Arterial thrombosis and acute myocardial infarction with angiographically normal coronary arteries in a woman heterozygous for both factor V Leiden and prothrombin mutation

Gaspar, João; Benchimol, Cláudio; Gadelha, Telma; Penna, Guilherme Loures

doi:10.1016/S0870-2551(11)70016-6

Revista Portuguesa de Cardiologia (English edition)

ISSN: 2174-2049

The Portuguese Journal of Cardiology, the official journal of the Portuguese Society of Cardiology, was founded in 1982 with the aim of keeping Portuguese cardiologists informed through the publication of scientific articles on areas such as arrhythmology and electrophysiology, cardiovascular surgery, intensive care, coronary artery disease, cardiovascular imaging, hypertension, heart failure and cardiovascular prevention. The Journal is a monthly publication with high standards of quality in terms of scientific content and production. Since 1999 it has been published in English as well as Portuguese, which has widened its readership abroad. It is distributed to all members of the Portuguese Societies of Cardiology, Internal Medicine, Pneumology and Cardiothoracic Surgery, as well as to leading non-Portuguese cardiologists and to virtually all cardiology societies worldwide. It has been referred in Medline since 1987.

Indexed in:

Index Medicus/Medline, Science Citation Index Expanded/Journal of Citation Reports, Scopus

Thirteen years after her last thrombotic event, anticoagulation was discontinued in a patient with combined thrombophilia involving mutation in factor V and G20210A polymorphism of the prothrombin gene. The only history was of arterial thrombosis. Three months later she presented a transmural myocardial infarction caused by coronary thrombosis.

Keywords:

Arterial thrombosis

Myocardial infarction

Thrombophilia

Resumo

Após treze anos do último evento trombótico, a anticoagulação foi interrompida numa paciente com associação de trombofilia factor V de Leiden e gene mutante da protrombina G20210A. Ela possuía história de tromboses arteriais. Três meses após, a paciente apresentou enfarte transmural do miocárdio devido à trombose coronariana.

Palavras-chave:

Trombose arterial

Enfarte do miocárdio

Trombofilia

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