Original articleWaist circumference, blood pressure, and lipid components of the metabolic syndrome
Section snippets
Subjects
Subjects consisted of healthy African-American (n = 70) and Caucasian (n = 97) youths who participated in various body composition and metabolic studies, some of whom have been reported previously.12, 13, 14 Study participants were recruited through the general media. The investigation was approved by the institutional review board. Parental informed consent and child assent were obtained from all subjects. All subjects were in good health on the basis of clinical history, physical examination,
Results
The subject characteristics are given in Table I. BMI percentile and WC were significantly (P < .05) associated with daytime and nighttime BP and with markers of dyslipidemia independent of race. In African-Americans and Caucasians, WC remained a significant (P < .05) correlate of daytime (r = .50 and .59) and nighttime (r = .49 and .62) systolic BP after controlling for BMI percentile. These relationships remained significant (P < .05) after further adjustment of height. In Caucasians alone,
Discussion
A growing body of evidence demonstrates that WC is an independent predictor of cardiovascular disease and insulin resistance in youths. Savva et al18 demonstrated that in European boys and girls, WC is a better predictor of BP, HDL, and LDL than BMI. We recently demonstrated that WC alone is a strong predictor of in vivo insulin sensitivity measured by the euglycemic clamp in African-American and Caucasian youths.12 In the Bogalusa Heart Study, central or abdominal fat deposition as assessed by
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Supported by the US Public Health Service (grants RO1-HD-27503, K24-HD-01357, and MO1-RR-00084), the General Clinical Research Center of Children’s Hospital of Pittsburgh, and Eli Lilly and Company.
None of the authors has any conflict of interest to declare.