TY - JOUR T1 - The role of biomarkers in dilated cardiomyopathy: Assessment of clinical severity and reverse remodeling JO - Revista Portuguesa de Cardiologia (English edition) T2 - AU - Amorim,Sandra AU - Campelo,Manuel AU - Moura,Brenda AU - Martins,Elisabete AU - Rodrigues,João AU - Barroso,Isaac AU - Faria,Margarida AU - Guimarães,Tiago AU - Macedo,Filipe AU - Silva-Cardoso,José AU - Maciel,Maria Júlia SN - 21742049 M3 - 10.1016/j.repce.2017.02.017 DO - 10.1016/j.repce.2017.02.017 UR - https://revportcardiol.org/en-the-role-biomarkers-in-dilated-articulo-S217420491730288X AB - IntroductionBiomarkers in dilated cardiomyopathy (DCM) reflect various pathobiological processes, including neurohormonal activation, oxidative stress, matrix remodeling, myocyte injury and myocyte stretch. We assessed the role of biomarkers in clinical and echocardiographic parameters and in left ventricular (LV) reverse remodeling (LVRR). MethodsIn this prospective study of 50 DCM patients (28 men, aged 59±10 years) with LV ejection fraction (LVEF) <40%, LVRR was defined as an increase of >10 U in LVEF after optimal medical therapy. ResultsBaseline LVEF was 25.4±9.8% and LV end-diastolic diameter (LVEDD)/body surface area (BSA) was 34.2±4.5 mm/m2. LVRR occurred in 34% of patients within 17.6±15.6 months. No correlation was found between B-type natriuretic peptide (BNP), 25-hydroxyvitamin D (25(OH)D), CA-125, high-sensitivity C-reactive protein (hs-CRP), lipoprotein(a) [Lp(a)], noradrenaline, adrenaline, renin or aldosterone and LVRR. Patients in NYHA class III or IV, with pulmonary congestion or ankle edema, had higher CA-125, cystatin C, BNP and hs-CRP levels (p<0.05). CA-125 was correlated with BNP (r=0.61), hs-CRP (r=0.56) and uric acid (r=0.52) (all p=0.01). BNP correlated directly with LVEDD (r=0.49), LV volumes (r=0.51), pulmonary artery systolic pressure (PASP) (r=0.43) and E/e′ (r=0.31), and was inversely correlated with LVEF (r=-0.50) and e′ velocity (r=-0.32) (p<0.05). CA-125 was positively correlated with left atrial volume/BSA (r=0.46), E/A ratio (r=0.60) and PASP (r=0.49) (p<0.05). ConclusionsNo correlation was found between biomarkers and LVRR, but CA-125, BNP and hs-CRP were predictors of clinical severity and congestion. BNP correlated with parameters of systolic and diastolic dysfunction, while CA-125 correlated with measures of diastolic dysfunction. ER -