Coronary Artery DiseaseComparison of Epicardial Adipose Tissue Volume and Coronary Artery Disease Severity in Asymptomatic Adults With Versus Without Diabetes Mellitus
Section snippets
Methods
Coronary computed tomography angiograms (CTAs) were used from the CTRAD study (Cardiac CT's Role in Asymptomatic Patients with DM-II) in which consecutive asymptomatic patients (n = 203) with type II DM from 3 community clinics of the University of California, Irvine, were randomly assigned to either undergo 64-slice computed tomography (CT) angiography or continue their usual care. Type II DM was defined as a fasting blood glucose of ≥126 mg/dl, a physician-documented diagnosis of DM, current
Results
Table 1 describes the clinical characteristics of the 362 study patients, of which 92 (25.4%) were patients with DM who had no symptoms of CAD and 270 asymptomatic patients without DM (non-DM). The mean age in the DM group and non-DM group were 56.2 ± 9.5 and 57.2 ± 9.7 years, respectively. In the DM group, 57.9% of the patients were women as were 60% of the patients in the non-DM group. The mean BMI for participants with DM and without DM was statistically significantly different (p <0.0001).
Discussion
CAD and its complications continue to be the leading cause of the death in the United States and in many countries abroad.13 With the obesity epidemic, consequent insulin resistance, and the increased prevalence of type II DM, death from CAD will remain high for the foreseeable future. Traditional markers of obesity including BMI rely on the global burden of body obesity, including less metabolically active subcutaneous generalized depots of adipose. There is a nonlinear association of BMI and
Disclosures
The authors have no conflicts of interest to disclose.
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Cited by (35)
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2018, Revista Portuguesa de CardiologiaCitation Excerpt :Epicardial adipose tissue (EAT) is the visceral fat depot covering the heart5 and can be measured with several imaging techniques including echocardiography, cardiac magnetic resonance imaging, or multidetector computed tomography.6 EAT thickness and volume have been associated with the severity and extent of atherosclerotic coronary artery disease.7–11 Increased EAT thickness is also strongly associated with increased cardiovascular disease, visceral obesity, subclinical atherosclerosis at multiple locations, and the metabolic syndrome,12–16 and is a useful parameter in predicting adverse cardiovascular events.17,18
We received grant funding from National Heart, Lung, Blood Institute (KHL097158A to S. Malik).
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