TY - JOUR T1 - Effect of beta-blocker dose on mortality after acute coronary syndrome JO - Revista Portuguesa de Cardiologia T2 - AU - Raposeiras-Roubin,Sergio AU - Abu-Assi,Emad AU - Caneiro-Queija,Berenice AU - Cobas-Paz,Rafael AU - Rioboo-Lestón,Lucía AU - García Rodríguez,Cristina AU - Giraldez Lemos,Cruz AU - Blanco Vidal,María AU - Ogando Guillán,Beatriz AU - Pérez Martínez,Isabel AU - Paredes-Galán,Emilio AU - Jimenez-Díaz,Víctor AU - Baz-Alonso,Jose Antonio AU - Calvo-Iglesias,Francisco AU - Íñiguez-Romo,Andrés SN - 08702551 M3 - 10.1016/j.repc.2017.06.022 DO - 10.1016/j.repc.2017.06.022 UR - https://revportcardiol.org/pt-effect-beta-blocker-dose-on-mortality-articulo-S0870255117302548 AB - IntroductionBeta-blocker doses that have been shown to be effective in randomized clinical trials are not commonly used in daily clinical practice. The aim of this study was to analyze whether there is a prognostic benefit of high rather than low doses of beta-blockers after an acute coronary syndrome (ACS). MethodsIn this retrospective cohort study, 2092 ACS patients discharged from hospital between June 2013 and January 2016 were classified according to the beta-blocker dose prescribed: high dose (≥50% of the target dose tested in clinical trials) and low dose (<50%). Two groups of 501 matched patients were obtained through propensity score matching according to treatment with high or low doses of beta-blockers. The prognostic impact (mortality) during follow-up of high vs. low dose was analyzed by Cox regression and represented by Kaplan-Meier curves. ResultsOf the 2092 patients, 80.5% were discharged under beta-blockers, with lower mortality during follow-up (18.6±9.7 months). Of the 1685 patients discharged under beta-blockers, only 31.4% received high doses. There were no differences in mortality during follow-up between patients under high-dose vs. low-dose beta-blockers (HR 0.935, 95% CI 0.628-1.392, p=0.740), and the equivalence between the two doses remained after propensity score matching (HR 1.183, 95% CI 0.715-1.958, p=0.513). ConclusionNo prognostic benefit was found in terms of mortality for high-dose vs. low-dose beta-blockers after an ACS. ER -