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rapid and irregular ventricular rates&#44; inadequate ventricular filling and loss of atrial contribution to cardiac output lead to an increase in oxygen demand&#44; causing further impairment in coronary perfusion and left ventricular &#40;LV&#41; systolic function&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Factors precipitating AF during acute coronary syndromes &#40;ACS&#41; include atrial ischemia or infarction&#44; right ventricular infarction&#44; pericardial inflammation&#44; acute hypoxia&#44; ionic disturbances such as hypokalemia&#44; hemodynamic impairment secondary to LV dysfunction&#44; and circulating catecholamines &#40;endogenous or exogenous&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6&#8211;8</span></a> The result is a vicious circle composed of AF&#44; myocardial ischemia and heart failure&#44; in which each element aggravates the other two&#46; In the early period of ACS&#44; several factors have been associated with the occurrence of AF&#44; such as advanced age&#44; heart failure&#44; LV dysfunction&#44; mitral regurgitation&#44; excessive sympathetic&#47;parasympathetic nerve stimulation&#44; pericarditis and activation of inflammation&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> It would be useful to identify predictors for the development of AF in the setting of ACS&#44; given that identification of high-risk patients would assist in the development of prophylactic antiarrhythmic therapies&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">The primary aim of this study was to identify the predictors and assess the prognosis of new-onset AF during ACS&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Methods</span><p id="par0045" class="elsevierStylePara elsevierViewall">This was a retrospective observational cohort study with a six-month follow-up&#46; All patients &#40;n&#61;902&#59; mean age 64 years&#44; 77&#46;5&#37; male&#41; consecutively admitted to the coronary care unit of a single center with a diagnosis of ACS between July 2009 and June 2011 were included&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Diagnoses of ACS and AF were made according to the European Society of Cardiology guidelines&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">10&#8211;12</span></a> Development of heart failure during hospital stay was defined as Killip class &#8805;2&#46; Patients with AF were divided according to the timing of the arrhythmia&#58; every patient who presented with AF for the first time &#40;i&#46;e&#46;&#44; who did not have previously documented AF&#41; at admission or during hospital stay was considered to have new-onset AF&#44; while those with previously documented AF were classified as having pre-existing AF and were excluded from the statistical analysis&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Demographic&#44; clinical&#44; laboratory&#44; echocardiographic and coronary angiographic data were collected&#46; Regarding laboratory data&#44; NT-proBNP and cystatin C values were obtained in the first 24 hours after admission&#44; and peak creatinine was considered to be the maximum value during hospitalization&#46; The first echocardiogram performed in hospital was used to provide echocardiographic data&#46; Coronary angiographic data were collected from coronary angiography performed during hospital stay&#46; Significant coronary artery disease &#40;CAD&#41; on coronary angiography was defined as at least one &#8805;50&#37; lesion in the left main artery and&#47;or &#8805;70&#37; in other coronary arteries&#46; Multivessel disease was defined as significant stenosis in two or more major epicardial arteries&#46; Although this was a retrospective cohort study&#44; all clinical and laboratory data were collected prospectively and recorded in a computerized database&#44; in accordance with our department&#39;s protocol for patients admitted to the coronary care unit with ACS&#46;</p><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Statistical analysis</span><p id="par0060" class="elsevierStylePara elsevierViewall">Univariate analysis of categorical variables was performed using the chi-square test&#44; with results expressed as percentages&#44; and of continuous variables using the Student&#39;s t test&#44; with results expressed as means &#177; standard deviation&#46; Multivariate logistic regression analysis was used to determine independent predictors of new-onset AF&#44; including only variables with statistical significance on univariate analysis&#46; Multivariate logistic analysis was also performed to determine independent predictors of overall mortality &#40;in-hospital and follow-up&#41;&#46; Kaplan&#8211;Meier analysis was used to illustrate six-month cumulative mortality according to the presence of new-onset AF&#46; Differences with p&#60;0&#46;05 were considered significant&#46; The statistical analysis was carried out using SPSS version 18&#46;0&#46;</p></span></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Results</span><p id="par0065" class="elsevierStylePara elsevierViewall">In the study population &#40;n&#61;902&#41;&#44; AF rhythm was identified in 13&#46;8&#37; patients &#40;n&#61;124&#41;&#44; of whom 73&#46;3&#37; &#40;n&#61;91&#41; presented new-onset AF and 26&#46;8&#37; &#40;n&#61;33&#41; pre-existing AF&#46; New-onset AF patients were studied according to their baseline characteristics&#44; in-hospital features and clinical outcomes&#46;</p><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Baseline characteristics and in-hospital data</span><p id="par0070" class="elsevierStylePara elsevierViewall">The baseline characteristics of the study population are shown in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0075" class="elsevierStylePara elsevierViewall">New-onset AF was more frequent in older &#40;p&#60;0&#46;001&#41;&#44; non-smoking &#40;p&#61;0&#46;013&#41; and hypertensive &#40;p&#61;0&#46;001&#41; patients&#44; as well as in those with previous valvular heart disease &#40;p&#60;0&#46;001&#41;&#44; history of coronary artery bypass grafting &#40;CABG&#41; &#40;p&#61;0&#46;049&#41; and previously treatment with aspirin &#40;p&#61;0&#46;005&#41;&#46; No differences were seen regarding other cardiovascular risk factors or history&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">During hospitalization&#44; patients with new-onset AF presented with higher heart rate &#40;p&#60;0&#46;001&#41; and had a higher prevalence of respiratory tract infections &#40;p&#61;0&#46;002&#41; and heart failure &#40;p&#60;0&#46;001&#41;&#46; Regarding laboratory parameters&#44; higher mean NT-proBNP &#40;p&#61;0&#46;007&#41;&#44; cystatin C &#40;p&#61;0&#46;033&#41; and peak creatinine &#40;p&#61;0&#46;001&#41; were recorded&#46; Echocardiographic data revealed an association between new-onset AF and greater left atrial &#40;LA&#41; diameter &#40;p&#60;0&#46;001&#41;&#44; significant mitral regurgitation &#40;grade &#8805;II&#47;IV&#59; p&#60;0&#46;001&#41; and LV ejection fraction &#40;LVEF&#41; &#8804;40&#37; &#40;p&#60;0&#46;001&#41;&#46; These patients were also less likely to have significant coronary lesions &#40;p&#61;0&#46;009&#41; or to have undergone coronary revascularization &#40;p&#60;0&#46;001&#41;&#44; the latter due to the lower number of percutaneous coronary interventions performed &#40;p&#61;0&#46;003&#41;&#46; The presence of multivessel disease was similar in the two groups&#46; Clinical information during hospital stay and laboratory&#44; echocardiographic&#44; coronary angiographic&#44; revascularization and mortality data are summarized in <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0085" class="elsevierStylePara elsevierViewall">In multivariate analysis&#44; age &#40;odds ratio &#91;OR&#93; 1&#46;06&#44; 95&#37; confidence interval &#91;CI&#93; 1&#46;01&#8211;1&#46;12&#44; p&#61;0&#46;021&#41;&#44; LVEF &#8804;40&#37; &#40;OR 4&#46;91&#44; 95&#37; CI 1&#46;77&#8211;13&#46;57&#44; p&#61;0&#46;002&#41; and LA diameter &#40;OR 1&#46;14&#44; 95&#37; CI 1&#46;03&#8211;1&#46;25&#44; p&#61;0&#46;008&#41; remained independent predictors of new-onset AF &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#41;&#46; Respiratory infection failed to reach statistical significance by a narrow margin &#40;OR 4&#46;17&#44; 95&#37; CI 0&#46;99&#8211;17&#46;38&#44; p&#61;0&#46;050&#41;&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Clinical outcomes and prognosis</span><p id="par0090" class="elsevierStylePara elsevierViewall">New-onset AF was a predictor of death &#40;p&#61;0&#46;044&#41; during hospital stay and showed a tendency towards higher mortality during follow-up &#40;6&#46;6&#37; vs&#46; 3&#46;7&#37;&#44; p&#61;0&#46;207&#59; mean follow-up 197&#177;78 days&#41;&#46; When both in-hospital and follow-up mortality were assessed collectively &#40;overall mortality&#41;&#44; new-onset AF was related to worse prognosis &#40;13&#46;4&#37; vs&#46; 5&#46;9&#37;&#44; log rank p&#61;0&#46;007&#41;&#44; as illustrated by the Kaplan&#8211;Meier curves in <a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a>&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0095" class="elsevierStylePara elsevierViewall">Together with age&#44; diabetes and maximum Killip class III and IV&#44; new-onset AF remained an independent predictor of overall mortality&#44; carrying a risk 3&#46;11 times higher than in the group without AF &#40;95&#37; CI 1&#46;10&#8211;8&#46;76&#44; p&#61;0&#46;032&#41;&#44; as shown in <a class="elsevierStyleCrossRef" href="#tbl0020">Table 4</a>&#46;</p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia></span></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Discussion</span><p id="par0100" class="elsevierStylePara elsevierViewall">Our group reported earlier<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> that in the context of ACS the presence of AF by itself&#44; documented in the first 48 hours of hospitalization&#44; was an independent predictor of in-hospital and six-month mortality&#46; The relevance of AF type &#40;pre-existing or new-onset&#41; was not assessed&#46; In this study we refined the definition of AF according to its timing to scrutinize the role of new-onset AF&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">The present study demonstrated that&#58; &#40;1&#41; age&#44; LVEF &#8804;40&#37; and LA diameter are independent predictors of new-onset AF&#59; &#40;2&#41; new-onset AF is associated with worse clinical features during hospital stay&#59; and &#40;3&#41; new-onset AF is associated with higher in-hospital and overall mortality and a tendency towards higher mortality during follow-up&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">The incidence of new-onset AF was 10&#46;1&#37; in our population&#44; which is similar to that described in the literature&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#8211;3&#44;14&#8211;17</span></a></p><p id="par0115" class="elsevierStylePara elsevierViewall">In a recent review regarding new-onset AF in the setting of ACS&#44; Lau et al&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a> reported several factors associated with new-onset AF following multivariate analysis&#44; including advanced age&#44; higher Killip class or heart failure&#44; hypotension&#44; higher heart rate&#44; history of hypertension&#44; history of stroke&#44; female gender&#44; increased peak creatinine and increased C-reactive protein levels&#46; Previous studies have also documented the association of new-onset AF with LV dysfunction&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> In our study&#44; some of these variables were also related to the development of new-onset AF in univariate analysis &#40;heart failure&#44; higher heart rate&#44; history of hypertension and increased peak creatinine&#41;&#44; but only advanced age and LV dysfunction remained as risk factors in multivariate analysis&#46; The mechanisms underlying the relation between AF and these factors include age-associated loss of atrial myocardium and conduction disturbances and the increased atrial pressure and volume overload&#44; secondary valvular dysfunction and chronic neurohormonal stimulation that occur in LV dysfunction and heart failure&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a></p><p id="par0120" class="elsevierStylePara elsevierViewall">Besides the well-known risk factors described above&#44; LA diameter remained an independent predictor for AF occurrence in our study&#46; LA diameter&#44; a parameter not often assessed in other studies&#44; is a marker of progressive dilatation and remodeling of LA myocardium&#44; which acts as a substrate for AF initiation and maintenance&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a> However&#44; this association may also be explained by the presence of other risk factors&#58; predictors of new-onset AF in univariate analysis such as hypertension&#44; a recognized risk factor for new-onset AF and AF-related complications&#44;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> and valvular heart disease&#44; a frequent finding in AF patients&#44;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> could have contributed to LA dilatation&#46; LA diameter is an easily obtainable parameter on the transthoracic echocardiogram that may help to stratify risk for new-onset AF in the setting of ACS&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">Patients with previous CABG also had a predisposition to development of AF in univariate analysis&#44; reinforcing the close relationship between CAD and this arrhythmia&#46; Aspirin use was a predictor in univariate analysis&#44; possibly because it is frequently prescribed in patients with documented CAD or at risk for CAD&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">Respiratory infection was a risk factor in univariate analysis and almost reached statistical significance in multivariate analysis&#46; This association has been described as a predictor of AF after CABG&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a> Inflammation and active infection promote the release of cytokines and upregulation of Toll-like receptor-2 expression on monocytes&#44; which may act as a trigger for AF&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a></p><p id="par0135" class="elsevierStylePara elsevierViewall">During hospital stay&#44; new-onset AF was associated with worse laboratory and echocardiographic features&#46; Elevated biomarkers associated with renal dysfunction &#40;peak creatinine and cystatin C&#41; and with heart failure &#40;NT-proBNP&#41; were recorded&#46; Besides the echocardiographic parameters &#40;LVEF &#8804;40&#37; and LA diameter&#41; described above&#44; significant mitral regurgitation &#40;grade &#62;II&#47;IV&#41; predicted new-onset AF in univariate analysis&#46; It is known that significant mitral regurgitation &#40;from degenerative causes or organic valvular abnormalities&#41;&#44; through increase in LA size&#44; is associated with development of AF&#44; at a rate of about 5&#37; per year&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a></p><p id="par0140" class="elsevierStylePara elsevierViewall">Coronary angiography revealed an association between new-onset AF and the absence of coronary lesions and lower rates of revascularization&#46; The former could be a consequence of early reperfusion after a thromboembolic event or simply the result of an imbalance between myocardial oxygen supply and demand caused by the tachyarrhythmia&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> The latter&#44; due to a lower rate of percutaneous coronary intervention &#40;CABG remained unchanged&#41;&#44; a finding also reported by other authors&#44;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a> might also be secondary to the hypotheses mentioned above&#44; but could additionally be associated with optimal medical treatment choice due to severe comorbidities or diffuse CAD not amenable to revascularization&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">Our analysis of new-onset AF in the setting of ACS showed that&#44; as in previous publications&#44;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">14&#8211;18</span></a> these patients had higher overall &#40;in-hospital plus follow-up&#41; mortality &#40;13&#46;4&#37; vs&#46; 5&#46;9&#37;&#44; log rank p&#61;0&#46;007&#41;&#46; As described by McManus et al&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">23</span></a> in the large multinational GRACE registry including 59 032 patients hospitalized with ACS&#44; new-onset AF was associated with high overall in-hospital mortality &#40;14&#46;5&#37;&#41;&#46; However&#44; in the latter study short-term mortality declined over the study period &#40;between 2000 and 2007&#41;&#44; likely reflecting enhanced treatment&#46; Improvements in ACS therapy in the last decade may also explain why we found lower in-hospital mortality in new-onset AF patients &#40;8&#46;8&#37;&#41;&#46; The relation between new-onset AF and worse prognosis could be explained as a function of the comorbidities associated with this arrhythmia&#44; since young patients with AF and no structural heart disease do not have increased mortality&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a> However&#44; new-onset AF remained an independent predictor of overall mortality in multivariate analysis&#44; and the literature indicates that AF is an independent powerful adverse prognostic factor&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;14&#8211;18&#44;25</span></a> Although not addressed by this study&#44; several other questions should be considered regarding the setting of new-onset AF and ACS&#46; During ACS&#44; the clinical impact and prognosis of AF type &#40;new-onset or pre-existing&#41; may be different&#44; but the published data are not consensual&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#8211;4&#44;26&#44;27</span></a> How should new-onset AF in this context be treated and prevented&#63; In terms of long-term management&#44; what therapeutic strategy &#40;rate control vs&#46; rhythm management&#41; should be preferred&#63; Do antiarrhythmic drugs have a role to play&#63; Should all patients be discharged under anticoagulation therapy&#63;</p><p id="par0150" class="elsevierStylePara elsevierViewall">The literature in these fields is scarce&#44; especially concerning optimal treatment modalities&#46; Randomized controlled trials are needed to clarify these issues&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Limitations</span><p id="par0155" class="elsevierStylePara elsevierViewall">There are several limitations to be considered in the interpretation of our study&#46; First&#44; this was a retrospective&#44; observational and non-randomized study conducted at a single hospital&#44; and as such&#44; both identified and unidentified confounders may have influenced the outcomes&#46; For instance&#44; the duration of new-onset AF could not be determined with certainty in patients without AF history who presented with this arrhythmia at admission&#44; and they may therefore have been misclassified&#46; Indeed&#44; patients with AF of different timing may have different clinical features and prognosis&#46; Second&#44; the number of patients studied with new-onset AF was small&#44; which could limit the number of independent predictors identified and the consistency of the results&#46; Third&#44; we did not investigate other potential risk factors described in the literature&#44; such as diastolic function&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">28</span></a> Fourth&#44; most variables were determined by consulting medical records that could have been incomplete&#46; Finally&#44; as stated above&#44; several other questions remain unanswered&#44; especially those regarding the effect of AF type and therapeutic management in the short and long term&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Conclusions</span><p id="par0160" class="elsevierStylePara elsevierViewall">Patients with new-onset AF in the context of ACS have worse clinical manifestations during hospitalization and adverse prognostic implications not only for the period of hospital stay but also throughout follow-up&#46; Age&#44; LV systolic dysfunction &#40;LVEF &#8804;40&#37;&#41; and greater LA diameter are risk factors for new-onset AF&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">Better data are needed to enable the development of strategies to stratify and treat these patients in the short and long term&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Ethical disclosures</span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Protection of human and animal subjects</span><p id="par0170" class="elsevierStylePara elsevierViewall">The authors declare that no experiments were performed on humans or animals for this study&#46;</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0135">Confidentiality of data</span><p id="par0175" class="elsevierStylePara elsevierViewall">The authors declare that they have followed the protocols of their work center on the publication of patient data&#46;</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0140">Right to privacy and informed consent</span><p id="par0180" class="elsevierStylePara elsevierViewall">The authors have obtained the written informed consent of the patients or subjects mentioned in the article&#46; The corresponding author is in possession of this document&#46;</p></span></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0145">Conflicts of interests</span><p id="par0185" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interests to declare&#46;</p></span></span>"
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        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0010">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">New-onset atrial fibrillation &#40;AF&#41; frequently complicates myocardial infarction&#44; with an incidence of 6&#8211;21&#37;&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0015">Objective</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">To assess the predictors and prognosis of new-onset AF during acute coronary syndromes &#40;ACS&#41;&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0020">Methods</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">We performed a retrospective observational cohort study including 902 consecutive patients &#40;mean age 64 years&#44; 77&#46;5&#37; male&#41; admitted to a single center over a two-year period&#44; with a six-month follow-up&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0025">Results</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">AF rhythm was identified in 13&#46;8&#37; patients&#44; of whom 73&#46;3&#37; presented new-onset AF and 26&#46;8&#37; pre-existing AF&#46; New-onset AF was more frequent in older &#40;p&#60;0&#46;001&#41; and hypertensive patients &#40;p&#61;0&#46;001&#41; and in those with previous valvular heart disease &#40;p&#60;0&#46;001&#41; and coronary artery bypass grafting &#40;p&#61;0&#46;049&#41;&#46; During hospitalization&#44; patients with new-onset AF more often had respiratory infection &#40;p&#61;0&#46;002&#41; and heart failure &#40;p&#60;0&#46;001&#41;&#44; and higher values of NT-proBNP &#40;p&#61;0&#46;007&#41; and peak creatinine &#40;p&#61;0&#46;001&#41;&#46; On echocardiography they had greater left atrial &#40;LA&#41; diameter &#40;p&#60;0&#46;001&#41; and more frequent significant mitral regurgitation &#40;p&#60;0&#46;001&#41; and left ventricular ejection fraction &#40;LVEF&#41; &#8804;40&#37; &#40;p&#60;0&#46;001&#41; and were less likely to have significant coronary lesions &#40;p&#61;0&#46;009&#41; or to have undergone coronary revascularization &#40;p&#60;0&#46;001&#41;&#46; In multivariate analysis&#44; age &#40;OR 1&#46;06&#44; p&#61;0&#46;021&#41;&#44; LVEF &#8804;40&#37; &#40;OR 4&#46;91&#44; p&#61;0&#46;002&#41; and LA diameter &#40;OR 1&#46;14&#44; p&#61;0&#46;008&#41; remained independent predictors of new-onset AF&#46; Together with age&#44; diabetes and maximum Killip class&#44; this arrhythmia was an independent predictor of overall mortality &#40;OR 3&#46;11&#44; p&#61;0&#46;032&#41;&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0030">Conclusions</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Age&#44; LVEF &#8804;40&#37; and LA diameter are independent predictors of new-onset AF during ACS&#46; This arrhythmia is associated with higher overall mortality &#40;in-hospital and in follow-up&#41;&#46;</p>"
      ]
      "pt" => array:2 [
        "titulo" => "Resumo"
        "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0040">Introdu&#231;&#227;o</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">A fibrilha&#231;&#227;o auricular &#40;FA&#41; de novo complica frequentemente o enfarte agudo do mioc&#225;rdio&#44; tendo uma incid&#234;ncia entre 6-21&#37;&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0045">Objetivos</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Determinar os preditores e progn&#243;stico da FA de novo nas s&#237;ndromes coron&#225;rias agudas &#40;SCA&#41;&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0050">M&#233;todos</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Estudo retrospetivo observacional de coorte&#44; incluindo 902 doentes consecutivos &#40;idade m&#233;dia&#58; 64 anos&#59; 77&#44;5&#37; homens&#41;&#44; admitidos num hospital&#44; durante dois anos&#44; com follow-up de seis meses&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0055">Resultados</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">O ritmo de FA foi identificado em 13&#44;8&#37; doentes&#44; dos quais 73&#44;3&#37; apresentaram FA de novo e 26&#44;8&#37; FA pr&#233;-existente&#46; A FA de novo ocorreu mais nos idosos &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#44; hipertensos &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#44; doentes com hist&#243;ria de patologia valvular &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41; e cirurgia de revasculariza&#231;&#227;o mioc&#225;rdica &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;049&#41;&#46; No internamento&#44; verificou-se maior incid&#234;ncia de infe&#231;&#227;o respirat&#243;ria &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;002&#41; e insufici&#234;ncia card&#237;aca &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#46; Aferiram-se valores superiores de NT-proBNP &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;007&#41; e creatinina pico &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#46; Na avalia&#231;&#227;o ecocardiogr&#225;fica observou-se um di&#226;metro superior da aur&#237;cula esquerda &#40;AE&#59; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#44; maior preval&#234;ncia de insufici&#234;ncia mitral significativa &#40;grau &#8805; II&#47;IV&#59; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41; e fra&#231;&#227;o de eje&#231;&#227;o ventricular esquerda &#8804; 40&#37; &#40;FEVE &#8804; 40&#37;&#59; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#46; Documentou-se aus&#234;ncia de les&#245;es coron&#225;rias significativas &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;009&#41; e n&#227;o-revasculariza&#231;&#227;o coron&#225;ria &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#46; Na an&#225;lise multivariada&#44; a idade &#40;OR 1&#44;06&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;021&#41;&#44; a FEVE &#8804; 40&#37; &#40;OR 4&#44;91&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;002&#41; e o di&#226;metro da AE &#40;OR 1&#44;14&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;008&#41; permaneceram preditores independentes da FA de novo&#46; Juntamente com a idade&#44; diabetes&#44; e classe de Killip m&#225;xima&#44; a FA de novo foi preditora independente da mortalidade global &#40;OR 3&#44;11&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;032&#41;&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0060">Conclus&#245;es</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">A idade&#44; FEVE&#8804;40&#37; e di&#226;metro da AE s&#227;o preditores independentes da FA de novo durante as SCA&#46; Esta arritmia acarreta uma maior mortalidade global &#40;mortalidade intra-hospitalar e durante o seguimento&#41;&#46;</p>"
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Please cite this article as&#58; Galv&#227;o Braga C&#44; Ramos V&#44; Vieira C&#44; Martins J&#44; Ribeiro S&#44; Gaspar A&#44; et al&#46; Fibrilha&#231;&#227;o auricular de novo no contexto das s&#237;ndromes coron&#225;rias agudas &#8211; preditores e progn&#243;stico&#46; Rev Port Cardiol&#46; 2014&#59;33&#58;281&#8211;287&#46;</p>"
      ]
    ]
    "nomenclatura" => array:1 [
      0 => array:3 [
        "identificador" => "nom0005"
        "titulo" => "<span class="elsevierStyleSectionTitle" id="sect0075">List of abbreviations</span>"
        "listaDefinicion" => array:1 [
          0 => array:1 [
            "definicion" => array:6 [
              0 => array:2 [
                "termino" => "ACS"
                "descripcion" => "<p id="par0005" class="elsevierStylePara elsevierViewall">acute coronary syndromes</p>"
              ]
              1 => array:2 [
                "termino" => "AF"
                "descripcion" => "<p id="par0010" class="elsevierStylePara elsevierViewall">atrial fibrillation</p>"
              ]
              2 => array:2 [
                "termino" => "LA"
                "descripcion" => "<p id="par0015" class="elsevierStylePara elsevierViewall">left atrial</p>"
              ]
              3 => array:2 [
                "termino" => "LV"
                "descripcion" => "<p id="par0020" class="elsevierStylePara elsevierViewall">left ventricular</p>"
              ]
              4 => array:2 [
                "termino" => "LVEF"
                "descripcion" => "<p id="par0025" class="elsevierStylePara elsevierViewall">left ventricular ejection fraction</p>"
              ]
              5 => array:2 [
                "termino" => "MI"
                "descripcion" => "<p id="par0030" class="elsevierStylePara elsevierViewall">myocardial infarction</p>"
              ]
            ]
          ]
        ]
      ]
    ]
    "multimedia" => array:5 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1841
            "Ancho" => 1663
            "Tamanyo" => 162920
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Kaplan&#8211;Meier curves representing overall mortality for patients with and without new-onset AF&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">ACEI&#58; angiotensin-converting enzyme inhibitor&#59; ARB&#58; angiotensin receptor blocker&#59; CABG&#58; coronary artery bypass grafting&#59; CV&#58; cardiovascular&#59; MI&#58; myocardial infarction&#59; SD&#58; standard deviation&#59; VHD&#58; valvular heart disease&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">With new-onset AF &#40;n&#61;91&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Without new-onset AF &#40;n&#61;778&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Demographics</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Age &#40;years&#41;&#44; mean &#40;SD&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">71 &#40;12&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">63 &#40;13&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Male&#44; &#37;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">71&#46;4&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">78&#46;4&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;130&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">CV risk factors&#44; &#37;</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Hypertension&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">79&#46;1&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">62&#46;1&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Diabetes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">29&#46;7&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">26&#46;5&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;515&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Dyslipidemia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">54&#46;9&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">53&#46;7&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;826&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Smoking&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18&#46;7&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">31&#46;4&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;013&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">History&#44; &#37;</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>MI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">22&#46;0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14&#46;7&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;067&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>CABG&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">7&#46;7&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;5&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">8&#46;8&#37;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1&#46;5&#37;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&#46;8&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#46;2&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">36&#46;3&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">22&#46;9&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>ACEI&#47;ARB&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">49&#46;5&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">42&#46;4&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Beta-blocker&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">27&#46;5&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20&#46;2&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&#46;106&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Statin&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">35&#46;2&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">34&#46;1&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;834&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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          "leyenda" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">ACS&#58; acute coronary syndrome&#59; CABG&#58; coronary artery bypass grafting&#59; CAD&#58; coronary artery disease&#59; CRP&#58; C-reactive protein&#59; LA&#58; left atrial&#59; LVEF&#58; left ventricular ejection fraction&#59; MR&#58; mitral regurgitation&#59; NT-proBNP&#58; N-terminal pro-brain natriuretic peptide&#59; PCI&#58; percutaneous coronary intervention&#59; SBP&#58; systolic blood pressure&#46;</p>"
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                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">With new-onset AF &#40;n&#61;91&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Without new-onset AF &#40;n&#61;778&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Heart rate &#40;bpm&#41;&#44;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a> mean &#40;SD&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">85 &#40;24&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">75 &#40;17&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>SBP &#40;mmHg&#41;&#44;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a> mean &#40;SD&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">128 &#40;29&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">128 &#40;27&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#46;779&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Heart failure&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">53&#46;8&#37;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">30&#46;8&#37;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20&#46;5&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#46;6&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;007&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>ST-elevation ACS&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">61&#46;5&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">52&#46;7&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;110&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Blood tests&#44; mean &#40;SD&#41;</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Peak creatinine &#40;mg&#47;dl&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;36 &#40;0&#46;85&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;15 &#40;0&#46;52&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Cystatin C &#40;mg&#47;l&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;03 &#40;1&#46;12&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;86 &#40;0&#46;56&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;033&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>CRP &#40;mg&#47;l&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">23 &#40;36&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16 &#40;33&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;104&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>NT-proBNP &#40;pg&#47;ml&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4495 &#40;8673&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2639 &#40;5393&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;007&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Echocardiography</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>LA diameter &#40;mm&#41;&#44; mean &#40;SD&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">46 &#40;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">42 &#40;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>LVEF &#8804;40&#37;&#44; &#37;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">53&#46;9&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">31&#46;0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>MR &#40;grade &#62;II&#47;IV&#41;&#44; &#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">33&#46;3&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13&#46;1&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Absence of significant CAD&#44; &#37;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13&#46;2&#37;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#46;9&#37;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&#46;009&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Multivessel disease&#44; &#37;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">64&#46;2&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">62&#46;6&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;778&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>PCI&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">49&#46;4&#37;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">66&#46;0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;003&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>CABG&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12&#46;9&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13&#46;7&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;847&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Total&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">62&#46;4&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">79&#46;7&#37;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Mortality</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>During hospital stay&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&#46;8&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#46;1&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;044&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>During follow-up&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#46;6&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;7&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;217&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Overall&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13&#46;4&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#46;9&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;010&nbsp;\t\t\t\t\t\t\n
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                  """
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                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Variables&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">OR&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">95&#37; CI&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;061&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1&#46;009&#8211;1&#46;115&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">LVEF &#8804;40&#37;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">LA diameter&nbsp;\t\t\t\t\t\t\n
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        0 => array:2 [
          "identificador" => "bibs0005"
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            0 => array:3 [
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                    0 => array:2 [
                      "titulo" => "Atrial fibrillation in acute myocardial infarction&#58; a systematic review of the incidence&#44; clinical features and prognostic implications"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "J&#46; Schmitt"
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                            2 => "B&#46;J&#46; Gersh"
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                      "doi" => "10.1093/eurheartj/ehn579"
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                        "tituloSerie" => "Eur Heart J"
                        "fecha" => "2009"
                        "volumen" => "30"
                        "paginaInicial" => "1038"
                        "paginaFinal" => "1045"
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                          0 => array:2 [
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                          "autores" => array:3 [
                            0 => "D&#46;H&#46; Lau"
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                            2 => "D&#46;P&#46; Chew"
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                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.amjcard.2009.06.055"
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                        "fecha" => "2009"
                        "volumen" => "104"
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                0 => array:2 [
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                          "autores" => array:3 [
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                        "tituloSerie" => "Am J Cardiol"
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                        "volumen" => "109"
                        "paginaInicial" => "1689"
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                        "tituloSerie" => "Jpn Circ J"
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Original Article
New-onset atrial fibrillation during acute coronary syndromes: Predictors and prognosis
Fibrilhação auricular de novo no contexto das síndromes coronárias agudas – preditores e prognóstico
Carlos Galvão Braga
Corresponding author
carlos.galvaobraga@gmail.com

Corresponding author.
, Vítor Ramos, Catarina Vieira, Juliana Martins, Sílvia Ribeiro, António Gaspar, Alberto Salgado, Pedro Azevedo, Miguel Álvares Pereira, Sónia Magalhães, Adelino Correia
Serviço de Cardiologia, Hospital de Braga, Braga, Portugal
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          "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Kaplan&#8211;Meier curves representing overall mortality for patients with and without new-onset AF&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Introduction</span><p id="par0035" class="elsevierStylePara elsevierViewall">Atrial &#64257;brillation &#40;AF&#41;&#44; the most commonly encountered clinical arrhythmia&#44; often occurs in the setting of myocardial infarction &#40;MI&#41;&#44; with a reported incidence between 6 and 21&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> New-onset AF should be differentiated from pre-existing AF&#44; since they may have different clinical and therapeutic implications&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3</span></a> Nevertheless&#44; the presence of AF is associated with a high risk of heart failure and mortality in MI patients&#44; regardless of its timing&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> During AF&#44; rapid and irregular ventricular rates&#44; inadequate ventricular filling and loss of atrial contribution to cardiac output lead to an increase in oxygen demand&#44; causing further impairment in coronary perfusion and left ventricular &#40;LV&#41; systolic function&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Factors precipitating AF during acute coronary syndromes &#40;ACS&#41; include atrial ischemia or infarction&#44; right ventricular infarction&#44; pericardial inflammation&#44; acute hypoxia&#44; ionic disturbances such as hypokalemia&#44; hemodynamic impairment secondary to LV dysfunction&#44; and circulating catecholamines &#40;endogenous or exogenous&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6&#8211;8</span></a> The result is a vicious circle composed of AF&#44; myocardial ischemia and heart failure&#44; in which each element aggravates the other two&#46; In the early period of ACS&#44; several factors have been associated with the occurrence of AF&#44; such as advanced age&#44; heart failure&#44; LV dysfunction&#44; mitral regurgitation&#44; excessive sympathetic&#47;parasympathetic nerve stimulation&#44; pericarditis and activation of inflammation&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> It would be useful to identify predictors for the development of AF in the setting of ACS&#44; given that identification of high-risk patients would assist in the development of prophylactic antiarrhythmic therapies&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">The primary aim of this study was to identify the predictors and assess the prognosis of new-onset AF during ACS&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Methods</span><p id="par0045" class="elsevierStylePara elsevierViewall">This was a retrospective observational cohort study with a six-month follow-up&#46; All patients &#40;n&#61;902&#59; mean age 64 years&#44; 77&#46;5&#37; male&#41; consecutively admitted to the coronary care unit of a single center with a diagnosis of ACS between July 2009 and June 2011 were included&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Diagnoses of ACS and AF were made according to the European Society of Cardiology guidelines&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">10&#8211;12</span></a> Development of heart failure during hospital stay was defined as Killip class &#8805;2&#46; Patients with AF were divided according to the timing of the arrhythmia&#58; every patient who presented with AF for the first time &#40;i&#46;e&#46;&#44; who did not have previously documented AF&#41; at admission or during hospital stay was considered to have new-onset AF&#44; while those with previously documented AF were classified as having pre-existing AF and were excluded from the statistical analysis&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Demographic&#44; clinical&#44; laboratory&#44; echocardiographic and coronary angiographic data were collected&#46; Regarding laboratory data&#44; NT-proBNP and cystatin C values were obtained in the first 24 hours after admission&#44; and peak creatinine was considered to be the maximum value during hospitalization&#46; The first echocardiogram performed in hospital was used to provide echocardiographic data&#46; Coronary angiographic data were collected from coronary angiography performed during hospital stay&#46; Significant coronary artery disease &#40;CAD&#41; on coronary angiography was defined as at least one &#8805;50&#37; lesion in the left main artery and&#47;or &#8805;70&#37; in other coronary arteries&#46; Multivessel disease was defined as significant stenosis in two or more major epicardial arteries&#46; Although this was a retrospective cohort study&#44; all clinical and laboratory data were collected prospectively and recorded in a computerized database&#44; in accordance with our department&#39;s protocol for patients admitted to the coronary care unit with ACS&#46;</p><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Statistical analysis</span><p id="par0060" class="elsevierStylePara elsevierViewall">Univariate analysis of categorical variables was performed using the chi-square test&#44; with results expressed as percentages&#44; and of continuous variables using the Student&#39;s t test&#44; with results expressed as means &#177; standard deviation&#46; Multivariate logistic regression analysis was used to determine independent predictors of new-onset AF&#44; including only variables with statistical significance on univariate analysis&#46; Multivariate logistic analysis was also performed to determine independent predictors of overall mortality &#40;in-hospital and follow-up&#41;&#46; Kaplan&#8211;Meier analysis was used to illustrate six-month cumulative mortality according to the presence of new-onset AF&#46; Differences with p&#60;0&#46;05 were considered significant&#46; The statistical analysis was carried out using SPSS version 18&#46;0&#46;</p></span></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Results</span><p id="par0065" class="elsevierStylePara elsevierViewall">In the study population &#40;n&#61;902&#41;&#44; AF rhythm was identified in 13&#46;8&#37; patients &#40;n&#61;124&#41;&#44; of whom 73&#46;3&#37; &#40;n&#61;91&#41; presented new-onset AF and 26&#46;8&#37; &#40;n&#61;33&#41; pre-existing AF&#46; New-onset AF patients were studied according to their baseline characteristics&#44; in-hospital features and clinical outcomes&#46;</p><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Baseline characteristics and in-hospital data</span><p id="par0070" class="elsevierStylePara elsevierViewall">The baseline characteristics of the study population are shown in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0075" class="elsevierStylePara elsevierViewall">New-onset AF was more frequent in older &#40;p&#60;0&#46;001&#41;&#44; non-smoking &#40;p&#61;0&#46;013&#41; and hypertensive &#40;p&#61;0&#46;001&#41; patients&#44; as well as in those with previous valvular heart disease &#40;p&#60;0&#46;001&#41;&#44; history of coronary artery bypass grafting &#40;CABG&#41; &#40;p&#61;0&#46;049&#41; and previously treatment with aspirin &#40;p&#61;0&#46;005&#41;&#46; No differences were seen regarding other cardiovascular risk factors or history&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">During hospitalization&#44; patients with new-onset AF presented with higher heart rate &#40;p&#60;0&#46;001&#41; and had a higher prevalence of respiratory tract infections &#40;p&#61;0&#46;002&#41; and heart failure &#40;p&#60;0&#46;001&#41;&#46; Regarding laboratory parameters&#44; higher mean NT-proBNP &#40;p&#61;0&#46;007&#41;&#44; cystatin C &#40;p&#61;0&#46;033&#41; and peak creatinine &#40;p&#61;0&#46;001&#41; were recorded&#46; Echocardiographic data revealed an association between new-onset AF and greater left atrial &#40;LA&#41; diameter &#40;p&#60;0&#46;001&#41;&#44; significant mitral regurgitation &#40;grade &#8805;II&#47;IV&#59; p&#60;0&#46;001&#41; and LV ejection fraction &#40;LVEF&#41; &#8804;40&#37; &#40;p&#60;0&#46;001&#41;&#46; These patients were also less likely to have significant coronary lesions &#40;p&#61;0&#46;009&#41; or to have undergone coronary revascularization &#40;p&#60;0&#46;001&#41;&#44; the latter due to the lower number of percutaneous coronary interventions performed &#40;p&#61;0&#46;003&#41;&#46; The presence of multivessel disease was similar in the two groups&#46; Clinical information during hospital stay and laboratory&#44; echocardiographic&#44; coronary angiographic&#44; revascularization and mortality data are summarized in <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0085" class="elsevierStylePara elsevierViewall">In multivariate analysis&#44; age &#40;odds ratio &#91;OR&#93; 1&#46;06&#44; 95&#37; confidence interval &#91;CI&#93; 1&#46;01&#8211;1&#46;12&#44; p&#61;0&#46;021&#41;&#44; LVEF &#8804;40&#37; &#40;OR 4&#46;91&#44; 95&#37; CI 1&#46;77&#8211;13&#46;57&#44; p&#61;0&#46;002&#41; and LA diameter &#40;OR 1&#46;14&#44; 95&#37; CI 1&#46;03&#8211;1&#46;25&#44; p&#61;0&#46;008&#41; remained independent predictors of new-onset AF &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#41;&#46; Respiratory infection failed to reach statistical significance by a narrow margin &#40;OR 4&#46;17&#44; 95&#37; CI 0&#46;99&#8211;17&#46;38&#44; p&#61;0&#46;050&#41;&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Clinical outcomes and prognosis</span><p id="par0090" class="elsevierStylePara elsevierViewall">New-onset AF was a predictor of death &#40;p&#61;0&#46;044&#41; during hospital stay and showed a tendency towards higher mortality during follow-up &#40;6&#46;6&#37; vs&#46; 3&#46;7&#37;&#44; p&#61;0&#46;207&#59; mean follow-up 197&#177;78 days&#41;&#46; When both in-hospital and follow-up mortality were assessed collectively &#40;overall mortality&#41;&#44; new-onset AF was related to worse prognosis &#40;13&#46;4&#37; vs&#46; 5&#46;9&#37;&#44; log rank p&#61;0&#46;007&#41;&#44; as illustrated by the Kaplan&#8211;Meier curves in <a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a>&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0095" class="elsevierStylePara elsevierViewall">Together with age&#44; diabetes and maximum Killip class III and IV&#44; new-onset AF remained an independent predictor of overall mortality&#44; carrying a risk 3&#46;11 times higher than in the group without AF &#40;95&#37; CI 1&#46;10&#8211;8&#46;76&#44; p&#61;0&#46;032&#41;&#44; as shown in <a class="elsevierStyleCrossRef" href="#tbl0020">Table 4</a>&#46;</p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia></span></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Discussion</span><p id="par0100" class="elsevierStylePara elsevierViewall">Our group reported earlier<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> that in the context of ACS the presence of AF by itself&#44; documented in the first 48 hours of hospitalization&#44; was an independent predictor of in-hospital and six-month mortality&#46; The relevance of AF type &#40;pre-existing or new-onset&#41; was not assessed&#46; In this study we refined the definition of AF according to its timing to scrutinize the role of new-onset AF&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">The present study demonstrated that&#58; &#40;1&#41; age&#44; LVEF &#8804;40&#37; and LA diameter are independent predictors of new-onset AF&#59; &#40;2&#41; new-onset AF is associated with worse clinical features during hospital stay&#59; and &#40;3&#41; new-onset AF is associated with higher in-hospital and overall mortality and a tendency towards higher mortality during follow-up&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">The incidence of new-onset AF was 10&#46;1&#37; in our population&#44; which is similar to that described in the literature&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#8211;3&#44;14&#8211;17</span></a></p><p id="par0115" class="elsevierStylePara elsevierViewall">In a recent review regarding new-onset AF in the setting of ACS&#44; Lau et al&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a> reported several factors associated with new-onset AF following multivariate analysis&#44; including advanced age&#44; higher Killip class or heart failure&#44; hypotension&#44; higher heart rate&#44; history of hypertension&#44; history of stroke&#44; female gender&#44; increased peak creatinine and increased C-reactive protein levels&#46; Previous studies have also documented the association of new-onset AF with LV dysfunction&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> In our study&#44; some of these variables were also related to the development of new-onset AF in univariate analysis &#40;heart failure&#44; higher heart rate&#44; history of hypertension and increased peak creatinine&#41;&#44; but only advanced age and LV dysfunction remained as risk factors in multivariate analysis&#46; The mechanisms underlying the relation between AF and these factors include age-associated loss of atrial myocardium and conduction disturbances and the increased atrial pressure and volume overload&#44; secondary valvular dysfunction and chronic neurohormonal stimulation that occur in LV dysfunction and heart failure&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a></p><p id="par0120" class="elsevierStylePara elsevierViewall">Besides the well-known risk factors described above&#44; LA diameter remained an independent predictor for AF occurrence in our study&#46; LA diameter&#44; a parameter not often assessed in other studies&#44; is a marker of progressive dilatation and remodeling of LA myocardium&#44; which acts as a substrate for AF initiation and maintenance&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a> However&#44; this association may also be explained by the presence of other risk factors&#58; predictors of new-onset AF in univariate analysis such as hypertension&#44; a recognized risk factor for new-onset AF and AF-related complications&#44;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> and valvular heart disease&#44; a frequent finding in AF patients&#44;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> could have contributed to LA dilatation&#46; LA diameter is an easily obtainable parameter on the transthoracic echocardiogram that may help to stratify risk for new-onset AF in the setting of ACS&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">Patients with previous CABG also had a predisposition to development of AF in univariate analysis&#44; reinforcing the close relationship between CAD and this arrhythmia&#46; Aspirin use was a predictor in univariate analysis&#44; possibly because it is frequently prescribed in patients with documented CAD or at risk for CAD&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">Respiratory infection was a risk factor in univariate analysis and almost reached statistical significance in multivariate analysis&#46; This association has been described as a predictor of AF after CABG&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a> Inflammation and active infection promote the release of cytokines and upregulation of Toll-like receptor-2 expression on monocytes&#44; which may act as a trigger for AF&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a></p><p id="par0135" class="elsevierStylePara elsevierViewall">During hospital stay&#44; new-onset AF was associated with worse laboratory and echocardiographic features&#46; Elevated biomarkers associated with renal dysfunction &#40;peak creatinine and cystatin C&#41; and with heart failure &#40;NT-proBNP&#41; were recorded&#46; Besides the echocardiographic parameters &#40;LVEF &#8804;40&#37; and LA diameter&#41; described above&#44; significant mitral regurgitation &#40;grade &#62;II&#47;IV&#41; predicted new-onset AF in univariate analysis&#46; It is known that significant mitral regurgitation &#40;from degenerative causes or organic valvular abnormalities&#41;&#44; through increase in LA size&#44; is associated with development of AF&#44; at a rate of about 5&#37; per year&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a></p><p id="par0140" class="elsevierStylePara elsevierViewall">Coronary angiography revealed an association between new-onset AF and the absence of coronary lesions and lower rates of revascularization&#46; The former could be a consequence of early reperfusion after a thromboembolic event or simply the result of an imbalance between myocardial oxygen supply and demand caused by the tachyarrhythmia&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> The latter&#44; due to a lower rate of percutaneous coronary intervention &#40;CABG remained unchanged&#41;&#44; a finding also reported by other authors&#44;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a> might also be secondary to the hypotheses mentioned above&#44; but could additionally be associated with optimal medical treatment choice due to severe comorbidities or diffuse CAD not amenable to revascularization&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">Our analysis of new-onset AF in the setting of ACS showed that&#44; as in previous publications&#44;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">14&#8211;18</span></a> these patients had higher overall &#40;in-hospital plus follow-up&#41; mortality &#40;13&#46;4&#37; vs&#46; 5&#46;9&#37;&#44; log rank p&#61;0&#46;007&#41;&#46; As described by McManus et al&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">23</span></a> in the large multinational GRACE registry including 59 032 patients hospitalized with ACS&#44; new-onset AF was associated with high overall in-hospital mortality &#40;14&#46;5&#37;&#41;&#46; However&#44; in the latter study short-term mortality declined over the study period &#40;between 2000 and 2007&#41;&#44; likely reflecting enhanced treatment&#46; Improvements in ACS therapy in the last decade may also explain why we found lower in-hospital mortality in new-onset AF patients &#40;8&#46;8&#37;&#41;&#46; The relation between new-onset AF and worse prognosis could be explained as a function of the comorbidities associated with this arrhythmia&#44; since young patients with AF and no structural heart disease do not have increased mortality&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a> However&#44; new-onset AF remained an independent predictor of overall mortality in multivariate analysis&#44; and the literature indicates that AF is an independent powerful adverse prognostic factor&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;14&#8211;18&#44;25</span></a> Although not addressed by this study&#44; several other questions should be considered regarding the setting of new-onset AF and ACS&#46; During ACS&#44; the clinical impact and prognosis of AF type &#40;new-onset or pre-existing&#41; may be different&#44; but the published data are not consensual&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#8211;4&#44;26&#44;27</span></a> How should new-onset AF in this context be treated and prevented&#63; In terms of long-term management&#44; what therapeutic strategy &#40;rate control vs&#46; rhythm management&#41; should be preferred&#63; Do antiarrhythmic drugs have a role to play&#63; Should all patients be discharged under anticoagulation therapy&#63;</p><p id="par0150" class="elsevierStylePara elsevierViewall">The literature in these fields is scarce&#44; especially concerning optimal treatment modalities&#46; Randomized controlled trials are needed to clarify these issues&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Limitations</span><p id="par0155" class="elsevierStylePara elsevierViewall">There are several limitations to be considered in the interpretation of our study&#46; First&#44; this was a retrospective&#44; observational and non-randomized study conducted at a single hospital&#44; and as such&#44; both identified and unidentified confounders may have influenced the outcomes&#46; For instance&#44; the duration of new-onset AF could not be determined with certainty in patients without AF history who presented with this arrhythmia at admission&#44; and they may therefore have been misclassified&#46; Indeed&#44; patients with AF of different timing may have different clinical features and prognosis&#46; Second&#44; the number of patients studied with new-onset AF was small&#44; which could limit the number of independent predictors identified and the consistency of the results&#46; Third&#44; we did not investigate other potential risk factors described in the literature&#44; such as diastolic function&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">28</span></a> Fourth&#44; most variables were determined by consulting medical records that could have been incomplete&#46; Finally&#44; as stated above&#44; several other questions remain unanswered&#44; especially those regarding the effect of AF type and therapeutic management in the short and long term&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Conclusions</span><p id="par0160" class="elsevierStylePara elsevierViewall">Patients with new-onset AF in the context of ACS have worse clinical manifestations during hospitalization and adverse prognostic implications not only for the period of hospital stay but also throughout follow-up&#46; Age&#44; LV systolic dysfunction &#40;LVEF &#8804;40&#37;&#41; and greater LA diameter are risk factors for new-onset AF&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">Better data are needed to enable the development of strategies to stratify and treat these patients in the short and long term&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Ethical disclosures</span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Protection of human and animal subjects</span><p id="par0170" class="elsevierStylePara elsevierViewall">The authors declare that no experiments were performed on humans or animals for this study&#46;</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0135">Confidentiality of data</span><p id="par0175" class="elsevierStylePara elsevierViewall">The authors declare that they have followed the protocols of their work center on the publication of patient data&#46;</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0140">Right to privacy and informed consent</span><p id="par0180" class="elsevierStylePara elsevierViewall">The authors have obtained the written informed consent of the patients or subjects mentioned in the article&#46; The corresponding author is in possession of this document&#46;</p></span></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0145">Conflicts of interests</span><p id="par0185" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interests to declare&#46;</p></span></span>"
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        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0010">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">New-onset atrial fibrillation &#40;AF&#41; frequently complicates myocardial infarction&#44; with an incidence of 6&#8211;21&#37;&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0015">Objective</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">To assess the predictors and prognosis of new-onset AF during acute coronary syndromes &#40;ACS&#41;&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0020">Methods</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">We performed a retrospective observational cohort study including 902 consecutive patients &#40;mean age 64 years&#44; 77&#46;5&#37; male&#41; admitted to a single center over a two-year period&#44; with a six-month follow-up&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0025">Results</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">AF rhythm was identified in 13&#46;8&#37; patients&#44; of whom 73&#46;3&#37; presented new-onset AF and 26&#46;8&#37; pre-existing AF&#46; New-onset AF was more frequent in older &#40;p&#60;0&#46;001&#41; and hypertensive patients &#40;p&#61;0&#46;001&#41; and in those with previous valvular heart disease &#40;p&#60;0&#46;001&#41; and coronary artery bypass grafting &#40;p&#61;0&#46;049&#41;&#46; During hospitalization&#44; patients with new-onset AF more often had respiratory infection &#40;p&#61;0&#46;002&#41; and heart failure &#40;p&#60;0&#46;001&#41;&#44; and higher values of NT-proBNP &#40;p&#61;0&#46;007&#41; and peak creatinine &#40;p&#61;0&#46;001&#41;&#46; On echocardiography they had greater left atrial &#40;LA&#41; diameter &#40;p&#60;0&#46;001&#41; and more frequent significant mitral regurgitation &#40;p&#60;0&#46;001&#41; and left ventricular ejection fraction &#40;LVEF&#41; &#8804;40&#37; &#40;p&#60;0&#46;001&#41; and were less likely to have significant coronary lesions &#40;p&#61;0&#46;009&#41; or to have undergone coronary revascularization &#40;p&#60;0&#46;001&#41;&#46; In multivariate analysis&#44; age &#40;OR 1&#46;06&#44; p&#61;0&#46;021&#41;&#44; LVEF &#8804;40&#37; &#40;OR 4&#46;91&#44; p&#61;0&#46;002&#41; and LA diameter &#40;OR 1&#46;14&#44; p&#61;0&#46;008&#41; remained independent predictors of new-onset AF&#46; Together with age&#44; diabetes and maximum Killip class&#44; this arrhythmia was an independent predictor of overall mortality &#40;OR 3&#46;11&#44; p&#61;0&#46;032&#41;&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0030">Conclusions</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Age&#44; LVEF &#8804;40&#37; and LA diameter are independent predictors of new-onset AF during ACS&#46; This arrhythmia is associated with higher overall mortality &#40;in-hospital and in follow-up&#41;&#46;</p>"
      ]
      "pt" => array:2 [
        "titulo" => "Resumo"
        "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0040">Introdu&#231;&#227;o</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">A fibrilha&#231;&#227;o auricular &#40;FA&#41; de novo complica frequentemente o enfarte agudo do mioc&#225;rdio&#44; tendo uma incid&#234;ncia entre 6-21&#37;&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0045">Objetivos</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Determinar os preditores e progn&#243;stico da FA de novo nas s&#237;ndromes coron&#225;rias agudas &#40;SCA&#41;&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0050">M&#233;todos</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Estudo retrospetivo observacional de coorte&#44; incluindo 902 doentes consecutivos &#40;idade m&#233;dia&#58; 64 anos&#59; 77&#44;5&#37; homens&#41;&#44; admitidos num hospital&#44; durante dois anos&#44; com follow-up de seis meses&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0055">Resultados</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">O ritmo de FA foi identificado em 13&#44;8&#37; doentes&#44; dos quais 73&#44;3&#37; apresentaram FA de novo e 26&#44;8&#37; FA pr&#233;-existente&#46; A FA de novo ocorreu mais nos idosos &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#44; hipertensos &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#44; doentes com hist&#243;ria de patologia valvular &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41; e cirurgia de revasculariza&#231;&#227;o mioc&#225;rdica &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;049&#41;&#46; No internamento&#44; verificou-se maior incid&#234;ncia de infe&#231;&#227;o respirat&#243;ria &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;002&#41; e insufici&#234;ncia card&#237;aca &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#46; Aferiram-se valores superiores de NT-proBNP &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;007&#41; e creatinina pico &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#46; Na avalia&#231;&#227;o ecocardiogr&#225;fica observou-se um di&#226;metro superior da aur&#237;cula esquerda &#40;AE&#59; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#44; maior preval&#234;ncia de insufici&#234;ncia mitral significativa &#40;grau &#8805; II&#47;IV&#59; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41; e fra&#231;&#227;o de eje&#231;&#227;o ventricular esquerda &#8804; 40&#37; &#40;FEVE &#8804; 40&#37;&#59; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#46; Documentou-se aus&#234;ncia de les&#245;es coron&#225;rias significativas &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;009&#41; e n&#227;o-revasculariza&#231;&#227;o coron&#225;ria &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#46; Na an&#225;lise multivariada&#44; a idade &#40;OR 1&#44;06&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;021&#41;&#44; a FEVE &#8804; 40&#37; &#40;OR 4&#44;91&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;002&#41; e o di&#226;metro da AE &#40;OR 1&#44;14&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;008&#41; permaneceram preditores independentes da FA de novo&#46; Juntamente com a idade&#44; diabetes&#44; e classe de Killip m&#225;xima&#44; a FA de novo foi preditora independente da mortalidade global &#40;OR 3&#44;11&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;032&#41;&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0060">Conclus&#245;es</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">A idade&#44; FEVE&#8804;40&#37; e di&#226;metro da AE s&#227;o preditores independentes da FA de novo durante as SCA&#46; Esta arritmia acarreta uma maior mortalidade global &#40;mortalidade intra-hospitalar e durante o seguimento&#41;&#46;</p>"
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Please cite this article as&#58; Galv&#227;o Braga C&#44; Ramos V&#44; Vieira C&#44; Martins J&#44; Ribeiro S&#44; Gaspar A&#44; et al&#46; Fibrilha&#231;&#227;o auricular de novo no contexto das s&#237;ndromes coron&#225;rias agudas &#8211; preditores e progn&#243;stico&#46; Rev Port Cardiol&#46; 2014&#59;33&#58;281&#8211;287&#46;</p>"
      ]
    ]
    "nomenclatura" => array:1 [
      0 => array:3 [
        "identificador" => "nom0005"
        "titulo" => "<span class="elsevierStyleSectionTitle" id="sect0075">List of abbreviations</span>"
        "listaDefinicion" => array:1 [
          0 => array:1 [
            "definicion" => array:6 [
              0 => array:2 [
                "termino" => "ACS"
                "descripcion" => "<p id="par0005" class="elsevierStylePara elsevierViewall">acute coronary syndromes</p>"
              ]
              1 => array:2 [
                "termino" => "AF"
                "descripcion" => "<p id="par0010" class="elsevierStylePara elsevierViewall">atrial fibrillation</p>"
              ]
              2 => array:2 [
                "termino" => "LA"
                "descripcion" => "<p id="par0015" class="elsevierStylePara elsevierViewall">left atrial</p>"
              ]
              3 => array:2 [
                "termino" => "LV"
                "descripcion" => "<p id="par0020" class="elsevierStylePara elsevierViewall">left ventricular</p>"
              ]
              4 => array:2 [
                "termino" => "LVEF"
                "descripcion" => "<p id="par0025" class="elsevierStylePara elsevierViewall">left ventricular ejection fraction</p>"
              ]
              5 => array:2 [
                "termino" => "MI"
                "descripcion" => "<p id="par0030" class="elsevierStylePara elsevierViewall">myocardial infarction</p>"
              ]
            ]
          ]
        ]
      ]
    ]
    "multimedia" => array:5 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1841
            "Ancho" => 1663
            "Tamanyo" => 162920
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Kaplan&#8211;Meier curves representing overall mortality for patients with and without new-onset AF&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">ACEI&#58; angiotensin-converting enzyme inhibitor&#59; ARB&#58; angiotensin receptor blocker&#59; CABG&#58; coronary artery bypass grafting&#59; CV&#58; cardiovascular&#59; MI&#58; myocardial infarction&#59; SD&#58; standard deviation&#59; VHD&#58; valvular heart disease&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">With new-onset AF &#40;n&#61;91&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Without new-onset AF &#40;n&#61;778&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Demographics</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Age &#40;years&#41;&#44; mean &#40;SD&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">71 &#40;12&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">63 &#40;13&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Male&#44; &#37;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">71&#46;4&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">78&#46;4&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;130&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">CV risk factors&#44; &#37;</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Hypertension&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">79&#46;1&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">62&#46;1&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Diabetes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">29&#46;7&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">26&#46;5&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;515&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Dyslipidemia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">54&#46;9&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">53&#46;7&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;826&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Smoking&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18&#46;7&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">31&#46;4&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;013&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">History&#44; &#37;</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>MI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">22&#46;0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14&#46;7&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;067&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>CABG&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">7&#46;7&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;5&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">8&#46;8&#37;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1&#46;5&#37;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&#46;8&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#46;2&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">36&#46;3&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">22&#46;9&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>ACEI&#47;ARB&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">49&#46;5&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">42&#46;4&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Beta-blocker&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">27&#46;5&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20&#46;2&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&#46;106&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Statin&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">35&#46;2&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">34&#46;1&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;834&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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          "leyenda" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">ACS&#58; acute coronary syndrome&#59; CABG&#58; coronary artery bypass grafting&#59; CAD&#58; coronary artery disease&#59; CRP&#58; C-reactive protein&#59; LA&#58; left atrial&#59; LVEF&#58; left ventricular ejection fraction&#59; MR&#58; mitral regurgitation&#59; NT-proBNP&#58; N-terminal pro-brain natriuretic peptide&#59; PCI&#58; percutaneous coronary intervention&#59; SBP&#58; systolic blood pressure&#46;</p>"
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                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">With new-onset AF &#40;n&#61;91&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Without new-onset AF &#40;n&#61;778&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Heart rate &#40;bpm&#41;&#44;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a> mean &#40;SD&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">85 &#40;24&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">75 &#40;17&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>SBP &#40;mmHg&#41;&#44;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a> mean &#40;SD&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">128 &#40;29&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">128 &#40;27&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#46;779&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Heart failure&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">53&#46;8&#37;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">30&#46;8&#37;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20&#46;5&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#46;6&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;007&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>ST-elevation ACS&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">61&#46;5&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">52&#46;7&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;110&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Blood tests&#44; mean &#40;SD&#41;</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Peak creatinine &#40;mg&#47;dl&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;36 &#40;0&#46;85&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;15 &#40;0&#46;52&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Cystatin C &#40;mg&#47;l&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;03 &#40;1&#46;12&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;86 &#40;0&#46;56&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;033&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>CRP &#40;mg&#47;l&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">23 &#40;36&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16 &#40;33&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;104&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>NT-proBNP &#40;pg&#47;ml&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4495 &#40;8673&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2639 &#40;5393&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;007&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Echocardiography</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>LA diameter &#40;mm&#41;&#44; mean &#40;SD&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">46 &#40;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">42 &#40;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>LVEF &#8804;40&#37;&#44; &#37;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">53&#46;9&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">31&#46;0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>MR &#40;grade &#62;II&#47;IV&#41;&#44; &#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">33&#46;3&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13&#46;1&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Absence of significant CAD&#44; &#37;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13&#46;2&#37;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#46;9&#37;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&#46;009&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Multivessel disease&#44; &#37;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">64&#46;2&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">62&#46;6&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;778&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>PCI&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">49&#46;4&#37;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">66&#46;0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;003&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>CABG&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12&#46;9&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13&#46;7&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;847&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Total&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">62&#46;4&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">79&#46;7&#37;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Mortality</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>During hospital stay&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&#46;8&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#46;1&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;044&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>During follow-up&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#46;6&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;7&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;217&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Overall&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13&#46;4&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#46;9&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;010&nbsp;\t\t\t\t\t\t\n
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                  """
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                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Variables&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">OR&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">95&#37; CI&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;061&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1&#46;009&#8211;1&#46;115&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">LVEF &#8804;40&#37;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">LA diameter&nbsp;\t\t\t\t\t\t\n
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        0 => array:2 [
          "identificador" => "bibs0005"
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            0 => array:3 [
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                    0 => array:2 [
                      "titulo" => "Atrial fibrillation in acute myocardial infarction&#58; a systematic review of the incidence&#44; clinical features and prognostic implications"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "J&#46; Schmitt"
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                            2 => "B&#46;J&#46; Gersh"
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                      "doi" => "10.1093/eurheartj/ehn579"
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                        "tituloSerie" => "Eur Heart J"
                        "fecha" => "2009"
                        "volumen" => "30"
                        "paginaInicial" => "1038"
                        "paginaFinal" => "1045"
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                          0 => array:2 [
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                          "autores" => array:3 [
                            0 => "D&#46;H&#46; Lau"
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                            2 => "D&#46;P&#46; Chew"
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                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.amjcard.2009.06.055"
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                        "fecha" => "2009"
                        "volumen" => "104"
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                0 => array:2 [
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                          "autores" => array:3 [
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                        "tituloSerie" => "Am J Cardiol"
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                        "volumen" => "109"
                        "paginaInicial" => "1689"
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                        "tituloSerie" => "Jpn Circ J"
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Article information
ISSN: 21742049
Original language: English
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Idiomas
Revista Portuguesa de Cardiologia (English edition)
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