na insufici&#234;ncia card&#237;aca cr&#243;nica &#40;ICC&#41; ainda n&#227;o est&#225; bem estabelecido&#46; Este estudo teve por objetivo avaliar a correla&#231;&#227;o do <span class="elsevierStyleItalic">strain</span> longitudinal global &#40;SLG&#41; do ventr&#237;culo esquerdo &#40;VE&#41; com indicadores cl&#237;nicos e progn&#243;sticos em doentes com ICC e disfun&#231;&#227;o sist&#243;lica&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0040">M&#233;todos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Doentes ambulatoriais&#44; com ICC e fra&#231;&#227;o de eje&#231;&#227;o do VE &#40;FEVE&#41; &#60;45&#37; realizaram ecocardiografia transtor&#225;cica bidimensional com Doppler&#44; com avalia&#231;&#227;o de SLG&#46; O indicador de <span class="elsevierStyleItalic">status</span> progn&#243;stico foi baseado na expectativa de vida estimada pelo modelo <span class="elsevierStyleItalic">Seattle Heart Failure Model</span> &#40;SHFM&#41;&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Inclu&#237;mos 54 doentes com ICC &#40;idade m&#233;dia de 55<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>12 anos&#44; 80&#37; do sexo masculino&#41;&#46; O SLG correlacionou-se significativamente com a classe funcional &#40;r&#61;0&#44;41&#44; p&#61;0&#44;002&#41;&#44; n&#237;veis de BNP &#40;r&#61;0&#44;47&#44; p&#61;0&#44;001&#41;&#44; FEVE &#40;r&#61;&#8722;0&#44;69&#44; p&#60;0&#44;001&#41;&#44; press&#227;o telediast&#243;lica do VE&#44; avaliada pela raz&#227;o E&#47;e&#8242; &#40;r&#61;0&#44;35&#44; p&#61;0&#44;014&#41; e pelo volume m&#225;ximo da aur&#237;cula esquerda &#40;r&#61;0&#44;57&#44; p&#60;0&#44;001&#41;&#46; Observou-se uma correla&#231;&#227;o significativa entre o SLG e a expectativa de vida estimada pelo modelo SHFM &#40;r&#61;&#8722;0&#44;41&#44; p&#61;0&#44;002&#41;&#46; Perante a an&#225;lise de regress&#227;o log&#237;stica multivariada&#44; o SLG mostrou ser um preditor independente de uma esperan&#231;a de vida estimada &#60;10 anos &#40;OR 2&#44;61 &#91;IC 95&#37; 1&#44;01&#8211;6&#44;76&#93;&#41;&#46; A &#225;rea sob a curva ROC foi de 0&#44;80 &#40;0&#44;65&#8211;0&#44;95&#41; e o melhor ponto de corte obtido foi &#8722;9&#44;5 &#40;80&#37; de sensibilidade&#44; especificidade de 65&#37;&#44; p&#61;0&#44;003&#41;&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0050">Conclus&#245;es</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">O SLG encontra-se associado a um estado de doen&#231;a de maior gravidade e foi preditor de uma esperan&#231;a de vida estimada mais baixa&#46;</p>"
      ]
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        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
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        "figura" => array:1 [
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        "descripcion" => array:1 [
          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">The area under the receiver operating characteristic curve for GLS to predict a life expectancy &#60;10 years&#46; AUC&#58; area under curve&#59; ROC&#58; receiver operating characteristic&#46;</p>"
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        "identificador" => "tbl0005"
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        "tabla" => array:3 [
          "leyenda" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Values are mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD or n &#40;&#37;&#41;&#46; ACEI&#58; angiotensin-converting enzyme inhibitor&#59; ARB&#58; angiotensin-receptor blocker&#59; BMI&#58; body mass index&#59; BNP&#58; B-type natriuretic peptide&#59; CHF&#58; chronic heart failure&#59; CRT-D&#58; cardiac resynchronization therapy defibrillator&#59; DT&#58; deceleration time&#59; E&#47;A ratio&#58; ratio of mitral peak velocity of early filling to mitral peak velocity of late filling&#59; E&#47;e&#8242; ratio&#58; ratio between early mitral inflow velocity and mitral annular early diastolic velocity&#59; EDV&#58; end-diastolic volume&#59; EF&#58; ejection fraction&#59; ESV&#58; end-systolic volume&#59; GLS&#58; global longitudinal strain&#59; ICD&#58; implantable cardioverter defibrillator&#59; LA&#58; left atrial&#59; LV&#58; left ventricular&#59; NYHA&#58; New York Heart Association&#59; RV&#58; right ventricular&#59; S&#8242;&#58; peak systolic velocity of the tricuspid annulus&#59; TDI&#58; tissue Doppler imaging&#46;</p>"
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                  \t\t\t\t">19 &#40;35&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Obesity &#40;BMI &#62;30&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18 &#40;33&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Renal insufficiency<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11 &#40;20&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Medical therapy&#44; n &#40;&#37;&#41;</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>ACEI and&#47;or ARB&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">51 &#40;94&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Beta-blockers&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">51 &#40;94&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Spironolactone&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">36 &#40;66&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Loop diuretics&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">38 &#40;70&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Calcium-blockers&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;11&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Statins&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">43 &#40;79&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Digoxin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10 &#40;18&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Devices therapy&#44; n &#40;&#37;&#41;</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>ICD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11 &#40;20&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>CRT-D&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;11&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">NYHA class I&#44; n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15 &#40;27&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">NYHA class II&#44; n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">32 &#40;59&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">NYHA class III&#44; n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7 &#40;13&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">BNP &#40;pg&#47;ml&#41;&#44; median &#40;P</span><span class="elsevierStyleInf"><span class="elsevierStyleItalic">25-75</span></span><span class="elsevierStyleItalic">&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">186&#46;3 &#40;55&#46;9&#8211;560&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Creatinine clearance &#40;ml&#47;min&#41;&#44; mean &#40;SD&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">88&#46;1 &#40;37&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Hemoglobin &#40;g&#47;dL&#41;&#44; mean &#40;SD&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14&#46;0 &#40;1&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Sinus rhythm&#44; N &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">49 &#40;90&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Echocardiography &#40;n&#61;54&#41;</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">GLS &#40;&#37;&#41;&#44; mean &#40;SD&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;10&#46;4 &#40;3&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">EF &#40;&#37;&#41;&#44; mean &#40;SD&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">27&#46;0 &#40;8&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">LV EDV index &#40;ml&#47;m</span><span class="elsevierStyleSup"><span class="elsevierStyleItalic">2</span></span><span class="elsevierStyleItalic">&#41;&#44; mean &#40;SD&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">116&#46;0 &#40;40&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">LV ESV index &#40;ml&#47;m</span><span class="elsevierStyleSup"><span class="elsevierStyleItalic">2</span></span><span class="elsevierStyleItalic">&#41;&#44; mean &#40;SD&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">86&#46;8 &#40;38&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">LV mass index &#40;g&#47;m</span><span class="elsevierStyleSup"><span class="elsevierStyleItalic">2</span></span><span class="elsevierStyleItalic">&#41;&#44; mean &#40;SD&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">173&#46;9 &#40;53&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">LA maximal volume index &#40;ml&#47;m</span><span class="elsevierStyleSup"><span class="elsevierStyleItalic">2</span></span><span class="elsevierStyleItalic">&#41;&#44; mean &#40;SD&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">35&#46;9 &#40;17&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Mitral E&#47;A ratio&#44; mean &#40;SD&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;3 &#40;0&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Mitral DT &#40;ms&#41;&#44; mean &#40;SD&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">192&#46;7 &#40;54&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">E&#47;e¿ ratio&#44; mean &#40;SD&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12&#46;7 &#40;5&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">RV S¿ TDI &#40;cm&#47;s&#41;&#44; mean &#40;SD&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11&#46;8 &#40;2&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">RV systolic dysfunction &#40;S¿ TDI&#60;10&#41;&#44; n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;11&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
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                0 => "xTab581533.png"
              ]
            ]
          ]
          "notaPie" => array:1 [
            0 => array:3 [
              "identificador" => "tblfn0005"
              "etiqueta" => "a"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Creatinine clearance &#60; 60<span class="elsevierStyleHsp" style=""></span>ml&#47;min &#40;estimated using Modification of Diet in Renal Disease &#40;MDRD&#41; formula&#46;</p>"
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Clinical and echocardiographic characteristics&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "tbl0010"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">BNP&#58; B-type natriuretic peptide&#59; E&#47;e&#8242; ratio&#58; ratio between early mitral inflow velocity and mitral annular early diastolic velocity&#59; EDV&#58; end-diastolic volume&#59; EF&#58; ejection fraction&#59; ESV&#58; end-systolic volume&#59; GLS&#58; global longitudinal strain&#59; LA&#58; left atrial&#59; LV&#58; left ventricular&#59; NS&#58; non-significant&#59; NYHA&#58; New York Heart Association&#59; RV&#58; right ventricular&#59; S&#8242;&#58; peak systolic velocity of the tricuspid annulus&#59; SHFM&#58; Seattle Heart Failure Model&#59; TDI&#58; tissue Doppler imaging&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Variable&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Pearson&#39;s r&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Age &#40;years&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;27&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NYHA class&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;41&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;002&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">BNP &#40;pg&#47;ml&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;47&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EF &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;69&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">LVEDV index &#40;ml&#47;m<span class="elsevierStyleSup">2</span>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">LVESV index &#40;ml&#47;m<span class="elsevierStyleSup">2</span>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;68&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">LV mass index &#40;g&#47;m<span class="elsevierStyleSup">2</span>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;29&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;046&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">LA maximal volume index &#40;ml&#47;m<span class="elsevierStyleSup">2</span>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;57&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">E&#47;e&#8242; ratio&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;35&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;014&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">RV S&#8242; TDI &#40;cm&#47;s&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;32&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;031&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">SHFM&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;41&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;002&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
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                0 => "xTab581534.png"
              ]
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        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Univariate correlations between LV GLS and clinical and echocardiographic indices&#46;</p>"
        ]
      ]
      3 => array:7 [
        "identificador" => "tbl0015"
        "etiqueta" => "Table 3"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">BNP&#58; B-type natriuretic peptide&#59; E&#47;e&#8242; ratio&#58; ratio between early mitral inflow velocity and mitral annular early diastolic velocity&#59; EDV&#58; end-diastolic volume&#59; GLS&#58; global longitudinal strain&#59; LA&#58; left atrial&#59; LV&#58; left ventricular&#59; NS&#58; non-significant&#59; RV&#58; right ventricular&#59; S&#8242;&#58; peak systolic velocity of the tricuspid annulus&#59; SHFM&#58; Seattle Heart Failure Model&#59; TDI&#58; tissue Doppler imaging&#46;</p>"
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              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Variable&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">HR &#40;95&#37; CI&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">HR &#40;95&#37; CI&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">BNP &#40;pg&#47;ml&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;001 &#40;1&#46;000&#8211;1&#46;002&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;013&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;001 &#40;1&#46;000&#8211;1&#46;003&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">GLS &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;544 &#40;1&#46;121&#8211;2&#46;128&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;008&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;614 &#40;1&#46;010&#8211;6&#46;763&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;048&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">LV EDV index &#40;ml&#47;m<span class="elsevierStyleSup">2</span>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;999 &#40;0&#46;977&#8211;1&#46;022&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NS&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#46;997 &#40;0&#46;983&#8211;1&#46;012&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">NS&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">RV S&#8242; TDI &#40;cm&#47;s&#41;&nbsp;\t\t\t\t\t\t\n
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                            0 => "W&#46;C&#46; Levy"
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                            0 => "R&#46;M&#46; Lang"
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Original Article
Global longitudinal strain as a potential prognostic marker in patients with chronic heart failure and systolic dysfunction
Strain longitudinal global como um potencial marcador de prognóstico em doentes com insuficiência cardíaca crónica e disfunção sistólica
Inês Rangela,b,
Corresponding author
inesrang@gmail.com

Corresponding author.
, Alexandra Gonçalvesb, Carla de Sousaa,b, Pedro Bernardo Almeidaa,b, João Rodriguesb, Filipe Macedoa,b, José Silva Cardosoa,b, Ma Júlia Maciela
a Cardiology Department, Centro Hospitalar de S. João, Porto, Portugal
b Faculty of Medicine of Porto University, Porto, Portugal
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based on the LV active shortening in the longitudinal direction&#44; which is more reproducible than LVEF and does not rely on geometrical assumptions&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7&#44;8</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Some authors have suggested that GLS is useful in the prediction of cardiovascular &#40;CV&#41; events&#44; in various heart diseases and clinical conditions&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9&#8211;11</span></a> Nahum et al<span class="elsevierStyleItalic">&#46;</span><a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> showed that in CHF patients&#44; GLS determined by speckle-tracking is superior to LVEF in identifying patients with poor clinical outcome&#46; However&#44; its ability to assess disease severity in CHF is still poorly addressed&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The Seattle Heart Failure Model Score &#40;SHFM&#41; is a validated multimarker risk assessment tool developed to predict prognosis in patients with CHF&#44; which was derived from a cohort of 1125 HF patients and was prospectively validated in five additional outpatient cohorts including 9942 HF patients&#46; It provides an accurate estimation of 1-&#44; 2-&#44; and 5-year survival&#44; as well as of life expectancy using commonly obtained clinical&#44; laboratory and therapeutic &#40;pharmacologic and device&#41; information&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">The purpose of this study was to evaluate the LV GLS association with clinical and prognostic indicators in patients with CHF and systolic dysfunction&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Methods</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Population study</span><p id="par0035" class="elsevierStylePara elsevierViewall">The present study consisted of a cross-sectional analysis of clinical and echocardiographic data from ambulatory CHF patients&#44; 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to tissue Doppler mitral annular early diastolic velocity &#40;e&#8242; by TDI&#41; was used to assess LV end-diastolic pressure &#40;LVEDP&#41;&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">LV longitudinal strain analysis</span><p id="par0080" class="elsevierStylePara elsevierViewall">GLS was assessed in the 18 LV segments from the three standard apical views &#40;4-chamber&#44; 2-chamber&#44; 3-chamber&#41;&#44; using a speckle tracking software&#46; For strain processing&#44; the peak of the R wave on the electrocardiogram was used as the reference time point for end-diastole&#46; The endocardial border was traced manually in the end-diastolic frame&#46; The software subsequently and automatically traced the borders in the other frames&#46; Segments which failed to track were manually adjusted by the operator&#46; Any segments which subsequently failed to track were excluded from the analysis&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">In AF patients&#44; cine loops were analyzed to determine which index beat should be used to GLS calculation&#46; The speckle tracking software was able to successfully and appropriately track the frame-to-frame movement of LV segments if cardiac cycle of the index beat was &#62;500 ms and if the preceding and pre preceding intervals of the index beat were of nearly equal duration &#40;&#60;60 ms&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a></p><p id="par0090" class="elsevierStylePara elsevierViewall">GLS was obtained only in the case of adequate tracking quality &#8805;5 of the six segments per view&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">Graphical displays of deformation parameters for each segment were then generated automatically&#46; GLS was obtained by averaging the peak strain values from the 18 regional longitudinal strain curves&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Reproducibility</span><p id="par0100" class="elsevierStylePara elsevierViewall">Fifteen patients were randomly selected for evaluation of the interobserver variability of GLS measurement by two independent observers&#46; To get the intraobsever variability&#44; the same measurement was repeated three to six months apart&#46; Reproducibility was expressed as the mean absolute difference&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Statistical analysis</span><p id="par0105" class="elsevierStylePara elsevierViewall">Continuous variables with normal distribution were expressed as mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD and skewed variables as median and quartiles&#46; Categorical variables were expressed as percentages&#46; The comparison of continuous variables was performed by an independent sample <span class="elsevierStyleItalic">t</span> test&#46; For categorical variables&#44; the chi-square test was used&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">A Pearson correlation analysis was used to evaluate the strength of the association between continuous variables&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">A logistic regression model was used for multivariate analysis to investigate which prognostic factors identified using univariate analysis were independently associated with a lower survival &#40;&#60;10 years of life expectancy derived from SHFM&#41;&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">Receiver-operating characteristic &#40;ROC&#41; curve analysis was used to determine optimal cutoff value of continuous variable&#46; The best cutoff value was defined as the point with the highest sum of sensitivity and specificity&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">Two-tailed p-values &#60;0&#46;05 were considered statistically significant&#46; Statistical analysis was performed using SPSS Statistics version 19&#46;0 &#40;SPSS Inc&#46;&#44; Chicago&#44; Illinois&#41;&#46;</p></span></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Results</span><p id="par0130" class="elsevierStylePara elsevierViewall">Of the 62 patients included&#44; adequate echocardiographic tracking quality of the LV segments&#44; allowing appropriate GLS analysis&#44; was feasible in 54 &#40;87&#37;&#41; patients &#40;54&#46;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>12&#46;1 years&#44; 79&#46;1&#37; men&#41;&#44; which constituted the final patient population&#46; Three of the eight excluded patients had AF&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">The clinical and echocardiographic characteristics of the overall patient population are summarized in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Patient population</span><p id="par0140" class="elsevierStylePara elsevierViewall">Dyslipidemia&#44; hypertension&#44; and diabetes were present in 43 &#40;80&#37;&#41;&#44; 23 &#40;43&#37;&#41; and 16 &#40;30&#37;&#41; patients&#44; respectively&#46; Ischemic etiology was present in 30&#37; and 59&#37; of the patients were in NYHA functional class II&#46; Median BNP level was relatively low&#58; 186&#46;3 &#91;P<span class="elsevierStyleInf">25-75</span> 55&#46;9&#8211;560&#46;1&#93; pg&#47;ml&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">Most patients were treated with beta-blockers &#40;94&#37;&#41; and angiotensin converting enzyme inhibitors or angiotensin-receptor blockers &#40;94&#37;&#41;&#46; Diuretics&#44; spironolactone and statins were also frequently used in this patient population &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">In addition&#44; 11 &#40;20&#37;&#41; patients had an implantable cardioverter defibrillator &#40;ICD&#41; device and 6 &#40;11&#37;&#41; had a cardiac resynchronization therapy defibrillator &#40;CRT-D&#41; device&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Baseline echocardiography</span><p id="par0155" class="elsevierStylePara elsevierViewall">End diastolic and systolic volumes averaged 116&#46;0<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>40&#46;25 ml&#47;m<span class="elsevierStyleSup">2</span> and 86&#46;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>38&#46;56 ml&#47;m<span class="elsevierStyleSup">2</span>&#44; respectively&#46; Mean LVEF was 27&#46;0<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>8&#46;8&#37; and E&#47;e&#8242; ratio averaged 12&#46;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#46;4&#46; RVSD was observed in 11&#37; of the patients and mean peak systolic velocity of the tricuspid annulus by tissue Doppler imaging &#40;RV S&#8242; TDI&#41; averaged 11&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#46;3 cm&#47;s&#46;</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">LV longitudinal strain analysis</span><p id="par0160" class="elsevierStylePara elsevierViewall">The mean GLS was &#8722;10&#46;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#46;1&#37;&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">GLS was found to be highly associated with various clinical and echocardiographic variables&#59; relevant correlations are summarized in <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0170" class="elsevierStylePara elsevierViewall">GLS was significantly related to NYHA functional class &#40;r&#61;0&#46;41&#44; p&#61;0&#46;002&#41; and BNP levels &#40;r&#61;0&#46;47&#44; p&#61;0&#46;001&#41;&#46;</p><p id="par0175" class="elsevierStylePara elsevierViewall">GLS presented a good correlation with LV end-diastolic volume index &#40;r&#61;0&#46;60&#44; p&#60;0&#46;001&#41;&#44; LV end-systolic volume index &#40;r&#61;0&#46;68&#44; p&#60;0&#46;001&#41; and with LVEF &#40;r&#61;-0&#46;69&#44; p&#60;0&#46;001&#41;&#46;</p><p id="par0180" class="elsevierStylePara elsevierViewall">The magnitude of GLS showed a moderate correlation with RVSF assessed by TDI-derived peak systolic tricuspid velocity &#40;r&#61;&#8722;0&#46;32&#44; p&#61;0&#46;031&#41; and <span class="elsevierStyleBold">LV filling pressure</span>&#44; assessed by E&#47;e&#8242; ratio &#40;r&#61;0&#46;35&#44; p&#61;0&#46;014&#41; and LA maximal volume index &#40;r&#61;0&#46;57&#44; p&#60;0&#46;001&#41;&#46;</p><p id="par0185" class="elsevierStylePara elsevierViewall">Finally&#44; a significant correlation was found between GLS and SHFM prognostic estimates for life expectancy &#40;r&#61;&#8722;0&#46;41&#44; p&#61;0&#46;002&#41;&#46;</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Predictors of worse prognosis</span><p id="par0190" class="elsevierStylePara elsevierViewall">Univariate analysis using a logistic regression model &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#41; showed that GLS predicted a life expectancy &#60;10 years&#44; derived from SHFM &#40;OR 1&#46;544&#44; p&#61;0&#46;008&#41;&#46; Other relevant variables found to be significantly associated to a worse survival included BNP levels &#40;OR 1&#46;001&#44; p&#61;0&#46;013&#41;&#44; E&#47;e&#8242; ratio &#40;OR 1&#46;241&#44; p&#61;0&#46;012&#41; and LA maximal volume &#40;OR 1&#46;071&#44; p&#61;0&#46;021&#41;&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0195" class="elsevierStylePara elsevierViewall">In a multivariate analysis adjusted to E&#47;e&#8242; ratio and BNP &#40;significant variables not contributing to the SHFM&#41;&#44; GLS remained a significant independent predictor of survival &#40;OR 2&#46;614&#44; 95&#37; CI&#58; 1&#46;010&#8211;6&#46;763&#44; p&#61;0&#46;048&#41;&#46;</p><p id="par0200" class="elsevierStylePara elsevierViewall">The area under the receiver operating characteristic curve &#40;AUC&#41; for GLS to predict a life expectancy &#60;10 years was highly relevant &#40;AUC&#58; 0&#46;802 &#91;0&#46;653&#8211;0&#46;951&#93;&#41; and a GLS cut-off &#62;&#8722;9&#46;5&#37; identified patients with poor prognosis &#40;80&#37; sensitivity&#44; 65&#37; specificity&#44; p&#61;0&#46;003&#41; &#8211; <a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a>&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0115" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Reproducibility</span><p id="par0205" class="elsevierStylePara elsevierViewall">The intraobserver and interobserver mean difference for GLS measurement were 0&#46;47<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;40 and 0&#46;86<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;56&#44; respectively&#46;</p></span></span><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0135">Discussion</span><p id="par0210" class="elsevierStylePara elsevierViewall">Myocardial function assessment significantly influences therapeutic decision making&#44; including devices implantation&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> In daily practice&#44; myocardial function is based on LVEF by echocardiography using the Simpson biplane model&#46; However&#44; this method has several limitations&#58; it is based on geometric assumptions and depends on image quality&#44; on load conditions and on the experience of the operator&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> In addition&#44; LVEF lacks sensitivity to accurately identify myocardial contractility impairment&#46;<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">16&#8211;18</span></a> In the present study&#44; global systolic LV myocardial function was determined with 2D speckle tracking strain analysis&#44; which is feasible&#44; reproducible&#44; angle independent and does not rely on geometry assumptions&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> 2D-echocardiographic TDI is also available to LVSF assessment&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a> However&#44; some limitations should be noted&#58; it is angle dependent and it appears more noised and less robust compared to speckle tracking modality&#46;</p><p id="par0215" class="elsevierStylePara elsevierViewall">The characteristics of this study population are partly different from other groups of CHF patients&#44; as our patients are younger and we present a high number of CHF patients with non-ischemic etiology&#44; like familial dilated cardiomyopathies&#46; This can be explained by the specific purposes of the outpatient clinic that receives potential candidates for cardiac transplantation&#46;</p><p id="par0220" class="elsevierStylePara elsevierViewall">NYHA functional class and BNP levels were significantly correlated with GLS&#46; Donal et al&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a> shown an important association between GLS and functional capacity&#44; assessed by cardiopulmonary exercise testing performance&#46; Yoneyama et al&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a> had also found a close correlation between longitudinal LV strain and BNP levels&#46; The apparent clinical stability and the exclusively outpatient setting probably contributed to the relatively low NYHA functional class and BNP levels for a CHF population with depressed LVEF&#46;</p><p id="par0225" class="elsevierStylePara elsevierViewall">The good correlation found in the current evaluation between GLS and LVEF is consistent with the scientific literature&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8&#44;22</span></a></p><p id="par0230" class="elsevierStylePara elsevierViewall">Furthermore&#44; a variety of echocardiographic parameters have been suggested to estimate LV filling pressure in CHF&#46; The E&#47;e&#8242; ratio is the most frequently used parameter for this purpose and&#44; along with E-wave deceleration time &#40;DT&#41;&#44; has become central in this evaluation&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">23</span></a></p><p id="par0235" class="elsevierStylePara elsevierViewall">LA maximal volume index is gaining incremental relevance and has been recognized as a reflection of severity and chronicity of diastolic dysfunction and as an independent predictor of mortality&#44; both CV as well as all-cause&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a> New studies are focusing in the role of LA function and LA strain in diastolic function evaluation and prognostic information&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">25</span></a> In this analysis&#44; a lower magnitude of GLS was associated with worsening LV diastolic function&#44; assessed by E&#47;e&#8242; ratio and LA maximal volume index&#46;</p><p id="par0240" class="elsevierStylePara elsevierViewall">Previous reports have already shown that GLS is a sensitive measure of LV mechanics and is a good predictor of CV events&#44; in various heart diseases and clinical conditions&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9&#8211;11</span></a> This study showed that GLS is highly associated to disease severity status and is an independent predictor of survival&#44; according to the integrated assessment provided by SHFM&#46; This model simultaneously weights a large number of clinical&#44; laboratory and therapeutics variables with established prognostic impact&#46; This is the first study that relates a myocardial deformation marker with a prognostic indicator derived by a multivariable risk assessment tool&#46; The SHFM integrated approach is highly advantageous and provides feasibility and accuracy to investigations&#46; For example&#44; because CHF etiology &#40;ischemic versus non ischemic&#41; corresponds to a SHFM integrated parameter&#44; additional population stratification is redundant&#44; since CHF etiology clinical impact has been already taken into account in the SHFM survival results&#46;</p><p id="par0245" class="elsevierStylePara elsevierViewall">LV GLS by speckle tracking seems to have a good ability to stratify HF patients prognosis&#46; In this study&#44; LV GLS &#62;&#8722;9&#46;5&#37; indicated an increased risk of worse outcome&#46; These results may have clinical and practical impact as these patients often require a more aggressive medical treatment and monitoring&#46; Thus&#44; LV function assessment by speckle tracking-derived GLS should be encouraged in clinical practice&#46;</p><p id="par0250" class="elsevierStylePara elsevierViewall">Nonetheless&#44; intrinsic limitations of speckle tracking should be considered and include&#58; frame rate dependency&#44; potential errors in epicardial or endocardial border tracing due to suboptimal image quality&#44; and need for an appropriate learning curve to achieve adequate experience in using analysis softwares&#46; Because of beat-to-beat variation in AF patients&#44; LV GLS calculation may be more difficult to estimate&#46; Besides this&#44; lack of standardization with intermachine variability and frequent software upgrades&#44; resulting in different and changing references values are also limiting characteristics of speckle-tracking software&#46;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">26</span></a></p><p id="par0255" class="elsevierStylePara elsevierViewall">It is important to note that this validated multivariate model application provides a prognostic status approximation and does not replace the clinical and prognostic relevance of the information derived from a real long-term follow-up of the patients&#46; Future robust prospective long-term follow-up investigations should confirm these study results and provide further insight into the impact of myocardial deformation assessment on medical decisions&#44; regarding device implantations or cardiac transplant proposal&#46; Additional investigations might also explore the presence of other relevant clinical associations in CHF patients&#44; such as any relation between echocardiographic GLS and quality of life&#46;</p><span id="sec0080" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0140">Limitations</span><p id="par0260" class="elsevierStylePara elsevierViewall">All conclusions are supported by a developed prognostic model and not on the real evolution and follow-up of a CHF population&#46; Nevertheless&#44; SHFM is a widely validated model for predicting survival and assessing disease severity in outpatients with CHF&#44; based on multiple clinical variables known to have prognostic impact in CHF patients&#46;</p><p id="par0265" class="elsevierStylePara elsevierViewall">Speckle tracking 2D strain is highly dependent on image quality and the inherent limitation therein&#46; In addition&#44; radial and circumferential strains were not explored&#46; However&#44; longitudinal deformation is a particular marker of subendocardial function&#44; which is frequently the first layer to be affected when myocardial function deteriorates&#46; Thus&#44; longitudinal deformation appears to be a more sensitive marker of cardiac function compared to radial or circumferential strain&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a></p><p id="par0270" class="elsevierStylePara elsevierViewall">Finally&#44; our conclusions apply to CHF outpatients and should not be extrapolated for hospitalized patients or acute heart failure patients&#46;</p></span></span><span id="sec0085" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0145">Conclusions</span><p id="par0275" class="elsevierStylePara elsevierViewall">2D-echocardiographic LV GLS&#44; determined by speckle-tracking&#44; was significantly correlated with clinical and echocardiographic parameters of recognized prognostic value&#44; in patients with CHF and systolic dysfunction&#46; GLS was strongly associated to a higher severity disease status and predicted a lower prognostic estimate for life expectancy&#46;</p><p id="par0280" class="elsevierStylePara elsevierViewall">Future longitudinal studies are required to confirm the potential prognostic value of GLS measurements in the CHF population&#46;</p></span><span id="sec0095" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0150">Ethical disclosures</span><span id="sec0100" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0155">Protection of human and animal subjects</span><p id="par0290" class="elsevierStylePara elsevierViewall">The authors declare that no experiments were performed on humans or animals for this study&#46;</p></span><span id="sec0105" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0160">Confidentiality of data</span><p id="par0295" class="elsevierStylePara elsevierViewall">The authors declare that they have followed the protocols of their work center on the publication of patient data</p></span><span id="sec0110" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0165">Right to privacy and informed consent</span><p id="par0300" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appear in this article</p></span></span><span id="sec0090" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0170">Conflicts of interest</span><p id="par0285" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
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        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0010">Introduction and objective</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">The prognostic value of myocardium deformation measurements in chronic heart failure &#40;CHF&#41; is still poorly addressed&#46; The purpose of this study was to evaluate the correlation of left ventricular &#40;LV&#41; global longitudinal strain &#40;GLS&#41; with clinical and prognostic indicators in patients with CHF and systolic dysfunction&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0015">Methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Ambulatory patients with CHF and LV ejection fraction &#40;LVEF&#41; &#60;45&#37; were studied by two-dimensional and Doppler transthoracic echocardiogram with assessment of GLS&#46; An indication of prognostic status was obtained by the Seattle Heart Failure Model &#40;SHFM&#41; prognostic estimates for life expectancy&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">We included 54 CHF patients &#40;mean age 55<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>12 years&#59; 80&#37; male&#41;&#46; GLS was significantly correlated with NYHA functional class &#40;r&#61;0&#46;41&#44; p&#61;0&#46;002&#41;&#44; BNP levels &#40;r&#61;0&#46;47&#44; p&#61;0&#46;001&#41;&#44; LVEF &#40;r&#61;&#8722;0&#46;69&#44; p&#60;0&#46;001&#41; and <span class="elsevierStyleBold">LV end-diastolic pressure</span>&#44; assessed by E&#47;e&#8217; ratio &#40;r&#61;0&#46;35&#44; p&#60;0&#46;014&#41; and left atrial maximal volume index &#40;r&#61;0&#46;57&#44; p&#60;0&#46;001&#41;&#46; A significant correlation was found between GLS and SHFM prognostic estimates for life expectancy &#40;r&#61;&#8722;0&#46;41&#44; p&#61;0&#46;002&#41;&#46; The multivariate logistic regression analysis showed that GLS independently predicted an estimated life expectancy &#60;10 years &#40;OR 2&#46;614 &#91;95&#37; CI 1&#46;010&#8211;6&#46;763&#93;&#41;&#46; The corresponding area under the ROC curve was 0&#46;802 &#40;0&#46;653&#8211;0&#46;951&#41; and the best obtained threshold was &#8722;9&#46;5 &#40;80&#37; sensitivity&#44; 65&#37; specificity&#44; p&#61;0&#46;003&#41;&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">GLS was strongly associated with a higher disease severity status and predicted a lower prognostic estimate for life expectancy&#46;</p>"
      ]
      "pt" => array:2 [
        "titulo" => "Resumo"
        "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0035">Introdu&#231;&#227;o e objetivo</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">O valor progn&#243;stico das medidas de deforma&#231;&#227;o mioc&#225;rdica na insufici&#234;ncia card&#237;aca cr&#243;nica &#40;ICC&#41; ainda n&#227;o est&#225; bem estabelecido&#46; Este estudo teve por objetivo avaliar a correla&#231;&#227;o do <span class="elsevierStyleItalic">strain</span> longitudinal global &#40;SLG&#41; do ventr&#237;culo esquerdo &#40;VE&#41; com indicadores cl&#237;nicos e progn&#243;sticos em doentes com ICC e disfun&#231;&#227;o sist&#243;lica&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0040">M&#233;todos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Doentes ambulatoriais&#44; com ICC e fra&#231;&#227;o de eje&#231;&#227;o do VE &#40;FEVE&#41; &#60;45&#37; realizaram ecocardiografia transtor&#225;cica bidimensional com Doppler&#44; com avalia&#231;&#227;o de SLG&#46; O indicador de <span class="elsevierStyleItalic">status</span> progn&#243;stico foi baseado na expectativa de vida estimada pelo modelo <span class="elsevierStyleItalic">Seattle Heart Failure Model</span> &#40;SHFM&#41;&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Inclu&#237;mos 54 doentes com ICC &#40;idade m&#233;dia de 55<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>12 anos&#44; 80&#37; do sexo masculino&#41;&#46; O SLG correlacionou-se significativamente com a classe funcional &#40;r&#61;0&#44;41&#44; p&#61;0&#44;002&#41;&#44; n&#237;veis de BNP &#40;r&#61;0&#44;47&#44; p&#61;0&#44;001&#41;&#44; FEVE &#40;r&#61;&#8722;0&#44;69&#44; p&#60;0&#44;001&#41;&#44; press&#227;o telediast&#243;lica do VE&#44; avaliada pela raz&#227;o E&#47;e&#8242; &#40;r&#61;0&#44;35&#44; p&#61;0&#44;014&#41; e pelo volume m&#225;ximo da aur&#237;cula esquerda &#40;r&#61;0&#44;57&#44; p&#60;0&#44;001&#41;&#46; Observou-se uma correla&#231;&#227;o significativa entre o SLG e a expectativa de vida estimada pelo modelo SHFM &#40;r&#61;&#8722;0&#44;41&#44; p&#61;0&#44;002&#41;&#46; Perante a an&#225;lise de regress&#227;o log&#237;stica multivariada&#44; o SLG mostrou ser um preditor independente de uma esperan&#231;a de vida estimada &#60;10 anos &#40;OR 2&#44;61 &#91;IC 95&#37; 1&#44;01&#8211;6&#44;76&#93;&#41;&#46; A &#225;rea sob a curva ROC foi de 0&#44;80 &#40;0&#44;65&#8211;0&#44;95&#41; e o melhor ponto de corte obtido foi &#8722;9&#44;5 &#40;80&#37; de sensibilidade&#44; especificidade de 65&#37;&#44; p&#61;0&#44;003&#41;&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0050">Conclus&#245;es</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">O SLG encontra-se associado a um estado de doen&#231;a de maior gravidade e foi preditor de uma esperan&#231;a de vida estimada mais baixa&#46;</p>"
      ]
    ]
    "multimedia" => array:4 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1590
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        "descripcion" => array:1 [
          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">The area under the receiver operating characteristic curve for GLS to predict a life expectancy &#60;10 years&#46; AUC&#58; area under curve&#59; ROC&#58; receiver operating characteristic&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:3 [
          "leyenda" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Values are mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD or n &#40;&#37;&#41;&#46; ACEI&#58; angiotensin-converting enzyme inhibitor&#59; ARB&#58; angiotensin-receptor blocker&#59; BMI&#58; body mass index&#59; BNP&#58; B-type natriuretic peptide&#59; CHF&#58; chronic heart failure&#59; CRT-D&#58; cardiac resynchronization therapy defibrillator&#59; DT&#58; deceleration time&#59; E&#47;A ratio&#58; ratio of mitral peak velocity of early filling to mitral peak velocity of late filling&#59; E&#47;e&#8242; ratio&#58; ratio between early mitral inflow velocity and mitral annular early diastolic velocity&#59; EDV&#58; end-diastolic volume&#59; EF&#58; ejection fraction&#59; ESV&#58; end-systolic volume&#59; GLS&#58; global longitudinal strain&#59; ICD&#58; implantable cardioverter defibrillator&#59; LA&#58; left atrial&#59; LV&#58; left ventricular&#59; NYHA&#58; New York Heart Association&#59; RV&#58; right ventricular&#59; S&#8242;&#58; peak systolic velocity of the tricuspid annulus&#59; TDI&#58; tissue Doppler imaging&#46;</p>"
          "tablatextoimagen" => array:1 [
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                  \t\t\t\t">43 &#40;79&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Ischemic&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">16 &#40;29&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Idiopathic&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">17 &#40;31&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Alcoholic&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">8 &#40;14&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Familial&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">5 &#40;9&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Other&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">8 &#40;14&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Comorbidities&#44; n &#40;&#37;&#41;</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">43 &#40;79&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">23 &#40;42&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">16 &#40;29&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Smoking&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">19 &#40;35&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Obesity &#40;BMI &#62;30&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">18 &#40;33&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11 &#40;20&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">51 &#40;94&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Beta-blockers&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">51 &#40;94&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Spironolactone&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">36 &#40;66&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Loop diuretics&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">38 &#40;70&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Calcium-blockers&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;11&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Statins&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">43 &#40;79&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Digoxin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10 &#40;18&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Devices therapy&#44; n &#40;&#37;&#41;</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>ICD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11 &#40;20&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>CRT-D&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;11&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">NYHA class I&#44; n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15 &#40;27&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">NYHA class II&#44; n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">32 &#40;59&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">NYHA class III&#44; n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7 &#40;13&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">BNP &#40;pg&#47;ml&#41;&#44; median &#40;P</span><span class="elsevierStyleInf"><span class="elsevierStyleItalic">25-75</span></span><span class="elsevierStyleItalic">&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">186&#46;3 &#40;55&#46;9&#8211;560&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Creatinine clearance &#40;ml&#47;min&#41;&#44; mean &#40;SD&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">88&#46;1 &#40;37&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Hemoglobin &#40;g&#47;dL&#41;&#44; mean &#40;SD&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14&#46;0 &#40;1&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Sinus rhythm&#44; N &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">49 &#40;90&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Echocardiography &#40;n&#61;54&#41;</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">GLS &#40;&#37;&#41;&#44; mean &#40;SD&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;10&#46;4 &#40;3&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">EF &#40;&#37;&#41;&#44; mean &#40;SD&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">27&#46;0 &#40;8&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">LV EDV index &#40;ml&#47;m</span><span class="elsevierStyleSup"><span class="elsevierStyleItalic">2</span></span><span class="elsevierStyleItalic">&#41;&#44; mean &#40;SD&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">116&#46;0 &#40;40&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">LV ESV index &#40;ml&#47;m</span><span class="elsevierStyleSup"><span class="elsevierStyleItalic">2</span></span><span class="elsevierStyleItalic">&#41;&#44; mean &#40;SD&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">86&#46;8 &#40;38&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">LV mass index &#40;g&#47;m</span><span class="elsevierStyleSup"><span class="elsevierStyleItalic">2</span></span><span class="elsevierStyleItalic">&#41;&#44; mean &#40;SD&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">173&#46;9 &#40;53&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">LA maximal volume index &#40;ml&#47;m</span><span class="elsevierStyleSup"><span class="elsevierStyleItalic">2</span></span><span class="elsevierStyleItalic">&#41;&#44; mean &#40;SD&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">35&#46;9 &#40;17&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Mitral E&#47;A ratio&#44; mean &#40;SD&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;3 &#40;0&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Mitral DT &#40;ms&#41;&#44; mean &#40;SD&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">192&#46;7 &#40;54&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">E&#47;e¿ ratio&#44; mean &#40;SD&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12&#46;7 &#40;5&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">RV S¿ TDI &#40;cm&#47;s&#41;&#44; mean &#40;SD&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11&#46;8 &#40;2&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">RV systolic dysfunction &#40;S¿ TDI&#60;10&#41;&#44; n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;11&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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          "leyenda" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">BNP&#58; B-type natriuretic peptide&#59; E&#47;e&#8242; ratio&#58; ratio between early mitral inflow velocity and mitral annular early diastolic velocity&#59; EDV&#58; end-diastolic volume&#59; EF&#58; ejection fraction&#59; ESV&#58; end-systolic volume&#59; GLS&#58; global longitudinal strain&#59; LA&#58; left atrial&#59; LV&#58; left ventricular&#59; NS&#58; non-significant&#59; NYHA&#58; New York Heart Association&#59; RV&#58; right ventricular&#59; S&#8242;&#58; peak systolic velocity of the tricuspid annulus&#59; SHFM&#58; Seattle Heart Failure Model&#59; TDI&#58; tissue Doppler imaging&#46;</p>"
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                  \t\t\t\t" style="border-bottom: 2px solid black">Variable&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">Pearson&#39;s r&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Age &#40;years&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;27&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NYHA class&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;41&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;002&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">BNP &#40;pg&#47;ml&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;47&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EF &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;69&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">LVEDV index &#40;ml&#47;m<span class="elsevierStyleSup">2</span>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">LVESV index &#40;ml&#47;m<span class="elsevierStyleSup">2</span>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;68&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">LV mass index &#40;g&#47;m<span class="elsevierStyleSup">2</span>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;29&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;046&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">LA maximal volume index &#40;ml&#47;m<span class="elsevierStyleSup">2</span>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;57&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">E&#47;e&#8242; ratio&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;35&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;014&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">RV S&#8242; TDI &#40;cm&#47;s&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;32&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;031&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">SHFM&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;41&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;002&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
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          "en" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Univariate correlations between LV GLS and clinical and echocardiographic indices&#46;</p>"
        ]
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      3 => array:7 [
        "identificador" => "tbl0015"
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        "tabla" => array:2 [
          "leyenda" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">BNP&#58; B-type natriuretic peptide&#59; E&#47;e&#8242; ratio&#58; ratio between early mitral inflow velocity and mitral annular early diastolic velocity&#59; EDV&#58; end-diastolic volume&#59; GLS&#58; global longitudinal strain&#59; LA&#58; left atrial&#59; LV&#58; left ventricular&#59; NS&#58; non-significant&#59; RV&#58; right ventricular&#59; S&#8242;&#58; peak systolic velocity of the tricuspid annulus&#59; SHFM&#58; Seattle Heart Failure Model&#59; TDI&#58; tissue Doppler imaging&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Variable&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">HR &#40;95&#37; CI&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">HR &#40;95&#37; CI&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">BNP &#40;pg&#47;ml&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;001 &#40;1&#46;000&#8211;1&#46;002&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;013&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;001 &#40;1&#46;000&#8211;1&#46;003&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">GLS &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;544 &#40;1&#46;121&#8211;2&#46;128&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;008&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;614 &#40;1&#46;010&#8211;6&#46;763&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;048&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">LV EDV index &#40;ml&#47;m<span class="elsevierStyleSup">2</span>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;999 &#40;0&#46;977&#8211;1&#46;022&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">LV mass index &#40;g&#47;m<span class="elsevierStyleSup">2</span>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;997 &#40;0&#46;983&#8211;1&#46;012&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">LA maximal volume index &#40;ml&#47;m<span class="elsevierStyleSup">2</span>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;071 &#40;1&#46;010&#8211;1&#46;135&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;021&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">E&#47;e¿ ratio&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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