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array:24 [ "pii" => "S2174204913001621" "issn" => "21742049" "doi" => "10.1016/j.repce.2013.10.007" "estado" => "S300" "fechaPublicacion" => "2013-07-01" "aid" => "297" "copyright" => "Sociedade Portuguesa de Cardiologia" "copyrightAnyo" => "2013" "documento" => "simple-article" "crossmark" => 0 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "dis" "cita" => "Rev Port Cardiol. 2013;32:577-9" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2960 "formatos" => array:3 [ "EPUB" => 141 "HTML" => 2262 "PDF" => 557 ] ] "itemSiguiente" => array:19 [ "pii" => "S2174204913001542" "issn" => "21742049" "doi" => "10.1016/j.repce.2013.09.004" "estado" => "S300" "fechaPublicacion" => "2013-07-01" "aid" => "256" "copyright" => "Sociedade Portuguesa de Cardiologia" "documento" => "article" "crossmark" => 0 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "fla" "cita" => "Rev Port Cardiol. 2013;32:581-91" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 9616 "formatos" => array:3 [ "EPUB" => 146 "HTML" => 8574 "PDF" => 896 ] ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>" "titulo" => "Syncope unit: Experience of a center using diagnostic flowcharts for syncope of uncertain etiology after initial assessment" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "pt" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "581" "paginaFinal" => "591" ] ] "contieneResumen" => array:2 [ "en" => true "pt" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0045" "etiqueta" => "Figure 9" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr9.jpeg" "Alto" => 996 "Ancho" => 1411 "Tamanyo" => 79951 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">Left ventricular systolic function estimated by echocardiography using Simpson's method. Good: left ventricular ejection fraction (LVEF) >50%; reasonable: LVEF 30-50%; poor: LVEF <30%.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Pedro Sousa, Nuno Marques, Ricardo Faria, Joana Trigo, Joana Chin, José Amado, Salomé Pereira, Rui Candeias, Ilídio de Jesus" "autores" => array:9 [ 0 => array:2 [ "nombre" => "Pedro" "apellidos" => "Sousa" ] 1 => array:2 [ "nombre" => "Nuno" "apellidos" => "Marques" ] 2 => array:2 [ "nombre" => "Ricardo" "apellidos" => "Faria" ] 3 => array:2 [ "nombre" => "Joana" "apellidos" => "Trigo" ] 4 => array:2 [ "nombre" => "Joana" "apellidos" => "Chin" ] 5 => array:2 [ "nombre" => "José" "apellidos" => "Amado" ] 6 => array:2 [ "nombre" => "Salomé" "apellidos" => "Pereira" ] 7 => array:2 [ "nombre" => "Rui" "apellidos" => "Candeias" ] 8 => array:2 [ "nombre" => "Ilídio" "apellidos" => "de Jesus" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204913001542?idApp=UINPBA00004E" "url" => "/21742049/0000003200000078/v1_201310270023/S2174204913001542/v1_201310270023/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S2174204913001591" "issn" => "21742049" "doi" => "10.1016/j.repce.2013.10.004" "estado" => "S300" "fechaPublicacion" => "2013-07-01" "aid" => "294" "copyright" => "Sociedade Portuguesa de Cardiologia" "documento" => "article" "crossmark" => 0 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "fla" "cita" => "Rev Port Cardiol. 2013;32:567-75" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2932 "formatos" => array:3 [ "EPUB" => 150 "HTML" => 2218 "PDF" => 564 ] ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>" "titulo" => "Characterization of acute heart failure hospitalizations in a Portuguese cardiology department" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "pt" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "567" "paginaFinal" => "575" ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Caracterização das hospitalizações por insuficiência cardíaca aguda num serviço de cardiologia português" ] ] "contieneResumen" => array:2 [ "en" => true "pt" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1268 "Ancho" => 2009 "Tamanyo" => 137828 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Oral medication on admission and at discharge for acute heart failure patients. McNemar test for related samples. ACEI: angiotensin-converting enzyme inhibitor; ARB: angiotensin receptor blocker; BB: beta-adrenergic receptor blocker; CCB: calcium channel blocker; MRA: mineralocorticoid receptor antagonist.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Ana Catarina Pinho-Gomes, José Silva Cardoso, Luís Filipe Azevedo, Rui Almeida, Teresa Pinho, Maria Júlia Maciel" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Ana Catarina" "apellidos" => "Pinho-Gomes" ] 1 => array:2 [ "nombre" => "José" "apellidos" => "Silva Cardoso" ] 2 => array:2 [ "nombre" => "Luís Filipe" "apellidos" => "Azevedo" ] 3 => array:2 [ "nombre" => "Rui" "apellidos" => "Almeida" ] 4 => array:2 [ "nombre" => "Teresa" "apellidos" => "Pinho" ] 5 => array:2 [ "nombre" => "Maria Júlia" "apellidos" => "Maciel" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2174204913001591?idApp=UINPBA00004E" "url" => "/21742049/0000003200000078/v1_201310270023/S2174204913001591/v1_201310270023/en/main.assets" ] "en" => array:14 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Editorial comment</span>" "titulo" => "Profile of the acute heart failure patient in Portugal" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "577" "paginaFinal" => "579" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "Dulce Brito" "autores" => array:1 [ 0 => array:3 [ "nombre" => "Dulce" "apellidos" => "Brito" "email" => array:1 [ 0 => "dulcebrito59@gmail.com" ] ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Cardiology Department, Santa Maria University Hospital, Lisbon; CCUL (Cardiology Centre, Lisbon University, Portugal" "identificador" => "aff0005" ] ] ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Perfil do doente com insuficiência cardíaca aguda em Portugal" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">This editorial refers to “Characterization of acute heart failure hospitalizations in a Portuguese cardiology department” by A.C. Pinho-Gomes et al.</p><p id="par0010" class="elsevierStylePara elsevierViewall">Acute heart failure (AHF) is a highly prevalent condition, a common cause of hospitalization associated with significant in-hospital mortality and poor short- and longer-term outcomes, and represents a significant burden on overall healthcare costs.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1–8</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">The condition is difficult to define and classify. The latest ESC guidelines on acute and chronic heart failure (HF) refer to AHF as “the term used to describe the rapid onset of, or change in, symptoms and signs of heart failure. It is a life-threatening condition that requires immediate medical attention and usually leads to urgent admission to hospital.”<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> The assumptions included in this apparently undefined “definition” of AHF in fact apply to all forms of acute heart failure, a complex clinical syndrome that varies widely in terms of underlying pathophysiologic mechanisms, clinical presentations and targeted therapies.</p><p id="par0020" class="elsevierStylePara elsevierViewall">Most AHF patients presenting to an emergency department are admitted to hospital<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">10–12</span></a> and it is the most common diagnosis at discharge in patients aged >65 years. The syndrome's high in-hospital mortality of 3-12% and short-term readmission rate of 25-30%, with the associated costs, are critical issues worldwide.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1–6,13,14</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">The heterogeneity of AHF syndrome(s) hinders any attempt at classification or application of a single-algorithm approach. AHF may present either as new-onset HF or worsening of pre-existing HF, and these two forms may differ in causes, precipitating factors, associated comorbidities, therapeutic options, in-hospital mortality and post-discharge prognosis.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1–4,13,15</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Regarding clinical presentations, data from the EuroHeart Failure Survey (EHFS) II (3580 patients with AHF enrolled) showed that 65.4% of patients presented with decompensated HF, 11.4% with hypertensive HF, 16.2% with pulmonary edema, 3.9% with cardiogenic shock, and 3.2% with isolated right HF.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Cardiac dysfunction may be due to different causes, including acute coronary syndromes, valve dysfunction, arrhythmias, pericardial disease, and increased left ventricular afterload. These different causes (which can also act as precipitating factors for the syndrome) may coexist and interact in the same patient, modulating clinical presentation and influencing management options and outcomes.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Data on AHF studies and registries provide valuable information regarding the pathophysiologic, therapeutic, and prognostic issues related to different clinical scenarios; they are useful for assessing the extent of compliance with heart failure management guidelines and can help improve clinical assessment and both short- and long-term outcome. Also, analysis of similarities and differences in patient characteristics and management in different centers and countries, in various settings, may help to determine the most useful independent predictors of a worse prognosis and to define better strategies to obtain more favorable outcomes.</p><p id="par0040" class="elsevierStylePara elsevierViewall">The paper by Pinho-Gomes et al. in this issue of the <span class="elsevierStyleItalic">Journal</span><a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a> presents the results of a hospital-based, observational, retrospective cohort study conducted in a single large Portuguese center (a teaching hospital), focusing on acute heart failure admissions to the cardiology department during 2010. Patients enrolled met the ESC criteria for HF<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> and were selected by review of the medical records of patients discharged with a diagnosis of AHF (either primary or secondary to another acute cardiac event). Acute coronary syndromes (ACS) patients were included. All patients were followed for at least 12 months after discharge.</p><p id="par0045" class="elsevierStylePara elsevierViewall">The study aimed to clarify the overall clinical characteristics of patients with AHF and their hospital management and outcomes, and also to identify predictors of rehospitalization or death at six and 12 months after discharge. Importantly, patients admitted in two different AHF clinical contexts − ACS vs. non-ACS − were compared.</p><p id="par0050" class="elsevierStylePara elsevierViewall">AHF accounted for 21% of all admissions (201/924) over the one-year inclusion period. Most were men (61%) and the mean age was 69 years. AHF was new-onset in 53% and most admissions (63%) were in the context of ACS.</p><p id="par0055" class="elsevierStylePara elsevierViewall">The prevalence of new-onset AHF as well as of ACS as the precipitating factor were both higher than in the EHFSII<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> and ALARM-HF<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> studies that included patients of a mixed provenance (internal medicine and cardiology wards). However, new-onset AHF was lower than in ATTEND,<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> an epidemiological study of AHF in the Asia Pacific region that excluded patients with ACS. Acute decompensated chronic heart failure (DCHF) was the clinical presentation in 46.8% of patients and pulmonary edema in 21.4%, similar to other studies.<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3,14</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">Comparison of AHF patients presenting with or without ACS showed significant differences, on the basis of which two different clinical profiles can be defined. Patients presenting with ACS as the precipitating event were younger, less often men, and more commonly had a history of chronic hypertension (72.4% vs. 55.4%) and coronary artery disease (45% vs. 27%). New-onset HF was the rule (74% vs. 17.6%) and pulmonary edema was a common clinical presentation (26% vs. 13.5%). In contrast, patients with non-ACS AHF were older and more often men, the cause of cardiac dysfunction was more frequently valve disease (31% vs. 5.5%) or dilated cardiomyopathy (17.6 vs. 1.6%), and a history of previous HF hospitalizations was more common (25.7% vs. 8.7%), as was atrial fibrillation (46% vs. 22%). The factor triggering AHF in this population was frequently arrhythmia (39.2%) and DCHF was the dominant acute clinical presentation (82.4%).</p><p id="par0065" class="elsevierStylePara elsevierViewall">The prevalence of cardiovascular diseases − hypertension and coronary artery disease being the most common − and of non-cardiovascular morbidities was comparable to those in previous larger surveys.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,3,13,14</span></a> Echocardiographic examination and plasma brain natriuretic peptide (BNP) measurement were performed on admission (or within a few days) in 96.5% and 90% of patients, respectively, showing good adherence to the ESC guidelines.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> Most patients (73.2%) had reduced ejection fraction (77.6% of ACS patients and 65% of non-ACS patients). However, in proportion, more non-ACS patients showed either more severe systolic dysfunction than ACS patients (42% vs. 32.8%, p=0.01) or preserved systolic function (34.8% vs. 22.4%, p=0.01), these dissimilar functional phenotypes being in line with the heterogeneity of AHF syndromes.</p><p id="par0070" class="elsevierStylePara elsevierViewall">On admission, blood pressure, heart rate, oxygen levels, serum hemoglobin, sodium and potassium, and creatinine clearance were similar in patients presenting with ACS to those with non-ACS presentation. Acute coronary syndrome patients, as expected, were admitted more often to the intensive cardiac care unit (ICCU), more frequently underwent coronary angiography and percutaneous interventions, and were more often treated with intravenous vasodilators, non-invasive ventilation and intra-aortic balloon pump. However, invasive ventilation was needed to a similar degree in both populations, as were therapy with intravenous diuretics and inotropes, renal filtration, and ICD implantation. Overall, acute care management was similar to previous studies, although intravenous inotropes were used less often<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,3,14</span></a> and percutaneous coronary interventions were performed more frequently<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,3</span></a> due to the high proportion of ST-segment elevation ACS patients in this study.<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a></p><p id="par0075" class="elsevierStylePara elsevierViewall">Rates of prescription of major oral HF medications increased from admission to discharge, a common observation in several previous studies.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,3,13</span></a> One possible reason in the study by Pinho-Gomes et al. may be the low (15%) rate of previous HF-related admissions.</p><p id="par0080" class="elsevierStylePara elsevierViewall">The mean total hospital stay was 11 days and in-hospital mortality was 5.5%, similar in patients with or without ACS presentation. A shorter in-hospital stay (4.3–9 days) was reported in ADHERE,<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> EHFS II<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> and ALARM-HF,<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> while in ATTEND a surprising long in-hospital stay (21 days) was observed.<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> In-hospital mortality also varied significantly between different studies, being 3.8% in ADHERE<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> and OPTIMIZE-HF,<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a> 6.7% in EHFS II,<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> 7.7% in ATTEND,<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> and 12% in ALARM-HF.<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> Lower in-hospital mortality may be related to shorter in-hospital stay, although this may not necessarily translate into better short- or long-term prognosis in HF patients.<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a> Several factors may be expected to be associated with longer in-hospital stay in AHF patients, particularly high BNP on admission and need for ICCU admission, both signs of worse clinical status.</p><p id="par0085" class="elsevierStylePara elsevierViewall">The HF rehospitalization rate and all-cause mortality in this study were respectively 20.9% and 10.9% at six months and 23.9% and 15.9% at 12 months, and did not differ in patients with or without ACS at index presentation. However, HF mortality at six months was significantly higher in patients outside the setting of ACS presentation at index admission (12.2% vs. 4.7%, p=0.053), a population that presented mostly with DCHF. In fact, post-discharge prognosis appears in general to be better in patients with new-onset AHF. Data from the Italian registries showed that post-discharge mortality at both six months and one year was lower in new-onset AHF patients than in those with pre-existing chronic HF, and the rehospitalization rate was also lower in the former group.<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2,8</span></a> In other studies<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4,7,15</span></a> the results were also consistent with a better clinical course in patients with new-onset HF, whereas a previous history of worsening HF was shown to be an independent predictor of mortality. There also appears to be a cumulative risk with increasing duration and number of HF hospitalizations.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a></p><p id="par0090" class="elsevierStylePara elsevierViewall">In the study by Pinho-Gomes et al., a previous history of HF hospitalization was an important predictor of rehospitalization or death during one-year follow-up after first hospital discharge (threefold increase in risk). Low sodium on admission and the presence of atrial fibrillation were the other predictors of higher risk, while reduced LVEF on admission conferred a decreased risk of rehospitalization or death. The reason for this latter finding is not clear, as reduced LVEF was similarly present on admission in patients with or without ACS, the former presenting mostly with new-onset AHF and having better associated long-term prognosis than the latter. Reduced LVEF on admission may have been modified after percutaneous coronary revascularization procedures (performed in half of ACS patients), or left ventricular remodeling may have occurred during follow-up after the ACS and be a confounding factor regarding the effect of initially measured LVEF on long-term prognosis. Also, patients with reduced or preserved ejection fraction on admission were not compared head-to-head. Comparison was mainly between AHF patients with and without ACS on presentation.</p><p id="par0095" class="elsevierStylePara elsevierViewall">When comparing AHF studies, several issues need to be clarified, particularly the criteria for syndrome definition on admission, the admission setting (emergency department, intensive care unit, cardiology ward or internal medicine ward) and types of patients included (ACS patients often require different and specific management). Also, HF with reduced and with preserved ejection fraction are to some extent different entities with distinct risk factors, management and prognosis.<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">18,19</span></a></p><p id="par0100" class="elsevierStylePara elsevierViewall">Each of these variables contributes to different results because the populations are dissimilar, are managed differently, and may have also different prognosis in both the short and long term. Despite the limitations pointed by the authors, the study by Pinho-Gomes et al.<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a> contributes significantly to our knowledge of the situation in Portugal concerning acute heart failure admissions and helps to identify a subset of high-risk patients most in need of close surveillance, ideally to be included in an HF management program.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of interest</span><p id="par0105" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Conflicts of interest" ] 1 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2013-03-22" "fechaAceptado" => "2013-03-22" "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:19 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Characteristics and outcomes of patients hospitalized for heart failure in the United States: rationale, design, and preliminary observations from the first 100,000 cases in the Acute Decompensated Heart Failure National Registry (ADHERE)" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "K.F. Adams Jr." 1 => "G.C. Fonarow" 2 => "C.L. Emerman" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ahj.2004.08.005" "Revista" => array:6 [ "tituloSerie" => "Am Heart J" "fecha" => "2005" "volumen" => "149" "paginaInicial" => "209" "paginaFinal" => "216" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15846257" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Nationwide survey on acute heart failure in cardiology ward services in Italy" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "L. Tavazzi" 1 => "A.P. Maggioni" 2 => "D. 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Year/Month | Html | Total | |
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2024 November | 6 | 4 | 10 |
2024 October | 41 | 31 | 72 |
2024 September | 40 | 20 | 60 |
2024 August | 49 | 30 | 79 |
2024 July | 41 | 21 | 62 |
2024 June | 53 | 30 | 83 |
2024 May | 36 | 29 | 65 |
2024 April | 34 | 28 | 62 |
2024 March | 29 | 20 | 49 |
2024 February | 30 | 21 | 51 |
2024 January | 28 | 24 | 52 |
2023 December | 31 | 20 | 51 |
2023 November | 24 | 26 | 50 |
2023 October | 22 | 12 | 34 |
2023 September | 29 | 19 | 48 |
2023 August | 14 | 17 | 31 |
2023 July | 21 | 7 | 28 |
2023 June | 16 | 14 | 30 |
2023 May | 28 | 22 | 50 |
2023 April | 18 | 6 | 24 |
2023 March | 17 | 21 | 38 |
2023 February | 30 | 26 | 56 |
2023 January | 42 | 9 | 51 |
2022 December | 39 | 15 | 54 |
2022 November | 55 | 28 | 83 |
2022 October | 37 | 13 | 50 |
2022 September | 14 | 28 | 42 |
2022 August | 28 | 27 | 55 |
2022 July | 27 | 26 | 53 |
2022 June | 24 | 20 | 44 |
2022 May | 25 | 31 | 56 |
2022 April | 22 | 17 | 39 |
2022 March | 34 | 23 | 57 |
2022 February | 23 | 20 | 43 |
2022 January | 24 | 22 | 46 |
2021 December | 30 | 26 | 56 |
2021 November | 28 | 39 | 67 |
2021 October | 34 | 35 | 69 |
2021 September | 20 | 17 | 37 |
2021 August | 24 | 39 | 63 |
2021 July | 28 | 20 | 48 |
2021 June | 21 | 18 | 39 |
2021 May | 30 | 43 | 73 |
2021 April | 66 | 56 | 122 |
2021 March | 42 | 19 | 61 |
2021 February | 49 | 13 | 62 |
2021 January | 26 | 5 | 31 |
2020 December | 24 | 12 | 36 |
2020 November | 34 | 15 | 49 |
2020 October | 18 | 5 | 23 |
2020 September | 38 | 5 | 43 |
2020 August | 22 | 8 | 30 |
2020 July | 33 | 7 | 40 |
2020 June | 33 | 4 | 37 |
2020 May | 27 | 5 | 32 |
2020 April | 30 | 11 | 41 |
2020 March | 27 | 4 | 31 |
2020 February | 31 | 21 | 52 |
2020 January | 17 | 4 | 21 |
2019 December | 19 | 5 | 24 |
2019 November | 23 | 1 | 24 |
2019 October | 14 | 3 | 17 |
2019 September | 41 | 13 | 54 |
2019 August | 25 | 5 | 30 |
2019 July | 29 | 9 | 38 |
2019 June | 21 | 6 | 27 |
2019 May | 15 | 7 | 22 |
2019 April | 20 | 14 | 34 |
2019 March | 25 | 12 | 37 |
2019 February | 48 | 17 | 65 |
2019 January | 24 | 8 | 32 |
2018 December | 39 | 7 | 46 |
2018 November | 67 | 6 | 73 |
2018 October | 94 | 9 | 103 |
2018 September | 30 | 12 | 42 |
2018 August | 22 | 8 | 30 |
2018 July | 31 | 5 | 36 |
2018 June | 22 | 5 | 27 |
2018 May | 58 | 5 | 63 |
2018 April | 44 | 11 | 55 |
2018 March | 67 | 4 | 71 |
2018 February | 87 | 4 | 91 |
2018 January | 38 | 2 | 40 |
2017 December | 103 | 7 | 110 |
2017 November | 31 | 7 | 38 |
2017 October | 16 | 4 | 20 |
2017 September | 26 | 9 | 35 |
2017 August | 29 | 9 | 38 |
2017 July | 16 | 11 | 27 |
2017 June | 24 | 14 | 38 |
2017 May | 25 | 5 | 30 |
2017 April | 22 | 3 | 25 |
2017 March | 29 | 9 | 38 |
2017 February | 38 | 3 | 41 |
2017 January | 23 | 2 | 25 |
2016 December | 38 | 8 | 46 |
2016 November | 17 | 8 | 25 |
2016 October | 13 | 2 | 15 |
2016 September | 14 | 2 | 16 |
2016 August | 1 | 0 | 1 |
2016 July | 4 | 2 | 6 |
2016 June | 4 | 3 | 7 |
2016 May | 10 | 3 | 13 |
2016 April | 12 | 8 | 20 |
2016 March | 24 | 7 | 31 |
2016 February | 39 | 17 | 56 |
2016 January | 35 | 13 | 48 |
2015 December | 23 | 7 | 30 |
2015 November | 30 | 10 | 40 |
2015 October | 30 | 15 | 45 |
2015 September | 38 | 12 | 50 |
2015 August | 18 | 6 | 24 |
2015 July | 15 | 5 | 20 |
2015 June | 8 | 2 | 10 |
2015 May | 15 | 7 | 22 |
2015 April | 19 | 7 | 26 |
2015 March | 19 | 5 | 24 |
2015 February | 15 | 6 | 21 |
2015 January | 27 | 4 | 31 |
2014 December | 38 | 6 | 44 |
2014 November | 17 | 5 | 22 |
2014 October | 27 | 5 | 32 |
2014 September | 27 | 9 | 36 |
2014 August | 29 | 3 | 32 |
2014 July | 47 | 10 | 57 |
2014 June | 24 | 5 | 29 |
2014 May | 32 | 12 | 44 |
2014 April | 31 | 8 | 39 |
2014 March | 32 | 9 | 41 |
2014 February | 45 | 8 | 53 |
2014 January | 39 | 13 | 52 |
2013 December | 35 | 15 | 50 |
2013 November | 45 | 8 | 53 |
2013 October | 5 | 2 | 7 |