CardiomyopathyPrognostic Usefulness of the Ballooning Pattern in Patients With Takotsubo Cardiomyopathy
Section snippets
Methods
Consecutive patients with TTC presenting to the University of Leipzig–Heart Center from January 2005 to December 2013 or the University Heart Center of Lübeck from February 2004 to April 2014 were prospectively identified and included in the trial. TTC was diagnosed based on the Mayo Clinic criteria.1 Coronary angiography was performed in all patients to exclude significant obstructive coronary artery disease (>50%) or evidence of acute plaque rupture. Furthermore, all patients underwent left
Results
TTC was diagnosed in 286 patients presenting to the 2 tertiary care centers during the study period. One patient demonstrated isolated right ventricular ballooning and was excluded from the study, resulting in 285 patients with TTC in the final analysis. Diagnosis confirmation through cardiovascular magnetic resonance was available in 125 patients (44%) and demonstrated focal myocardial edema in 89% and subtle fibrosis or necrosis (3 standard deviations above remote myocardium) in 9% of
Discussion
The present study compared short-term and long-term mortality rates in patients with TTC with typical and atypical ballooning patterns. The data show that typical apical ballooning is associated with more severe LV dysfunction and higher mortality rates within the first 6 months after the initial event. Thereafter, LV function has recovered completely in patients with typical and in those with atypical TTC resulting in a similar prognosis.
The distinctive LV contraction pattern with apical
Disclosures
The authors have no conflicts of interest to disclose.
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