Neuropeptide Y-induced coronary microvascular dysfunction: A significant contributor to the adverse outcomes in stress cardiomyopathy?

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The authors of this manuscript have certified that they comply with the Principles of Ethical Publishing in the International Journal of Cardiology [6].

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Cited by (11)

  • Impact of persistent ST elevation on outcome in patients with Takotsubo syndrome. Results from the GErman Italian STress Cardiomyopathy (GEIST) registry

    2018, International Journal of Cardiology
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    In this regard, it is of note that endothelin preferentially constricts the microcirculation [18] and it is also an independent predictor of the no-reflow phenomenon in ACS [19]. Moreover, due to sympathetic activation higher levels of neuropeptide-Y have been reported in TTS that may induce local microvascular constriction as well [20]. Another potential factor contributing to STE in TTS could be mechano-electric effects due to wall motion abnormalities causing an endo-epicardial tension gradient [21] which could be proved by ECG signs.

  • Neuropeptide y damages the integrity of mitochondrial structure and disrupts energy metabolism in cultured neonatal rat cardiomyocytes

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    The actions of endogenous NPY on energy intake are likely far more complex in vivo than any model described to this point [1,35]. The role of NPY in cardiomyopathy-associated diseases has been garnered more attention and necessary studies in the various types of cardiomyopathies including stress cardiomyopathy [14,38], diabetic cardiomyopathy [39], ischemic cardiomyopathy, restrictive cardiomyopathy, inflammatory cardiomyopathy, and so on [11]. Demonstration of an association with the peptide is an essential first step in proving causality or establishing a role as a contributing factor in the many diseases.

  • Role of neuropeptides in cardiomyopathies

    2014, Peptides
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    NPY is potent vasoconstrictor. Its release can induce intense coronary vessels spasm and repeated episodes of coronary spasm can lead to focal cardiomyocyte injury which is consistent with the histopathologic changes associated with stress cardiomyopathy [71]. Diabetic cardiomyopathy refers to a condition which affects the myocardium in some persons with diabetes mellitus.

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