Coronary Artery DiseasePatterns of Cardiovascular Mortality for HIV-Infected Adults in the United States: 1999 to 2013
Section snippets
Methods
We conducted the analysis using the publicly available detailed mortality database from the Centers for Disease Control and Prevention (CDC) Wide-Ranging Online Data for Epidemiologic Research (WONDER). The CDC WONDER database has been described previously and used for large epidemiologic studies published in recent years.17, 18, 19 The detailed mortality database within CDC WONDER consists of county-level national mortality and population data on the basis of death certificates of US
Results
Characteristics of the HIV-infected and general populations of persons aged 25 years and older at the time of death are provided in Table 1. Compared with the general population, HIV-infected subjects dying from CVD were more likely to be men, black, younger, urban-dwelling, and to have died in a medical facility. Among HIV-infected persons dying from any cause, those dying from CVD tended to be older.
For the overall HIV-infected population, CVD mortality increased from 1999 to 2013 but total
Discussion
In this study, we used a national US database of mortality data and found that the proportion of deaths related to CVD increased more than twofold in HIV-infected subjects between 1999 and 2013. This pattern was particularly apparent in men and contrasts sharply against the decrease in proportionate CVD-related mortality for the general US population and patients with inflammatory polyarthropathies during the same period. The increase in proportionate CVD mortality in HIV-infected persons is
Acknowledgment
The authors thank the Centers for Disease Control and Prevention (CDC) for the publicly available data from the CDC WONDER online database (http://wonder.cdc.gov/).
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