Clinical InvestigationValvular and Congenital Heart DiseaseExcess mortality and morbidity in patients surviving infective endocarditis
Section snippets
Study population
This study took place in the Cardiology Department of La Timone Hospital, Marseille, France, a University-affiliated medical center for adults. In this center, a specific database was created in 1992 to prospectively collect information on the patients with a suspected diagnosis of IE.
From January 2002 to December 2008, all consecutive patients admitted with a first definite diagnosis of IE according to the modified Duke criteria21 were eligible for participation in the study. Among these, only
Patients
The study flow chart is presented in Figure 1. The study population ultimately included 328 patients. Their baseline characteristics are summarized in Table I. The 328 patients were followed up for 731 person-years (median, 2.2 years; range, 6 days to 7 years).
Survival
Fifty-five patients (16.8%) died during the follow up. Among them, 21 were women and 34 were men. The cause of death was unknown in 11 patients; known causes of death included cancer (n = 11), heart failure (n = 11), new sepsis (n = 10 [8
Discussion
Using a relative survival approach, we demonstrated IE excess mortality and morbidity, especially during the first year after hospital discharge. We identified comorbidity, recurrence, and aortic IE localization in women as predictors of this excess mortality.
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Cited by (99)
Infective endocarditis in paediatrics
2022, Paediatrics and Child Health (United Kingdom)Emergency Considerations of Infective Endocarditis
2022, Emergency Medicine Clinics of North AmericaInfective endocarditis: Epidemiology and prognosis
2022, Revista Portuguesa de CardiologiaCitation Excerpt :If it is true that the European guidelines for prevention and treatment of IE recommend active surveillance of signs and symptoms of IE recurrence for 12 months after completion of treatment,2 the data on mortality risk among these patients in the short and long-term remain controversial. Some studies report that mortality is highest in the first year and then decreases, although it remains high compared to the general population.52,53 A Swedish study based on the entire population of the country with IE, showed that the increased risk of long-term mortality persists for more than 5 years after the IE episode.54
Epidemiology and pathophysiology of infective endocarditis
2022, Infective Endocarditis: A Multidisciplinary ApproachInfective endocarditis, is there a goal beyond antibiotics and surgery?
2021, European Journal of Internal MedicinePredictors of long-term mortality in left-sided infective endocarditis: an historical cohort study in 414 patients
2021, European Journal of Internal MedicineCitation Excerpt :Predictors of a poor 6/12 month prognosis are similarly represented by S. aureus infection, advanced age, embolism during the active disease phase, and contraindication to surgical therapy of IE [9]. Fewer data are available concerning long-term outcome of IE (i.e. beyond 1 year from IE clinical onset) [4,5,8,10-16]. Age at IE onset, heart failure and prior comorbidities appeared to play a role in influencing long-term prognosis.