Genetic and environmental risk factors for atherosclerosis regulate transcription of phosphatase and actin regulating gene PHACTR1
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Graphical abstract
Keywords
Myocardial infarction
Atherosclerosis
Functional genomics
Genetic polymorphism
Genomics
Low-density lipoprotein (LDL)
Genetic disease
PHACTR1
Expression quantitative trait locus (eQTL)
Oxidized low density lipoprotein (oxLDL)
Abbreviations
CAD
coronary artery disease
GWAS
genome wide association studies
SNP
single nucleotide polymorphism
PHACTR1
phosphatase and actin regulator 1
oxLDL
oxidized low density lipoprotein
PP1
protein phosphatase 1
PBMC
peripheral blood mononuclear cells
TSS
transcription start site
RACE
rapid amplification of cDNA ends
HAEC
human aortic endothelial cells
LPS
lipopolysaccharide
NLS
nuclear localization signal
DAB
diaminobenzidine
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© 2016 The Authors. Published by Elsevier Ireland Ltd.