Coronary artery diseaseRelation of C-Reactive Protein to Coronary Collaterals in Patients With Stable Angina Pectoris and Coronary Artery Disease
Section snippets
Methods and Results
The patients included in this study were prospectively selected from a total of 3,021 consecutive patients who were referred for coronary angiography at our institution between November 2004 and April 2006. Inclusion criteria were stable angina pectoris with a stenosis of ≥90% in ≥1 coronary vessel. Exclusion criteria included (1) any known inflammatory, neoplastic or infectious disease, (2) treatment with steroids, immunosuppressive drugs or nonsteroidal anti-inflammatory drugs except for
Discussion
The results of the present prospective study demonstrate a graded inverse independent association between CRP levels and collateral development in patients with chronic stable angina pectoris. These findings are consistent with several recent reports. Seiler et al8 demonstrated that tumor necrosis factor-α was detectable more often in patients with insufficient collaterals compared with those with sufficient collaterals. Guray et al9 reported an association between poor coronary collateral
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