TY - JOUR T1 - Post-procedural N-terminal pro-brain natriuretic peptide predicts one-year mortality after transcatheter aortic valve implantation JO - Revista Portuguesa de Cardiologia (English edition) T2 - AU - Vale,Nelson Carlos AU - Campante Teles,Rui AU - Madeira,Sérgio AU - Brito,João AU - Sousa Almeida,Manuel AU - Nolasco,Tiago AU - Abecasis,Joao AU - Rodrigues,Gustavo AU - Carmo,João AU - Furstenau,Maria AU - Ribeiras,Regina AU - Neves,José Pedro AU - Mendes,Miguel SN - 21742049 M3 - 10.1016/j.repce.2018.02.010 DO - 10.1016/j.repce.2018.02.010 UR - https://revportcardiol.org/en-post-procedural-n-terminal-pro-brain-natriuretic-peptide-articulo-S2174204918300230 AB - IntroductionNatriuretic peptides are ubiquitously used for diagnosis, follow-up and prognostic assessment in various heart conditions. N-terminal pro-brain natriuretic peptide (NT-proBNP) correlates with aortic stenosis severity, however its significance after transcatheter aortic valve implantation (TAVI) is not well established. AimWe aimed to assess the prognostic value of NT-proBNP at one year in patients undergoing TAVI. MethodsThis single-center retrospective analysis included 151 patients in whom both baseline and one-month post-procedure NT-proBNP were measured, from 206 consecutive patients undergoing TAVI between November 2008 and December 2014. The best cut-off values of both baseline and one-month post-TAVI NT-proBNP for one-year mortality were determined by receiver operating characteristic curve analysis. Independent predictors of one-year mortality were assessed by Cox regression. ResultsThe areas under the curve of baseline and post-procedural NT-proBNP for one-year mortality were 0.60 and 0.72, with the best cut-off values of 1350 and 2500 pg/ml, respectively. Atrial fibrillation, procedure-related major bleeding, baseline NT-proBNP higher than 1350 pg/ml, post-procedural NT-proBNP higher than 2500 pg/ml, higher creatinine and Society of Thoracic Surgeons score, and lower left ventricular ejection fraction were associated with one-year mortality. Only post-procedural NT-proBNP was independently and negatively associated with one-year survival (HR 5.9, 95% CI 1.6-21.7, p=0.008). ConclusionsBaseline NT-proBNP did not predict one-year mortality; on the other hand one-month post-procedural NT-proBNP higher than 2500 pg/ml may identify a high-risk subset of patients, allowing better management, care and hypothetically outcome. ER -