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obese &#40;weight 26<span class="elsevierStyleHsp" style=""></span>kg&#44; height 117<span class="elsevierStyleHsp" style=""></span>cm&#44; BMI &#62;97th percentile&#41;&#44; with a history of bronchial asthma&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Three days before admission to the first hospital he presented vomiting&#44; diarrhea&#44; cough and fever&#46; Initial examination revealed gallop rhythm&#44; bilateral rales and hepatomegaly 3<span class="elsevierStyleHsp" style=""></span>cm below the right costal margin&#46; The chest X-ray showed a cardiothoracic index of 65&#37; and diffuse interstitial infiltrate&#46; On echocardiography there was severe left ventricular &#40;LV&#41; dilatation&#44; reduced global contractility&#44; mild mitral regurgitation and pericardial effusion&#46; LV end-diastolic diameter &#40;LVEDD&#41; in parasternal long-axis M-mode was 54<span class="elsevierStyleHsp" style=""></span>mm &#40;z-score<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>5&#46;5&#41; and LV fractional shortening &#40;LVFS&#41; was 22&#37;&#46; He was admitted and dopamine&#44; milrinone and noradrenaline&#44; furosemide&#44; broad-spectrum antibiotic therapy and invasive mechanical ventilation were begun&#46; During endotracheal intubation he suffered cardiopulmonary arrest and was resuscitated&#46; Digoxin was begun on the third day of hospitalization and a course of levosimendan was begun on the seventh day&#46; Despite this treatment&#44; his condition worsened progressively&#44; with generalized edema and 6-cm hepatomegaly and worsening ventricular function&#46; Etiological study revealed positive serology for parvovirus B19 and Ebstein-Barr virus&#46; His fever persisted despite triple antibiotic therapy&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">On the 15th day of hospital stay he was transferred to our center for placement of a VAD as a bridge to heart transplantation due to failure of conventional therapy&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Under inotropic therapy&#44; 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and two 9&#47;12-mm cannulas were introduced into the apical region of the left ventricle and the ascending aorta above the origin of the coronary arteries&#46; The aortic cannula was positioned at an angle of 85&#176; to the aorta&#46; The procedure was performed under cardiopulmonary bypass &#40;103<span class="elsevierStyleHsp" style=""></span>min&#41;&#59; the operation lasted three hours and was uneventful&#46; RV function was preserved and there were no signs of RV failure&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">The patient was extubated on the fifth day following implantation&#44; without complications&#44; and inotropic support was discontinued on the eighth day&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Rigorous anticoagulation control&#44; which is essential for the correct function of the assist device&#44; was maintained throughout the postoperative period&#46; Intravenous heparin perfusion was begun six hours after implantation at an initial dose of 20<span class="elsevierStyleHsp" style=""></span>U&#47;kg&#47;h&#44; 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with a good response&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Myocardial biopsy performed at the time of implantation showed moderate subendocardial fibroelastosis but no inflammatory infiltrate or thrombi&#44; but with one focus of myofibroblast proliferation and focal myocytolysis&#46;The following parameters were assessed by serial transthoracic echocardiography&#58; LVEF&#44; LVFS&#44; LVEDD&#44; LVESD&#44; LV outflow tract time&#47;velocity integral&#44; and degree of mitral regurgitation&#46; Progressive improvement in LV contractility was observed &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a>&#41;&#59; the pump frequency of the VAD was reduced to 30<span class="elsevierStyleHsp" style=""></span>cycles&#47;min and on the 19th day after implantation the patient was transferred to the ward&#46; On the 27th day LV function was assessed with the Berlin Heart Excor<span class="elsevierStyleSup">&#174;</span> stopped&#59; an increase in cardiac output was seen&#44; 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with normal LVEF and being weaned from medication&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Discussion</span><p id="par0060" class="elsevierStylePara elsevierViewall">Viral myocarditis is rare in children and its clinical course is mostly benign&#44; but occasionally it can evolve to severe acute heart failure or to late dilated cardiomyopathy&#46; In such cases&#44; a VAD can act as a last-resort measure&#44; as a bridge to transplantation or recovery&#46; Several devices are available for adults and adolescents&#44; but for children with body surface area of less than 1&#46;20<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span> there are only two extracorporeal pulsatile alternatives&#58; the Berlin Heart Excor&#174; &#40;Berlin Heart AG&#44; Berlin&#44; Germany&#41; and the Medos HIA device &#40;Medos Medizintechnik AG&#44; Stolberg&#44; Germany&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> of which the more widely used is the Berlin Heart Excor&#174;&#46; This can be used in single- or biventricular mode&#59; in the former&#44; the pump has two chambers &#40;air and blood&#41; separated by a triple-layer polyurethane membrane&#44; with the air chamber connected to the main apparatus by a tube that transmits the air pressure pulse to move the membrane&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> The blood chamber is connected by two cannulas to the LV apex or the left atrium and the ascending aorta&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">There have been various advances in recent years in adapting VADs for use in pediatric patients&#44; particularly in size of cannulas&#44; chambers and connectors&#44; heparin coating of the blood pump inner surface&#44; and anticoagulant therapy&#44;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> and the technique can now be used at all ages from newborns to adults&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> The throughput of the device can be varied by regulating the pump frequency&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">First used in 1990&#44; the Berlin Heart Excor<span class="elsevierStyleSup">&#174;</span> had been implanted in 500 pediatric patients by May 2009&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0075" class="elsevierStylePara elsevierViewall">VAD implantation should be carefully planned and every effort should be made to begin ventricular assistance on an urgent rather than emergent basis&#44; before the onset of target-organ dysfunction or cardiogenic shock&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> As myocarditis is generally self-limiting and cardiac function usually recovers&#44; the use of ventricular assistance in children with severe ventricular dysfunction can be an effective and safe solution&#59; the VAD can remain in place for relatively long periods and can even avoid the need for transplantation&#46; Careful anticoagulation control is required to prevent thromboembolic complications&#44; and clinical and laboratory signs of infection must be closely monitored&#46; The timing for weaning from the device is of great importance&#59; cardiac function must be systematically assessed with the device both on and off&#44; and medical therapy must be optimized&#46; If the device is removed too soon&#44; there is a risk of LV failure necessitating a return to ventricular assistance&#44; while prolonging assistance longer than absolutely necessary carries a high risk of infection and thromboembolic events&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">In the case presented&#44; although the biopsy showed subendocardial fibrosis&#44; cardiac function recovered&#46; The presence of fibrosis on biopsy is not a mandatory indication for transplantation or a contraindication to the implantation of a ventricular assist device as a bridge to recovery&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conflicts of interest</span><p id="par0085" class="elsevierStylePara elsevierViewall">The authors have no conflict of interest to declare&#46;</p></span></span>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Viral myocarditis can lead to heart failure that is refractory to medication&#46; In these cases&#44; a ventricular assist device is a good therapeutic option that can be used as a bridge to transplantation or recovery&#46; We describe the first case in Portugal of recovery with ventricular assistance after severe myocarditis&#46;</p> <span class="elsevierStyleSectionTitle">Case report</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A five-year-old boy with no previous cardiac disease presented with severe viral myocarditis&#44; refractory to medical treatment&#44; with positive serology for parvovirus B19 and Ebstein-Barr virus&#46; A Berlin Heart Excor<span class="elsevierStyleSup">&#174;</span> was implanted 15 days after diagnosis&#46; A biopsy at the time of implantation showed subendocardial fibrosis&#46; After 40 days of assistance ventricular function recovered and the device was explanted&#46; The patient was discharged from hospital 15 days later&#46;</p> <span class="elsevierStyleSectionTitle">Discussion</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Survival of children with ventricular assistance has improved significantly because of earlier implantation and coagulation monitoring&#46; The presence of subendocardial fibrosis in the context of myocarditis is not a mandatory indication for transplantation&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Introdu&#231;&#227;o</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">A miocardite viral pode cursar com insufici&#234;ncia card&#237;aca refract&#225;ria &#224; medica&#231;&#227;o&#46; Nestes casos&#44; a assist&#234;ncia ventricular externa &#233; uma alternativa que pode ser usada como ponte para transplante ou para recupera&#231;&#227;o&#46; Descrevemos o primeiro caso em Portugal de recupera&#231;&#227;o da fun&#231;&#227;o ventricular ap&#243;s assist&#234;ncia ventricular por miocardite grave&#46;</p> <span class="elsevierStyleSectionTitle">Caso Cl&#237;nico</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Apresentamos o caso de uma crian&#231;a de cinco anos&#44; sexo masculino&#44; sem doen&#231;a card&#237;aca pr&#233;via&#44; com miocardite viral grave&#44; insufici&#234;ncia card&#237;aca refract&#225;ria &#224; medica&#231;&#227;o e serologias positivas para Parvov&#237;rus B19 e v&#237;rus Ebstein-Barr&#46; Foi implantado o Berlin Heart Excor<span class="elsevierStyleSup">&#174;</span> 15 dias ap&#243;s o diagn&#243;stico&#46; A biopsia card&#237;aca&#44; na altura da implanta&#231;&#227;o&#44; mostrava &#225;reas de fibrose subendoc&#225;rdica&#46; Verificou-se recupera&#231;&#227;o da fun&#231;&#227;o mioc&#225;rdica&#44; tendo sido retirada a assist&#234;ncia ventricular ap&#243;s 40 dias da implanta&#231;&#227;o&#46; O doente teve alta 15 dias depois&#46;</p> <span class="elsevierStyleSectionTitle">Discuss&#227;o</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">A sobrevida das crian&#231;as em assist&#234;ncia ventricular tem vindo a melhorar significativamente&#44; devido ao planeamento atempado e &#224; optimiza&#231;&#227;o da anti-coagula&#231;&#227;o&#46; A presen&#231;a de fibrose subendoc&#225;rdica no contexto de miocardite n&#227;o constitui uma indica&#231;&#227;o formal para transplante&#46;</p>"
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        "nota" => "<p class="elsevierStyleNotepara">Please cite this article as&#58; Silva&#44; M&#46; Assist&#234;ncia ventricular esquerda numa crian&#231;a de cinco anos &#8211; ponte para recupera&#231;&#227;o num caso de miocardite viral&#46; Rev Port Cardiol&#46; 2012&#59;<span class="elsevierStyleBold">31&#40;7-8&#41;</span>&#58;521-524&#46;</p>"
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Case report
Left ventricular assist device in a five-year-old child: A bridge to recovery in a case of viral myocarditis
Assistência ventricular esquerda numa criança de cinco anos – ponte para recuperação num caso de miocardite viral
Margarida Silvaa,
Corresponding author
margaridaoms@gmail.com

Corresponding author.
, Nuno Carvalhoa, Graça Nogueiraa, Patrícia Costab, Rui Rodriguesc, Miguel Abecasisc, Manuela Nunesd, Rui Anjosa, José Nevesc
a Serviços de Cardiologia Pediátrica, Hospital de Santa Cruz, Carnaxide, Portugal
b Serviço de Cardiologia Pediátrica, Hospital de São João, Porto, Portugal
c Cirurgia Cardio-Torácica, Hospital de Santa Cruz, Carnaxide, Portugal
d Anestesia, Hospital de Santa Cruz, Carnaxide, Portugal
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            "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Coronary computerized tomography&#46; &#40;A&#41; Axial image showing a giant thrombosed right coronary aneurysm with maximum dimensions of 40&#46;4<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>54&#46;5<span class="elsevierStyleHsp" style=""></span>mm&#44; thus demonstrating that the true size of the aneurysms had been significantly underestimated on angiography&#46; &#40;B&#41; Volume-rendered MDCT reconstruction showing the 3D relationship of the giant aneurysm &#40;yellow arrows&#41; to adjacent cardiac structures&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Viral myocarditis is rare in children&#59; its real incidence in the general population is unknown&#46; Histologically it is characterized by a mononuclear inflammatory cell infiltrate&#44; interstitial edema and&#44; in some cases&#44; necrosis&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Its clinical course is mostly benign&#44; with cardiac function recovering spontaneously after a few months&#44; but there can be extensive myocardial necrosis&#44; the necrotic tissue subsequently being replaced by fibrous tissue&#46; The most severe cases progress to dilated cardiomyopathy with heart failure refractory to medication&#59; in such situations a ventricular assist device &#40;VAD&#41; can be used as a bridge to transplantation&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">We describe the first case in Portugal of recovery with ventricular assistance after severe myocarditis&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Case report</span><p id="par0015" class="elsevierStylePara elsevierViewall">We present the case of a five-year-old boy&#44; obese &#40;weight 26<span class="elsevierStyleHsp" style=""></span>kg&#44; height 117<span class="elsevierStyleHsp" style=""></span>cm&#44; BMI &#62;97th percentile&#41;&#44; with a history of bronchial asthma&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Three days before admission to the first hospital he presented vomiting&#44; diarrhea&#44; cough and fever&#46; Initial examination revealed gallop rhythm&#44; bilateral rales and hepatomegaly 3<span class="elsevierStyleHsp" style=""></span>cm below the right costal margin&#46; The chest X-ray showed a cardiothoracic index of 65&#37; and diffuse interstitial infiltrate&#46; On echocardiography there was severe left ventricular &#40;LV&#41; dilatation&#44; reduced global contractility&#44; mild mitral regurgitation and pericardial effusion&#46; LV end-diastolic diameter &#40;LVEDD&#41; in parasternal long-axis M-mode was 54<span class="elsevierStyleHsp" style=""></span>mm &#40;z-score<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>5&#46;5&#41; and LV fractional shortening &#40;LVFS&#41; was 22&#37;&#46; He was admitted and dopamine&#44; milrinone and noradrenaline&#44; furosemide&#44; broad-spectrum antibiotic therapy and invasive mechanical ventilation were begun&#46; During endotracheal intubation he suffered cardiopulmonary arrest and was resuscitated&#46; Digoxin was begun on the third day of hospitalization and a course of levosimendan was begun on the seventh day&#46; Despite this treatment&#44; his condition worsened progressively&#44; with generalized edema and 6-cm hepatomegaly and worsening ventricular function&#46; Etiological study revealed positive serology for parvovirus B19 and Ebstein-Barr virus&#46; His fever persisted despite triple antibiotic therapy&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">On the 15th day of hospital stay he was transferred to our center for placement of a VAD as a bridge to heart transplantation due to failure of conventional therapy&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Under inotropic therapy&#44; echocardiography confirmed a highly dilated left ventricle &#40;LVEDD<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>60<span class="elsevierStyleHsp" style=""></span>mm&#59; z-score<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>7&#46;5&#41;&#44; dilatation of the inferior vena cava &#40;8<span class="elsevierStyleHsp" style=""></span>mm&#41; and moderate mitral regurgitation&#46; LV end-systolic diameter &#40;LVESD&#41; was 49<span class="elsevierStyleHsp" style=""></span>mm &#40;z-score<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>9&#41; and LV ejection fraction &#40;LVEF&#41; was 30&#37;&#46; Right ventricular &#40;RV&#41; pressure and function were normal&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">A Berlin Heart Excor<span class="elsevierStyleSup">&#174;</span> was implanted&#44; with a 50-ml blood pump&#44; and two 9&#47;12-mm cannulas were introduced into the apical region of the left ventricle and the ascending aorta above the origin of the coronary arteries&#46; The aortic cannula was positioned at an angle of 85&#176; to the aorta&#46; The procedure was performed under cardiopulmonary bypass &#40;103<span class="elsevierStyleHsp" style=""></span>min&#41;&#59; the operation lasted three hours and was uneventful&#46; RV function was preserved and there were no signs of RV failure&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">The patient was extubated on the fifth day following implantation&#44; without complications&#44; and inotropic support was discontinued on the eighth day&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Rigorous anticoagulation control&#44; which is essential for the correct function of the assist device&#44; was maintained throughout the postoperative period&#46; Intravenous heparin perfusion was begun six hours after implantation at an initial dose of 20<span class="elsevierStyleHsp" style=""></span>U&#47;kg&#47;h&#44; which was then adjusted every six hours during the first week according to activated partial thromboplastin time and platelet count&#46; Thromboelastography was performed and levels of antithrombin III&#44; fibrinogen&#44; d-dimers&#44; platelets&#44; leukocytes and C-reactive protein were assessed daily&#46; Oral anticoagulation with warfarin was begun on the fifth postoperative day and heparin perfusion was discontinued once INR 3&#46;0&#8211;3&#46;5 was achieved&#46; There were no thromboembolic or bleeding complications&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">With regard to the infection&#44; high fever that was difficult to control persisted until the fifth postoperative day&#44; with positive inflammatory markers&#46; Broad-spectrum antibiotics were administered with a good response&#46; Microbiological exams were all negative&#46; On the 15th postoperative day the fever returned&#44; with positive inflammatory markers&#46; <span class="elsevierStyleItalic">Staphylococcus sanguis</span> was isolated from blood cultures and bronchial secretions and he was treated with antibiotics following antibiotic sensitivity testing&#44; with a good response&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Myocardial biopsy performed at the time of implantation showed moderate subendocardial fibroelastosis but no inflammatory infiltrate or thrombi&#44; but with one focus of myofibroblast proliferation and focal myocytolysis&#46;The following parameters were assessed by serial transthoracic echocardiography&#58; LVEF&#44; LVFS&#44; LVEDD&#44; LVESD&#44; LV outflow tract time&#47;velocity integral&#44; and degree of mitral regurgitation&#46; Progressive improvement in LV contractility was observed &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a>&#41;&#59; the pump frequency of the VAD was reduced to 30<span class="elsevierStyleHsp" style=""></span>cycles&#47;min and on the 19th day after implantation the patient was transferred to the ward&#46; On the 27th day LV function was assessed with the Berlin Heart Excor<span class="elsevierStyleSup">&#174;</span> stopped&#59; an increase in cardiac output was seen&#44; due to significantly increased heart rate&#44; and carvedilol was begun&#46; LV function was again assessed with the VAD stopped on the 34th day&#44; with good results&#46; Forty days after implantation&#44; after another course of levosimendan&#44; the Berlin Heart Excor<span class="elsevierStyleSup">&#174;</span> was explanted electively&#46; The postoperative period was uneventful&#46; He was extubated and inotropic support was withdrawn within 24 hours&#44; and he was transferred back to the ward on the fourth postoperative day&#46; The last echocardiogram before discharge showed LVEF of 60&#37; and LVEDD of 37 mm &#40;z-score<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#8722;0&#46;03&#41;&#46; The patient was discharged clinically asymptomatic on the 55th day of hospital stay and 15 days after withdrawal of the VAD&#44; medicated with furosemide&#44; spironolactone&#44; aspirin&#44; digoxin&#44; carvedilol and captopril&#46; Three months after discharge he was in NYHA class I&#44; with normal LVEF and being weaned from medication&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Discussion</span><p id="par0060" class="elsevierStylePara elsevierViewall">Viral myocarditis is rare in children and its clinical course is mostly benign&#44; but occasionally it can evolve to severe acute heart failure or to late dilated cardiomyopathy&#46; In such cases&#44; a VAD can act as a last-resort measure&#44; as a bridge to transplantation or recovery&#46; Several devices are available for adults and adolescents&#44; but for children with body surface area of less than 1&#46;20<span class="elsevierStyleHsp" style=""></span>m<span class="elsevierStyleSup">2</span> there are only two extracorporeal pulsatile alternatives&#58; the Berlin Heart Excor&#174; &#40;Berlin Heart AG&#44; Berlin&#44; Germany&#41; and the Medos HIA device &#40;Medos Medizintechnik AG&#44; Stolberg&#44; Germany&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> of which the more widely used is the Berlin Heart Excor&#174;&#46; This can be used in single- or biventricular mode&#59; in the former&#44; the pump has two chambers &#40;air and blood&#41; separated by a triple-layer polyurethane membrane&#44; with the air chamber connected to the main apparatus by a tube that transmits the air pressure pulse to move the membrane&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> The blood chamber is connected by two cannulas to the LV apex or the left atrium and the ascending aorta&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">There have been various advances in recent years in adapting VADs for use in pediatric patients&#44; particularly in size of cannulas&#44; chambers and connectors&#44; heparin coating of the blood pump inner surface&#44; and anticoagulant therapy&#44;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> and the technique can now be used at all ages from newborns to adults&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> The throughput of the device can be varied by regulating the pump frequency&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">First used in 1990&#44; the Berlin Heart Excor<span class="elsevierStyleSup">&#174;</span> had been implanted in 500 pediatric patients by May 2009&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0075" class="elsevierStylePara elsevierViewall">VAD implantation should be carefully planned and every effort should be made to begin ventricular assistance on an urgent rather than emergent basis&#44; before the onset of target-organ dysfunction or cardiogenic shock&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> As myocarditis is generally self-limiting and cardiac function usually recovers&#44; the use of ventricular assistance in children with severe ventricular dysfunction can be an effective and safe solution&#59; the VAD can remain in place for relatively long periods and can even avoid the need for transplantation&#46; Careful anticoagulation control is required to prevent thromboembolic complications&#44; and clinical and laboratory signs of infection must be closely monitored&#46; The timing for weaning from the device is of great importance&#59; cardiac function must be systematically assessed with the device both on and off&#44; and medical therapy must be optimized&#46; If the device is removed too soon&#44; there is a risk of LV failure necessitating a return to ventricular assistance&#44; while prolonging assistance longer than absolutely necessary carries a high risk of infection and thromboembolic events&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">In the case presented&#44; although the biopsy showed subendocardial fibrosis&#44; cardiac function recovered&#46; 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            0 => "Assisted circulation"
            1 => "Circulatory assist devices"
            2 => "Heart failure"
            3 => "Viral myocarditis"
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            0 => "Assist&#234;ncia ventricular externa"
            1 => "Berlin Heart Excor<span class="elsevierStyleSup">&#174;</span>"
            2 => "Insufici&#234;ncia card&#237;aca"
            3 => "Miocardite viral"
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        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Viral myocarditis can lead to heart failure that is refractory to medication&#46; In these cases&#44; a ventricular assist device is a good therapeutic option that can be used as a bridge to transplantation or recovery&#46; We describe the first case in Portugal of recovery with ventricular assistance after severe myocarditis&#46;</p> <span class="elsevierStyleSectionTitle">Case report</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A five-year-old boy with no previous cardiac disease presented with severe viral myocarditis&#44; refractory to medical treatment&#44; with positive serology for parvovirus B19 and Ebstein-Barr virus&#46; A Berlin Heart Excor<span class="elsevierStyleSup">&#174;</span> was implanted 15 days after diagnosis&#46; A biopsy at the time of implantation showed subendocardial fibrosis&#46; After 40 days of assistance ventricular function recovered and the device was explanted&#46; The patient was discharged from hospital 15 days later&#46;</p> <span class="elsevierStyleSectionTitle">Discussion</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Survival of children with ventricular assistance has improved significantly because of earlier implantation and coagulation monitoring&#46; The presence of subendocardial fibrosis in the context of myocarditis is not a mandatory indication for transplantation&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Introdu&#231;&#227;o</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">A miocardite viral pode cursar com insufici&#234;ncia card&#237;aca refract&#225;ria &#224; medica&#231;&#227;o&#46; Nestes casos&#44; a assist&#234;ncia ventricular externa &#233; uma alternativa que pode ser usada como ponte para transplante ou para recupera&#231;&#227;o&#46; Descrevemos o primeiro caso em Portugal de recupera&#231;&#227;o da fun&#231;&#227;o ventricular ap&#243;s assist&#234;ncia ventricular por miocardite grave&#46;</p> <span class="elsevierStyleSectionTitle">Caso Cl&#237;nico</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Apresentamos o caso de uma crian&#231;a de cinco anos&#44; sexo masculino&#44; sem doen&#231;a card&#237;aca pr&#233;via&#44; com miocardite viral grave&#44; insufici&#234;ncia card&#237;aca refract&#225;ria &#224; medica&#231;&#227;o e serologias positivas para Parvov&#237;rus B19 e v&#237;rus Ebstein-Barr&#46; Foi implantado o Berlin Heart Excor<span class="elsevierStyleSup">&#174;</span> 15 dias ap&#243;s o diagn&#243;stico&#46; A biopsia card&#237;aca&#44; na altura da implanta&#231;&#227;o&#44; mostrava &#225;reas de fibrose subendoc&#225;rdica&#46; Verificou-se recupera&#231;&#227;o da fun&#231;&#227;o mioc&#225;rdica&#44; tendo sido retirada a assist&#234;ncia ventricular ap&#243;s 40 dias da implanta&#231;&#227;o&#46; O doente teve alta 15 dias depois&#46;</p> <span class="elsevierStyleSectionTitle">Discuss&#227;o</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">A sobrevida das crian&#231;as em assist&#234;ncia ventricular tem vindo a melhorar significativamente&#44; devido ao planeamento atempado e &#224; optimiza&#231;&#227;o da anti-coagula&#231;&#227;o&#46; A presen&#231;a de fibrose subendoc&#225;rdica no contexto de miocardite n&#227;o constitui uma indica&#231;&#227;o formal para transplante&#46;</p>"
      ]
    ]
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      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara">Please cite this article as&#58; Silva&#44; M&#46; Assist&#234;ncia ventricular esquerda numa crian&#231;a de cinco anos &#8211; ponte para recupera&#231;&#227;o num caso de miocardite viral&#46; Rev Port Cardiol&#46; 2012&#59;<span class="elsevierStyleBold">31&#40;7-8&#41;</span>&#58;521-524&#46;</p>"
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          "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Gradual improvement in cardiac function and reduction in left ventricular dilatation after implantation of the ventricular assist device&#46; The arrows indicate the days on which the device was implanted &#40;left&#41; and explanted &#40;right&#41;&#46; Admit&#58; day admitted&#59; D13 VAD&#44; D18 VAD&#44; D24 VAD&#58; 13th&#44; 18th&#44; 24th day after implantation of the ventricular assist device&#59; D2 post-VAD&#44; D6 post-VAD&#44; D13 post-VAD&#58; 2nd&#44; 6th&#44; 13th day after explantation of the ventricular assist device&#46; LVEF&#58; left ventricular ejection fraction&#59; LVFS&#58; left ventricular fractional shortening&#59; LVEDD&#58; left ventricular end-diastolic diameter in parasternal long-axis M-mode&#59; TVI&#58; left ventricular outflow tract time&#47;velocity integral&#46;</p>"
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                      "titulo" => "Myocarditis in infants and children&#58; a review for the paediatrician"
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                        "tituloSerie" => "Paediatr Child Health"
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                  "referenciaCompleta" => "Berlin Heart GmbH&#46; Excor Pediatric &#8211; Medical Professionals&#46; <a class="elsevierStyleInterRef" href="http://www.berlinheart.com/englisch/medpro/excor-pediatric/">http&#58;&#47;&#47;www&#46;berlinheart&#46;com&#47;englisch&#47;medpro&#47;excor-pediatric&#47;</a>&#59; 2010 &#91;consulted on October 21&#93;&#46;"
                ]
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        "texto" => "<p id="par0095" class="elsevierStylePara elsevierViewall">We thank Nuno Raposo of the Cardiothoracic Surgery Department of Hospital de Santa Cruz&#46;</p>"
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Article information
ISSN: 21742049
Original language: English
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Revista Portuguesa de Cardiologia (English edition)
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